Atreleuton (BioDeep_00000837677)

   


代谢物信息卡片


Atreleuton

化学式: C16H15FN2O2S (318.0838)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C#CC1=CC=C(S1)CC2=CC=C(C=C2)F)N(C(=O)N)O
InChI: InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1

描述信息

D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors
C471 - Enzyme Inhibitor > C1322 - Lipooxygenase Inhibitor

同义名列表

1 个代谢物同义名

Atreleuton



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kerstin Hiesinger, Jan S Kramer, Sandra Beyer, Timon Eckes, Steffen Brunst, Cathrin Flauaus, Sandra K Wittmann, Lilia Weizel, Astrid Kaiser, Simon B M Kretschmer, Sven George, Carlo Angioni, Jan Heering, Gerd Geisslinger, Manfred Schubert-Zsilavecz, Achim Schmidtko, Denys Pogoryelov, Josef Pfeilschifter, Bettina Hofmann, Dieter Steinhilber, Stephanie Schwalm, Ewgenij Proschak. Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. Journal of medicinal chemistry. 2020 10; 63(20):11498-11521. doi: 10.1021/acs.jmedchem.0c00561. [PMID: 33044073]
  • Jean-Claude Tardif, Philippe L L'allier, Reda Ibrahim, Jean C Grégoire, Anna Nozza, Mariève Cossette, Simon Kouz, Marc-André Lavoie, Janie Paquin, Tilmann M Brotz, Rebecca Taub, Josephine Pressacco. Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome. Circulation. Cardiovascular imaging. 2010 May; 3(3):298-307. doi: 10.1161/circimaging.110.937169. [PMID: 20190281]
  • Yihong Qiu, James J Fort, Jay Trivedi, Armin H Gerhardt, Peter Mayer, Jacqueline Briskin, Robert J Schilling. Effect of physicochemical and formulation variables on the in vivo absorption of ABT-761. Drug development and industrial pharmacy. 2002 Mar; 28(3):287-95. doi: 10.1081/ddc-120002844. [PMID: 12026221]
  • J J Reid. ABT-761 (Abbott). Current opinion in investigational drugs (London, England : 2000). 2001 Jan; 2(1):68-71. doi: NULL. [PMID: 11527015]
  • S L Wong, J H Cavanaugh, J Qian, R Hansen, W M Awni. Lack of cytochrome P450 1A2 interaction effect of ABT-761 on the pharmacokinetics of theophylline. American journal of therapeutics. 1998 Sep; 5(5):303-6. doi: 10.1097/00045391-199809000-00005. [PMID: 10099073]
  • S L Wong, J Drajesk, M S Chang, G Witt, W M Awni. Dose-proportional pharmacokinetics of a new 5-lipoxygenase inhibitor, ABT-761, in healthy volunteers. Biopharmaceutics & drug disposition. 1998 Apr; 19(3):159-62. doi: 10.1002/(sici)1099-081x(199804)19:3<159::aid-bdd80>3.0.co;2-o. [PMID: 9569998]
  • S L Wong, J Drajesk, M Chang, C Lanni, G Witt, R Hansen, W M Awni. Pharmacokinetics and pharmacodynamics of single and multiple oral doses of a novel 5-lipoxygenase inhibitor (ABT-761) in healthy volunteers. Clinical pharmacology and therapeutics. 1998 Mar; 63(3):324-31. doi: 10.1016/s0009-9236(98)90164-3. [PMID: 9542476]
  • B Lehnigk, K F Rabe, G Dent, R S Herst, P J Carpentier, H Magnussen. Effects of a 5-lipoxygenase inhibitor, ABT-761, on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients. The European respiratory journal. 1998 Mar; 11(3):617-23. doi: NULL. [PMID: 9596112]
  • A T Hopper, D T Witiak, J Ziemniak. Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid. Journal of medicinal chemistry. 1998 Feb; 41(4):420-7. doi: 10.1021/jm970034q. [PMID: 9484493]
  • J Van Schoor, G F Joos, J C Kips, J F Drajesk, P J Carpentier, R A Pauwels. The effect of ABT-761, a novel 5-lipoxygenase inhibitor, on exercise- and adenosine-induced bronchoconstriction in asthmatic subjects. American journal of respiratory and critical care medicine. 1997 Mar; 155(3):875-80. doi: 10.1164/ajrccm.155.3.9117020. [PMID: 9117020]