Carisbamate (BioDeep_00000837675)
代谢物信息卡片
化学式: C9H10ClNO3 (215.0349)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(COC(=O)N)O)Cl
InChI: InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135966
- KEGGdrug: D06573
- PubChem: 6918474
- DrugBank: DB12338
- ChEMBL: CHEMBL2087003
- CAS: 194085-75-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Do Young Kim, Fang-Xiong Zhang, Stan T Nakanishi, Timothy Mettler, Ik-Hyun Cho, Younghee Ahn, Florian Hiess, Lina Chen, Patrick G Sullivan, S R Wayne Chen, Gerald W Zamponi, Jong M Rho. Carisbamate blockade of T-type voltage-gated calcium channels.
Epilepsia.
2017 04; 58(4):617-626. doi:
10.1111/epi.13710
. [PMID: 28230232] - Ravi Kanth Bhamidipati, Ramesh Mullangi, Nuggehally R Srinivas. Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Feb; 47(2):112-118. doi:
10.3109/00498254.2016.1166290
. [PMID: 27093131] - Martha Gonzalez, Peter Zannikos, Allitia DiBernardo, H Robert Brashear, Jay Ariyawansa. Effect of carisbamate on the pharmacokinetics and pharmacodynamics of warfarin in healthy participants.
Journal of clinical pharmacology.
2012 Sep; 52(9):1420-9. doi:
10.1177/0091270011415412
. [PMID: 22011511] - Kenneth Moore, Peter Zannikos, Bhavna Solanki, Andrew Greenspan, Tom Verhaeghe, H Robert Brashear. Effect of mild and moderate hepatic impairment on the pharmacokinetics and safety of carisbamate.
Journal of clinical pharmacology.
2012 May; 52(5):738-46. doi:
10.1177/0091270011403313
. [PMID: 21566203] - Clifford L Eastman, Derek R Verley, Jason S Fender, Tessandra H Stewart, Eytan Nov, Giulia Curia, Raimondo D'Ambrosio. Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.
The Journal of pharmacology and experimental therapeutics.
2011 Mar; 336(3):779-90. doi:
10.1124/jpet.110.175133
. [PMID: 21123672] - Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications.
Current neuropharmacology.
2010 Sep; 8(3):254-67. doi:
10.2174/157015910792246254
. [PMID: 21358975] - Peter Zannikos, Gerald Novak, Caiping Yao, Tom Verhaeghe, Monique A Franc, Bhavna Solanki, Meir Bialer. Pharmacokinetics of carisbamate (RWJ-333369) in healthy Japanese and Western subjects.
Epilepsia.
2009 Aug; 50(8):1850-9. doi:
10.1111/j.1528-1167.2009.02081.x
. [PMID: 19453703] - Rene Levy, Isabelle Ragueneau-Majlessi, Bhavna Solanki, Peter Zannikos, Caiping Yao, Gerald Novak. Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.
Epilepsy research.
2008 Mar; 79(1):22-30. doi:
10.1016/j.eplepsyres.2007.12.013
. [PMID: 18280116] - Dorothée G A Kasteleijn-Nolst Trenité, Jacqueline A French, Edouard Hirsch, Jean-Paul Macher, Bernd-Ulrich Meyer, Pascal A Grosse, Bassel W Abou-Khalil, William E Rosenfeld, Joop van Gerven, Gerald P Novak, Lucio Parmeggiani, Bernd Schmidt, David Gibson, Renzo Guerrini. Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled study.
Epilepsy research.
2007 May; 74(2-3):193-200. doi:
10.1016/j.eplepsyres.2007.03.012
. [PMID: 17448639] - G S J Mannens, J Hendrickx, C G M Janssen, S Chien, B Van Hoof, T Verhaeghe, M Kao, M F Kelley, I Goris, M Bockx, B Verreet, M Bialer, W Meuldermans. The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Apr; 35(4):554-65. doi:
10.1124/dmd.106.011940
. [PMID: 16936066] - Rao N V S Mamidi, Geert Mannens, Pieter Annaert, Jan Hendrickx, Ivo Goris, Mark Bockx, Cor G M Janssen, Mark Kao, Michael F Kelley, Willem Meuldermans. Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Apr; 35(4):566-75. doi:
10.1124/dmd.106.012336
. [PMID: 17220243]