Tetrathiomolybdate (BioDeep_00000837641)
代谢物信息卡片
Tetrathiomolybdate
化学式: H2MoS4-2 (227.8093422)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [SH-].[SH-].S=[Mo]=S
InChI: /p-2
描述信息
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
D064449 - Sequestering Agents > D002614 - Chelating Agents
D006133 - Growth Substances > D006131 - Growth Inhibitors
D004791 - Enzyme Inhibitors
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1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Rocío Ayelem Conforti, María Belén Delsouc, Ana Sofia Zabala, Sandra Silvina Vallcaneras, Marilina Casais. The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice.
Scientific reports.
2023 06; 13(1):10354. doi:
10.1038/s41598-023-37031-1. [PMID: 37365216] - Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka. Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
Life science alliance.
2022 03; 5(3):. doi:
10.26508/lsa.202101164. [PMID: 34857647] - María Belén Delsouc, Rocío Ayelem Conforti, Daiana Luján Vitale, Laura Alaniz, Pablo Pacheco, Sebastián Andujar, Sandra Silvina Vallcaneras, Marilina Casais. Antiproliferative and antiangiogenic effects of ammonium tetrathiomolybdate in a model of endometriosis.
Life sciences.
2021 Dec; 287(?):120099. doi:
10.1016/j.lfs.2021.120099. [PMID: 34715139] - Thomas Plitz, Lee Boyling. Metabolic disposition of WTX101 (bis-choline tetrathiomolybdate) in a rat model of Wilson disease.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Mar; 49(3):332-338. doi:
10.1080/00498254.2018.1443352. [PMID: 29460662] - Karl Heinz Weiss, Frederick K Askari, Anna Czlonkowska, Peter Ferenci, Jeff M Bronstein, Danny Bega, Aftab Ala, David Nicholl, Susan Flint, Lars Olsson, Thomas Plitz, Carl Bjartmar, Michael L Schilsky. Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase 2 study.
The lancet. Gastroenterology & hepatology.
2017 12; 2(12):869-876. doi:
10.1016/s2468-1253(17)30293-5. [PMID: 28988934] - Cristine L Chisholm, Haitao Wang, Ada Hang-Heng Wong, Guelaguetza Vazquez-Ortiz, Weiping Chen, Xiaoling Xu, Chu-Xia Deng. Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin.
Oncotarget.
2016 Dec; 7(51):84439-84452. doi:
10.18632/oncotarget.12992. [PMID: 27806319] - Wen-Jie Li, Chen Chen, Zhi-Fei You, Ren-Min Yang, Xiao-Ping Wang. Current Drug Managements of Wilson's Disease: From West to East.
Current neuropharmacology.
2016; 14(4):322-5. doi:
10.2174/1570159x14666151130222427. [PMID: 26639459] - Christina M Chan, Daniel K Langlois, John P Buchweitz, Andreas F Lehner, N Bari Olivier, Thomas H Herdt, Marc B Bailie, William D Schall. Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs.
American journal of veterinary research.
2015 May; 76(5):445-53. doi:
10.2460/ajvr.76.5.445. [PMID: 25909377] - Ji-Wei Zhang, Jun-Xiu Liu, Hai-Man Hou, Ding-Bang Chen, Li Feng, Chao Wu, Li-Ting Wei, Xun-Hua Li. Effects of tetrathiomolybdate and penicillamine on brain hydroxyl radical and free copper levels: a microdialysis study in vivo.
Biochemical and biophysical research communications.
2015 Feb; 458(1):82-5. doi:
10.1016/j.bbrc.2015.01.071. [PMID: 25634697] - Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison, Joseph F Quinn. Modulation of tau phosphorylation by environmental copper.
Translational neurodegeneration.
2014; 3(1):24. doi:
10.1186/2047-9158-3-24. [PMID: 25671100] - Z Mareček, R Brůha. [Wilsons disease].
Vnitrni lekarstvi.
2013 Jul; 59(7):578-83. doi:
. [PMID: 23909262] - Jianqing Lin, Marianna Zahurak, Tomasz M Beer, Charles J Ryan, George Wilding, Paul Mathew, Michael Morris, Jennifer A Callahan, Gilad Gordon, Steven D Reich, Michael A Carducci, Emmanuel S Antonarakis. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer.
Urologic oncology.
2013 Jul; 31(5):581-8. doi:
10.1016/j.urolonc.2011.04.009. [PMID: 21816640] - N F Suttle. Rates of change in liver copper concentration in cattle given a copper-deficient diet, with or without pre-treatment with tetrathiomolybdate, for evaluation of two parenteral copper supplements.
New Zealand veterinary journal.
2013 May; 61(3):154-8. doi:
10.1080/00480169.2012.721161. [PMID: 23013209] - Katrijn De Brucker, Anna Bink, Els Meert, Bruno P A Cammue, Karin Thevissen. Potentiation of antibiofilm activity of amphotericin B by superoxide dismutase inhibition.
Oxidative medicine and cellular longevity.
2013; 2013(?):704654. doi:
10.1155/2013/704654. [PMID: 24078861] - Ji Young Yoo, Jason Pradarelli, Amy Haseley, Jeffrey Wojton, Azeem Kaka, Anna Bratasz, Christopher A Alvarez-Breckenridge, Jun-Ge Yu, Kimerly Powell, Andrew P Mazar, Theodoros N Teknos, E Antonio Chiocca, Joseph C Glorioso, Matthew Old, Balveen Kaur. Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Sep; 18(18):4931-41. doi:
10.1158/1078-0432.ccr-12-0697. [PMID: 22753591] - N F Suttle. Responsiveness of prehaemolytic copper poisoning in sheep from a specific pathogen-free environment to a relatively high dose of tetrathiomolybdate.
The Veterinary record.
2012 Sep; 171(10):246. doi:
10.1136/vr.100722. [PMID: 22798346] - Neville F Suttle. Copper imbalances in ruminants and humans: unexpected common ground.
Advances in nutrition (Bethesda, Md.).
2012 Sep; 3(5):666-74. doi:
10.3945/an.112.002220. [PMID: 22983845] - Hao Wei, Wei-Jian Zhang, Timothy S McMillen, Renee C Leboeuf, Balz Frei. Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice.
Atherosclerosis.
2012 Aug; 223(2):306-13. doi:
10.1016/j.atherosclerosis.2012.06.013. [PMID: 22770994] - N F Suttle. Residual effects of Mycobacterium avium infection on susceptibility of sheep to copper toxicity and efficacy of treatment with tetrathiomolybdate.
The Veterinary record.
2012 Jul; 171(1):18. doi:
10.1136/vr.100716. [PMID: 22645152] - S R Gooneratne. Effects of clonidine and idazoxan on tetrathiomolybdate-induced copper and lysosomal enzyme excretion into sheep bile.
Research in veterinary science.
2012 Jun; 92(3):456-61. doi:
10.1016/j.rvsc.2011.04.013. [PMID: 21570700] - Ming Song, Zhanxiang Zhou, Theresa Chen, Jingwen Zhang, Craig J McClain. Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats.
The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):298-306. doi:
10.1124/jpet.111.184325. [PMID: 21784888] - Hao Wei, Balz Frei, Joseph S Beckman, Wei-Jian Zhang. Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo.
American journal of physiology. Heart and circulatory physiology.
2011 Sep; 301(3):H712-20. doi:
10.1152/ajpheart.01299.2010. [PMID: 21724870] - George J Brewer, Fred Askari, Robert B Dick, Julia Sitterly, John K Fink, Martha Carlson, Karen J Kluin, Matthew T Lorincz. Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine.
Translational research : the journal of laboratory and clinical medicine.
2009 Aug; 154(2):70-7. doi:
10.1016/j.trsl.2009.05.002. [PMID: 19595438] - Elaina M Gartner, Kent A Griffith, Quintin Pan, George J Brewer, Gwen F Henja, Sofia D Merajver, Mark M Zalupski. A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer.
Investigational new drugs.
2009 Apr; 27(2):159-65. doi:
10.1007/s10637-008-9165-9. [PMID: 18712502] - Limei Zhang, Josef Lichtmannegger, Karl H Summer, Samuel Webb, Ingrid J Pickering, Graham N George. Tracing copper-thiomolybdate complexes in a prospective treatment for Wilson's disease.
Biochemistry.
2009 Feb; 48(5):891-7. doi:
10.1021/bi801926e. [PMID: 19146437] - Ayako Tanaka, Hideaki Kaneto, Takeshi Miyatsuka, Kaoru Yamamoto, Kazutomi Yoshiuchi, Yoshimitsu Yamasaki, Iichiro Shimomura, Taka-Aki Matsuoka, Munehide Matsuhisa. Role of copper ion in the pathogenesis of type 2 diabetes.
Endocrine journal.
2009; 56(5):699-706. doi:
10.1507/endocrj.k09e-051. [PMID: 19461160] - Sarah A Lowndes, Avril Adams, Anthony Timms, Nita Fisher, Jon Smythe, Suzanne M Watt, Simon Joel, Fernando Donate, Carolyn Hayward, Steven Reich, Mark Middleton, Andrew Mazar, Adrian L Harris. Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008 Nov; 14(22):7526-34. doi:
10.1158/1078-0432.ccr-08-0315. [PMID: 19010871] - Guoqing Hou, Gerald D Abrams, Robert Dick, George J Brewer. Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis.
Translational research : the journal of laboratory and clinical medicine.
2008 Nov; 152(5):239-44. doi:
10.1016/j.trsl.2008.09.003. [PMID: 19010295] - Eiichi Tokuda, Shin-ichi Ono, Kumiko Ishige, Shunsuke Watanabe, Eriko Okawa, Yoshihisa Ito, Takashi Suzuki. Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis.
Experimental neurology.
2008 Sep; 213(1):122-8. doi:
10.1016/j.expneurol.2008.05.011. [PMID: 18617166] - Claudia Di Serio, Laura Doria, Silvia Pellerito, Igor Prudovsky, Isabella Micucci, Daniela Massi, Matteo Landriscina, Niccolò Marchionni, Giulio Masotti, Francesca Tarantini. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.
Cancer letters.
2008 Aug; 267(1):67-74. doi:
10.1016/j.canlet.2008.03.001. [PMID: 18400376] - Ming Song, Zhenyuan Song, Shirish Barve, Jingwen Zhang, Theresa Chen, Marcia Liu, Gavin E Arteel, George J Brewer, Craig J McClain. Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.
The Journal of pharmacology and experimental therapeutics.
2008 May; 325(2):409-16. doi:
10.1124/jpet.107.131227. [PMID: 18299419] - J Joseph, T Alleyne, A Adogwa. Marginally low copper causes lesions of the midbrain in animal models: the implications for man.
The West Indian medical journal.
2007 Dec; 56(6):481-6. doi:
NULL. [PMID: 18646489] - Victoria E Lee, Joshua M Schulman, Edward I Stiefel, Catherine Coyle Lee. Reversible precipitation of bovine serum albumin by metal ions and synthesis, structure and reactivity of new tetrathiometallate chelating agents.
Journal of inorganic biochemistry.
2007 Nov; 101(11-12):1707-18. doi:
10.1016/j.jinorgbio.2007.07.015. [PMID: 17804073] - Raffaella Soldi, Anna Mandinova, Krishnan Venkataraman, Timoty Hla, Mathew Vadas, Stuart Pitson, Maria Duarte, Irene Graziani, Vihren Kolev, Doreen Kacer, Aleksandr Kirov, Thomas Maciag, Igor Prudovsky. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway.
Experimental cell research.
2007 Sep; 313(15):3308-18. doi:
10.1016/j.yexcr.2007.05.031. [PMID: 17643421] - V Medici, L Rossaro, G C Sturniolo. Wilson disease--a practical approach to diagnosis, treatment and follow-up.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2007 Jul; 39(7):601-9. doi:
10.1016/j.dld.2006.12.095. [PMID: 17382611] - Basil Hassouneh, Mozaffarul Islam, Thomas Nagel, Quintin Pan, Sofia D Merajver, Theodoros N Teknos. Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer.
Molecular cancer therapeutics.
2007 Mar; 6(3):1039-45. doi:
10.1158/1535-7163.mct-06-0524. [PMID: 17363496] - Aftab Ala, Ann P Walker, Keyoumars Ashkan, James S Dooley, Michael L Schilsky. Wilson's disease.
Lancet (London, England).
2007 Feb; 369(9559):397-408. doi:
10.1016/s0140-6736(07)60196-2. [PMID: 17276780] - Mark D McCubbin, Guoqing Hou, Gerald D Abrams, Robert Dick, Zhan Zhang, George J Brewer. Tetrathiomolybdate is effective in a mouse model of arthritis.
The Journal of rheumatology.
2006 Dec; 33(12):2501-6. doi:
NULL. [PMID: 17143984] - L Mandinov, K L Moodie, A Mandinova, Z Zhuang, F Redican, D Baklanov, V Lindner, T Maciag, M Simons, E D de Muinck. Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries.
American journal of physiology. Heart and circulatory physiology.
2006 Dec; 291(6):H2692-7. doi:
10.1152/ajpheart.00148.2006. [PMID: 16731651] - Valentina Medici, Carlo Pietro Trevisan, Maria Assunta Bigotto, Renata D'Incà, Diego Martines, Elisabetta Dal Pont, Giacomo Carlo Sturniolo. Adverse reaction after tetrathiomolybdate treatment for Wilson's disease: a case report.
Movement disorders : official journal of the Movement Disorder Society.
2006 Nov; 21(11):2030-2. doi:
10.1002/mds.21109. [PMID: 16991142] - S B Telfer, N R Kendall, D V Illingworth, A M Mackenzie. Caeruloplasmin: plasma copper ratios in cows.
The Veterinary record.
2006 Oct; 159(18):607-8; author reply 608. doi:
10.1136/vr.159.18.607-b. [PMID: 17071683] - N R Kendall, P Marsters, L Guo, R J Scaramuzzi, B K Campbell. Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro.
The Journal of endocrinology.
2006 Jun; 189(3):455-63. doi:
10.1677/joe.1.06278. [PMID: 16731777] - N Lynn Henry, Rodney Dunn, Sofia Merjaver, Quintin Pan, Kenneth J Pienta, George Brewer, David C Smith. Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer.
Oncology.
2006; 71(3-4):168-75. doi:
10.1159/000106066. [PMID: 17641535] - Guoqing Hou, Robert Dick, Gerald D Abrams, George J Brewer. Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice.
The Journal of laboratory and clinical medicine.
2005 Nov; 146(5):299-303. doi:
10.1016/j.lab.2005.07.004. [PMID: 16242529] - Sarah A Lowndes, Adrian L Harris. The role of copper in tumour angiogenesis.
Journal of mammary gland biology and neoplasia.
2005 Oct; 10(4):299-310. doi:
10.1007/s10911-006-9003-7. [PMID: 16924372] - George J Brewer. Copper lowering therapy with tetrathiomolybdate as an antiangiogenic strategy in cancer.
Current cancer drug targets.
2005 May; 5(3):195-202. doi:
10.2174/1568009053765807. [PMID: 15892619] - Atsushi Omoto, Yutaka Kawahito, Igor Prudovsky, Yasunori Tubouchi, Mizuho Kimura, Hidetaka Ishino, Makoto Wada, Makie Yoshida, Masataka Kohno, Rikio Yoshimura, Toshikazu Yoshikawa, Hajime Sano. Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats.
Arthritis research & therapy.
2005; 7(6):R1174-82. doi:
10.1186/ar1801. [PMID: 16277669] - George J Brewer. Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.
CNS drugs.
2005; 19(3):185-92. doi:
10.2165/00023210-200519030-00001. [PMID: 15740174] - Alexander V Lyubimov, Jeffry A Smith, Serge D Rousselle, Michael D Mercieca, Joseph E Tomaszewski, Adaline C Smith, Barry S Levine. The effects of tetrathiomolybdate (TTM, NSC-714598) and copper supplementation on fertility and early embryonic development in rats.
Reproductive toxicology (Elmsford, N.Y.).
2004 Dec; 19(2):223-33. doi:
10.1016/j.reprotox.2004.07.006. [PMID: 15501388] - Fred K Askari, Robert Dick, Maria Mao, George J Brewer. Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice.
Experimental biology and medicine (Maywood, N.J.).
2004 Sep; 229(8):857-63. doi:
10.1177/153537020422900820. [PMID: 15337842] - T F Lang, R Glynne-Jones, S Blake, A Taylor, J D S Kay. Iatrogenic copper deficiency following information and drugs obtained over the Internet.
Annals of clinical biochemistry.
2004 Sep; 41(Pt 5):417-20. doi:
10.1258/0004563041731574. [PMID: 15333197] - S Haywood, Z Dincer, B Jasani, M J Loughran. Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdate.
Journal of comparative pathology.
2004 Jan; 130(1):21-31. doi:
10.1016/s0021-9975(03)00065-3. [PMID: 14693121] - N R Kendall, P Marsters, R J Scaramuzzi, B K Campbell. Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media.
Reproduction (Cambridge, England).
2003 May; 125(5):657-65. doi:
10.1530/rep.0.1250657. [PMID: 12713428] - Bruce G Redman, Peg Esper, Quintin Pan, Rodney L Dunn, Hero K Hussain, Thomas Chenevert, George J Brewer, Sofia D Merajver. Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 May; 9(5):1666-72. doi:
NULL. [PMID: 12738719] - George J Brewer, Matthew R Ullenbruch, Robert Dick, Leovigildo Olivarez, Sem H Phan. Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice.
The Journal of laboratory and clinical medicine.
2003 Mar; 141(3):210-6. doi:
10.1067/mlc.2003.20. [PMID: 12624602] - Alexandra Herbik, Christian Bölling, Thomas J Buckhout. The involvement of a multicopper oxidase in iron uptake by the green algae Chlamydomonas reinhardtii.
Plant physiology.
2002 Dec; 130(4):2039-48. doi:
10.1104/pp.013060. [PMID: 12481087] - George J Brewer, Sofia D Merajver. Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper--a review.
Integrative cancer therapies.
2002 Dec; 1(4):327-37. doi:
10.1177/1534735402238185. [PMID: 14664727] - Kenneth L van Golen, LiWei Bao, George J Brewer, Kenneth J Pienta, Jeffrey M Kamradt, Donna L Livant, Sofia D Merajver. Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma.
Neoplasia (New York, N.Y.).
2002 Sep; 4(5):373-9. doi:
10.1038/sj.neo.7900258. [PMID: 12192595] - Mimi Liu, Elisabeth J Cohen, George J Brewer, Peter R Laibson. Kayser-Fleischer ring as the presenting sign of Wilson disease.
American journal of ophthalmology.
2002 Jun; 133(6):832-4. doi:
10.1016/s0002-9394(02)01408-3. [PMID: 12036681] - Jason D Czachor, M George Cherian, James Koropatnick. Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.
Journal of inorganic biochemistry.
2002 Jan; 88(2):213-22. doi:
10.1016/s0162-0134(01)00383-x. [PMID: 11803042] - Andrew K Vine, George J Brewer. Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration.
Transactions of the American Ophthalmological Society.
2002; 100(?):73-6; discussion 76. doi:
NULL. [PMID: 12545680] - E K Quagraine, H B Kraatz, R S Reid. Peptides mimicking the N-terminal Cu(II)-binding site of bovine serum albumin: synthesis, characterization and coordination with Cu(II) ions.
Journal of inorganic biochemistry.
2001 May; 85(1):23-32. doi:
10.1016/s0162-0134(00)00227-0. [PMID: 11377692] - E K Quagraine, R S Reid. UV/visible spectrophotometric studies of the interactions of thiomolybdates, copper(II) and other ligands.
Journal of inorganic biochemistry.
2001 May; 85(1):53-60. doi:
10.1016/s0162-0134(00)00223-3. [PMID: 11377695] - C Cox, T N Teknos, M Barrios, G J Brewer, R D Dick, S D Merajver. The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma.
The Laryngoscope.
2001 Apr; 111(4 Pt 1):696-701. doi:
10.1097/00005537-200104000-00024. [PMID: 11359142] - Y Komatsu, I Sadakata, Y Ogra, K T Suzuki. Excretion of copper complexed with thiomolybdate into the bile and blood in LEC rats.
Chemico-biological interactions.
2000 Feb; 124(3):217-31. doi:
10.1016/s0009-2797(99)00159-3. [PMID: 10728780] - Y Ogra, H Chikusa, K T Suzuki. Metabolic fate of the insoluble copper/tetrathiomolybdate complex formed in the liver of LEC rats with excess tetrathiomolybdate.
Journal of inorganic biochemistry.
2000 Jan; 78(2):123-8. doi:
10.1016/s0162-0134(99)00218-4. [PMID: 10766335] - G J Brewer, R D Dick, D K Grover, V LeClaire, M Tseng, M Wicha, K Pienta, B G Redman, T Jahan, V K Sondak, M Strawderman, G LeCarpentier, S D Merajver. Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2000 Jan; 6(1):1-10. doi:
NULL. [PMID: 10656425] - Y Ogra, Y Komada, K T Suzuki. Comparative mechanism and toxicity of tetra- and dithiomolybdates in the removal of copper.
Journal of inorganic biochemistry.
1999 Jun; 75(3):199-204. doi:
10.1016/s0162-0134(99)00057-4. [PMID: 10474204] - N Sugawara, T Ikeda, Y R Lai, C Sugawara. The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon rat, a bona fide animal model for Wilson's disease.
Pharmacology & toxicology.
1999 May; 84(5):211-7. doi:
10.1111/j.1600-0773.1999.tb01485.x. [PMID: 10361977] - N Sugawara, Y R Lai, C Sugawara. Therapeutic effects of tetrathiomolybdate on hepatic dysfunction occurring naturally in Long-Evans Cinnamon (LEC) rats: a bona fide animal model for Wilson's disease.
Research communications in molecular pathology and pharmacology.
1999 Feb; 103(2):177-87. doi:
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Journal of inorganic biochemistry.
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