Florbetapir F-18 (BioDeep_00000837640)
代谢物信息卡片
Florbetapir F-18
化学式: C20H25FN2O3 (360.1849112)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC1=CC=C(C=C1)C=CC2=CN=C(C=C2)OCCOCCOCCF
InChI: InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1
描述信息
V - Various > V09 - Diagnostic radiopharmaceuticals > V09A - Central nervous system
C1446 - Radiopharmaceutical Compound > C2124 - Radioconjugate
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:66880
- KEGGdrug: D09617
- PubChem: 24822371
- DrugBank: DB09149
- ChEMBL: CHEMBL1774461
- CAS: 956103-76-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kun He, Binyin Li, Lin Huang, Jun Zhao, Fengchun Hua, Tao Wang, Junpeng Li, Jie Wang, Qi Huang, Keliang Chen, Shasha Xu, Shuhua Ren, Huawei Cai, Donglang Jiang, Jingchao Hu, Xingmin Han, Yihui Guan, Kewei Chen, Qihao Guo, Fang Xie. Positive rate and quantification of amyloid pathology with [18F]florbetapir in the urban Chinese population.
European radiology.
2024 May; 34(5):3331-3341. doi:
10.1007/s00330-023-10366-z. [PMID: 37889270] - Alexis Moscoso, Jesús Silva-Rodríguez, Jose Manuel Aldrey, Julia Cortés, Juan Manuel Pías-Peleteiro, Álvaro Ruibal, Pablo Aguiar. 18F-florbetapir PET as a marker of myelin integrity across the Alzheimer's disease spectrum.
European journal of nuclear medicine and molecular imaging.
2022 03; 49(4):1242-1253. doi:
10.1007/s00259-021-05493-y. [PMID: 34581847] - Felix D Nguyen, Mario Rodriguez, Chayakrit Krittanawong, Ronald Witteles, Daniel J Lenihan. Misconceptions and Facts About Cardiac Amyloidosis.
The American journal of cardiology.
2021 12; 160(?):99-105. doi:
10.1016/j.amjcard.2021.08.045. [PMID: 34610875] - Sander Cj Verfaillie, Sandeep Sv Golla, Tessa Timmers, Hayel Tuncel, Chris Wj van der Weijden, Patrick Schober, Robert C Schuit, Wiesje M van der Flier, Albert D Windhorst, Adriaan A Lammertsma, Bart Nm van Berckel, Ronald Boellaard. Repeatability of parametric methods for [18F]florbetapir imaging in Alzheimer's disease and healthy controls: A test-retest study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2021 03; 41(3):569-578. doi:
10.1177/0271678x20915403. [PMID: 32321347] - Grazia Daniela Femminella, Denise Harold, James Scott, Julie Williams, Paul Edison. The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2021; 79(1):127-139. doi:
10.3233/jad-200578. [PMID: 33216025] - Breton M Asken, Fanny M Elahi, Renaud La Joie, Amelia Strom, Adam M Staffaroni, Cutter A Lindbergh, Alexandra C Apple, Michelle You, Sophia Weiner-Light, Nivetha Brathaban, Nicole Fernandes, Anna Karydas, Paul Wang, Julio C Rojas, Adam L Boxer, Bruce L Miller, Gil D Rabinovici, Joel H Kramer, Kaitlin B Casaletto. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Journal of Alzheimer's disease : JAD.
2020; 78(1):265-276. doi:
10.3233/jad-200755. [PMID: 32986672] - Sandeep Sv Golla, Sander Cj Verfaillie, Ronald Boellaard, Sofie M Adriaanse, Marissa D Zwan, Robert C Schuit, Tessa Timmers, Colin Groot, Patrick Schober, Philip Scheltens, Wiesje M van der Flier, Albert D Windhorst, Bart Nm van Berckel, Adriaan A Lammertsma. Quantification of [18F]florbetapir: A test-retest tracer kinetic modelling study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2019 11; 39(11):2172-2180. doi:
10.1177/0271678x18783628. [PMID: 29897009] - Eric C Ehman, M Samir El-Sady, Marie F Kijewski, Yiu Ming Khor, Sophia Jacob, Frederick L Ruberg, Vaishali Sanchorawala, Heather Landau, Andrew J Yee, Giada Bianchi, Marcelo F Di Carli, Rodney H Falk, Hyewon Hyun, Sharmila Dorbala. Early Detection of Multiorgan Light-Chain Amyloidosis by Whole-Body 18F-Florbetapir PET/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2019 09; 60(9):1234-1239. doi:
10.2967/jnumed.118.221770. [PMID: 30954943] - Itziar de Rojas, J Romero, O Rodríguez-Gomez, P Pesini, A Sanabria, A Pérez-Cordon, C Abdelnour, I Hernández, M Rosende-Roca, A Mauleón, L Vargas, M Alegret, A Espinosa, G Ortega, S Gil, M Guitart, A Gailhajanet, M A Santos-Santos, Sonia Moreno-Grau, O Sotolongo-Grau, S Ruiz, L Montrreal, E Martín, E Pelejà, F Lomeña, F Campos, A Vivas, M Gómez-Chiari, M A Tejero, J Giménez, V Pérez-Grijalba, G M Marquié, G Monté-Rubio, S Valero, A Orellana, L Tárraga, M Sarasa, A Ruiz, M Boada. Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI).
Alzheimer's research & therapy.
2018 11; 10(1):119. doi:
10.1186/s13195-018-0444-1. [PMID: 30497535] - Claudie Hooper, Philipe De Souto Barreto, Christelle Cantet, Matteo Cesari, Pierre Payoux, Anne Sophie Salabert, Bruno Vellas. Chronically raised C-reactive protein is inversely associated with cortical β-amyloid in older adults with subjective memory complaints.
Experimental gerontology.
2018 07; 108(?):226-230. doi:
10.1016/j.exger.2018.04.014. [PMID: 29704641] - T Wagner, J Page, M Burniston, A Skillen, J C Ross, R Manwani, D McCool, P N Hawkins, Ashutosh D Wechalekar. Extracardiac 18F-florbetapir imaging in patients with systemic amyloidosis: more than hearts and minds.
European journal of nuclear medicine and molecular imaging.
2018 07; 45(7):1129-1138. doi:
10.1007/s00259-018-3995-2. [PMID: 29651545] - Fati Nourhashemi, Claudie Hooper, Christelle Cantet, Catherine Féart, Isabelle Gennero, Pierre Payoux, Anne Sophie Salabert, Sophie Guyonnet, Philipe De Souto Barreto, Bruno Vellas. Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia.
Alzheimer's research & therapy.
2018 04; 10(1):43. doi:
10.1186/s13195-018-0371-1. [PMID: 29695305] - Kuan-Yi Wu, Ing-Tsung Hsiao, Chia-Hsiang Chen, Chia-Yih Liu, Jung-Lung Hsu, Sheng-Yao Huang, Tzu-Chen Yen, Kun-Ju Lin. Plasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder.
Scientific reports.
2018 02; 8(1):2739. doi:
10.1038/s41598-018-21140-3. [PMID: 29426824] - Chiho Shoda, Yorihisa Kitagawa, Hiroyuki Shimada, Mitsuko Yuzawa, Amane Tateno, Yoshiro Okubo. Relationship of Area of Soft Drusen in Retina with Cerebral Amyloid-β Accumulation and Blood Amyloid-β Level in the Elderly.
Journal of Alzheimer's disease : JAD.
2018; 62(1):239-245. doi:
10.3233/jad-170956. [PMID: 29439351] - I Moonga, F Niccolini, H Wilson, G Pagano, M Politis. Hypertension is associated with worse cognitive function and hippocampal hypometabolism in Alzheimer's disease.
European journal of neurology.
2017 09; 24(9):1173-1182. doi:
10.1111/ene.13374. [PMID: 28752644] - Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Leonie Wyffels, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Steven Deleye, Tobi Van den Bossche, Sara Van Mossevelde, Sarah Ceyssens, Jan Versijpt, Sigrid Stroobants, Sebastiaan Engelborghs, Steven Staelens. Validation of the Semiquantitative Static SUVR Method for 18F-AV45 PET by Pharmacokinetic Modeling with an Arterial Input Function.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2017 09; 58(9):1483-1489. doi:
10.2967/jnumed.116.184481. [PMID: 28336779] - Nelson Leung, Marina Ramirez-Alvarado, Samih H Nasr, Bradley J Kemp, Geoffrey B Johnson. Detection of ALECT2 amyloidosis by positron emission tomography-computed tomography imaging with florbetapir.
British journal of haematology.
2017 04; 177(1):12. doi:
10.1111/bjh.14519. [PMID: 28107549] - Kuan-Yi Wu, Chia-Yih Liu, Cheng-Sheng Chen, Chia-Hsiang Chen, Ing-Tsung Hsiao, Chia-Ju Hsieh, Chin-Pang Lee, Tzu-Chen Yen, Kun-Ju Lin. Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study.
European journal of nuclear medicine and molecular imaging.
2016 Jun; 43(6):1067-76. doi:
10.1007/s00259-015-3291-3. [PMID: 26739329] - V K Ramanan, S L Risacher, K Nho, S Kim, S Swaminathan, L Shen, T M Foroud, H Hakonarson, M J Huentelman, P S Aisen, R C Petersen, R C Green, C R Jack, R A Koeppe, W J Jagust, M W Weiner, A J Saykin. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
Molecular psychiatry.
2014 Mar; 19(3):351-7. doi:
10.1038/mp.2013.19. [PMID: 23419831] - Wei Yin, Xue Zhou, Jinping Qiao, Lin Zhu. Study the pharmacokinetics of AV-45 in rat plasma and metabolism in liver microsomes by ultra-performance liquid chromatography with mass spectrometry.
Biomedical chromatography : BMC.
2012 May; 26(5):666-71. doi:
10.1002/bmc.1714. [PMID: 21932381]