Samidorphan (BioDeep_00000837633)

   


代谢物信息卡片


Samidorphan

化学式: C21H26N2O4 (370.1892)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC1CN2CCC34CC(=O)CCC3(C2CC5=C4C(=C(C=C5)C(=O)N)O)O
InChI: InChI=1S/C21H26N2O4/c22-19(26)15-4-3-13-9-16-21(27)6-5-14(24)10-20(21,17(13)18(15)25)7-8-23(16)11-12-1-2-12/h3-4,12,16,25,27H,1-2,5-11H2,(H2,22,26)/t16-,20-,21-/m1/s1

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist

同义名列表

1 个代谢物同义名

Samidorphan



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hesham Salem, Ebtihal Samir, Dina Z Mazen, Hoda Madian, Alshimaa E Elkhateeb, Manar Elaraby, Manar I Rasekh, Aliaa Gamal. Spectrofluorimetric first derivative synchronous approach for determination of olanzapine and samidorphan used for treatment of schizophrenia in pharmaceutical formulations and human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Jun; 274(?):121105. doi: 10.1016/j.saa.2022.121105. [PMID: 35272122]
  • Frederico G S Toledo, William F Martin, Linda Morrow, Carine Beysen, Daiva Bajorunas, Ying Jiang, Bernard L Silverman, David McDonnell, Mark N Namchuk, John W Newcomer, Christine Graham. Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022 02; 47(3):696-703. doi: 10.1038/s41386-021-01244-7. [PMID: 34887529]
  • Lei Sun, Zoe Barter, Lisa von Moltke, Karen Rowland Yeo. Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet. CPT: pharmacometrics & systems pharmacology. 2021 09; 10(9):1071-1080. doi: 10.1002/psp4.12675. [PMID: 34185436]
  • René S Kahn, Bernard L Silverman, Lauren DiPetrillo, Christine Graham, Ying Jiang, Jiani Yin, Adam Simmons, Vasudev Bhupathi, Bei Yu, Sergey Yagoda, Craig Hopkinson, David McDonnell. A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: Results from the ENLIGHTEN-2 long-term extension. Schizophrenia research. 2021 06; 232(?):45-53. doi: 10.1016/j.schres.2021.04.009. [PMID: 34015555]
  • Lei Sun, Lisa von Moltke, Karen Rowland Yeo. Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination. Clinical pharmacokinetics. 2021 05; 60(5):637-647. doi: 10.1007/s40262-020-00969-w. [PMID: 33313995]
  • Lei Sun, Sergey Yagoda, Hongqi Xue, Randy Brown, Narinder Nangia, David McDonnell, Bhaskar Rege, Lisa von Moltke, Borje Darpo. Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study. Progress in neuro-psychopharmacology & biological psychiatry. 2020 06; 100(?):109881. doi: 10.1016/j.pnpbp.2020.109881. [PMID: 32004636]
  • Lei Sun, Sergey Yagoda, Baiyun Yao, Christine Graham, Lisa von Moltke. Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate. Clinical drug investigation. 2020 Jan; 40(1):55-64. doi: 10.1007/s40261-019-00860-y. [PMID: 31584140]
  • Vipul Kumar, Hong Lu, Marjie Hard, Lisa von Moltke. Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age. Drugs in R&D. 2019 Sep; 19(3):277-287. doi: 10.1007/s40268-019-00280-5. [PMID: 31463821]
  • Lei Sun, David McDonnell, Miao Yu, Vipul Kumar, Lisa von Moltke. A Phase I Open-Label Study to Evaluate the Effects of Rifampin on the Pharmacokinetics of Olanzapine and Samidorphan Administered in Combination in Healthy Human Subjects. Clinical drug investigation. 2019 May; 39(5):477-484. doi: 10.1007/s40261-019-00775-8. [PMID: 30888624]
  • Sharon L Smith, Reginald L Dean, Mark S Todtenkopf, David J Heal. Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats. Journal of psychopharmacology (Oxford, England). 2019 03; 33(3):383-391. doi: 10.1177/0269881118822111. [PMID: 30676189]
  • Lei Sun, Sergey Yagoda, Yangchun Du, Lisa von Moltke. Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet. Drug design, development and therapy. 2019; 13(?):2941-2955. doi: 10.2147/dddt.s205000. [PMID: 31686778]
  • Lei Sun, David McDonnell, Lisa von Moltke. Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia. Clinical therapeutics. 2018 11; 40(11):1845-1854.e2. doi: 10.1016/j.clinthera.2018.09.002. [PMID: 30348514]
  • Mario P Sgro, Deah L Modlin, Daniel R Deaver, Mary J Kallman, Mark S Todtenkopf. Evaluation of samidorphan, a μ-opioid antagonist, in a drug discrimination assay in rats. Drug development research. 2018 08; 79(5):234-238. doi: 10.1002/ddr.21437. [PMID: 30188587]
  • Ryan Turncliff, Lauren DiPetrillo, Bernard Silverman, Elliot Ehrich. Single- and multiple-dose pharmacokinetics of samidorphan, a novel opioid antagonist, in healthy volunteers. Clinical therapeutics. 2015 Feb; 37(2):338-48. doi: 10.1016/j.clinthera.2014.10.001. [PMID: 25456560]