Nemorexant (BioDeep_00000837629)
代谢物信息卡片
化学式: C23H23ClN6O2 (450.1570928)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC2=C1N=C(N2)C3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl
InChI: InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1
描述信息
C78272 - Agent Affecting Nervous System > C142786 - Orexin Receptor Antagonist
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Martine Gehin, Jolanta Wierdak, Giancarlo Sabattini, Patricia N Sidharta, Jasper Dingemanse. Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist.
British journal of clinical pharmacology.
2022 02; 88(2):810-819. doi:
10.1111/bcp.15029. [PMID: 34371524] - Benjamin Berger, Clemens Muehlan, Gernot Klein, Jasper Dingemanse. Pharmacokinetics of daridorexant, a dual orexin receptor antagonist, are not affected by renal impairment.
Clinical and translational science.
2021 11; 14(6):2132-2138. doi:
10.1111/cts.13079. [PMID: 34121345] - Benjamin Berger, Jasper Dingemanse, Giancarlo Sabattini, Stéphane Delahaye, Urs Duthaler, Clemens Muehlan, Stephan Krähenbühl. Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist.
Clinical pharmacokinetics.
2021 10; 60(10):1349-1360. doi:
10.1007/s40262-021-01028-8. [PMID: 34002356] - Marie-Laure Boof, Jasper Dingemanse, Mareile Brunke, Albert Esselmann, Peter Heymer, Olaf Kestermann, Katharina Lederer, Ingo Fietze, Mike Ufer. Effect of the novel dual orexin receptor antagonist daridorexant on night-time respiratory function and sleep in patients with moderate chronic obstructive pulmonary disease.
Journal of sleep research.
2021 08; 30(4):e13248. doi:
10.1111/jsr.13248. [PMID: 33417730] - Uta Schilling, Andrea Henrich, Clemens Muehlan, Andreas Krause, Jasper Dingemanse, Mike Ufer. Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.
Clinical drug investigation.
2021 Aug; 41(8):711-721. doi:
10.1007/s40261-021-01062-1. [PMID: 34331678] - Marie-Laure Boof, Jasper Dingemanse, Katharina Lederer, Ingo Fietze, Mike Ufer. Effect of the new dual orexin receptor antagonist daridorexant on nighttime respiratory function and sleep in patients with mild and moderate obstructive sleep apnea.
Sleep.
2021 06; 44(6):. doi:
10.1093/sleep/zsaa275. [PMID: 33305817] - Benjamin Berger, Sander Brooks, Rob Zuiker, Muriel Richard, Clemens Muehlan, Jasper Dingemanse. Pharmacological Interactions between the Dual Orexin Receptor Antagonist Daridorexant and Ethanol in a Double-Blind, Randomized, Placebo-Controlled, Double-Dummy, Four-Way Crossover Phase I Study in Healthy Subjects.
CNS drugs.
2020 12; 34(12):1253-1266. doi:
10.1007/s40263-020-00768-8. [PMID: 33205362] - Clemens Muehlan, Margaux Boehler, Sander Brooks, Rob Zuiker, Joop van Gerven, Jasper Dingemanse. Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration.
Journal of psychopharmacology (Oxford, England).
2020 03; 34(3):326-335. doi:
10.1177/0269881119882854. [PMID: 31642731] - Clemens Muehlan, Hartmut Fischer, Dieter Zimmer, Hamed Aissaoui, Julien Grimont, Christoph Boss, Marie Croft, Joop van Gerven, Stephan Krähenbühl, Jasper Dingemanse. Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry.
Current drug metabolism.
2019; 20(4):254-265. doi:
10.2174/1389200220666190206141814. [PMID: 30727881]