VIBEGRON (BioDeep_00000837626)
代谢物信息卡片
化学式: C26H28N4O3 (444.2161)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(NC1CC2=CC=C(C=C2)NC(=O)C3CCC4=NC=CC(=O)N34)C(C5=CC=CC=C5)O
InChI: InChI=1S/C26H28N4O3/c31-24-14-15-27-23-13-12-22(30(23)24)26(33)29-19-8-6-17(7-9-19)16-20-10-11-21(28-20)25(32)18-4-2-1-3-5-18/h1-9,14-15,20-22,25,28,32H,10-13,16H2,(H,29,33)/t20-,21+,22-,25+/m0/s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:142418
- KEGGdrug: D10433
- PubChem: 44472635
- DrugBank: DB14895
- ChEMBL: CHEMBL2107826
- CAS: 1190389-15-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder.
International journal of urology : official journal of the Japanese Urological Association.
2021 Dec; 28(12):1298-1303. doi:
10.1111/iju.14696. [PMID: 34545632] - Masaki Yoshida, Masayuki Takeda, Momokazu Gotoh, Osamu Yokoyama, Hidehiro Kakizaki, Satoru Takahashi, Naoya Masumori, Shinji Nagai, Kazuyoshi Minemura. Cardiovascular safety of vibegron, a new β3-adrenoceptor agonist, in older patients with overactive bladder: Post-hoc analysis of a randomized, placebo-controlled, double-blind comparative phase 3 study.
Neurourology and urodynamics.
2021 08; 40(6):1651-1660. doi:
10.1002/nau.24732. [PMID: 34139038] - Keisuke Ishikawa, Akira Tsujimura, Miho Miyoshi, Yuto Miyoshi, Taiki Ogasa, Ippei Hiramatsu, Yuka Uesaka, Taiji Nozaki, Masato Shirai, Isao Mitsuhashi, Sosuke Sugimura, Taiki Mizuno, Kensho Noto, Yasuhiro Shigeta, Shinichi Honda, Shinji Iwata, Shigeo Horie. Efficacy and Safety of Vibegron Add-on Therapy in Men With Persistent Storage Symptoms After Receiving Alpha 1-Blocker or Phosphodiesterase 5 Inhibitor: A Preliminary Study.
Urology.
2021 07; 153(?):256-263. doi:
10.1016/j.urology.2021.01.021. [PMID: 33484823] - Taiki Kato, Kentaro Mizuno, Hidenori Nishio, Takahiro Yasui, Yutaro Hayashi. Urodynamic effectiveness of a beta-3 adrenoreceptor agonist (vibegron) for a pediatric patient with anticholinergic-resistant neurogenic detrusor overactivity: a case report.
Journal of medical case reports.
2021 Feb; 15(1):86. doi:
10.1186/s13256-020-02564-w. [PMID: 33602290] - Akira Furuta, Yasuyuki Suzuki, Taro Igarashi, Yusuke Koike, Takahiro Kimura, Shin Egawa, Naoki Yoshimura. Additive effects of intravenous and intravesical application of vibegron, a β3-adrenoceptor agonist, on bladder function in rats with bladder overactivity.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 11; 393(11):2073-2080. doi:
10.1007/s00210-020-01921-2. [PMID: 32556396] - Masaki Yoshida, Hidehiro Kakizaki, Satoru Takahashi, Shinji Nagai, Takafumi Kurose. Long-term safety and efficacy of the novel β3 -adrenoreceptor agonist vibegron in Japanese patients with overactive bladder: A phase III prospective study.
International journal of urology : official journal of the Japanese Urological Association.
2018 07; 25(7):668-675. doi:
10.1111/iju.13596. [PMID: 29752752] - Scott D Edmondson, Cheng Zhu, Nam Fung Kar, Jerry Di Salvo, Hiroshi Nagabukuro, Beatrice Sacre-Salem, Karen Dingley, Richard Berger, Stephen D Goble, Gregori Morriello, Bart Harper, Christopher R Moyes, Dong-Ming Shen, Liping Wang, Richard Ball, Aileen Fitzmaurice, Tara Frenkl, Loise N Gichuru, Sookhee Ha, Amanda L Hurley, Nina Jochnowitz, Dorothy Levorse, Shruty Mistry, Randy R Miller, James Ormes, Gino M Salituro, Anthony Sanfiz, Andra S Stevenson, Katherine Villa, Beata Zamlynny, Stuart Green, Mary Struthers, Ann E Weber. Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Journal of medicinal chemistry.
2016 Jan; 59(2):609-23. doi:
10.1021/acs.jmedchem.5b01372. [PMID: 26709102]
