Plazomicin (BioDeep_00000837620)
代谢物信息卡片
化学式: C25H48N6O10 (592.3431747999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CNCCO)N)N)NC(=O)C(CCN)O)O
InChI: InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10151
- PubChem: 42613186
- DrugBank: DB12615
- ChEMBL: CHEMBL1650559
- CAS: 1154757-24-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- William Earle, Ramón G B Bonegio, Donald B Smith, Westyn Branch-Elliman. Plazomicin for the treatment of multidrug-resistant Klebsiella bacteraemia in a patient with underlying chronic kidney disease and acute renal failure requiring renal replacement therapy.
BMJ case reports.
2021 Aug; 14(8):. doi:
10.1136/bcr-2021-243609. [PMID: 34413038] - Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics.
Bioorganic & medicinal chemistry letters.
2020 07; 30(13):127218. doi:
10.1016/j.bmcl.2020.127218. [PMID: 32360102] - Louis D Saravolatz, Gary E Stein. Plazomicin: A New Aminoglycoside.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 02; 70(4):704-709. doi:
10.1093/cid/ciz640. [PMID: 31328228] - Jonathan Gall, Taylor Choi, Valerie Riddle, Scott Van Wart, Jacqueline A Gibbons, Julie Seroogy. A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics.
Clinical pharmacology in drug development.
2019 11; 8(8):1032-1041. doi:
10.1002/cpdd.653. [PMID: 30650259] - Tomefa E Asempa, Joseph L Kuti, Julie D Seroogy, Allison S Komirenko, David P Nicolau. Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00148-19. [PMID: 31358580] - Taylor Choi, Allison S Komirenko, Valerie Riddle, Aryun Kim, Shyeilla V Dhuria. No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects.
Clinical pharmacology in drug development.
2019 08; 8(6):818-826. doi:
10.1002/cpdd.648. [PMID: 30605260] - Michael Trang, Julie D Seroogy, Scott A Van Wart, Sujata M Bhavnani, Aryun Kim, Jacqueline A Gibbons, Paul G Ambrose, Christopher M Rubino. Population Pharmacokinetic Analyses for Plazomicin Using Pooled Data from Phase 1, 2, and 3 Clinical Studies.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02329-18. [PMID: 30670433] - Allison S Komirenko, Valerie Riddle, Jacqueline A Gibbons, Scott Van Wart, Julie D Seroogy. A Phase 1 Study To Assess the Pharmacokinetics of Intravenous Plazomicin in Adult Subjects with Varying Degrees of Renal Function.
Antimicrobial agents and chemotherapy.
2018 12; 62(12):. doi:
10.1128/aac.01128-18. [PMID: 30275092] - Lynn E Connolly, Valerie Riddle, Deborah Cebrik, Eliana S Armstrong, Loren G Miller. A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.01989-17. [PMID: 29378708] - George Louis Drusano, Weiguo Liu, Steven Fikes, Ryan Cirz, Nichole Robbins, Stephanie Kurhanewicz, Jaime Rodriquez, David Brown, Dodge Baluya, Arnold Louie. Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model.
The Journal of infectious diseases.
2014 Oct; 210(8):1319-24. doi:
10.1093/infdis/jiu237. [PMID: 24760199] - Robert T Cass, Carter D Brooks, Nancy A Havrilla, Kenneth J Tack, Marie T Borin, Don Young, Jon B Bruss. Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects.
Antimicrobial agents and chemotherapy.
2011 Dec; 55(12):5874-80. doi:
10.1128/aac.00624-11. [PMID: 21911572]