Gefapixant (BioDeep_00000837615)

   


代谢物信息卡片


Gefapixant

化学式: C14H19N5O4S (353.11576940000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
InChI: InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)

描述信息

R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants
C78272 - Agent Affecting Nervous System > C177180 - P2X Purinoreceptor Antagonist
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis[1][2][3].

同义名列表

3 个代谢物同义名

Gefapixant; MK-7264; AF-219



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dong-Ping Wang, Meng Zhang, Ming Li, Xiao-Na Yang, Changzhu Li, Peng Cao, Michael X Zhu, Yun Tian, Ye Yu, Yun-Tao Lei. Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of Sivopixant/S-600918 and its analogue DDTPA. British journal of pharmacology. 2023 Nov; ?(?):. doi: 10.1111/bph.16273. [PMID: 37921202]
  • Chang-Run Guo, Zhong-Zhe Zhang, Xing Zhou, Meng-Yang Sun, Tian-Tian Li, Yun-Tao Lei, Yu-Hao Gao, Qing-Quan Li, Chen-Xi Yue, Yu Gao, Yi-Yu Lin, Cui-Yun Hao, Chang-Zhu Li, Peng Cao, Michael X Zhu, Ming-Qiang Rong, Wen-Hui Wang, Ye Yu. Chronic cough relief by allosteric modulation of P2X3 without taste disturbance. Nature communications. 2023 09; 14(1):5844. doi: 10.1038/s41467-023-41495-0. [PMID: 37730705]
  • Yan-Zhao Wei, Shuang Yang, Wei Li, Yan-Hong Tang. Gefapixant, a Novel P2X3 Antagonist, Protects against Post Myocardial Infarction Cardiac Dysfunction and Remodeling Via Suppressing NLRP3 Inflammasome. Current medical science. 2023 Jan; ?(?):. doi: 10.1007/s11596-022-2658-5. [PMID: 36622629]
  • Jacqueline B McCrea, Azher Hussain, Bennett Ma, Graigory C Garrett, Raymond Evers, John E Laabs, S Aubrey Stoch, Marian Iwamoto. Assessment of Pharmacokinetic Interaction Between Gefapixant (MK-7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin. Clinical pharmacology in drug development. 2022 03; 11(3):406-412. doi: 10.1002/cpdd.1047. [PMID: 34821075]
  • Jesse C Nussbaum, Azher Hussain, Bennett Ma, K Chris Min, Qing Chen, Charles Tomek, Marian Iwamoto, S Aubrey Stoch. Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans. Pharmacology research & perspectives. 2022 02; 10(1):e00924. doi: 10.1002/prp2.924. [PMID: 35106949]
  • Jesse C Nussbaum, Azher Hussain, Bennett Ma, K Chris Min, Raymond Evers, Yun Li, Graigory Garrett, S Aubrey Stoch, Marian Iwamoto. Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist. Clinical pharmacology in drug development. 2022 01; 11(1):123-128. doi: 10.1002/cpdd.988. [PMID: 34145987]
  • Brad Roadcap, Azher Hussain, Dan Dreyer, Keynu Carter, Neal Dube, Yang Xu, Melanie Anderson, Erwin Berthier, Faye Vazvaei, Kevin Bateman, Eric Woolf. Clinical application of volumetric absorptive microsampling to the gefapixant development program. Bioanalysis. 2020 Jul; 12(13):893-904. doi: 10.4155/bio-2020-0074. [PMID: 32648772]
  • Jin Wang, Yao Wang, Wen-Wen Cui, Yichen Huang, Yang Yang, Yan Liu, Wen-Shan Zhao, Xiao-Yang Cheng, Wang-Sheng Sun, Peng Cao, Michael X Zhu, Rui Wang, Motoyuki Hattori, Ye Yu. Druggable negative allosteric site of P2X3 receptors. Proceedings of the National Academy of Sciences of the United States of America. 2018 05; 115(19):4939-4944. doi: 10.1073/pnas.1800907115. [PMID: 29674445]
  • Kenneth A Jacobson, Christa E Müller. Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology. 2016 05; 104(?):31-49. doi: 10.1016/j.neuropharm.2015.12.001. [PMID: 26686393]
  • Fernando Ochoa-Cortes, Andromeda Liñán-Rico, Kenneth A Jacobson, Fievos L Christofi. Potential for developing purinergic drugs for gastrointestinal diseases. Inflammatory bowel diseases. 2014 Jul; 20(7):1259-87. doi: 10.1097/mib.0000000000000047. [PMID: 24859298]