Oliceridine (BioDeep_00000837602)
代谢物信息卡片
化学式: C22H30N2O2S (386.202788)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(SC=C1)CNCCC2(CCOC3(C2)CCCC3)C4=CC=CC=N4
InChI: InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3/t21-/m1/s1
描述信息
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
N - Nervous system > N02 - Analgesics > N02A - Opioids
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11214
- PubChem: 66553195
- DrugBank: DB14881
- ChEMBL: CHEMBL2443262
- CAS: 1401028-24-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk.
Heart rhythm.
2021 12; 18(12):2177-2186. doi:
10.1016/j.hrthm.2021.08.028. [PMID: 34481984] - Daniel A Hussar. New Drugs 2021, Part 2.
Nursing.
2021 Oct; 51(10):18-29. doi:
10.1097/01.nurse.0000791756.56705.dd. [PMID: 34580258] - Xuan Jiang, Shuxiang Li, Hongbin Zhang, Liang-Liang Wang. Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation.
Computational biology and chemistry.
2021 Feb; 90(?):107405. doi:
10.1016/j.compbiolchem.2020.107405. [PMID: 33184004] - Anne N Nafziger, Kelly A Arscott, Kristina Cochrane, Franck Skobieranda, David A Burt, Michael J Fossler. The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine.
Clinical pharmacology in drug development.
2020 07; 9(5):639-650. doi:
10.1002/cpdd.750. [PMID: 31697049] - Michael J Fossler, Brian M Sadler, Colm Farrell, David A Burt, Maria Pitsiu, Franck Skobieranda, David G Soergel. Oliceridine, a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model.
Journal of clinical pharmacology.
2018 06; 58(6):762-770. doi:
10.1002/jcph.1075. [PMID: 29393971] - Michael J Fossler, Brian M Sadler, Colm Farrell, David A Burt, Maria Pitsiu, Franck Skobieranda, David G Soergel. Oliceridine (TRV130), a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model.
Journal of clinical pharmacology.
2018 06; 58(6):750-761. doi:
10.1002/jcph.1076. [PMID: 29412458]