N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide (BioDeep_00000837598)
代谢物信息卡片
化学式: C14H21N5O2S (323.14158860000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3
InChI: InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)
描述信息
D - Dermatologicals > D11 - Other dermatological preparations > D11A - Other dermatological preparations > D11AH - Agents for dermatitis, excluding corticosteroids
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C172200 - JAK Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D11400
- PubChem: 78323835
- DrugBank: DB14973
- ChEMBL: CHEMBL3655081
- ChEMBL: CHEMBL4101725
- CAS: 1622902-68-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qingying He, Xin Xie, Qian Chen, Wenquan Li, Zongzhou Song, Xurui Wang, Xiao Ma, Jinhao Zeng, Jing Guo. Janus kinase inhibitors in atopic dermatitis: an umbrella review of meta-analyses.
Frontiers in immunology.
2024; 15(?):1342810. doi:
10.3389/fimmu.2024.1342810. [PMID: 38464512] - Weiwei Jiang, Xiuliang Ma, Tao Guo, Mengmeng Song, Junling Zhang. Abrocitinib-A promising option for patients with refractory bullous pemphigoid.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2024 Jan; 38(1):e119-e121. doi:
10.1111/jdv.19475. [PMID: 37653285] - Xiaoxing Wang, Martin E Dowty, Ann Wouters, Svitlana Tatulych, Carol A Connell, Vu H Le, Sakambari Tripathy, Melissa T O'Gorman, Jennifer A Winton, Natalie Yin, Hernan Valdez, Bimal K Malhotra. Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals.
European journal of drug metabolism and pharmacokinetics.
2022 May; 47(3):419-429. doi:
10.1007/s13318-021-00745-6. [PMID: 35226304] - Jessica Wojciechowski, Bimal K Malhotra, Xiaoxing Wang, Luke Fostvedt, Hernan Valdez, Timothy Nicholas. Population Pharmacokinetics of Abrocitinib in Healthy Individuals and Patients with Psoriasis or Atopic Dermatitis.
Clinical pharmacokinetics.
2022 05; 61(5):709-723. doi:
10.1007/s40262-021-01104-z. [PMID: 35061234] - Ellen Q Wang, Vu Le, Jennifer A Winton, Sakambari Tripathy, Sangeeta Raje, Lisy Wang, Martin E Dowty, Bimal K Malhotra. Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.
Journal of clinical pharmacology.
2022 04; 62(4):505-519. doi:
10.1002/jcph.1980. [PMID: 34637151] - Sakambari Tripathy, Daria Wentzel, Xia Katty Wan, Olga Kavetska. Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma.
Bioanalysis.
2021 Oct; 13(19):1477-1486. doi:
10.4155/bio-2021-0128. [PMID: 34601943] - Ellen Q Wang, Vu Le, Melissa O'Gorman, Sakambari Tripathy, Martin E Dowty, Lisy Wang, Bimal K Malhotra. Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.
Journal of clinical pharmacology.
2021 10; 61(10):1311-1323. doi:
10.1002/jcph.1858. [PMID: 33749838] - Eric L Simpson, Jonathan I Silverberg, Audrey Nosbaum, Kevin L Winthrop, Emma Guttman-Yassky, Karin M Hoffmeister, Alexander Egeberg, Hernan Valdez, Min Zhang, Saleem A Farooqui, William Romero, Andrew J Thorpe, Ricardo Rojo, Susan Johnson. Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program.
American journal of clinical dermatology.
2021 Sep; 22(5):693-707. doi:
10.1007/s40257-021-00618-3. [PMID: 34406619] - Shelley K Uppal, Donovan G Kearns, Vipawee S Chat, Jashin J Wu. Understanding the Potential Role of Abrocitinib in the Time of SARS-CoV-2.
Journal of drugs in dermatology : JDD.
2021 Jul; 20(7):806. doi:
10.36849/jdd.5544. [PMID: 34232002] - Elena Peeva, Martin R Hodge, Elizabeth Kieras, Michael L Vazquez, Kosalaram Goteti, Sanela G Tarabar, Christine W Alvey, Christopher Banfield. Evaluation of a Janus kinase 1 inhibitor, PF-04965842, in healthy subjects: A phase 1, randomized, placebo-controlled, dose-escalation study.
British journal of clinical pharmacology.
2018 08; 84(8):1776-1788. doi:
10.1111/bcp.13612. [PMID: 29672897]