Eravacycline (BioDeep_00000837595)
代谢物信息卡片
化学式: C27H31FN4O8 (558.2125818)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C1C2CC3CC4=C(C=C(C(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F
InChI: InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34-35,38,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:177804
- KEGGdrug: D10369
- PubChem: 54726192
- DrugBank: DB12329
- ChEMBL: CHEMBL4597183
- ChEMBL: CHEMBL1951095
- CAS: 1207283-85-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yener Özel, İbrahim Çavuş, Mehmet Ünlü, Ahmet Özbilgin. [Investigation of the Efficacy of Cinnamaldehyde, Cannabidiol and Eravacycline in a Malaria Model].
Mikrobiyoloji bulteni.
2023 Oct; 57(4):608-624. doi:
10.5578/mb.20239949. [PMID: 37885389] - Ying-Chun Chien, Yu-Lin Lee, Po-Yu Liu, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Shu-Hsing Cheng, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Yen-Hsu Chen, Wen-Chien Ko, Po-Ren Hsueh. National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017-2020.
Journal of global antimicrobial resistance.
2021 09; 26(?):308-316. doi:
10.1016/j.jgar.2021.07.005. [PMID: 34289409] - Junmei Wang. Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study.
Journal of chemical information and modeling.
2020 06; 60(6):3277-3286. doi:
10.1021/acs.jcim.0c00179. [PMID: 32315171] - Joseph V Newman, Jian Zhou, Sergey Izmailyan, Larry Tsai. Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects.
Antimicrobial agents and chemotherapy.
2019 03; 63(3):. doi:
10.1128/aac.01810-18. [PMID: 30559132] - Joseph V Newman, Jian Zhou, Sergey Izmailyan, Larry Tsai. Randomized, Double-Blind, Placebo-Controlled Studies of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Eravacycline.
Antimicrobial agents and chemotherapy.
2018 11; 62(11):. doi:
10.1128/aac.01174-18. [PMID: 30150464] - Vidmantas Petraitis, Ruta Petraitiene, Bo Bo W Maung, Farehin Khan, Ieva Alisauskaite, Melanie Olesky, Joseph Newman, Abdul Mutlib, Xiaoyun Niu, Michael Satlin, Ravi S Singh, Harmut Derendorf, Thomas J Walsh. Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00275-18. [PMID: 29941646] - Miao Zhao, Alexander J Lepak, Karen Marchillo, Jamie VanHecker, David R Andes. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model.
Antimicrobial agents and chemotherapy.
2017 07; 61(7):. doi:
10.1128/aac.00250-17. [PMID: 28416552] - George G Zhanel, Doris Cheung, Heather Adam, Sheryl Zelenitsky, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew Walkty, Alfred S Gin, Daryl J Hoban, James A Karlowsky. Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent.
Drugs.
2016 Apr; 76(5):567-88. doi:
10.1007/s40265-016-0545-8. [PMID: 26863149] - Trudy H Grossman, Timothy M Murphy, Andrew M Slee, Denene Lofland, Joyce A Sutcliffe. Eravacycline (TP-434) is efficacious in animal models of infection.
Antimicrobial agents and chemotherapy.
2015 May; 59(5):2567-71. doi:
10.1128/aac.04354-14. [PMID: 25691636] - Kevin P Connors, Seth T Housman, J Samuel Pope, John Russomanno, Edward Salerno, Eric Shore, Susan Redican, David P Nicolau. Phase I, open-label, safety and pharmacokinetic study to assess bronchopulmonary disposition of intravenous eravacycline in healthy men and women.
Antimicrobial agents and chemotherapy.
2014; 58(4):2113-8. doi:
10.1128/aac.02036-13. [PMID: 24468780]