Dequalinium (BioDeep_00000837590)

   


代谢物信息卡片


Dequalinium

化学式: C30H40N4+2 (456.32528)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=[N+](C2=CC=CC=C2C(=C1)N)CCCCCCCCCC[N+]3=C(C=C(C4=CC=CC=C43)N)C
InChI: InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2

描述信息

G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AC - Quinoline derivatives
D - Dermatologicals > D08 - Antiseptics and disinfectants > D08A - Antiseptics and disinfectants > D08AH - Quinoline derivatives
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AA - Antiseptics
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D000890 - Anti-Infective Agents

同义名列表

1 个代谢物同义名

Dequalinium



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Félix Sauvage, François-Xavier Legrand, Michel Roux, Ivan Rajkovic, Thomas M Weiss, Zoltán Varga, Luc Augis, Guillaume Nugue, Jean-Claude Debouzy, Juliette Vergnaud-Gauduchon, Gillian Barratt. Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines. Journal of colloid and interface science. 2019 Mar; 537(?):704-715. doi: 10.1016/j.jcis.2018.11.059. [PMID: 30497059]
  • Xin Wang, Lan Cheng, Hong-Jun Xie, Rui-Jun Ju, Yao Xiao, Min Fu, Jing-Jing Liu, Xue-Tao Li. Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup2):1154-1169. doi: 10.1080/21691401.2018.1481082. [PMID: 30043652]
  • Michael Timaner, Rotem Bril, Orit Kaidar-Person, Chen Rachman-Tzemah, Dror Alishekevitz, Ruslana Kotsofruk, Valeria Miller, Alexander Nevelsky, Shahar Daniel, Ziv Raviv, Susan A Rotenberg, Yuval Shaked. Dequalinium blocks macrophage-induced metastasis following local radiation. Oncotarget. 2015 Sep; 6(29):27537-54. doi: 10.18632/oncotarget.4826. [PMID: 26348470]
  • Non Miyata, Janos Steffen, Meghan E Johnson, Sonia Fargue, Christopher J Danpure, Carla M Koehler. Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct; 111(40):14406-11. doi: 10.1073/pnas.1408401111. [PMID: 25237136]
  • Xiu-Ying Li, Yao Zhao, Meng-Ge Sun, Ji-Feng Shi, Rui-Jun Ju, Cheng-Xiang Zhang, Xue-Tao Li, Wei-Yu Zhao, Li-Min Mu, Fan Zeng, Jin-Ning Lou, Wan-Liang Lu. Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma. Biomaterials. 2014 Jul; 35(21):5591-604. doi: 10.1016/j.biomaterials.2014.03.049. [PMID: 24726749]
  • V Chubanov, M Mederos y Schnitzler, M Meißner, S Schäfer, K Abstiens, T Hofmann, T Gudermann. Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. British journal of pharmacology. 2012 Jun; 166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x. [PMID: 22242975]
  • Maria-Teresa Gutierrez-Lugo, Heather Baker, Joseph Shiloach, Helena Boshoff, Carole A Bewley. Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. Journal of biomolecular screening. 2009 Jul; 14(6):643-52. doi: 10.1177/1087057109335743. [PMID: 19525487]
  • Juan R Rodrigues, Neira D Gamboa. Effect of dequalinium on the oxidative stress in Plasmodium berghei-infected erythrocytes. Parasitology research. 2009 Jun; 104(6):1491-6. doi: 10.1007/s00436-009-1355-7. [PMID: 19205739]
  • Zhanguang Chen, Yurui Peng, Junhui Chen, Li Zhu. Determination of antibacterial quaternary ammonium compound in lozenges and human serum by resonance light scattering technique. Journal of pharmaceutical and biomedical analysis. 2008 Nov; 48(3):946-50. doi: 10.1016/j.jpba.2008.05.019. [PMID: 18585882]
  • In-Hwan Lee, Hui-Young Kim, Myunghye Kim, Ji-Sook Hahn, Seung R Paik. Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein. Neurochemical research. 2008 Jul; 33(7):1393-400. doi: 10.1007/s11064-008-9598-8. [PMID: 18322792]
  • Gerard G M D'Souza, Sarathi V Boddapati, Volkmar Weissig. Mitochondrial leader sequence--plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion. 2005 Oct; 5(5):352-8. doi: 10.1016/j.mito.2005.07.001. [PMID: 16154389]
  • Bo Tang, Baoxiu Jia, Xifeng Shi. Flow injection spectrofluorimetric study of the supramolecular interaction between beta-cyclodextrin and dequalinium chloride and its analytical application. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2005 Jul; 61(9):2203-9. doi: 10.1016/j.saa.2004.08.019. [PMID: 15911412]
  • Wei Qu, Andrew J Moorhouse, Trevor M Lewis, Kerry D Pierce, Peter H Barry. Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel. European biophysics journal : EBJ. 2005 Jul; 34(5):442-53. doi: 10.1007/s00249-005-0479-7. [PMID: 15928936]
  • Gerard G M D'Souza, Volkmar Weissig. Approaches to mitochondrial gene therapy. Current gene therapy. 2004 Sep; 4(3):317-28. doi: 10.2174/1566523043346200. [PMID: 15384945]
  • Liping Nie, Haitao Song, Mei-Fang Chen, Nipavan Chiamvimonvat, Kirk W Beisel, Ebenezer N Yamoah, Ana E Vázquez. Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. Journal of neurophysiology. 2004 Apr; 91(4):1536-44. doi: 10.1152/jn.00630.2003. [PMID: 14657188]
  • Gerard G M D'Souza, Ram Rammohan, Shing-Ming Cheng, Vladimir P Torchilin, Volkmar Weissig. DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. Journal of controlled release : official journal of the Controlled Release Society. 2003 Sep; 92(1-2):189-97. doi: 10.1016/s0168-3659(03)00297-9. [PMID: 14499196]
  • Carmen Lizano, Volkmar Weissig, Vladimir P Torchilin, Pilar Sancho, Ana Isabel García-Pérez, Montserrat Pinilla. In vivo biodistribution of erythrocytes and polyethyleneglycol-phosphatidylethanolamine micelles carrying the antitumour agent dequalinium. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2003 Sep; 56(2):153-7. doi: 10.1016/s0939-6411(03)00089-4. [PMID: 12957627]
  • Josephine S Modica-Napolitano, Raffi Nalbandian, Marianne E Kidd, Angele Nalbandian, Chilinh C Nguyen. The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations. Cancer letters. 2003 Jul; 198(1):59-68. doi: 10.1016/s0304-3835(03)00274-x. [PMID: 12893431]
  • Mansoor Abdul, Naseema Hoosein. Voltage-gated potassium ion channels in colon cancer. Oncology reports. 2002 Sep; 9(5):961-4. doi: 10.3892/or.9.5.961. [PMID: 12168055]
  • K Finlayson, J McLuckie, J Hern, I Aramori, H J Olverman, J S Kelly. Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes. Neuropharmacology. 2001 Sep; 41(3):341-50. doi: 10.1016/s0028-3908(01)00067-3. [PMID: 11522325]
  • J S Modica-Napolitano, J R Aprille. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Advanced drug delivery reviews. 2001 Jul; 49(1-2):63-70. doi: 10.1016/s0169-409x(01)00125-9. [PMID: 11377803]
  • V P Torchilin. Structure and design of polymeric surfactant-based drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society. 2001 Jun; 73(2-3):137-72. doi: 10.1016/s0168-3659(01)00299-1. [PMID: 11516494]
  • J C Dreixler, J Bian, Y Cao, M T Roberts, J D Roizen, K M Houamed. Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. European journal of pharmacology. 2000 Jul; 401(1):1-7. doi: 10.1016/s0014-2999(00)00401-5. [PMID: 10915830]
  • M Shah, D G Haylett. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. British journal of pharmacology. 2000 Feb; 129(4):627-30. doi: 10.1038/sj.bjp.0703111. [PMID: 10683185]
  • J Lasch, A Meye, H Taubert, R Koelsch, J Mansa-ard, V Weissig. Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack. Biological chemistry. 1999 Jun; 380(6):647-52. doi: 10.1515/bc.1999.080. [PMID: 10430028]
  • M Kawakami, K Koya, T Ukai, N Tatsuta, A Ikegawa, K Ogawa, T Shishido, L B Chen. Synthesis and evaluation of novel rhodacyanine dyes that exhibit antitumor activity. Journal of medicinal chemistry. 1997 Sep; 40(20):3151-60. doi: 10.1021/jm9702692. [PMID: 9379434]
  • A E Vercesi, C F Bernardes, M E Hoffmann, F R Gadelha, R Docampo. Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. The Journal of biological chemistry. 1991 Aug; 266(22):14431-4. doi: 10.1016/s0021-9258(18)98703-x. [PMID: 1860850]
  • J D Steichen, M J Weiss, D R Elmaleh, R L Martuza. Enhanced in vitro uptake and retention of 3H-tetraphenylphosphonium by nervous system tumor cells. Journal of neurosurgery. 1991 Jan; 74(1):116-22. doi: 10.3171/jns.1991.74.1.0116. [PMID: 1984490]
  • I Gruber, T Bork. [The efficacy of dequalinium chloride/benzalkonium chloride as well as medicinal plants on the gingiva]. Deutsche Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt. 1991; 79(1):3-8. doi: ". [PMID: 9272987]
  • F D D'Auria, G Simonetti, V Strippoli. [Antimicrobial characteristics of a tincture of dequalinium chloride]. Annali di igiene : medicina preventiva e di comunita. 1989 Sep; 1(5):1227-41. doi: NULL. [PMID: 2483904]
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