Omadacycline (BioDeep_00000837585)
代谢物信息卡片
Omadacycline
化学式: C29H40N4O7 (556.289685)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)CNCC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
InChI: InChI=1S/C29H40N4O7/c1-28(2,3)12-31-11-14-10-17(32(4)5)15-8-13-9-16-21(33(6)7)24(36)20(27(30)39)26(38)29(16,40)25(37)18(13)23(35)19(15)22(14)34/h10,13,16,21,31,34-35,38,40H,8-9,11-12H2,1-7H3,(H2,30,39)/t13-,16-,21-,29-/m0/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:177758
- KEGGdrug: D09647
- PubChem: 54697325
- DrugBank: DB12455
- ChEMBL: CHEMBL1689772
- CAS: 389139-89-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianfeng Wang, Jiahuan Tong, Ying Wang, Yan Chen. Omadacycline use in a traveler with severe Legionella pneumonia.
Travel medicine and infectious disease.
2023 Nov; 56(?):102654. doi:
10.1016/j.tmaid.2023.102654. [PMID: 37858711] - Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler. Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility.
Microbiology spectrum.
2022 06; 10(3):e0054222. doi:
10.1128/spectrum.00542-22. [PMID: 35647655] - Christian M Gill, Andrew J Fratoni, Ashley K Shepard, Joseph L Kuti, David P Nicolau. Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1372-1378. doi:
10.1093/jac/dkac055. [PMID: 35194643] - Ying-Chun Chien, Yu-Lin Lee, Po-Yu Liu, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Shu-Hsing Cheng, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Yen-Hsu Chen, Wen-Chien Ko, Po-Ren Hsueh. National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017-2020.
Journal of global antimicrobial resistance.
2021 09; 26(?):308-316. doi:
10.1016/j.jgar.2021.07.005. [PMID: 34289409] - Thomas L Hunt, Evan Tzanis, Stephen Bai, Amy Manley, Surya Chitra, Paul C McGovern. The Effect of Verapamil, a P-gp Inhibitor, on the Pharmacokinetics, Safety, and Tolerability of Omadacycline in Healthy Adults: A Phase I, Open-Label, Single-Sequence Study.
European journal of drug metabolism and pharmacokinetics.
2021 Jan; 46(1):85-92. doi:
10.1007/s13318-020-00651-3. [PMID: 33180250] - Maryn McKenna. The antibiotic paradox: why companies can't afford to create life-saving drugs.
Nature.
2020 08; 584(7821):338-341. doi:
10.1038/d41586-020-02418-x. [PMID: 32814891] - Paul Pagano, Andrea Marra, Dean Shinabarger, Chris Pillar. In vitro activity of omadacycline and levofloxacin against Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus in human urine supplemented with calcium and magnesium.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2160-2163. doi:
10.1093/jac/dkaa138. [PMID: 32428235] - Elizabeth A Lakota, Scott A Van Wart, Michael Trang, Evan Tzanis, Sujata M Bhavnani, M Courtney Safir, Lawrence Friedrich, Judith N Steenbergen, Paul G Ambrose, Christopher M Rubino. Population Pharmacokinetic Analyses for Omadacycline Using Phase 1 and 3 Data.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.02263-19. [PMID: 32340986] - Keith A Rodvold, Rodrigo M Burgos, Xing Tan, Manjunath P Pai. Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics.
Clinical pharmacokinetics.
2020 04; 59(4):409-425. doi:
10.1007/s40262-019-00843-4. [PMID: 31773505] - George G Zhanel, Jenine Esquivel, Sheryl Zelenitsky, Courtney K Lawrence, Heather J Adam, Alyssa Golden, Rachel Hink, Liam Berry, Frank Schweizer, Michael A Zhanel, Denice Bay, Philippe R S Lagacé-Wiens, Andrew J Walkty, Joseph P Lynch, James A Karlowsky. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent.
Drugs.
2020 Feb; 80(3):285-313. doi:
10.1007/s40265-020-01257-4. [PMID: 31970713] - Alexander J Lepak, Miao Zhao, Karen Marchillo, Jamie VanHecker, David R Andes. In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model.
Antimicrobial agents and chemotherapy.
2020 01; 64(2):. doi:
10.1128/aac.02058-19. [PMID: 31712210] - Borje Darpo, Hongqi Xue, S Ken Tanaka, Evan Tzanis. Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00922-19. [PMID: 31405867] - Keith A Rodvold, Manjunath P Pai. Pharmacokinetics and Pharmacodynamics of Oral and Intravenous Omadacycline.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 08; 69(Suppl 1):S16-S22. doi:
10.1093/cid/ciz309. [PMID: 31367744] - James A Karlowsky, Judith Steenbergen, George G Zhanel. Microbiology and Preclinical Review of Omadacycline.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 08; 69(Suppl 1):S6-S15. doi:
10.1093/cid/ciz395. [PMID: 31367743] - J Scott Overcash, Pouru Bhiwandi, Lynne Garrity-Ryan, Judith Steenbergen, Stephen Bai, Surya Chitra, Amy Manley, Evan Tzanis. Pharmacokinetics, Safety, and Clinical Outcomes of Omadacycline in Women with Cystitis: Results from a Phase 1b Study.
Antimicrobial agents and chemotherapy.
2019 05; 63(5):. doi:
10.1128/aac.02083-18. [PMID: 30858208] - Jolene K Berg, Evan Tzanis, Lynne Garrity-Ryan, Stephen Bai, Surya Chitra, Amy Manley, Stephen Villano. Pharmacokinetics and Safety of Omadacycline in Subjects with Impaired Renal Function.
Antimicrobial agents and chemotherapy.
2018 02; 62(2):. doi:
10.1128/aac.02057-17. [PMID: 29158281] - Lu Ann Bundrant, Evan Tzanis, Lynne Garrity-Ryan, Stephen Bai, Surya Chitra, Amy Manley, Stephen Villano. Safety and Pharmacokinetics of the Aminomethylcycline Antibiotic Omadacycline Administered to Healthy Subjects in Oral Multiple-Dose Regimens.
Antimicrobial agents and chemotherapy.
2018 02; 62(2):. doi:
10.1128/aac.01487-17. [PMID: 29180524] - Mark H Gotfried, Karolyn Horn, Lynne Garrity-Ryan, Stephen Villano, Evan Tzanis, Surya Chitra, Amy Manley, S Ken Tanaka, Keith A Rodvold. Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.01135-17. [PMID: 28696233] - Jimmy Flarakos, Yancy Du, Helen Gu, Lai Wang, Heidi J Einolf, Dung Y Chun, Bing Zhu, Natalia Alexander, Adrienne Natrillo, Imad Hanna, Lillian Ting, Wei Zhou, Kiran Dole, Haiying Sun, Steven J Kovacs, Daniel S Stein, S Ken Tanaka, Stephen Villano, James B Mangold. Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Aug; 47(8):682-696. doi:
10.1080/00498254.2016.1213465. [PMID: 27499331] - Alexander J Lepak, Miao Zhao, Karen Marchillo, Jamie VanHecker, David R Andes. In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02368-16. [PMID: 28193651] - Wen Lin, Jimmy Flarakos, Yancy Du, Wenyu Hu, Handan He, James Mangold, S Ken Tanaka, Stephen Villano. Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.01784-16. [PMID: 27821446] - Haiying Sun, Lillian Ting, Surendra Machineni, Jens Praestgaard, Andreas Kuemmell, Daniel S Stein, Gangadhar Sunkara, Steven J Kovacs, Stephen Villano, S Ken Tanaka. Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7431-7435. doi:
10.1128/aac.01393-16. [PMID: 27736760]