Vericiguat (BioDeep_00000837582)

   


代谢物信息卡片


Vericiguat

  化学式: C19H16F2N8O2 (426.1364)
中文名称:
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N
InChI: InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

1 个代谢物同义名

Vericiguat



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Juan Xia, Nan Hui, Lei Tian, Chengyuan Liang, Jie Zhang, Jifang Liu, Jun Wang, Xiaodong Ren, Xiaolin Xie, Kun Wang. Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112894. doi: 10.1016/j.biopha.2022.112894. [PMID: 35367763]
  • Jaewon Oh, Chan Joo Lee, Jin Joo Park, Sang Eun Lee, Min-Seok Kim, Hyun-Jai Cho, Jin-Oh Choi, Hae-Young Lee, Kyung-Kuk Hwang, Kye Hun Kim, Byung-Su Yoo, Dong-Ju Choi, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Seok-Min Kang. Real-world eligibility for vericiguat in decompensated heart failure with reduced ejection fraction. ESC heart failure. 2022 04; 9(2):1492-1495. doi: 10.1002/ehf2.13837. [PMID: 35142095]
  • Hauke Ruehs, Dagmar Klein, Matthias Frei, Joachim Grevel, Rupert Austin, Corina Becker, Lothar Roessig, Burkert Pieske, Dirk Garmann, Michaela Meyer. Population Pharmacokinetics and Pharmacodynamics of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. Clinical pharmacokinetics. 2021 11; 60(11):1407-1421. doi: 10.1007/s40262-021-01024-y. [PMID: 34086190]
  • Adriaan A Voors, Hillary Mulder, Eugene Reyes, Martin R Cowie, Johan Lassus, Adrian F Hernandez, Justin A Ezekowitz, Javed Butler, Christopher M O'Connor, Joerg Koglin, Carolyn S P Lam, Burkert Pieske, Lothar Roessig, Piotr Ponikowski, Kevin J Anstrom, Paul W Armstrong. Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction: insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial. European journal of heart failure. 2021 08; 23(8):1313-1321. doi: 10.1002/ejhf.2221. [PMID: 33999486]
  • Amr Abdin, Michael Böhm. Renal function and vericiguat in heart failure patients: light at the end of the tunnel!. European journal of heart failure. 2021 08; 23(8):1322-1324. doi: 10.1002/ejhf.2280. [PMID: 34173701]
  • Michael Boettcher, Dirk Thomas, Wolfgang Mueck, Stephanie Loewen, Erich Arens, Kenichi Yoshikawa, Corina Becker. Safety, pharmacodynamic, and pharmacokinetic characterization of vericiguat: results from six phase I studies in healthy subjects. European journal of clinical pharmacology. 2021 Apr; 77(4):527-537. doi: 10.1007/s00228-020-03023-7. [PMID: 33125516]
  • Michael Boettcher, Michael Gerisch, Maximilian Lobmeyer, Nina Besche, Dirk Thomas, Mireille Gerrits, Julia Lemmen, Wolfgang Mueck, Martin Radtke, Corina Becker. Metabolism and Pharmacokinetic Drug-Drug Interaction Profile of Vericiguat, A Soluble Guanylate Cyclase Stimulator: Results From Preclinical and Phase I Healthy Volunteer Studies. Clinical pharmacokinetics. 2020 11; 59(11):1407-1418. doi: 10.1007/s40262-020-00895-x. [PMID: 32458378]
  • Xiaoming Jia, Mahmoud Al Rifai, Jing Liu, Anandita Agarwala, Martha Gulati, Salim S Virani. Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session. Current atherosclerosis reports. 2020 06; 22(8):32. doi: 10.1007/s11883-020-00856-6. [PMID: 32556778]
  • Andrew J S Coats. Vericiguat for heart failure and the VICTORIA trial - the dog that didn't bark?. European journal of heart failure. 2020 04; 22(4):576-577. doi: 10.1002/ejhf.1778. [PMID: 32115834]
  • Stefanie Breitenstein, Lothar Roessig, Peter Sandner, Kelly S Lewis. Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure. Handbook of experimental pharmacology. 2017; 243(?):225-247. doi: 10.1007/164_2016_100. [PMID: 27900610]


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