Voclosporin (BioDeep_00000837564)
代谢物信息卡片
化学式: C63H111N11O12 (1213.8413246)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC=C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InChI: InChI=1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
描述信息
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AD - Calcineurin inhibitors
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D003524 - Cyclosporins
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135957
- KEGGdrug: D09033
- PubChem: 6918486
- DrugBank: DB11693
- CAS: 515814-00-3
- CAS: 515814-01-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Teun van Gelder, Edgar Lerma, Kory Engelke, Robert B Huizinga. Voclosporin: a novel calcineurin inhibitor for the treatment of lupus nephritis.
Expert review of clinical pharmacology.
2022 May; 15(5):515-529. doi:
10.1080/17512433.2022.2092470. [PMID: 35763288] - Teun van Gelder, Robert B Huizinga, Laura Lisk, Neil Solomons. Voclosporin: a novel calcineurin inhibitor with no impact on mycophenolic acid levels in patients with SLE.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2022 04; 37(5):917-922. doi:
10.1093/ndt/gfab022. [PMID: 33527141] - Olena Mandrik, James Fotheringham, Shijie Ren, Jeffrey A Tice, Richard H Chapman, Matthew D Stevenson, Steven D Pearson, Serina Herron-Smith, Foluso Agboola, Praveen Thokala. The Cost-Effectiveness of Belimumab and Voclosporin for Patients with Lupus Nephritis in the United States.
Clinical journal of the American Society of Nephrology : CJASN.
2022 03; 17(3):385-394. doi:
10.2215/cjn.13030921. [PMID: 35115304] - Natacha S Ogando, Erik Metscher, Dirk Jan A R Moes, Eline J Arends, Ali Tas, Jennifer Cross, Eric J Snijder, Y K Onno Teng, Aiko P J de Vries, Martijn J van Hemert. The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture.
Transplant international : official journal of the European Society for Organ Transplantation.
2022; 35(?):10369. doi:
10.3389/ti.2022.10369. [PMID: 35812159] - Ioannis Parodis, Frederic A Houssiau. From sequential to combination and personalised therapy in lupus nephritis: moving towards a paradigm shift?.
Annals of the rheumatic diseases.
2022 01; 81(1):15-19. doi:
10.1136/annrheumdis-2021-221270. [PMID: 34521616] - Juan M Mejía-Vilet, Juanita Romero-Díaz. Voclosporin: a novel calcineurin inhibitor for the management of lupus nephritis.
Expert review of clinical immunology.
2021 09; 17(9):937-945. doi:
10.1080/1744666x.2021.1967747. [PMID: 34392746] - Brad H Rovin, Y K Onno Teng, Ellen M Ginzler, Cristina Arriens, Dawn J Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V Parikh, Simrat Randhawa, Neil Solomons, Robert B Huizinga. Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.
Lancet (London, England).
2021 05; 397(10289):2070-2080. doi:
10.1016/s0140-6736(21)00578-x. [PMID: 33971155] - Young-A Heo. Voclosporin: First Approval.
Drugs.
2021 Apr; 81(5):605-610. doi:
10.1007/s40265-021-01488-z. [PMID: 33788181] - Yan Li, Maria Palmisano, Duxin Sun, Simon Zhou. Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies.
Clinical pharmacology : advances and applications.
2020; 12(?):83-96. doi:
10.2147/cpaa.s255789. [PMID: 32669879] - Howard Trachtman, Arthur L Caplan. Data monitoring committees and randomized clinical trials.
Kidney international.
2019 04; 95(4):992. doi:
10.1016/j.kint.2018.12.012. [PMID: 30904070] - Brad H Rovin, Neil Solomons, Robert B Huizinga. The authors reply.
Kidney international.
2019 04; 95(4):992-993. doi:
10.1016/j.kint.2018.12.010. [PMID: 30904071] - Brad H Rovin, Neil Solomons, William F Pendergraft, Mary Anne Dooley, James Tumlin, Juanita Romero-Diaz, Lidia Lysenko, Sandra V Navarra, Robert B Huizinga. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis.
Kidney international.
2019 01; 95(1):219-231. doi:
10.1016/j.kint.2018.08.025. [PMID: 30420324] - Jonathan C Craig. Interpreting trial results-time for confidence and magnitude and not P values please.
Kidney international.
2019 01; 95(1):28-30. doi:
10.1016/j.kint.2018.11.006. [PMID: 30606426] - P R Mayo, S Y Ling, R B Huizinga, D G Freitag, L J Aspeslet, R T Foster. Population PKPD of voclosporin in renal allograft patients.
Journal of clinical pharmacology.
2014 May; 54(5):537-45. doi:
10.1002/jcph.237. [PMID: 24243422] - S Busque, M Cantarovich, S Mulgaonkar, R Gaston, A O Gaber, P R Mayo, S Ling, R B Huizinga, H-U Meier-Kriesche. The PROMISE study: a phase 2b multicenter study of voclosporin (ISA247) versus tacrolimus in de novo kidney transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Dec; 11(12):2675-84. doi:
10.1111/j.1600-6143.2011.03763.x. [PMID: 21943027] - J E Cooper, A C Wiseman. Novel immunosuppressive agents in kidney transplantation.
Clinical nephrology.
2010 May; 73(5):333-43. doi:
10.5414/cnp73333. [PMID: 20420793] - Clare R Gregory, Andrew E Kyles, Lynda Bernsteen, Gerhardt S Wagner, Alice F Tarantal, Kari L Christe, Lori Brignolo, Abigail Spinner, Stephen M Griffey, Ricardo T Paniagua, Richard W Hubble, Dominic C Borie, Randall E Morris. Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model.
Transplantation.
2004 Sep; 78(5):681-5. doi:
10.1097/01.tp.0000131950.75697.71. [PMID: 15371668] - Francis J Dumont. ISAtx-247 (Isotechnika/Roche).
Current opinion in investigational drugs (London, England : 2000).
2004 May; 5(5):542-50. doi:
NULL. [PMID: 15202729]