Ganaxolone (BioDeep_00000837562)
代谢物信息卡片
化学式: C22H36O2 (332.2715)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)(C)O)C)C
InChI: InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
D018377 - Neurotransmitter Agents > D000081227 - Neurosteroids
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:177658
- KEGGdrug: D04300
- PubChem: 6918305
- DrugBank: DB05087
- ChEMBL: CHEMBL1568698
- CAS: 38398-32-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jiahao Meng, Zeya Yan, Xinyu Tao, Wei Wang, Fei Wang, Tao Xue, Yanfei Liu, Zhong Wang. The efficacy and safety of ganaxolone for the treatment of refractory epilepsy: A meta-analysis from randomized controlled trials.
Epilepsia open.
2023 03; 8(1):90-99. doi:
10.1002/epi4.12669. [PMID: 36333279] - Gabrielle K Crombie, Hannah K Palliser, Julia C Shaw, Deborah M Hodgson, David W Walker, Jonathan J Hirst. Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders.
Psychoneuroendocrinology.
2021 11; 133(?):105423. doi:
10.1016/j.psyneuen.2021.105423. [PMID: 34601389] - Doodipala Samba Reddy, Chase Matthew Carver, Bryan Clossen, Xin Wu. Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.
Epilepsia.
2019 04; 60(4):730-743. doi:
10.1111/epi.14693. [PMID: 30895610] - Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski. Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.
Epilepsia.
2018 10; 59 Suppl 2(?):220-227. doi:
10.1111/epi.13999. [PMID: 29453777] - Soroush Sardari, Motahareh Amiri, Hourieh Rahimi, Mohammad Kamalinejad, Jamshid Narenjkar, Mohammad Sayyah. Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.
Iranian biomedical journal.
2015; 19(1):45-50. doi:
10.6091/ibj.1391.2014. [PMID: 25605489] - A M Paul, W G Branton, J G Walsh, M J Polyak, J-Q Lu, G B Baker, C Power. GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Neuroscience.
2014 Jul; 273(?):24-38. doi:
10.1016/j.neuroscience.2014.04.037. [PMID: 24814730] - K Ram, G N Lam, B Chien. A high-performance liquid chromatography-tandem mass spectrometric method for the determination of pharmacokinetics of ganaxolone in rat, monkey, dog and human plasma.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Feb; 751(1):49-59. doi:
10.1016/s0378-4347(00)00447-3. [PMID: 11232855] - D S Reddy, M A Rogawski. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself.
The Journal of pharmacology and experimental therapeutics.
2000 Dec; 295(3):1241-8. doi:
NULL. [PMID: 11082461] - D S Reddy, M A Rogawski. Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
The Journal of pharmacology and experimental therapeutics.
2000 Sep; 294(3):909-15. doi:
NULL. [PMID: 10945840] - E P Monaghan, L A Navalta, L Shum, D W Ashbrook, D A Lee. Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity.
Epilepsia.
1997 Sep; 38(9):1026-31. doi:
10.1111/j.1528-1157.1997.tb01486.x. [PMID: 9579942]
