Duvelisib (BioDeep_00000837561)
代谢物信息卡片
化学式: C22H17ClN6O (416.1152302)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
InChI: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EM - Phosphatidylinositol-3-kinase (pi3k) inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2152 - Phosphatidylinositide 3-Kinase Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:131169
- KEGGdrug: D10555
- PubChem: 50905713
- DrugBank: DB11952
- ChEMBL: CHEMBL3039502
- CAS: 1201438-56-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Joanna Randall, Kathryn Evans, Ben Watts, Christopher M Smith, Keira Hughes, Eric J Earley, Stephen W Erickson, Jonathan A Pachter, Beverly A Teicher, Malcolm A Smith, Richard B Lock. In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts.
Pediatric blood & cancer.
2023 May; ?(?):e30398. doi:
10.1002/pbc.30398. [PMID: 37140091] - Anup Siddesh, Dhurvu Sriram, Ashok Zakkula, Rajnish Kumar, Sreekanth Dittakavi, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi. Validated HPLC-UV method for simultaneous quantification of phosphatidylinositol 3-kinase inhibitors, copanlisib, duvelisib and idelalisib, in rat plasma: Application to a pharmacokinetic study in rats.
Biomedical chromatography : BMC.
2021 Apr; 35(4):e5015. doi:
10.1002/bmc.5015. [PMID: 33125719] - Ahmed Y Sayed, Nasr Y Khalil, Aliyah Almomen, Nourah Z Alzoman, Abdulrahman A Almehizia, Ibrahim A Darwish. A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats.
Drug design, development and therapy.
2021; 15(?):2667-2677. doi:
10.2147/dddt.s318714. [PMID: 34188446] - Yuanyuan Shao, Saili Xie, Huidan Zhu, Xiaoxiang Du, Ren-Ai Xu. Development of a novel and quick UPLC-MS/MS method for the pharmacokinetic analysis of duvelisib in beagle dogs.
Journal of pharmaceutical and biomedical analysis.
2020 Aug; 187(?):113355. doi:
10.1016/j.jpba.2020.113355. [PMID: 32442869] - Nicole Willemsen-Seegers, Joost C M Uitdehaag, Martine B W Prinsen, Judith R F de Vetter, Jos de Man, Masaaki Sawa, Yusuke Kawase, Rogier C Buijsman, Guido J R Zaman. Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.
Journal of molecular biology.
2017 02; 429(4):574-586. doi:
10.1016/j.jmb.2016.12.019. [PMID: 28043854] - David L Boyle, Hae-Rim Kim, Katharyn Topolewski, Beatrix Bartok, Gary S Firestein. Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics.
2014 Feb; 348(2):271-80. doi:
10.1124/jpet.113.205955. [PMID: 24244039]