Desvenlafaxine succinate (BioDeep_00000835470)
代谢物信息卡片
Desvenlafaxine succinate
化学式: C20H33NO7 (399.22569080000005)
中文名称: 琥珀酸去甲文拉法辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O
InChI: 1H2
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Veronia R Ayoub, Mona M A Abdel-Mottaleb, Ismail T Ibrahem, Mohamed A Motaleb, Ahmed S Geneidi. Novel radioiodinated desvenlafaxine-loaded lipid nanocapsule for brain delivery.
Archiv der Pharmazie.
2024 Apr; 357(4):e2300618. doi:
10.1002/ardp.202300618. [PMID: 38161231] - Tim Boogaerts, Maarten Quireyns, Hans De Loof, Xander Bertels, Natan Van Wichelen, Bram Pussig, Jan Saevels, Lies Lahousse, Pauline Bonmariage, Wouter Hamelinck, Bert Aertgeerts, Adrian Covaci, Alexander L N van Nuijs. Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use?.
The Science of the total environment.
2023 Feb; ?(?):162342. doi:
10.1016/j.scitotenv.2023.162342. [PMID: 36842581] - Ilaeira Rapti, Theodora Kourkouta, Evrydiki-Maria Malisova, Triantafyllos Albanis, Ioannis Konstantinou. Photocatalytic Degradation of Inherent Pharmaceutical Concentration Levels in Real Hospital WWTP Effluents Using g-C3N4 Catalyst on CPC Pilot Scale Reactor.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031170. [PMID: 36770837] - Christine Wegler, Aljona Saleh, Annika Lindqvist, Hedvig Nordeng, John Smeraglia, Pawel Baranczewski. Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Aug; 1205(?):123340. doi:
10.1016/j.jchromb.2022.123340. [PMID: 35732105] - Hazuki Komahashi-Sasaki, Norio Yasui-Furukori, Taro Sasaki, Masataka Shinozaki, Yuki Hayashi, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Takashi Watanabe, Norio Sugawara, Kazutaka Shimoda. Effects of CYP2D6 Genotypes on Venlafaxine Metabolism in Japanese Psychiatric Patients With Depression.
Therapeutic drug monitoring.
2021 10; 43(5):681-687. doi:
10.1097/ftd.0000000000000854. [PMID: 33306568] - Eduardo Tozatto, Jhohann Richard de Lima Benzi, Adriana Rocha, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Nifedipine Does Not Alter the Pharmacokinetics of Venlafaxine Enantiomers in Healthy Subjects Phenotyped for CYP2D6, CYP2C19, and CYP3A.
Journal of clinical pharmacology.
2021 03; 61(3):319-327. doi:
10.1002/jcph.1745. [PMID: 32974907] - Khalid Saad Alharbi. Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice.
Brazilian journal of biology = Revista brasleira de biologia.
2021; 83(?):e246194. doi:
10.1590/1519-6984.246194. [PMID: 34468514] - Jéssica Domingos da Silva, Valéria Pereira de Sousa, Lucio Mendes Cabral, Marcelo Gomes Davanço, Jessica Meulman, Patrícia de Oliveira Carvalho, Daniel Rossi Campos. In Vitro-In Vivo Correlation for Desvenlafaxine Succinate Monohydrate Extended Release Tablets.
AAPS PharmSciTech.
2020 Jul; 21(5):195. doi:
10.1208/s12249-020-01740-x. [PMID: 32666354] - Yu Sun, Wayne Drevets, Gustavo Turecki, Qingqin S Li. The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine.
Brain, behavior, and immunity.
2020 07; 87(?):404-412. doi:
10.1016/j.bbi.2020.01.011. [PMID: 31978524] - Emily J Cicali, D Max Smith, Benjamin Q Duong, Lukas G Kovar, Larisa H Cavallari, Julie A Johnson. A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.
Clinical pharmacology and therapeutics.
2020 07; 108(1):116-125. doi:
10.1002/cpt.1768. [PMID: 31910286] - Zhan-Zhang Wang, Shu-Hua Deng, Hao-Yang Lu, Lu Li, Xiu-Qing Zhu, Jin-Qing Hu, Huan-Shan Xie, Hong-Zhen Chen, Yu-Qing Chen, Ming Zhang, Zi-Yan Fang, Yu-Guan Wen, De-Wei Shang. Effect of venlafaxine dosage, valproic acid concentration, sex, and age on steady state dose-corrected concentrations of venlafaxine and O-desmethylvenlafaxine: A retrospective analysis of therapeutic drug monitoring data in a Chinese population.
Human psychopharmacology.
2020 05; 35(3):e2733. doi:
10.1002/hup.2733. [PMID: 32239743] - Michael Paulzen, Georgios Schoretsanitis, Gerhard Gründer, Cordula Franz, Julia C Stingl, Marc Augustin. Pregnancy exposure to venlafaxine-Therapeutic drug monitoring in maternal blood, amniotic fluid and umbilical cord blood and obstetrical outcomes.
Journal of affective disorders.
2020 04; 266(?):578-584. doi:
10.1016/j.jad.2020.02.010. [PMID: 32056930] - Marianne K Kringen, Line S Bråten, Tore Haslemo, Espen Molden. The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O-Desmethylvenlafaxine Concentrations in a Large Patient Cohort.
Journal of clinical psychopharmacology.
2020 Mar; 40(2):137-144. doi:
10.1097/jcp.0000000000001174. [PMID: 32134850] - Huma Rao, Saeed Ahmad, Asadullah Madni, Imtiaz Ahmad, Muhammad Nadeem Shahzad. Single-step extraction for simultaneous quantification of desvenlafaxine and alprazolam in human spiked plasma by RP-HPLC.
PloS one.
2020; 15(9):e0238954. doi:
10.1371/journal.pone.0238954. [PMID: 32941505] - Feifei Chen, Hui Jiang, Jia Xu, Shuanghu Wang, Deru Meng, Peiwu Geng, Dapeng Dai, Quan Zhou, Yunfang Zhou. In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine.
Drug design, development and therapy.
2020; 14(?):4815-4824. doi:
10.2147/dddt.s276704. [PMID: 33204067] - Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Katharina Endres, Florian Ridders, Tanja Veselinovic, Gerhard Gründer, Michael Paulzen. Pharmacokinetic correlates of venlafaxine: associated adverse reactions.
European archives of psychiatry and clinical neuroscience.
2019 Oct; 269(7):851-857. doi:
10.1007/s00406-019-01005-0. [PMID: 30923938] - Christoph Kowalewski, Ekkehard Haen, Christoph Hiemke, Florian Ridders, Katharina Endres, Gerhard Gründer, Michael Paulzen, Georgios Schoretsanitis. Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine.
International clinical psychopharmacology.
2019 09; 34(5):241-246. doi:
10.1097/yic.0000000000000268. [PMID: 31094902] - Georgios Schoretsanitis, Ekkehard Haen, Gerhard Gründer, Christoph Hiemke, Katharina Endres, Florian Ridders, Christoph U Correll, Michael Paulzen. Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database.
European journal of clinical pharmacology.
2019 Aug; 75(8):1109-1116. doi:
10.1007/s00228-019-02675-4. [PMID: 30968172] - Birgit M Wollmann, Hilde A Lunde, Lene K Støten, Niclas Lunder, Espen Molden. Substantial Differences in Serum Concentrations of Psychoactive Drugs Measured in Samples Stored for 2 Days or More on Standard Serum Tubes Versus Serum Tubes Containing Gel Separators.
Therapeutic drug monitoring.
2019 06; 41(3):396-400. doi:
10.1097/ftd.0000000000000592. [PMID: 30540671] - Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
International clinical psychopharmacology.
2019 03; 34(2):93-100. doi:
10.1097/yic.0000000000000250. [PMID: 30557209] - Yong-Liang Zhu, Shuang-Long Li, Ke-Li Chen, Kun-Peng Ma, De-Qian Wu, Xiang-Jun Qiu. Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles.
Drug design, development and therapy.
2019; 13(?):3343-3355. doi:
10.2147/dddt.s221927. [PMID: 31571835] - Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Christoph U Correll, Gerhard Gründer, Michael Paulzen. Sex and body weight are major determinants of venlafaxine pharmacokinetics.
International clinical psychopharmacology.
2018 11; 33(6):322-329. doi:
10.1097/yic.0000000000000234. [PMID: 30028351] - Michael Paulzen, Georgios Schoretsanitis, Christoph Hiemke, Gerhard Gründer, Ekkehard Haen, Marc Augustin. Reduced clearance of venlafaxine in a combined treatment with quetiapine.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 07; 85(?):116-121. doi:
10.1016/j.pnpbp.2018.04.014. [PMID: 29702137] - Katharina Ebert, Elena Maurice, Richard Lukačin, Christian Fleischhaker, Eberhard Schulz, Dieter Ebert, Hans-Willi Clement. Serum and Saliva Concentrations of Venlafaxine, O-Desmethylvenlafaxine, Quetiapine, and Citalopram in Psychiatric Patients.
Therapeutic drug monitoring.
2018 06; 40(3):351-355. doi:
10.1097/ftd.0000000000000508. [PMID: 29746434] - W Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran. An open-label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R)-(-)-O-desmethylvenlafaxine and racemic O-desmethylvenlafaxine.
Synapse (New York, N.Y.).
2018 03; 72(3):. doi:
10.1002/syn.22021. [PMID: 29216407] - Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Gerhard Gründer, Georgios Schoretsanitis. Antidepressant polypharmacy and the potential of pharmacokinetic interactions: Doxepin but not mirtazapine causes clinically relevant changes in venlafaxine metabolism.
Journal of affective disorders.
2018 02; 227(?):506-511. doi:
10.1016/j.jad.2017.11.046. [PMID: 29156365] - T Michael Farley, Emily N Anderson, Jade N Feller. False-positive phencyclidine (PCP) on urine drug screen attributed to desvenlafaxine (Pristiq) use.
BMJ case reports.
2017 Nov; 2017(?):. doi:
10.1136/bcr-2017-222106. [PMID: 29170178] - Morten Rix Hansen, Ida Berglund Kuhlmann, Anton Pottegård, Per Damkier. Therapeutic Drug Monitoring of Venlafaxine in an Everyday Clinical Setting: Analysis of Age, Sex and Dose Concentration Relationships.
Basic & clinical pharmacology & toxicology.
2017 Oct; 121(4):298-302. doi:
10.1111/bcpt.12796. [PMID: 28397349] - Manjanath Patgar, Amar Durgannavar, Sharanappa Nandibewoor, Shivamurti Chimatadar. Spectroscopic exploration and thermodynamic characterization of desvenlafaxine interacting with fluorescent bovine serum albumin.
Journal of molecular recognition : JMR.
2017 02; 30(2):. doi:
10.1002/jmr.2567. [PMID: 27696548] - Robert L Findling, James Groark, Karen A Tourian, Sara A Ramaker, Deborah Chiles, Lingfeng Yang, Alice I Nichols. Pharmacokinetics and Tolerability of Single-Ascending Doses of Desvenlafaxine Administered to Children and Adolescents with Major Depressive Disorder.
Journal of child and adolescent psychopharmacology.
2016 12; 26(10):909-921. doi:
10.1089/cap.2016.0009. [PMID: 27428303] - C H Ng, C Bousman, D J Smith, N Dowling, K Byron, J King, J Sarris. A Prospective Study of Serotonin and Norepinephrine Transporter Genes and the Response to Desvenlafaxine Over 8 Weeks in Major Depressive Disorder.
Pharmacopsychiatry.
2016 Sep; 49(5):210-212. doi:
10.1055/s-0042-103968. [PMID: 27023264] - Luis Felippe C Miranda, Diego S Domingues, Maria Eugênia C Queiroz. Selective solid-phase extraction using molecularly imprinted polymers for analysis of venlafaxine, O-desmethylvenlafaxine, and N-desmethylvenlafaxine in plasma samples by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2016 Aug; 1458(?):46-53. doi:
10.1016/j.chroma.2016.06.024. [PMID: 27388659] - Mahdi Ghorbani, Mahmoud Chamsaz, Gholam Hossein Rounaghi. Glycine functionalized multiwall carbon nanotubes as a novel hollow fiber solid-phase microextraction sorbent for pre-concentration of venlafaxine and o-desmethylvenlafaxine in biological and water samples prior to determination by high-performance liquid chromatography.
Analytical and bioanalytical chemistry.
2016 Jun; 408(16):4247-56. doi:
10.1007/s00216-016-9518-8. [PMID: 27108286] - José I Serrano-Contreras, Isabel García-Pérez, María E Meléndez-Camargo, Luis G Zepeda-Vallejo. NMR-based metabonomic analysis of normal rat urine and faeces in response to (±)-venlafaxine treatment.
Journal of pharmaceutical and biomedical analysis.
2016 May; 123(?):82-92. doi:
10.1016/j.jpba.2016.01.044. [PMID: 26895493] - Pushpa Kumari Kancharla, Venu Gopal Raju Kondru, Gowri Sankar Dannana. Novel LC- ESI-MS/MS method for desvenlafaxine estimation human plasma: application to pharmacokinetic study.
Biomedical chromatography : BMC.
2016 Feb; 30(2):249-55. doi:
10.1002/bmc.3542. [PMID: 26095112] - Sandra N Staeheli, Dominic Gascho, Juergen Fornaro, Patrick Laberke, Lars C Ebert, Rosa Maria Martinez, Michael J Thali, Thomas Kraemer, Andrea E Steuer. Development of CT-guided biopsy sampling for time-dependent postmortem redistribution investigations in blood and alternative matrices--proof of concept and application on two cases.
Analytical and bioanalytical chemistry.
2016 Feb; 408(4):1249-58. doi:
10.1007/s00216-015-9234-9. [PMID: 26677021] - Márcia Calheiros Chaves Silva, Caren Nádia Soares de Sousa, Patrícia Xavier Lima Gomes, Gersilene Valente de Oliveira, Fernanda Yvelize Ramos Araújo, Naiara Coelho Ximenes, Jéssica Calheiros da Silva, Germana Silva Vasconcelos, Luzia Kalyne Almeida Moreira Leal, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos. Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2016 Jan; 64(?):142-8. doi:
10.1016/j.pnpbp.2015.08.002. [PMID: 26265141] - R Ghosh, R Gupta, M S Bhatia, A K Tripathi, L K Gupta. Comparison of efficacy, safety and brain derived neurotrophic factor (BDNF) levels in patients of major depressive disorder, treated with fluoxetine and desvenlafaxine.
Asian journal of psychiatry.
2015 Dec; 18(?):37-41. doi:
10.1016/j.ajp.2015.10.006. [PMID: 26514447] - Yijin Liu, Michael Jann, Chad Vandenberg, Chin B Eap, Shahab A Shamsi. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction.
Journal of chromatography. A.
2015 Nov; 1420(?):119-28. doi:
10.1016/j.chroma.2015.09.088. [PMID: 26460073] - Christel Renoux, Lisa M Lix, Valérie Patenaude, Lauren C Bresee, J Michael Paterson, Jean-Philippe Lafrance, Hala Tamim, Salaheddin M Mahmud, Mhd Wasem Alsabbagh, Brenda Hemmelgarn, Colin R Dormuth, Pierre Ernst. Serotonin-Norepinephrine Reuptake Inhibitors and the Risk of AKI: A Cohort Study of Eight Administrative Databases and Meta-Analysis.
Clinical journal of the American Society of Nephrology : CJASN.
2015 Oct; 10(10):1716-22. doi:
10.2215/cjn.11271114. [PMID: 26231193] - F Franek, A Jarlfors, F Larsen, P Holm, B Steffansen. In vitro solubility, dissolution and permeability studies combined with semi-mechanistic modeling to investigate the intestinal absorption of desvenlafaxine from an immediate- and extended release formulation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Sep; 77(?):303-13. doi:
10.1016/j.ejps.2015.06.012. [PMID: 26091569] - H P Sigurdsson, G Hefner, N Ben-Omar, A Köstlbacher, K Wenzel-Seifert, C Hiemke, E Haen. Steady-state serum concentrations of venlafaxine in patients with late-life depression. Impact of age, sex and BMI.
Journal of neural transmission (Vienna, Austria : 1996).
2015 May; 122(5):721-9. doi:
10.1007/s00702-014-1317-9. [PMID: 25257248] - Yin-xia Chen, Jiang-bo Du, Yi-fan Zhang, Xiao-yan Chen, Da-fang Zhong. [The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Apr; 50(4):486-91. doi:
NULL. [PMID: 26223133] - Lauren B Stadler, Lijuan Su, Christopher J Moline, Alexi S Ernstoff, Diana S Aga, Nancy G Love. Effect of redox conditions on pharmaceutical loss during biological wastewater treatment using sequencing batch reactors.
Journal of hazardous materials.
2015 Jan; 282(?):106-15. doi:
10.1016/j.jhazmat.2014.08.002. [PMID: 25200120] - Michael Paulzen, Sarah Groppe, Simone C Tauber, Tanja Veselinovic, Christoph Hiemke, Gerhard Gründer. Venlafaxine and O-desmethylvenlafaxine concentrations in plasma and cerebrospinal fluid.
The Journal of clinical psychiatry.
2015 Jan; 76(1):25-31. doi:
10.4088/jcp.13m08921. [PMID: 25188033] - F Proft, J Kopf, D Olmes, S Hempel, B Schmidt, P Riederer, J Deckert, B Pfuhlmann, A Reif, S Unterecker. SLC6A2 and SLC6A4 variants interact with venlafaxine serum concentrations to influence therapy outcome.
Pharmacopsychiatry.
2014 Nov; 47(7):245-50. doi:
10.1055/s-0034-1390412. [PMID: 25295552] - Alice I Nichols, Shannon Lubaczewski, Yali Liang, Kyle Matschke, Gabriel Braley, Tanya Ramey. Open-label, 2-period sequential drug interaction study to evaluate the effect of a 100-mg dose of desvenlafaxine on the pharmacokinetics of tamoxifen when coadministered in healthy postmenopausal female subjects.
International journal of clinical pharmacology and therapeutics.
2014 10; 52(10):830-41. doi:
10.5414/cp201958. [PMID: 25138680] - Renli Teng, Mirjana Kujacic, Judith Hsia. Evaluation of the pharmacokinetic interaction between ticagrelor and venlafaxine, a cytochrome P-450 2D6 substrate, in healthy subjects.
Clinical therapeutics.
2014 Sep; 36(9):1217-25. doi:
10.1016/j.clinthera.2014.06.024. [PMID: 25069798] - T J Stamm, D Becker, L M Sondergeld, K Wiethoff, C Hiemke, G O'Malley, R Ricken, M Bauer, M Adli. Prediction of antidepressant response to venlafaxine by a combination of early response assessment and therapeutic drug monitoring.
Pharmacopsychiatry.
2014 Jul; 47(4-5):174-9. doi:
10.1055/s-0034-1383565. [PMID: 25054625] - E J J Berm, E Brummel-Mulder, J Paardekooper, E Hak, B Wilffert, J G Maring. Determination of venlafaxine and O-desmethylvenlafaxine in dried blood spots for TDM purposes, using LC-MS/MS.
Analytical and bioanalytical chemistry.
2014 Apr; 406(9-10):2349-53. doi:
10.1007/s00216-014-7619-9. [PMID: 24493333] - Stefan Unterecker, Florian Proft, Peter Riederer, Martin Lauer, Jürgen Deckert, Bruno Pfuhlmann. The comparison of brand-name and generic formulations of venlafaxine: a therapeutic drug monitoring analysis.
Therapeutic drug monitoring.
2014 Apr; 36(2):269-72. doi:
10.1097/ftd.0000000000000008. [PMID: 24365982] - Ellise D Liew, Christopher P Alderman. Syndrome of inappropriate antidiuretic hormone secretion associated with desvenlafaxine.
International journal of clinical pharmacy.
2014 Apr; 36(2):253-5. doi:
10.1007/s11096-013-9870-0. [PMID: 24234943] - Paulo Magalhães, Gilberto Alves, Márcio Rodrigues, Adrián LLerena, Amílcar Falcão. First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma.
Bioanalysis.
2014; 6(22):3025-38. doi:
10.4155/bio.14.222. [PMID: 25496255] - Corbin Bachmeier, Gary M Levin, David Beaulieu-Abdelahad, Jon Reed, Michael Mullan. Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo.
Journal of pharmaceutical sciences.
2013 Oct; 102(10):3838-43. doi:
10.1002/jps.23680. [PMID: 23897419] - Ewelina Dziurkowska, Marek Wesołowski. [Extraction techniques for analysis of venlafaxine and its metabolites in biological matrices].
Psychiatria polska.
2013 Sep; 47(5):909-20. doi:
NULL. [PMID: 25011236] - Fei Dai, Yong Lei, Shiying Li, Gengqing Song, Jiande D Z Chen. Desvenlafaxine succinate ameliorates visceral hypersensitivity but delays solid gastric emptying in rats.
American journal of physiology. Gastrointestinal and liver physiology.
2013 Aug; 305(4):G333-9. doi:
10.1152/ajpgi.00224.2012. [PMID: 23764892] - Susan Baird-Bellaire, Jessica A Behrle, Vernon D Parker, Alain Patat, Jeffrey Paul, Alice I Nichols. An open-label, single-dose, parallel-group study of the effects of chronic hepatic impairment on the safety and pharmacokinetics of desvenlafaxine.
Clinical therapeutics.
2013 Jun; 35(6):782-94. doi:
10.1016/j.clinthera.2013.03.013. [PMID: 23623756] - Lalit Dutta, Syed Imran Ahmad, Subhra Kanti Mukherjee, Sanjeev Mishra, Arshad Khuroo, Tausif Monif. Liquid chromatography tandem mass spectrometry method for the simultaneous stereoselective determination of venlafaxine and its major metabolite, O-desmethylvenlafaxine, in human plasma.
Biomedical chromatography : BMC.
2013 May; 27(5):622-35. doi:
10.1002/bmc.2837. [PMID: 23166015] - J Jornil, T S Nielsen, I Rosendal, J Ahlner, A L Zackrisson, L W T Boel, B Brock. A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine.
Forensic science international.
2013 Mar; 226(1-3):e26-31. doi:
10.1016/j.forsciint.2012.12.020. [PMID: 23332809] - Alice I Nichols, Madelyn Abell, Abell Madelyn, Yang Chen, Jessica A Behrle, Glen Frick, Jeffrey Paul. Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults.
International clinical psychopharmacology.
2013 Mar; 28(2):99-105. doi:
10.1097/yic.0b013e32835c1f49. [PMID: 23221858] - Patrícia da Fonseca, Pierina Sueli Bonato. Hollow-fiber liquid-phase microextraction and chiral LC-MS/MS analysis of venlafaxine and its metabolites in plasma.
Bioanalysis.
2013 Mar; 5(6):721-30. doi:
10.4155/bio.13.22. [PMID: 23484789] - S Unterecker, C Hiemke, C Greiner, E Haen, B Jabs, J Deckert, B Pfuhlmann. The effect of age, sex, smoking and co-medication on serum levels of venlafaxine and O-desmethylvenlafaxine under naturalistic conditions.
Pharmacopsychiatry.
2012 Sep; 45(6):229-35. doi:
10.1055/s-0031-1301366. [PMID: 22426847] - Klaus Martiny, Marianne Lunde, Per Bech, Per Plenge. A short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression.
Nordic journal of psychiatry.
2012 Jun; 66(3):147-54. doi:
10.3109/08039488.2012.674553. [PMID: 22458638] - Michael W Jann, Vicky Spratlin, Kathryn Momary, Hailing Zhang, David Turner, Scott R Penzak, Alan Wright, Chad VanDenBerg. Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir.
European journal of clinical pharmacology.
2012 May; 68(5):715-21. doi:
10.1007/s00228-011-1180-7. [PMID: 22173281] - Paola C Rúa-Gómez, Wilhelm Püttmann. Impact of wastewater treatment plant discharge of lidocaine, tramadol, venlafaxine and their metabolites on the quality of surface waters and groundwater.
Journal of environmental monitoring : JEM.
2012 May; 14(5):1391-9. doi:
10.1039/c2em10950f. [PMID: 22446514] - Thomas Guttuso. Effective and clinically meaningful non-hormonal hot flash therapies.
Maturitas.
2012 May; 72(1):6-12. doi:
10.1016/j.maturitas.2012.01.023. [PMID: 22377187] - Marco Vinetti, Vincent Haufroid, Arnaud Capron, Jean-François Classen, Sebastien Marchandise, Philippe Hantson. Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms.
Clinical toxicology (Philadelphia, Pa.).
2011 Nov; 49(9):865-9. doi:
10.3109/15563650.2011.626421. [PMID: 22077251] - Victoria Samanidou, Chrysa Nazyropoulou, Leda Kovatsi. A simple HPLC method for the simultaneous determination of venlafaxine and its major metabolite O-desmethylvenlafaxine in human serum.
Bioanalysis.
2011 Aug; 3(15):1713-8. doi:
10.4155/bio.11.161. [PMID: 21827270] - Jonathan Rampono, Stephanie Teoh, L Peter Hackett, Rolland Kohan, Kenneth F Ilett. Estimation of desvenlafaxine transfer into milk and infant exposure during its use in lactating women with postnatal depression.
Archives of women's mental health.
2011 Feb; 14(1):49-53. doi:
10.1007/s00737-010-0188-9. [PMID: 20960017] - Alice I Nichols, Kristen Focht, Qin Jiang, Sheldon H Preskorn, Cecelia P Kane. Pharmacokinetics of venlafaxine extended release 75 mg and desvenlafaxine 50 mg in healthy CYP2D6 extensive and poor metabolizers: a randomized, open-label, two-period, parallel-group, crossover study.
Clinical drug investigation.
2011; 31(3):155-67. doi:
10.2165/11586630-000000000-00000. [PMID: 21288052] - Jørgen Hasselstrøm. Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jan; 879(1):123-8. doi:
10.1016/j.jchromb.2010.11.024. [PMID: 21163713] - A I Nichols, L S Richards, J A Behrle, J A Posener, S B McGrory, J Paul. The pharmacokinetics and safety of desvenlafaxine in subjects with chronic renal impairment.
International journal of clinical pharmacology and therapeutics.
2011 Jan; 49(1):3-13. doi:
10.5414/cpp49003. [PMID: 21176719] - Kenneth F Ilett, Felice Watt, L Peter Hackett, Rolland Kohan, Stephanie Teoh. Assessment of infant dose through milk in a lactating woman taking amisulpride and desvenlafaxine for treatment-resistant depression.
Therapeutic drug monitoring.
2010 Dec; 32(6):704-7. doi:
10.1097/ftd.0b013e3181f88f70. [PMID: 20926994] - Maria Kingbäck, Martin Josefsson, Louise Karlsson, Johan Ahlner, Finn Bengtsson, Fredrik C Kugelberg, Björn Carlsson. Stereoselective determination of venlafaxine and its three demethylated metabolites in human plasma and whole blood by liquid chromatography with electrospray tandem mass spectrometric detection and solid phase extraction.
Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):583-90. doi:
10.1016/j.jpba.2010.03.043. [PMID: 20435422] - Kasia W Lobello, Sheldon H Preskorn, Christine J Guico-Pabia, Qin Jiang, Jeffrey Paul, Alice I Nichols, Albena Patroneva, Philip T Ninan. Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.
The Journal of clinical psychiatry.
2010 Nov; 71(11):1482-7. doi:
10.4088/jcp.08m04773blu. [PMID: 20441720] - Mani Kandasamy, P Srinivas, Kala Subramaniam, Sandhya Ravi, James John, Radha Shekar, Nuggehally Srinivas, Saral Thangam. Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes--focus on venlafaxine and O-desmethylvenlafaxine.
European journal of clinical pharmacology.
2010 Sep; 66(9):879-87. doi:
10.1007/s00228-010-0829-y. [PMID: 20446083] - Feng Qin, Ning Li, Ting Qin, Yi Zhang, Famei Li. Simultaneous quantification of venlafaxine and O-desmethylvenlafaxine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Mar; 878(7-8):689-94. doi:
10.1016/j.jchromb.2010.01.007. [PMID: 20133212] - Sujana Reddy, Cecelia Kane, Bruno Pitrosky, Jeff Musgnung, Philip T Ninan, Christine J Guico-Pabia. Clinical utility of desvenlafaxine 50 mg/d for treating MDD: a review of two randomized placebo-controlled trials for the practicing physician.
Current medical research and opinion.
2010 Jan; 26(1):139-50. doi:
10.1185/03007990903408678. [PMID: 19919295] - Ho-Jun Seo, Manmohandeep Singh Sohi, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae. Desvenlafaxine succinate: a newer antidepressant for the treatment of depression and somatic symptoms.
Postgraduate medicine.
2010 Jan; 122(1):125-38. doi:
10.3810/pgm.2010.01.2106. [PMID: 20107296] - D Rajasekhar, I Jaswanth Kumar, P Venkateswarlu. Rapid high-performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of venlafaxine and O-desmethylvenlafaxine in human plasma and its application in comparative bioavailability study.
Biomedical chromatography : BMC.
2009 Dec; 23(12):1300-7. doi:
10.1002/bmc.1253. [PMID: 19517423] - Gaurang R Shah, Bharat T Thaker, Kiran R Surati, Minu H Parabia. Simultaneous determination of venlafaxine and its main active metabolite O-desmethyl venlafaxine in rat plasma by LC-MS/MS.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2009 Oct; 25(10):1207-10. doi:
10.2116/analsci.25.1207. [PMID: 19822964] - D Jeffrey Newport, James C Ritchie, Bettina T Knight, Bailey A Glover, Elizabeth B Zach, Zachary N Stowe. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure.
The Journal of clinical psychiatry.
2009 Sep; 70(9):1304-10. doi:
10.4088/jcp.08m05001. [PMID: 19607765] - Alice I Nichols, Kasia Lobello, Christine J Guico-Pabia, Jeff Paul, Sheldon H Preskorn. Venlafaxine metabolism as a marker of cytochrome P450 enzyme 2D6 metabolizer status.
Journal of clinical psychopharmacology.
2009 Aug; 29(4):383-6. doi:
10.1097/jcp.0b013e3181acc4dd. [PMID: 19593180] - Richard Perry, Manouchkathe Cassagnol. Desvenlafaxine: a new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder.
Clinical therapeutics.
2009 Jun; 31 Pt 1(?):1374-404. doi:
10.1016/j.clinthera.2009.07.012. [PMID: 19698900] - Alice I Nichols, Penny Fatato, Magdy Shenouda, Jeffrey Paul, Jennifer A Isler, Ronald D Pedersen, Qin Jiang, Saeeduddin Ahmed, Albena Patroneva. The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.
Journal of clinical pharmacology.
2009 Feb; 49(2):219-28. doi:
10.1177/0091270008326716. [PMID: 19001559] - Sheldon Preskorn, Albena Patroneva, Heather Silman, Qin Jiang, Jennifer A Isler, Michael E Burczynski, Saeeduddin Ahmed, Jeffrey Paul, Alice I Nichols. Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers.
Journal of clinical psychopharmacology.
2009 Feb; 29(1):39-43. doi:
10.1097/jcp.0b013e318192e4c1. [PMID: 19142106] - Albena Patroneva, Sandra M Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A Isler, Michael E Burczynski, Alice I Nichols. An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Dec; 36(12):2484-91. doi:
10.1124/dmd.108.021527. [PMID: 18809731] - Sheldon H Preskorn, Alice I Nichols, Jeffrey Paul, Albena L Patroneva, Eileen C Helzner, Christine J Guico-Pabia. Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system.
Journal of psychiatric practice.
2008 Nov; 14(6):368-78. doi:
10.1097/01.pra.0000341891.43501.6b. [PMID: 19057238] - Bhavin N Patel, Naveen Sharma, Mallika Sanyal, Pranav S Shrivastav. Liquid chromatography tandem mass spectrometry assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma and its application to a bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2008 Jul; 47(3):603-11. doi:
10.1016/j.jpba.2008.02.015. [PMID: 18387768] - M Hermann, M Hendset, K Fosaas, M Hjerpset, H Refsum. Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele.
European journal of clinical pharmacology.
2008 May; 64(5):483-7. doi:
10.1007/s00228-007-0453-7. [PMID: 18214456] - V-V Hynninen, K T Olkkola, L Bertilsson, K Kurkinen, P J Neuvonen, K Laine. Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine.
Clinical pharmacology and therapeutics.
2008 Feb; 83(2):342-8. doi:
10.1038/sj.clpt.6100311. [PMID: 17687273] - John N Mason, Darlene C Deecher, Rhonda L Richmond, Gary Stack, Paige E Mahaney, Eugene Trybulski, Richard C Winneker, Randy D Blakely. Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
The Journal of pharmacology and experimental therapeutics.
2007 Nov; 323(2):720-9. doi:
10.1124/jpet.107.125716. [PMID: 17673606] - Roberto Mandrioli, Laura Mercolini, Roberta Cesta, Salvatore Fanali, Mario Amore, Maria Augusta Raggi. Analysis of the second generation antidepressant venlafaxine and its main active metabolite O-desmethylvenlafaxine in human plasma by HPLC with spectrofluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):88-94. doi:
10.1016/j.jchromb.2007.05.046. [PMID: 17581798] - Robert L Findling, Laurence L Greenhill, Nora K McNamara, Christine A Demeter, Lisa A Kotler, Mary Ann O'Riordan, Carolyn Myers, Michael D Reed. Venlafaxine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder.
Journal of child and adolescent psychopharmacology.
2007 Aug; 17(4):433-45. doi:
10.1089/cap.2007.0119. [PMID: 17822339] - Wen Liu, Feng Wang, Huan-de Li. Simultaneous stereoselective analysis of venlafaxine and O-desmethylvenlafaxine enantiomers in human plasma by HPLC-ESI/MS using a vancomycin chiral column.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):183-9. doi:
10.1016/j.jchromb.2006.11.021. [PMID: 17140867] - Hendrik B Theron, Marthinus J van der Merwe, Kenneth J Swart, Jan H van der Westhuizen. Employing atmospheric pressure photoionization in liquid chromatography/tandem mass spectrometry to minimize ion suppression and matrix effects for the quantification of venlafaxine and O-desmethylvenlafaxine.
Rapid communications in mass spectrometry : RCM.
2007; 21(10):1680-6. doi:
10.1002/rcm.3006. [PMID: 17465011] - M E E Shams, B Arneth, C Hiemke, A Dragicevic, M J Müller, R Kaiser, K Lackner, S Härtter. CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.
Journal of clinical pharmacy and therapeutics.
2006 Oct; 31(5):493-502. doi:
10.1111/j.1365-2710.2006.00763.x. [PMID: 16958828] - Darlene C Deecher, Chad E Beyer, Grace Johnston, Jenifer Bray, S Shah, M Abou-Gharbia, Terrance H Andree. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.
The Journal of pharmacology and experimental therapeutics.
2006 Aug; 318(2):657-65. doi:
10.1124/jpet.106.103382. [PMID: 16675639] - Peter D Alfinito, Christine Huselton, Xiaohong Chen, Darlene C Deecher. Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats.
Brain research.
2006 Jul; 1098(1):71-8. doi:
10.1016/j.brainres.2006.04.057. [PMID: 16764833]