BMS 345541 (BioDeep_00000835287)
代谢物信息卡片
化学式: C14H17N5 (255.1483882)
中文名称: N-(1,8-二甲基咪唑并[1,2-a]喹喔啉-4-基)-1,2-乙二胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN
InChI: InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex.
Pflugers Archiv : European journal of physiology.
2020 11; 472(11):1577-1586. doi:
10.1007/s00424-020-02461-7. [PMID: 32915316] - Xiaohua Zhu, Qiugen Li, Guozhu Hu, Jun Wang, Qinghua Hu, Zhiqiang Liu, Gang Wu, Ying Zhong. BMS‑345541 inhibits airway inflammation and epithelial‑mesenchymal transition in airway remodeling of asthmatic mice.
International journal of molecular medicine.
2018 Oct; 42(4):1998-2008. doi:
10.3892/ijmm.2018.3762. [PMID: 30015827] - Yan-Hua Xie, Si-Wang Wang, Yaping Zhang, Lars Edvinsson, Cang-Bao Xu. Nuclear Factor-kappaB-Mediated Endothelin Receptor Up-Regulation Increases Renal Artery Contractility in Rats.
Basic & clinical pharmacology & toxicology.
2013 Dec; 113(6):401-10. doi:
10.1111/bcpt.12123. [PMID: 24034179] - Julie Tsai, Rianna Zhang, Wei Qiu, Qiaozhu Su, Mark Naples, Khosrow Adeli. Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Jun; 296(6):G1287-98. doi:
10.1152/ajpgi.90540.2008. [PMID: 19342510] - Kazuto Takahashi, Shinya Yamaguchi, Tatsuhiro Shimoyama, Hiroyuki Seki, Kaoru Miyokawa, Hidenori Katsuta, Toshiaki Tanaka, Katsuhiko Yoshimoto, Hideki Ohno, Shinya Nagamatsu, Hitoshi Ishida. JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro.
American journal of physiology. Endocrinology and metabolism.
2008 May; 294(5):E898-909. doi:
10.1152/ajpendo.00131.2007. [PMID: 18303122] - Zachary A Knight, Kevan M Shokat. Features of selective kinase inhibitors.
Chemistry & biology.
2005 Jun; 12(6):621-37. doi:
10.1016/j.chembiol.2005.04.011. [PMID: 15975507] - James R Burke, Mark A Pattoli, Kurt R Gregor, Patrick J Brassil, John F MacMaster, Kim W McIntyre, Xiaoxia Yang, Violetta S Iotzova, Wendy Clarke, Joann Strnad, Yuping Qiu, F Christopher Zusi. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.
The Journal of biological chemistry.
2003 Jan; 278(3):1450-6. doi:
10.1074/jbc.m209677200. [PMID: 12403772]