Bitopertin (BioDeep_00000835285)
代谢物信息卡片
化学式: C21H20F7N3O4S (543.1062684000001)
中文名称: Bitopertin
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F
InChI: InChI=1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/t12-/m0/s1
描述信息
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10186
- PubChem: 24946690
- DrugBank: DB12426
- ChEMBL: CHEMBL1171829
- CAS: 845614-11-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Ali T Taher, Vip Viprakasit, Maria Domenica Cappellini, Dominik Kraus, Patrick Cech, Dietmar Volz, Erica Winter, Stephane Nave, Juergen Dukart, Omar Khwaja, Annette Koerner, Ricardo Hermosilla, Carlo Brugnara. Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non-transfusion-dependent β-thalassaemia.
British journal of haematology.
2021 07; 194(2):474-477. doi:
10.1111/bjh.17479
. [PMID: 33931857] - Azadeh Shahsavar, Peter Stohler, Gleb Bourenkov, Iwan Zimmermann, Martin Siegrist, Wolfgang Guba, Emmanuel Pinard, Steffen Sinning, Markus A Seeger, Thomas R Schneider, Roger J P Dawson, Poul Nissen. Structural insights into the inhibition of glycine reuptake.
Nature.
2021 03; 591(7851):677-681. doi:
10.1038/s41586-021-03274-z
. [PMID: 33658720] - Andrew R Hudson, Vincent J Santora, Robert E Petroski, Theresa A Almos, Gary Anderson, Richard Barido, Jillian Basinger, Chris L Bellows, Brett C Bookser, Nicola J Broadbent, Clifford Cabebe, Chih-Kun Chai, Mi Chen, Stephine Chow, De Michael Chung, Lindsay Heger, Anne M Danks, Graeme C Freestone, Dany Gitnick, Varsha Gupta, Christine Hoffmaster, Alan P Kaplan, Michael R Kennedy, Dong Lee, James Limberis, Kiev Ly, Chi Ching Mak, Brittany Masatsugu, Andrew C Morse, Jim Na, David Neul, John Nikpur, Joel Renick, Kristen Sebring, Samantha Sevidal, Ali Tabatabaei, Jenny Wen, Shouzhen Xia, Yingzhuo Yan, Zachary W Yoder, Douglas Zook, Marco Peters, J Guy Breitenbucher. Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.
Bioorganic & medicinal chemistry letters.
2020 07; 30(14):127214. doi:
10.1016/j.bmcl.2020.127214
. [PMID: 32527538] - Alessandro Matte, Enrica Federti, Michael Winter, Annette Koerner, Anja Harmeier, Norman Mazer, Tomas Tomka, Maria Luisa Di Paolo, Luigia De Falco, Immacolata Andolfo, Elisabetta Beneduce, Achille Iolascon, Alejandra Macias-Garcia, Jane-Jane Chen, Anne Janin, Christhophe Lebouef, Franco Turrini, Carlo Brugnara, Lucia De Franceschi. Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia.
JCI insight.
2019 11; 4(22):. doi:
10.1172/jci.insight.130111
. [PMID: 31593554] - Willi Amberg, Udo E W Lange, Michael Ochse, Frauke Pohlki, Berthold Behl, Ana Lucia Relo, Wilfried Hornberger, Carolin Hoft, Mario Mezler, Jens Sydor, Ying Wang, Hongyu Zhao, Jason T Brewer, Justin Dietrich, Huanqiu Li, Irini Akritopoulou-Zanze, Yanbin Lao, Steven M Hannick, Yi-Yin Ku, Anil Vasudevan. Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.
Journal of medicinal chemistry.
2018 09; 61(17):7503-7524. doi:
10.1021/acs.jmedchem.8b00300
. [PMID: 30080045] - Emmanuel Pinard, Edilio Borroni, Annette Koerner, Daniel Umbricht, Daniela Alberati. Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient.
Chimia.
2018 Aug; 72(7):477-484. doi:
10.2533/chimia.2018.477
. [PMID: 30158010] - Joshua T Kantrowitz, Karen A Nolan, Michael L Epstein, Nayla Lehrfeld, Constance Shope, Eva Petkova, Daniel C Javitt. Neurophysiological Effects of Bitopertin in Schizophrenia.
Journal of clinical psychopharmacology.
2017 Aug; 37(4):447-451. doi:
10.1097/jcp.0000000000000722
. [PMID: 28590364] - Michael Winter, Jürgen Funk, Annette Körner, Daniela Alberati, Francois Christen, Georg Schmitt, Bernd Altmann, Andreas Pospischil, Thomas Singer. Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats.
Experimental hematology.
2016 10; 44(10):964-974.e4. doi:
10.1016/j.exphem.2016.07.003
. [PMID: 27403535] - Andrea Greiter-Wilke, Ted Baird, Kyle O'Donohue, Annette Koerner. Cardiovascular safety assessments in the cynomolgus monkey: Unmasking potential background arrhythmias in general toxicity studies.
Journal of pharmacological and toxicological methods.
2016 Sep; 81(?):144-50. doi:
10.1016/j.vascn.2016.03.001
. [PMID: 26957141] - Carsten Hofmann, Flavia Pizzagalli, Christophe Boetsch, Daniela Alberati, Larry Ereshefsky, Stanford Jhee, Alain Patat, Bruno Boutouyrie-Dumont, Meret Martin-Facklam. Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Psychopharmacology.
2016 07; 233(13):2429-39. doi:
10.1007/s00213-016-4317-7
. [PMID: 27178435] - Paul Barrow, Neil Parrott, Daniela Alberati, Axel Paehler, Annette Koerner. Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor.
Birth defects research. Part B, Developmental and reproductive toxicology.
2016 Jun; 107(3):148-56. doi:
10.1002/bdrb.21179
. [PMID: 27221585] - Christophe Boetsch, Neil Parrott, Stephen Fowler, Agnes Poirier, Dominik Hainzl, Ludger Banken, Meret Martin-Facklam, Carsten Hofmann. Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Clinical pharmacokinetics.
2016 Feb; 55(2):237-47. doi:
10.1007/s40262-015-0312-0
. [PMID: 26341813] - Neil Parrott, Dominik Hainzl, Emmanuel Scheubel, Siegfried Krimmer, Christophe Boetsch, Elena Guerini, Meret Martin-Facklam. Physiologically based absorption modelling to predict the impact of drug properties on pharmacokinetics of bitopertin.
The AAPS journal.
2014 Sep; 16(5):1077-84. doi:
10.1208/s12248-014-9639-y
. [PMID: 24970349] - Donald C Goff. Bitopertin: the good news and bad news.
JAMA psychiatry.
2014 Jun; 71(6):621-2. doi:
10.1001/jamapsychiatry.2014.257
. [PMID: 24696065] - Daniel Umbricht, Daniela Alberati, Meret Martin-Facklam, Edilio Borroni, Eriene A Youssef, Michael Ostland, Tanya L Wallace, Frédéric Knoflach, Ernest Dorflinger, Joseph G Wettstein, Alexander Bausch, George Garibaldi, Luca Santarelli. Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study.
JAMA psychiatry.
2014 Jun; 71(6):637-46. doi:
10.1001/jamapsychiatry.2014.163
. [PMID: 24696094] - Elie Dolgin. Therapeutics: Negative feedback.
Nature.
2014 Apr; 508(7494):S10-1. doi:
10.1038/508s10a
. [PMID: 24695327] - Katie Kingwell. Schizophrenia drug gets negative results for negative symptoms.
Nature reviews. Drug discovery.
2014 Apr; 13(4):244-5. doi:
10.1038/nrd4294
. [PMID: 24687052] - Donnie Eddins, Terence G Hamill, Vanita Puri, Christopher E Cannon, Jeffrey A Vivian, Sandra M Sanabria-Bohórquez, Jacquelynn J Cook, John A Morrow, Fiona Thomson, Jason M Uslaner. The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.
Psychopharmacology.
2014 Feb; 231(3):511-9. doi:
10.1007/s00213-013-3260-0
. [PMID: 24051602] - Neil Parrott, Dominik Hainzl, Daniela Alberati, Carsten Hofmann, Richard Robson, Bruno Boutouyrie, Meret Martin-Facklam. Physiologically based pharmacokinetic modelling to predict single- and multiple-dose human pharmacokinetics of bitopertin.
Clinical pharmacokinetics.
2013 Aug; 52(8):673-83. doi:
10.1007/s40262-013-0061-x
. [PMID: 23591780] - Edilio Borroni, Yun Zhou, Susanne Ostrowitzki, Daniela Alberati, Anil Kumar, Dominik Hainzl, Thomas Hartung, John Hilton, Robert F Dannals, Dean F Wong. Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography.
NeuroImage.
2013 Jul; 75(?):291-300. doi:
10.1016/j.neuroimage.2011.11.090
. [PMID: 22178811] - Dean F Wong, Susanne Ostrowitzki, Yun Zhou, Vanessa Raymont, Carsten Hofmann, Edilio Borroni, Anil Kumar, Nikhat Parkar, James R Brašić, John Hilton, Robert F Dannals, Meret Martin-Facklam. Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans.
NeuroImage.
2013 Jul; 75(?):282-290. doi:
10.1016/j.neuroimage.2011.11.052
. [PMID: 22155032] - Meret Martin-Facklam, Flavia Pizzagalli, Yun Zhou, Susanne Ostrowitzki, Vanessa Raymont, James R Brašić, Nikhat Parkar, Daniel Umbricht, Robert F Dannals, Ron Goldwater, Dean F Wong. Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 Feb; 38(3):504-12. doi:
10.1038/npp.2012.212
. [PMID: 23132267] - Carsten Hofmann, Ludger Banken, Michael Hahn, Dennis Swearingen, Sandra Nagel, Meret Martin-Facklam. Evaluation of the effects of bitopertin (RG1678) on cardiac repolarization: a thorough corrected QT study in healthy male volunteers.
Clinical therapeutics.
2012 Oct; 34(10):2061-71. doi:
10.1016/j.clinthera.2012.08.010
. [PMID: 22980315] - Daniel C Javitt. Glycine transport inhibitors in the treatment of schizophrenia.
Handbook of experimental pharmacology.
2012; ?(213):367-99. doi:
10.1007/978-3-642-25758-2_12
. [PMID: 23027421] - Corey R Hopkins. ACS chemical neuroscience molecule spotlight on RG1678.
ACS chemical neuroscience.
2011 Dec; 2(12):685-6. doi:
10.1021/cn200108z
. [PMID: 22860161] - Emmanuel Pinard, Alexander Alanine, Daniela Alberati, Markus Bender, Edilio Borroni, Patrick Bourdeaux, Virginie Brom, Serge Burner, Holger Fischer, Dominik Hainzl, Remy Halm, Nicole Hauser, Synese Jolidon, Judith Lengyel, Hans-Peter Marty, Thierry Meyer, Jean-Luc Moreau, Roland Mory, Robert Narquizian, Mathias Nettekoven, Roger D Norcross, Bernd Puellmann, Philipp Schmid, Sebastien Schmitt, Henri Stalder, Roger Wermuth, Joseph G Wettstein, Daniel Zimmerli. Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
Journal of medicinal chemistry.
2010 Jun; 53(12):4603-14. doi:
10.1021/jm100210p
. [PMID: 20491477]