Olesoxime (BioDeep_00000834987)
代谢物信息卡片
化学式: C27H45NO (399.350096)
中文名称: 奥利索西
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4=CC(=NO)CCC34C)C
InChI: InChI=1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21-
描述信息
Olesoxime (TRO 19622) is a mitochondrial-targeted neuroprotective compound with mean EC50 value for increasing cell survival is 3.2±0.2 μM.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D11213
- PubChem: 9930827
- PubChem: 5354851
- CAS: 66538-08-7
- CAS: 22033-87-0
- medchemexpress: HY-14796
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guzalia F Zakyrjanova, Amir I Gilmutdinov, Andrey N Tsentsevitsky, Alexey M Petrov. Olesoxime, a cholesterol-like neuroprotectant restrains synaptic vesicle exocytosis in the mice motor nerve terminals: Possible role of VDACs.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 09; 1865(9):158739. doi:
10.1016/j.bbalip.2020.158739. [PMID: 32428575] - Amandine Rovini, Philip A Gurnev, Alexandra Beilina, María Queralt-Martín, William Rosencrans, Mark R Cookson, Sergey M Bezrukov, Tatiana K Rostovtseva. Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.
Cellular and molecular life sciences : CMLS.
2020 Sep; 77(18):3611-3626. doi:
10.1007/s00018-019-03386-w. [PMID: 31760463] - Gunter P Eckert, Schamim H Eckert, Janett Eckmann, Stephanie Hagl, Walter E Muller, Kristina Friedland. Olesoxime improves cerebral mitochondrial dysfunction and enhances Aβ levels in preclinical models of Alzheimer's disease.
Experimental neurology.
2020 07; 329(?):113286. doi:
10.1016/j.expneurol.2020.113286. [PMID: 32199815] - Hélène Blasco, Franck Patin, Amandine Descat, Guillaume Garçon, Philippe Corcia, Patrick Gelé, Timothée Lenglet, Peter Bede, Vincent Meininger, David Devos, Jean François Gossens, Pierre-François Pradat. A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression.
PloS one.
2018; 13(6):e0198116. doi:
10.1371/journal.pone.0198116. [PMID: 29870556] - S Martínez-Abad, M Castillo-Martín, B Gadani, J E Rodríguez-Gil, S Bonet, M Yeste. Voltage-dependent anion channel 2 is involved in in vitro capacitation of boar sperm.
Reproduction in domestic animals = Zuchthygiene.
2017 Oct; 52 Suppl 4(?):65-68. doi:
10.1111/rda.13060. [PMID: 29052329] - M R Kasimov, G F Zakyrjanova, A R Giniatullin, A L Zefirov, A M Petrov. Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction.
Biochimica et biophysica acta.
2016 Jul; 1861(7):606-16. doi:
10.1016/j.bbalip.2016.04.010. [PMID: 27102612] - Muhammad K Rafiq, Ellen Lee, Michael Bradburn, Christopher J McDermott, Pamela J Shaw. Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial.
Amyotrophic lateral sclerosis & frontotemporal degeneration.
2015; 16(7-8):478-84. doi:
10.3109/21678421.2015.1062517. [PMID: 26161993] - G Duffour, G Srougi, N Bressot, J Alquier, J Castel, R Jean. [Biological and hormonal balance during oral nutrition, exclusive perenteral and mixed nutrition in children].
Annales de l'anesthesiologie francaise.
1977; 18(12):1063-70. doi:
NULL. [PMID: 24393]