Saredutant (BioDeep_00000834727)
代谢物信息卡片
Saredutant
化学式: C31H35Cl2N3O2 (551.210619)
中文名称: 沙瑞度坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1(CCN(CC1)CCC(CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4
InChI: InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1
描述信息
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
Saredutant is a selective NK2 receptor antagonist.
同义名列表
3 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 104974
- DrugBank: DB06660
- ChEMBL: CHEMBL308148
- CAS: 142001-63-6
- medchemexpress: HY-106910
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alessandra Tamburella, Gian Marco Leggio, Vincenzo Micale, Andrea Navarria, Claudio Bucolo, Valentina Cicirata, Filippo Drago, Salvatore Salomone. Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.
The international journal of neuropsychopharmacology.
2013 May; 16(4):813-23. doi:
10.1017/s1461145712000612. [PMID: 22695046] - Takahiro Tanaka, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Yasushi Fujioka, Hidenori Kamiguchi, Masashi Yamaguchi, Akio Imanishi, Makiko Kawamoto, Kasei Miura, Yoichi Nishikawa, Yasuhiro Tsukimi. Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.
Journal of pharmacological sciences.
2012; 118(4):487-95. doi:
10.1254/jphs.11245fp. [PMID: 22447303] - Akhil Hegde, Yung-Hua Koh, Shabbir M Moochhala, Madhav Bhatia. Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights.
International journal of inflammation.
2010 Sep; 2010(?):601098. doi:
10.4061/2010/601098. [PMID: 21188216] - Soraia K P Costa, Aila Mirtes Teles, Yoshito Kumagai, Susan D Brain, Simone A Teixeira, Ana A Varriano, Maria Alice A G Barreto, Wothan Tavares de Lima, Edson Antunes, Marcelo N Muscará, Soraia K P Costa. Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ).
Archives of toxicology.
2010 Feb; 84(2):109-17. doi:
10.1007/s00204-009-0427-x. [PMID: 19399481] - Yoko Shibata, Jim F White, Maria J Serrano-Vega, Francesca Magnani, Amanda L Aloia, Reinhard Grisshammer, Christopher G Tate. Thermostabilization of the neurotensin receptor NTS1.
Journal of molecular biology.
2009 Jul; 390(2):262-77. doi:
10.1016/j.jmb.2009.04.068. [PMID: 19422831] - Josef Donnerer, Ingrid Liebmann, Rufina Schuligoi. Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Basic & clinical pharmacology & toxicology.
2009 Jan; 104(1):11-6. doi:
10.1111/j.1742-7843.2008.00338.x. [PMID: 19152548] - Ping-Chia Li, Wen-Chung Chen, Li-Ching Chang, Shao-Chieh Lin. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
American journal of physiology. Lung cellular and molecular physiology.
2008 May; 294(5):L912-20. doi:
10.1152/ajplung.00443.2007. [PMID: 18326823] - Dorota Kakol-Palm, Mikael Brusberg, Elin Sand, Håkan Larsson, Vicente Martinez, Anders Johansson, Bengt von Mentzer, Ingrid Påhlman, Erik Lindström. Role of tachykinin NK(1) and NK(2) receptors in colonic sensitivity and stress-induced defecation in gerbils.
European journal of pharmacology.
2008 Mar; 582(1-3):123-31. doi:
10.1016/j.ejphar.2007.12.002. [PMID: 18234189] - Ping-Chia Li, Chen-Fu Shaw, Tin-Fan Kuo, Chiang-Ting Chien. Inducible nitric oxide synthase evoked nitric oxide counteracts capsaicin-induced airway smooth muscle contraction, but exacerbates plasma extravasation.
Neuroscience letters.
2005 Apr; 378(2):117-22. doi:
10.1016/j.neulet.2004.12.020. [PMID: 15774269] - Júlia M M Santos, Maria Aparecida K F Tatsuo, Regina Maria M Turchetti-Maia, Marcela C G Lisboa, Janetti N de Francischi. Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Journal of pharmacological sciences.
2004 Apr; 94(4):384-92. doi:
10.1254/jphs.94.384. [PMID: 15107578] - Andrew D Grant, Roksana Akhtar, Norma P Gerard, Susan D Brain. Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
The Journal of physiology.
2002 Sep; 543(Pt 3):1007-14. doi:
10.1113/jphysiol.2002.018846. [PMID: 12231654] - Soraia K P Costa, Ronilson A Moreno, Laura C M Esquisatto, Luiz Juliano, Susan D Brain, Gilberto De Nucci, Edson Antunes. Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
Neuroscience letters.
2002 Feb; 318(3):158-62. doi:
10.1016/s0304-3940(01)02498-3. [PMID: 11803123] - P R Bernstein, D Aharony, J S Albert, D Andisik, H G Barthlow, R Bialecki, T Davenport, R F Dedinas, B T Dembofsky, G Koether, B J Kosmider, K Kirkland, C J Ohnmacht, W Potts, W L Rumsey, L Shen, A Shenvi, S Sherwood, D Stollman, K Russell. Discovery of novel, orally active dual NK1/NK2 antagonists.
Bioorganic & medicinal chemistry letters.
2001 Oct; 11(20):2769-73. doi:
10.1016/s0960-894x(01)00572-8. [PMID: 11591520] - F F Lam, A L Yip. Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint.
European journal of pharmacology.
2000 Jul; 400(2-3):327-35. doi:
10.1016/s0014-2999(00)00400-3. [PMID: 10988351] - A Linardi, S K Costa, G R da Silva, E Antunes. Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
European journal of pharmacology.
2000 Jul; 399(2-3):235-42. doi:
10.1016/s0014-2999(00)00375-7. [PMID: 10884525] - E J Oh, L P Thompson, D Weinreich. Sexually dimorphic regulation of NK-1 receptor-mediated electrophysiological responses in vagal primary afferent neurons.
Journal of neurophysiology.
2000 Jul; 84(1):51-6. doi:
10.1152/jn.2000.84.1.51. [PMID: 10899182] - B J Gu, O Ishizuka, Y Igawa, O Nishizawa, K E Andersson. Role of supraspinal tachykinins for micturition in conscious rats with and without bladder outlet obstruction.
Naunyn-Schmiedeberg's archives of pharmacology.
2000 May; 361(5):543-8. doi:
10.1007/s002100000228. [PMID: 10832609] - N Yonehara, M Yoshimura. Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.
Neuroscience research.
2000 Jan; 36(1):35-43. doi:
10.1016/s0168-0102(99)00107-8. [PMID: 10678530] - O Ishizuka, Y Igawa, O Nishizawa, K E Andersson. Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats.
Neurourology and urodynamics.
2000; 19(1):101-9. doi:
10.1002/(sici)1520-6777(2000)19:1<101::aid-nau10>3.0.co;2-g. [PMID: 10602251] - J Gay, J Fioramonti, R Garcia-Villar, X Emonds-Alt, L Bueno. Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.
Gut.
1999 Apr; 44(4):497-503. doi:
10.1136/gut.44.4.497. [PMID: 10075956] - P Baluk, G Thurston, T J Murphy, N W Bunnett, D M McDonald. Neurogenic plasma leakage in mouse airways.
British journal of pharmacology.
1999 Jan; 126(2):522-8. doi:
10.1038/sj.bjp.0702323. [PMID: 10077247] - M Tramontana, R Patacchini, S Giuliani, A Lippi, A Lecci, P Santicioli, M Criscuoli, C A Maggi. Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.
European journal of pharmacology.
1998 Jul; 352(2-3):279-88. doi:
10.1016/s0014-2999(98)00376-8. [PMID: 9716365] - S Daoui, C Cognon, E Naline, X Emonds-Alt, C Advenier. Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs.
American journal of respiratory and critical care medicine.
1998 Jul; 158(1):42-8. doi:
10.1164/ajrccm.158.1.9705052. [PMID: 9655705] - R D Bukoski, K Bian, Y Wang, M Mupanomunda. Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Hypertension (Dallas, Tex. : 1979).
1997 Dec; 30(6):1431-9. doi:
10.1161/01.hyp.30.6.1431. [PMID: 9403564] - S Daoui, Y Y Cui, V Lagente, X Emonds-Alt, C Advenier. A tachykinin NK3 receptor antagonist, SR 142801 (osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs.
Pulmonary pharmacology & therapeutics.
1997 Oct; 10(5-6):261-70. doi:
10.1006/pupt.1998.0104. [PMID: 9778489] - H M Sarau, D E Griswold, W Potts, J J Foley, D B Schmidt, E F Webb, L D Martin, M E Brawner, N A Elshourbagy, A D Medhurst, G A Giardina, D W Hay. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
1997 Jun; 281(3):1303-11. doi:
NULL. [PMID: 9190866] - K Biyah, M Molimard, X Emonds-Alt, C Advenier. SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways.
European journal of pharmacology.
1996 Jul; 308(3):325-8. doi:
10.1016/0014-2999(96)00335-4. [PMID: 8858307] - P R Germonpré, G F Joos, E Everaert, J C Kips, R A Pauwels. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
American journal of respiratory and critical care medicine.
1995 Dec; 152(6 Pt 1):1796-804. doi:
10.1164/ajrccm.152.6.8520739. [PMID: 8520739] - C Savoie, C Tousignant, I W Rodger, C C Chan. Involvement of NK1 and NK2 receptors in pulmonary responses elicited by non-adrenergic, non-cholinergic vagal stimulation in guinea-pigs.
The Journal of pharmacy and pharmacology.
1995 Nov; 47(11):914-20. doi:
10.1111/j.2042-7158.1995.tb03270.x. [PMID: 8708985] - M A Dias, A H Campos, V Cechinel Filho, R A Yunes, J B Calixto. Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
The Journal of pharmacy and pharmacology.
1995 Oct; 47(10):846-51. doi:
10.1111/j.2042-7158.1995.tb05752.x. [PMID: 8583354] - C T O'Shaughnessy, H E Connor. Investigation of the role of tachykinin NK1, NK2 receptors and CGRP receptors in neurogenic plasma protein extravasation in dura mater.
European journal of pharmacology.
1994 Sep; 263(1-2):193-8. doi:
10.1016/0014-2999(94)90541-x. [PMID: 7821352] - A Ahluwalia, C A Maggi, P Santicioli, A Lecci, S Giuliani. Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder.
British journal of pharmacology.
1994 Apr; 111(4):1017-22. doi:
10.1111/j.1476-5381.1994.tb14845.x. [PMID: 8032584] - S Auberson, J M Lundberg. Lactic acid-induced plasma protein extravasation in rat airways by stimulation of sensory nerves and NK1 receptor activation.
Pharmacology & toxicology.
1993 Dec; 73(6):305-10. doi:
10.1111/j.1600-0773.1993.tb01356.x. [PMID: 8153052] - Y Hirayama, R Yasumitsu, A Kawamura, T Fujii. NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.
Agents and actions.
1993 Nov; 40(3-4):171-5. doi:
10.1007/bf01984057. [PMID: 7517617] - Y Qian, X Emonds-Alt, C Advenier. Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Pulmonary pharmacology.
1993 Mar; 6(1):63-7. doi:
10.1006/pulp.1993.1009. [PMID: 7682876] - M Nicolau, M G Sirois, M Bui, G E Plante, P Sirois, D Regoli. Plasma extravasation induced by neurokinins in conscious rats: receptor characterization with agonists and antagonists.
Canadian journal of physiology and pharmacology.
1993 Mar; 71(3-4):217-21. doi:
10.1139/y93-034. [PMID: 7691388] - C Tousignant, C C Chan, D Guevremont, C Brideau, J J Hale, M MacCoss, I W Rodger. NK2 receptors mediate plasma extravasation in guinea-pig lower airways.
British journal of pharmacology.
1993 Feb; 108(2):383-6. doi:
10.1111/j.1476-5381.1993.tb12813.x. [PMID: 8383563] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
Biochimica et biophysica acta.
1976 Apr; 428(2):525-31. doi:
10.1016/0304-4165(76)90061-1. [PMID: 6049]