Nepicastat (BioDeep_00000834386)

   


代谢物信息卡片


Nepicastat

化学式: C14H15F2N3S (295.0955)
中文名称: 5-(氨甲基)-1-((S)-5,7-二氟-1,2,3,4-四氢-2-萘)-4-咪唑啉-2-硫酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2=C(CC1N3C(=CNC3=S)CN)C=C(C=C2F)F
InChI: InChI=1S/C14H15F2N3S/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20/h3,5,7,10H,1-2,4,6,17H2,(H,18,20)/t10-/m0/s1

描述信息

C471 - Enzyme Inhibitor

同义名列表

1 个代谢物同义名

Nepicastat



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Diogo Nóbrega Catelas, Maria Paula Serrão, Patricio Soares-Da-Silva. Effects of nepicastat upon dopamine-β-hydroxylase activity and dopamine and norepinephrine levels in the rat left ventricle, kidney, and adrenal gland. Clinical and experimental hypertension (New York, N.Y. : 1993). 2020; 42(2):118-125. doi: 10.1080/10641963.2019.1583245. [PMID: 30821508]
  • Joana Bicker, Gilberto Alves, Ana Fortuna, Patrício Soares-da-Silva, Amílcar Falcão. In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 May; 117(?):35-40. doi: 10.1016/j.ejps.2018.02.006. [PMID: 29428540]
  • Ana I Loureiro, Maria João Bonifácio, Carlos Fernandes-Lopes, Nuno Pires, Bruno Igreja, Lyndon C Wright, Patrício Soares-da-Silva. Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(9):828-39. doi: 10.3109/00498254.2015.1018985. [PMID: 25915108]
  • Meriem Gaval-Cruz, Jason P Schroeder, L Cameron Liles, Martin A Javors, David Weinshenker. Effects of disulfiram and dopamine beta-hydroxylase knockout on cocaine-induced seizures. Pharmacology, biochemistry, and behavior. 2008 Jun; 89(4):556-62. doi: 10.1016/j.pbb.2008.02.009. [PMID: 18329701]
  • H N Sabbah, W C Stanley, V G Sharov, T Mishima, M Tanimura, C R Benedict, S Hegde, S Goldstein. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation. 2000 Oct; 102(16):1990-5. doi: 10.1161/01.cir.102.16.1990. [PMID: 11034950]
  • S S Hegde, K F Friday. Dopamine-beta-hydroxylase inhibition: a novel sympatho-modulatory approach for the treatment of congestive heart failure. Current pharmaceutical design. 1998 Dec; 4(6):469-79. doi: NULL. [PMID: 10197057]
  • W C Stanley, K Lee, L G Johnson, R L Whiting, R M Eglen, S S Hegde. Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. Journal of cardiovascular pharmacology. 1998 Jun; 31(6):963-70. doi: 10.1097/00005344-199806000-00023. [PMID: 9641484]
  • W C Stanley, B Li, D W Bonhaus, L G Johnson, K Lee, S Porter, K Walker, G Martinez, R M Eglen, R L Whiting, S S Hegde. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. British journal of pharmacology. 1997 Aug; 121(8):1803-9. doi: 10.1038/sj.bjp.0701315. [PMID: 9283721]