Norfenefrine hydrochloride (BioDeep_00000832736)

   


代谢物信息卡片


Norphenylephrine Hydrochloride

化学式: C8H12ClNO2 (189.0556522)
中文名称: 盐酸去氧肾上腺素(苯肾上腺素杂质A), 3-(2-氨基-1-羟乙基)苯酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC(=C1)O)C(CN)O.Cl
InChI: 1H

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence[1][2].

同义名列表

3 个代谢物同义名

Norphenylephrine Hydrochloride; Norfenefrine hydrochloride; Norfenefrine (hydrochloride)



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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文献列表

  • M Flechtner-Mors, C P Jenkinson, A Alt, G Adler, H H Ditschuneit. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. The Journal of pharmacology and experimental therapeutics. 2002 Apr; 301(1):229-33. doi: 10.1124/jpet.301.1.229. [PMID: 11907178]
  • A Tanaka. [Application of radionuclides in pharmaceutical fields]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2000 Jun; 120(6):506-19. doi: 10.1248/yakushi1947.120.6_506. [PMID: 10860484]
  • O Oldenburg, M Karliova, S Koeppen, F Weber, R Erbel, T Philipp, A Kribben. [Shy-Drager syndrome: a rare cause of orthostatic hypotension]. Deutsche medizinische Wochenschrift (1946). 1999 Jan; 124(1-2):8-12. doi: 10.1055/s-2008-1062602. [PMID: 9951452]
  • E Diernaes, P Rix, T Sørensen, N Alexander. Norfenefrine in the treatment of female urinary stress incontinence assessed by one-hour pad weighing test. Urologia internationalis. 1989; 44(1):28-31. doi: 10.1159/000281445. [PMID: 2568712]
  • M W Couch, D M Greer, C M Williams. Excretion of octopamine metabolites in neuroblastoma. Clinica chimica acta; international journal of clinical chemistry. 1986 Jul; 158(1):109-14. doi: 10.1016/0009-8981(86)90121-x. [PMID: 3091293]
  • K E Ibrahim, M W Couch, C M Williams, M J Fregly, J M Midgley. m-Octopamine: normal occurrence with p-octopamine in mammalian sympathetic nerves. Journal of neurochemistry. 1985 Jun; 44(6):1862-7. doi: 10.1111/j.1471-4159.1985.tb07180.x. [PMID: 3921667]
  • K E Ibrahim, M W Couch, C M Williams. Increased urinary excretion of m-octopamine in neuroblastoma. Biochemical medicine. 1985 Feb; 33(1):53-9. doi: 10.1016/0006-2944(85)90126-7. [PMID: 3994701]
  • J A Hoskins, A M Greenway. The metabolism of L-m-tyrosine: the use of a putative precursor to investigate the increased production of m-hydroxymandelic acid in phenylketonuria. Clinica chimica acta; international journal of clinical chemistry. 1983 Jun; 130(3):329-38. doi: 10.1016/0009-8981(83)90307-8. [PMID: 6872265]
  • W M Schmitt, W Kindermann, E Stengele, W André. [The effect of norfenefrine on circulation, plasma catecholamines and metabolism at rest and during exertion]. Zeitschrift fur Kardiologie. 1983 Jun; 72(6):321-6. doi: NULL. [PMID: 6351455]
  • M A Rahmani, S Sen, L Amin, R Henderson. Comparative estimation of octopamine in the aortic smooth muscle, plasma and red blood cells of spontaneously hypertensive and Wistar Koyoto control rats. Cytobios. 1983; 38(150):83-9. doi: . [PMID: 6416750]
  • J R Crowley, M W Couch, C M Williams, M I James, K E Ibrahim, J M Midgley. Identification and quantitative determination of m-hydroxyphenylglycol in mammalian urine. Biomedical mass spectrometry. 1982 Apr; 9(4):146-52. doi: 10.1002/bms.1200090404. [PMID: 7093439]
  • R Laven, E A Schäfer. [Release of norfenefrine from sustained-release formulations by an in vitro dissolution model. Simulation of 'drug levels' by calculation using pharmacokinetical constants and comparison with in vivo course of action (author's transl)]. Arzneimittel-Forschung. 1981; 31(2):353-6. doi: NULL. [PMID: 7194653]