Picryl chloride (BioDeep_00000832678)
代谢物信息卡片
2,4,6-trinitrochlorobenzene
化学式: C6H2ClN3O6 (246.9632142)
中文名称: 2,4,6-三硝基氯苯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])Cl)[N+](=O)[O-])[N+](=O)[O-]
InChI: InChI=1S/C6H2ClN3O6/c7-6-4(9(13)14)1-3(8(11)12)2-5(6)10(15)16/h1-2H
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Byung-Hak Kim, Sanghyun Lee. Sophoricoside from Styphnolobium japonicum improves experimental atopic dermatitis in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Feb; 82(?):153463. doi:
10.1016/j.phymed.2021.153463. [PMID: 33545490] - Takao Setsu, Yusuke Hamada, Daisuke Oikawa, Tomohisa Mori, Yozo Ishiuji, Daisuke Sato, Michiko Narita, Shogo Miyazaki, Eri Furuta, Yukari Suda, Hiroyasu Sakai, Takahiro Ochiya, Hiroyuki Tezuka, Masako Iseki, Eiichi Inada, Akihiro Yamanaka, Naoko Kuzumaki, Minoru Narita. Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch.
Biochemical and biophysical research communications.
2021 01; 534(?):624-631. doi:
10.1016/j.bbrc.2020.11.030. [PMID: 33220930] - Yoon Hwan Kim, Tae Hyeong Kim, Min Soo Kang, Jin Ok Ahn, Jung Hoon Choi, Jin Young Chung. Comparison of the presentation of atopic dermatitis induced by trinitrochlorobenzene and house dust mite in NC/Nga mice.
Journal of veterinary science.
2020 Jul; 21(4):e59. doi:
10.4142/jvs.2020.21.e59. [PMID: 32735097] - Katsuhiko Matsui, Yuki Nojima, Yuka Kajiwara, Kana Busujima, Yuki Mori. Topical Application of Doxycycline Inhibits Th2 Cell Development Mediated by Langerhans Cells and Exerts a Therapeutic Effect on Atopic Dermatitis.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2020; 23(1):86-99. doi:
10.18433/jpps30847. [PMID: 32338591] - Masafumi Noda, Nasrin Sultana, Ikue Hayashi, Mitsuhiro Fukamachi, Masanori Sugiyama. Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis.
Molecules (Basel, Switzerland).
2019 Aug; 24(16):. doi:
10.3390/molecules24162970. [PMID: 31426284] - Eri Hotta, Risa Tamagawa-Mineoka, Norito Katoh. Platelets are important for the development of immune tolerance: Possible involvement of TGF-β in the mechanism.
Experimental dermatology.
2019 07; 28(7):801-808. doi:
10.1111/exd.13940. [PMID: 30991458] - Tomohiro Arakawa, Takahiro Sugiyama, Haruka Matsuura, Tomofumi Okuno, Hirofumi Ogino, Fumitoshi Sakazaki, Hitoshi Ueno. Effects of Supplementary Seleno-L-methionine on Atopic Dermatitis-Like Skin Lesions in Mice.
Biological & pharmaceutical bulletin.
2018; 41(9):1456-1462. doi:
10.1248/bpb.b18-00349. [PMID: 30175780] - Risa Yasuike, Risa Tamagawa-Mineoka, Mayumi Ueta, Naomi Nakamura, Shigeru Kinoshita, Norito Katoh. The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation.
Journal of dermatological science.
2017 Nov; 88(2):184-191. doi:
10.1016/j.jdermsci.2017.07.017. [PMID: 28807557] - Hyun Joo Lee, Sang Hyun Cho. Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism.
Journal of Korean medical science.
2017 Apr; 32(4):679-687. doi:
10.3346/jkms.2017.32.4.679. [PMID: 28244297] - Katsuhiko Matsui, Kanta Tachioka, Kei Onodera, Reiko Ikeda. Topical Application of Josamycin Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2017; 20(?):38-47. doi:
10.18433/j3gw3d. [PMID: 28459659] - Young Mi Seo, Seok Hee Jeong. [Effects of Blending Oil of Lavender and Thyme on Oxidative Stress, Immunity, and Skin Condition in Atopic Dermatitis Induced Mice].
Journal of Korean Academy of Nursing.
2015 Jun; 45(3):367-77. doi:
10.4040/jkan.2015.45.3.367. [PMID: 26159138] - A Matsushita, M Seike, T Hagiwara, A Sato, H Ohtsu. Close relationship between T helper (Th)17 and Th2 response in murine allergic contact dermatitis.
Clinical and experimental dermatology.
2014 Dec; 39(8):924-31. doi:
10.1111/ced.12425. [PMID: 25196929] - Kazuya Murata, Yumi Abe, Megumi Futamura-Masudaa, Akemi Uwaya, Fumiyuki Isami, Hideaki Matsuda. Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents.
Natural product communications.
2014 Apr; 9(4):445-50. doi:
". [PMID: 24868850] - Chin-Tung Wu, Keng-Shiang Huang, Chih-Hui Yang, Yu-Chang Chen, Jiunn-Wang Liao, Chao-Lin Kuo, Chung-Li Chen, Shu-Fang Lo, Chang-Chi Hsieh, Hsin-Sheng Tsay. Inhibitory effects of cultured Dendrobium tosaense on atopic dermatitis murine model.
International journal of pharmaceutics.
2014 Mar; 463(2):193-200. doi:
10.1016/j.ijpharm.2013.08.015. [PMID: 23958754] - Reginald Bayani Salonga, Shinsuke Hisaka, Mitsuhiko Nose. Effect of the hot water extract of Artocarpus camansi leaves on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity in mice.
Biological & pharmaceutical bulletin.
2014; 37(3):493-7. doi:
10.1248/bpb.b13-00738. [PMID: 24583870] - Eujin Cho, Sang Hyun Cho. Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.
Journal of ethnopharmacology.
2013 Jan; 145(1):294-302. doi:
10.1016/j.jep.2012.11.006. [PMID: 23149290] - E Takita, S Yokota, Y Tahara, A Hirao, N Aoki, Y Nakamura, A Nakao, S Shibata. Biological clock dysfunction exacerbates contact hypersensitivity in mice.
The British journal of dermatology.
2013 Jan; 168(1):39-46. doi:
10.1111/j.1365-2133.2012.11176.x. [PMID: 22834538] - Kaori Sadakane, Takamichi Ichinose, Hirohisa Takano, Rie Yanagisawa, Ken-ichiro Inoue, Hiroaki Kawazato, Aiko Yasuda, Kazuichi Hayakawa. Organic chemicals in diesel exhaust particles enhance picryl chloride-induced atopic dermatitis in NC/Nga mice.
International archives of allergy and immunology.
2013; 162(1):7-15. doi:
10.1159/000350765. [PMID: 23817207] - Katsunori Yamaura, Makiko Ishiwatari, Masao Yamamoto, Maki Shimada, Yuanyuan Bi, Koichi Ueno. Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation.
Journal of food science.
2012 Dec; 77(12):H262-7. doi:
10.1111/j.1750-3841.2012.02974.x. [PMID: 23164040] - Jing Tian, Huilian Che, Da Ha, Yeping Wei, Shuyun Zheng. Characterization and anti-allergic effect of a polysaccharide from the flower buds of Lonicera japonica.
Carbohydrate polymers.
2012 Nov; 90(4):1642-7. doi:
10.1016/j.carbpol.2012.07.044. [PMID: 22944428] - T Fukuyama, T Kosaka, L Miyashita, R Nishino, K Wada, K Hayashi, H Ueda, T Harada. Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.
Toxicology letters.
2012 Sep; 213(3):392-401. doi:
10.1016/j.toxlet.2012.07.018. [PMID: 22842586] - Ayuko Matsushita, Masahiro Seike, Haruka Okawa, Yayoi Kadawaki, Hiroshi Ohtsu. Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis.
Experimental dermatology.
2012 Sep; 21(9):714-5. doi:
10.1111/j.1600-0625.2012.01559.x. [PMID: 22897580] - Satoshi Seino, Yurie Tanaka, Taro Honma, Miyuki Yanaka, Kenta Sato, Nahoko Shinohara, Junya Ito, Tsuyoshi Tsuduki, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Ikeda. Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse.
Journal of clinical biochemistry and nutrition.
2012 Mar; 50(2):152-7. doi:
10.3164/jcbn.11-29. [PMID: 22448097] - Nlandu Roger Ngatu, Maiko K Okajima, Maki Yokogawa, Ryoji Hirota, Masamitsu Eitoku, Basilua Andre Muzembo, Narongpon Dumavibhat, Mikiro Takaishi, Shigetoshi Sano, Tatsuo Kaneko, Takumi Tanaka, Hiroyuki Nakamura, Narufumi Suganuma. Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2012 Feb; 108(2):117-22. doi:
10.1016/j.anai.2011.10.013. [PMID: 22289731] - Sunmin Park, Jung Bok Lee, Suna Kang. Topical Application of Chrysanthemum indicum L. Attenuates the Development of Atopic Dermatitis-Like Skin Lesions by Suppressing Serum IgE Levels, IFN-γ, and IL-4 in Nc/Nga Mice.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):821967. doi:
10.1155/2012/821967. [PMID: 22454686] - Daisuke Hayashi, Hotaka Sugaya, Takayuki Ohkoshi, Kaori Sekizawa, Hirokatsu Takatsu, Tadashi Shinkai, Shiro Urano. Vitamin E improves biochemical indices associated with symptoms of atopic dermatitis-like inflammation in NC/Nga mice.
Journal of nutritional science and vitaminology.
2012; 58(3):161-8. doi:
10.3177/jnsv.58.161. [PMID: 22878385] - Andreas Natsch, Tina Haupt, Heike Laue. Relating skin sensitizing potency to chemical reactivity: reactive Michael acceptors inhibit NF-κB signaling and are less sensitizing than S(N)Ar- and S(N)2- reactive chemicals.
Chemical research in toxicology.
2011 Nov; 24(11):2018-27. doi:
10.1021/tx2003678. [PMID: 22023385] - Atsuto Ogata, Yusuke Fujieda, Maki Terakawa, Tsuyoshi Muto, Taisaku Tanaka, Hiroshi Maruoka, Kazuhiro Nagahira, Yoshiaki Fukuda, Yoshiaki Tomimori, Naohiro Watanabe. Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients.
International immunopharmacology.
2011 Oct; 11(10):1628-32. doi:
10.1016/j.intimp.2011.05.025. [PMID: 21642018] - Eriko Suwa, Katsunori Yamaura, Manabu Oda, Takao Namiki, Koichi Ueno. Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model.
European journal of pharmacology.
2011 Sep; 667(1-3):383-8. doi:
10.1016/j.ejphar.2011.05.037. [PMID: 21664903] - Katsunori Yamaura, Ryosuke Doi, Eriko Suwa, Koichi Ueno. A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin.
The Journal of toxicological sciences.
2011 Aug; 36(4):395-401. doi:
10.2131/jts.36.395. [PMID: 21804303] - Noriyuki Nakayama, Katsunori Yamaura, Maki Shimada, Koichi Ueno. Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.
Pharmacognosy research.
2011 Jul; 3(3):155-9. doi:
10.4103/0974-8490.84999. [PMID: 22022162] - Adam V Wisnewski, Lan Xu, Eve Robinson, Jian Liu, Carrie A Redlich, Christina A Herrick. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(?):6. doi:
10.1186/1745-6673-6-6. [PMID: 21414210] - Christian Lass, Irmgard Merfort, Stefan F Martin. In vitro and in vivo analysis of pro- and anti-inflammatory effects of weak and strong contact allergens.
Experimental dermatology.
2010 Nov; 19(11):1007-13. doi:
10.1111/j.1600-0625.2010.01136.x. [PMID: 20701630] - Zenro Ikezawa, Junko Komori, Yuko Ikezawa, Yusuke Inoue, Mio Kirino, Masako Katsuyama, Michiko Aihara. A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis.
Allergy, asthma & immunology research.
2010 Oct; 2(4):235-46. doi:
10.4168/aair.2010.2.4.235. [PMID: 20885908] - Bock Gie Jung, Sun Ju Cho, Jae Hyung Ko, Bong Joo Lee. Inhibitory effects of interleukin-10 plasmid DNA on the development of atopic dermatitis-like skin lesions in NC/Nga mice.
Journal of veterinary science.
2010 Sep; 11(3):213-20. doi:
10.4142/jvs.2010.11.3.213. [PMID: 20706028] - Onseok Lee, Myeunghun Choi, Seunghan Ha, Gunwoo Lee, Jaeyoung Kim, Gyuman Park, Minwon Lee, Youngwook Choi, Mingi Kim, Chil Hwan Oh. Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga mice.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2010 Aug; 16(3):371-7. doi:
10.1111/j.1600-0846.2010.00443.x. [PMID: 20637007] - Akihiko Sugiyama, Sayaka Hata, Kengo Suzuki, Eriko Yoshida, Ryohei Nakano, Sharbanee Mitra, Ryo Arashida, Yuta Asayama, Yukinori Yabuta, Takashi Takeuchi. Oral administration of paramylon, a beta-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice.
The Journal of veterinary medical science.
2010 Jun; 72(6):755-63. doi:
10.1292/jvms.09-0526. [PMID: 20160419] - Xiao-Feng Yang, Zhuan Su, Chenghai Liu, Haiping Qi, Minglei Zhao. A thiol-selective fluorogenic probe based on the cleavage of 4-methylumbelliferyl-2',4',6'-trinitropheyl ether.
Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2667-74. doi:
10.1007/s00216-010-3475-4. [PMID: 20143223] - Hideki Hokazono, Toshiro Omori, Kazuhisa Ono. Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice.
Bioscience, biotechnology, and biochemistry.
2010; 74(1):135-9. doi:
10.1271/bbb.90653. [PMID: 20057128] - Takayuki Ohbuchi, Makoto Sakaino, Tetsunari Takahashi, Naoya Azumi, Kotaro Ishikawa, Sadahiro Kawazoe, Yukiko Kobayashi, Yasuhiro Kido. Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice.
Journal of nutritional science and vitaminology.
2010; 56(1):54-9. doi:
10.3177/jnsv.56.54. [PMID: 20354347] - Satomi Yano, Daisuke Umeda, Shuya Yamashita, Koji Yamada, Hirofumi Tachibana. Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice.
The Journal of nutritional biochemistry.
2009 Nov; 20(11):876-81. doi:
10.1016/j.jnutbio.2008.08.002. [PMID: 18993046] - Kimihisa Itoh, Megumi Masuda, Shunsuke Naruto, Kazuya Murata, Hideaki Matsuda. Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.
Journal of natural medicines.
2009 Oct; 63(4):443-50. doi:
10.1007/s11418-009-0349-1. [PMID: 19603253] - Kinichi Imura, Takeshi Yoshioka, Tsutomu Hirasawa, Tsuneaki Sakata. Role of TRPV3 in immune response to development of dermatitis.
Journal of inflammation (London, England).
2009 May; 6(?):17. doi:
10.1186/1476-9255-6-17. [PMID: 19463197] - Robert E Cone, Subhasis Chattopadhyay, Roshanak Sharafieh, Yen Lemire, James O'Rourke, Richard A Flavell, Robert B Clark. T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber.
International immunology.
2009 May; 21(5):567-74. doi:
10.1093/intimm/dxp023. [PMID: 19325036] - Yang Sun, Yi Dong, Hui-Juan Jiang, Tian-Tian Cai, Liang Chen, Xiang Zhou, Ting Chen, Qiang Xu. Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice.
Life sciences.
2009 Mar; 84(11-12):337-44. doi:
10.1016/j.lfs.2008.12.023. [PMID: 19211027] - Yosuke Sunada, Syoji Nakamura, Chiaki Kamei. Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice.
International immunopharmacology.
2008 Dec; 8(13-14):1761-6. doi:
10.1016/j.intimp.2008.08.011. [PMID: 18790088] - Ye Yin, Fang-Yuan Gong, Xing-Xin Wu, Yang Sun, Yi-Hua Li, Ting Chen, Qiang Xu. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.
Journal of ethnopharmacology.
2008 Oct; 120(1):1-6. doi:
10.1016/j.jep.2008.07.029. [PMID: 18721870] - Christian Lass, Marc Vocanson, Steffen Wagner, Christoph M Schempp, Jean-Francois Nicolas, Irmgard Merfort, Stefan F Martin. Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica montana L.
Experimental dermatology.
2008 Oct; 17(10):849-57. doi:
10.1111/j.1600-0625.2008.00717.x. [PMID: 18341569] - Noriko Hirata, Shunsuke Naruto, Kazunori Inaba, Kimihisa Itoh, Masashi Tokunaga, Munekazu Iinuma, Hideaki Matsuda. Histamine release inhibitory activity of Piper nigrum leaf.
Biological & pharmaceutical bulletin.
2008 Oct; 31(10):1973-6. doi:
10.1248/bpb.31.1973. [PMID: 18827366] - Tadashi Fujita, Takehumi Shiura, Megumi Masuda, Masashi Tokunaga, Atsushi Kawase, Masahiro Iwaki, Takeshi Gato, Masahiko Fumuro, Katsuaki Sasaki, Naoki Utsunomiya, Hideaki Matsuda. Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice.
Journal of natural medicines.
2008 Apr; 62(2):202-6. doi:
10.1007/s11418-007-0208-x. [PMID: 18404324] - Eui-Chul Kim, Hyung-Suk Lee, Sun Kwang Kim, Myoung-Suk Choi, Seungeun Lee, Jae-Bok Han, Hyo-Jin An, Jae-Young Um, Hyung-Min Kim, Na-Youn Lee, Hyunsu Bae, Byung-Il Min. The bark of Betula platyphylla var. japonica inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice.
Journal of ethnopharmacology.
2008 Mar; 116(2):270-8. doi:
10.1016/j.jep.2007.11.042. [PMID: 18191513] - Tomohiro Ito, Kaoru Inouye, Keiko Nohara, Chiharu Tohyama, Hidekazu Fujimaki. TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice.
Toxicology letters.
2008 Feb; 177(1):31-7. doi:
10.1016/j.toxlet.2007.12.011. [PMID: 18272299] - Hideyuki Wakabayashi, Chie Nariai, Fumiyo Takemura, Wakako Nakao, Daisuke Fujiwara. Dietary supplementation with lactic acid bacteria attenuates the development of atopic-dermatitis-like skin lesions in NC/Nga mice in a strain-dependent manner.
International archives of allergy and immunology.
2008; 145(2):141-51. doi:
10.1159/000108139. [PMID: 17848807] - Myoung Suk Choi, Eui Chul Kim, Hyung Suk Lee, Sun Kwang Kim, Hyun Myung Choi, Jung Hyuk Park, Jae-Bok Han, Hyo Jin An, Jae Young Um, Hyung Min Kim, Ah-Reum Han, Moo Chang Hong, Hyunsu Bae, Byung-Il Min. Inhibitory effects of Saururus chinensis (LOUR.) BAILL on the development of atopic dermatitis-like skin lesions in NC/Nga mice.
Biological & pharmaceutical bulletin.
2008 Jan; 31(1):51-6. doi:
10.1248/bpb.31.51. [PMID: 18175941] - Yuuichi Ukawa, Yoshiya Izumi, Takayuki Ohbuchi, Tetsunari Takahashi, Shoichi Ikemizu, Yasushi Kojima. Oral administration of the extract from Hatakeshimeji (Lyophyllum decastes sing.) mushroom inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice.
Journal of nutritional science and vitaminology.
2007 Jun; 53(3):293-6. doi:
10.3177/jnsv.53.293. [PMID: 17874836] - Hong-Yue Ma, Jun-Ping Kou, Jing-Rong Wang, Bo-Yang Yu. Evaluation of the anti-inflammatory and analgesic activities of Liu-Shen-Wan and its individual fractions.
Journal of ethnopharmacology.
2007 May; 112(1):108-14. doi:
10.1016/j.jep.2007.02.008. [PMID: 17368990] - Jianming Guo, Feng Qian, Jianxin Li, Qiang Xu, Ting Chen. Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis.
Clinical chemistry.
2007 Mar; 53(3):465-71. doi:
10.1373/clinchem.2006.077297. [PMID: 17272490] - Li Zhang, Yi Dong, Yang Sun, Ting Chen, Qiang Xu. Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice.
The Journal of pharmacy and pharmacology.
2006 Sep; 58(9):1257-64. doi:
10.1211/jpp.58.9.0013. [PMID: 16945185] - Ehsanollah Esfandiari, Michael Bailey, Christopher R Stokes, Timothy M Cox, Martin J Evans, Alison R Hayman. TRACP Influences Th1 pathways by affecting dendritic cell function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2006 Sep; 21(9):1367-76. doi:
10.1359/jbmr.060611. [PMID: 16939395] - Junping Kou, Minda Si, Guofei Dai, Yuwen Lin, Danni Zhu. Antiinflammatory activity of Polygala japonica extract.
Fitoterapia.
2006 Sep; 77(6):411-5. doi:
10.1016/j.fitote.2006.04.011. [PMID: 16814958] - H-S Lee, S-K Kim, J-B Han, H-M Choi, J-H Park, E-C Kim, M-S Choi, H-J An, J-Y Um, H-M Kim, B-I Min. Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice.
The British journal of dermatology.
2006 Jul; 155(1):33-8. doi:
10.1111/j.1365-2133.2006.07303.x. [PMID: 16792749] - Chikako Arai, Tomoki Tatefuji, Tetsuya Mori, Akiko Mizote, Keizo Kohno, Tsunetaka Ohta, Shigeharu Fukuda. Effect of AgK114 on picryl chloride-induced chronic contact hypersensitivity responses.
In vivo (Athens, Greece).
2006 May; 20(3):347-51. doi:
NULL. [PMID: 16724668] - Nalan Tepe, Leah A Shimko, Metin Duran. Toxic effects of thiol-reactive compounds on anaerobic biomass.
Bioresource technology.
2006 Mar; 97(4):592-8. doi:
10.1016/j.biortech.2005.03.029. [PMID: 15913993] - Daisuke Harada, Yukihito Tsukumo, Yuko Takashima, Haruhiko Manabe. Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application.
European journal of pharmacology.
2006 Feb; 532(1-2):128-37. doi:
10.1016/j.ejphar.2005.12.005. [PMID: 16442096] - Kenji Ishihara, Chiaki Oyamada, Ryoji Matsushima, Masakazu Murata, Toshihiko Muraoka. Inhibitory effect of porphyran, prepared from dried 'Nori', on contact hypersensitivity in mice.
Bioscience, biotechnology, and biochemistry.
2005 Oct; 69(10):1824-30. doi:
10.1271/bbb.69.1824. [PMID: 16244430] - Katsuo Matsumoto, Koji Mizukoshi, Midori Oyobikawa, Hiroshi Ohshima, Yuji Sakai, Hachiro Tagami. Objective evaluation of the efficacy of daily topical applications of cosmetics bases using the hairless mouse model of atopic dermatitis.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2005 Aug; 11(3):209-17. doi:
10.1111/j.1600-0846.2005.00106.x. [PMID: 15998334] - Li Zhang, Yang Sun, Ting Chen, Qiang Xu. Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytes.
International immunopharmacology.
2005 Jul; 5(7-8):1193-204. doi:
10.1016/j.intimp.2005.02.015. [PMID: 15914324] - Genta Kakiyama, Shinji Sadakiyo, Takashi Iida, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara. Chemical synthesis of 24-beta-D-galactopyranosides of bile acids: a new type of bile acid conjugates in human urine.
Chemistry and physics of lipids.
2005 Apr; 134(2):141-50. doi:
10.1016/j.chemphyslip.2005.01.002. [PMID: 15784232] - Setsuko Matsukura, Michiko Aihara, Tsutomu Hirasawa, Zenro Ikezawa. Effects of TNCB sensitization in DS-Nh mice, serving as a model of atopic dermatitis, in comparison with NC/Nga mice.
International archives of allergy and immunology.
2005 Feb; 136(2):173-80. doi:
10.1159/000083326. [PMID: 15650316] - Jule Wang, Yang Sun, Yihua Li, Qiang Xu. Aqueous extract from aerial parts of Artemisia vestita, a traditional Tibetan medicine, reduces contact sensitivity in mice by down-regulating the activation, adhesion and metalloproteinase production of T lymphocytes.
International immunopharmacology.
2005 Feb; 5(2):407-15. doi:
10.1016/j.intimp.2004.10.007. [PMID: 15652769] - Tsuyoshi Ohmura, Ayako Konomi, Yayoi Satoh, Toshihiro Hayashi, Ichiro Tsunenari, Toshihito Kadota, Maret J Panzenbeck, Hisashi Satoh. Suppression of atopic-like dermatitis by treatment with antibody to lymphocyte function-associated antigen-1 in NC/Nga mouse.
European journal of pharmacology.
2004 Nov; 504(1-2):113-7. doi:
10.1016/j.ejphar.2004.09.035. [PMID: 15507227] - Xingya Li, Yafei Wang, David Urso, James O'Rourke, Robert E Cone. Thymocytes induced by antigen injection into the anterior chamber activate splenic CD8+ suppressor cells and enhance the antigen-induced production of immunoglobulin G1 antibodies.
Immunology.
2004 Sep; 113(1):44-56. doi:
10.1111/j.1365-2567.2004.01928.x. [PMID: 15312135] - Xingya Li, Shiv Taylor, Benjamin Zegarelli, Shujing Shen, James O'Rourke, Robert E Cone. The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system.
Journal of neuroimmunology.
2004 Aug; 153(1-2):40-9. doi:
10.1016/j.jneuroim.2004.04.008. [PMID: 15265662] - Y Nakano. Stress-induced modulation of skin immune function: two types of antigen-presenting cells in the epidermis are differentially regulated by chronic stress.
The British journal of dermatology.
2004 Jul; 151(1):50-64. doi:
10.1111/j.1365-2133.2004.05980.x. [PMID: 15270872] - Katsuo Matsumoto, Koji Mizukoshi, Midori Oyobikawa, Hiroshi Ohshima, Hachiro Tagami. Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non-invasive biophysical instruments.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2004 May; 10(2):122-9. doi:
10.1111/j.1600-0846.2004.00062.x. [PMID: 15059180] - Tsuyoshi Ohmura, Ichiro Tsunenari, Toshihiro Hayashi, Yayoi Satoh, Ayako Konomi, Hirotoshi Nanri, Mamoru Kawachi, Makoto Morikawa, Toshihito Kadota, Hisashi Satoh. Role of substance P in an NC/Nga mouse model of atopic dermatitis-like disease.
International archives of allergy and immunology.
2004 Apr; 133(4):389-97. doi:
10.1159/000077359. [PMID: 15031613] - Yusuke Kawase, Tomoaki Hoshino, Koichi Yokota, Akemi Kuzuhara, Yasuyuki Kirii, Eiji Nishiwaki, Yu Maeda, Junji Takeda, Masaki Okamoto, Seiya Kato, Toshihiro Imaizumi, Hisamichi Aizawa, Kohichiro Yoshino. Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin.
The Journal of investigative dermatology.
2003 Sep; 121(3):502-9. doi:
10.1046/j.1523-1747.2003.12407.x. [PMID: 12925208] - Bing Zhang, Michael D Walsh, Kim B Nguyen, Narelle C Hillyard, Alice C Cavanagh, Pamela A McCombe, Halle Morton. Early pregnancy factor treatment suppresses the inflammatory response and adhesion molecule expression in the spinal cord of SJL/J mice with experimental autoimmune encephalomyelitis and the delayed-type hypersensitivity reaction to trinitrochlorobenzene in normal BALB/c mice.
Journal of the neurological sciences.
2003 Aug; 212(1-2):37-46. doi:
10.1016/s0022-510x(03)00103-5. [PMID: 12809997] - Jieyun Jiang, Chunxiang Zhou, Qiang Xu. Alleviating effects of si-ni-san, a traditional Chinese prescription, on experimental liver injury and its mechanisms.
Biological & pharmaceutical bulletin.
2003 Aug; 26(8):1089-94. doi:
10.1248/bpb.26.1089. [PMID: 12913256] - Yoshifumi Inoue, Masakazu Isobe, Tetsuo Shiohara, Hideya Hayashi. Inhibitory activity of CX-659S, a novel diaminouracil derivative, against the rebound phenomenon following withdrawal of corticosteroid therapy for chronic contact hypersensitivity responses.
International archives of allergy and immunology.
2003 Jun; 131(2):143-52. doi:
10.1159/000070930. [PMID: 12811023] - Ji-Youn Jung, Akira Yasoshima, Junzo Saegusa, Hiroyuki Nakayama, Kunio Doi. Ultrastructural features of mast cells in picryl chloride (PCL)-induced contact dermatitis in IQI/Jic mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2003 Mar; 54(4):265-71. doi:
10.1078/0940-2993-00261. [PMID: 12710708] - Y Inoue, M Isobe, T Shiohara, Y Goto, H Hayashi. Protective and curative effects of topically applied CX-659S, a novel diaminouracil derivative, on chronic picryl chloride-induced contact hypersensitivity responses.
The British journal of dermatology.
2002 Oct; 147(4):675-82. doi:
10.1046/j.1365-2133.2002.04917.x. [PMID: 12366412] - Hiroshi Ohtsu, Atsuo Kuramasu, Satoshi Tanaka, Tadashi Terui, Noriyasu Hirasawa, Masahiro Hara, Yoko Makabe-Kobayashi, Noboru Yamada, Kazuhiko Yanai, Eiko Sakurai, Mikiko Okada, Kazuo Ohuchi, Atsushi Ichikawa, Andras Nagy, Takehiko Watanabe. Plasma extravasation induced by dietary supplemented histamine in histamine-free mice.
European journal of immunology.
2002 Jun; 32(6):1698-708. doi:
10.1002/1521-4141(200206)32:6<1698::aid-immu1698>3.0.co;2-7. [PMID: 12115653] - Tsutomu Nakada, Kenji Watanabe, Tsukasa Matsumoto, Kazuki Santa, Kazuo Triizuka, Toshihiko Hanawa. Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen.
International immunopharmacology.
2002 Jun; 2(7):901-11. doi:
10.1016/s1567-5769(02)00027-9. [PMID: 12188032] - Hideaki Matsuda, Norimichi Tomohiro, Yasuko Ido, Michinori Kubo. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
Biological & pharmaceutical bulletin.
2002 Jun; 25(6):809-12. doi:
10.1248/bpb.25.809. [PMID: 12081154] - Qiang Xu, Zhaohua Lu, Xianming Zhang. A novel role of alkaline phosphatase in protection from immunological liver injury in mice.
Liver.
2002 Feb; 22(1):8-14. doi:
10.1034/j.1600-0676.2002.220102.x. [PMID: 11906613] - J Hosoi, M Tanida, T Tsuchiya. Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation.
The British journal of dermatology.
2001 Nov; 145(5):716-9. doi:
10.1046/j.1365-2133.2001.04409.x. [PMID: 11736894] - R M Moison, G M Beijersbergen Van Henegouwen. Dietary eicosapentaenoic acid prevents systemic immunosuppression in mice induced by UVB radiation.
Radiation research.
2001 Jul; 156(1):36-44. doi:
10.1667/0033-7587(2001)156[0036:deapsi]2.0.co;2. [PMID: 11418071] - F Wu, J Cao, J Jiang, B Yu, Q Xu. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes.
The Journal of pharmacy and pharmacology.
2001 May; 53(5):681-8. doi:
10.1211/0022357011775802. [PMID: 11370707] - X Chen, J Cao, Q Xu. Endotoxin exacerbates immunologically induced liver injury in cooperation with interferon-gamma.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2000 Nov; 49(11):571-7. doi:
10.1007/s000110050633. [PMID: 11131296] - J Cao, Q Xu, A Koda. Protective involvement of nitric oxide in the liver injury induced by delayed-type hypersensitivity to picryl chloride.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2000 Nov; 49(11):578-83. doi:
10.1007/s000110050634. [PMID: 11131297] - M Tobe, Y Isobe, Y Goto, F Obara, M Tsuchiya, J Matsui, K Hirota, H Hayashi. Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction.
Bioorganic & medicinal chemistry.
2000 Aug; 8(8):2037-47. doi:
10.1016/s0968-0896(00)00126-7. [PMID: 11003148] - M Ikeda, K Kuroki, H Suzuki, H Nakayama, J Saegusa, K Doi. Picryl chloride-induced allergic dermatitis in IQI/Jic female mice.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2000 Jun; 52(3):235-40. doi:
10.1016/s0940-2993(00)80037-8. [PMID: 10930124] - P H Hart, M A Grimbaldeston, A Jaksic, J E Tan, G J Swift, E K Hosszu, G M Halliday, J J Finlay-Jones. Ultraviolet B-induced suppression of immune responses in interleukin-4-/- mice: relationship to dermal mast cells.
The Journal of investigative dermatology.
2000 Mar; 114(3):508-13. doi:
10.1046/j.1523-1747.2000.00909.x. [PMID: 10692110] - Q Xu, J Cao, F Wu, Y Hayakawa, I Saiki, A Koda. Role of Th1 and Th2 cytokines in regulating the liver injury induced by delayed-type hypersensitivity to picryl chloride.
Liver.
1999 Dec; 19(6):473-80. doi:
10.1111/j.1478-3231.1999.tb00079.x. [PMID: 10661680] - Q Xu, F Wu, J Cao, T Chen, J Jiang, I Saiki, A Koda. Astilbin selectively induces dysfunction of liver-infiltrating cells--novel protection from liver damage.
European journal of pharmacology.
1999 Jul; 377(1):93-100. doi:
10.1016/s0014-2999(99)00401-x. [PMID: 10448932] - C K Lee, S S Han, Y K Shin, M H Chung, Y I Park, S K Lee, Y S Kim. Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components.
International journal of immunopharmacology.
1999 May; 21(5):303-10. doi:
10.1016/s0192-0561(99)00012-0. [PMID: 10408627] - J Cao, J Lu, F Wu, X Cheng, Q Xu. Effects of several drugs on the liver injury induced by delayed-type hypersensitivity to picryl chloride by regulating suppressor or helper T cells.
Pharmacological research.
1999 Feb; 39(2):97-102. doi:
10.1006/phrs.1998.0410. [PMID: 10072699] - M Nose, J Sakushima, D Harada, Y Ogihara. Comparison of immunopharmacological actions of 8 kinds of kampo-hozais clinically used in atopic dermatitis on delayed-type hypersensitivity in mice.
Biological & pharmaceutical bulletin.
1999 Jan; 22(1):48-54. doi:
10.1248/bpb.22.48. [PMID: 9989661]