N-Desethyl Sunitinib (BioDeep_00000831751)
代谢物信息卡片
N-Desethyl Sunitinib
化学式: C20H23FN4O2 (370.18049499999995)
中文名称: N-去乙基舒尼替尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNCCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
InChI: InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-
相关代谢途径
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代谢反应
1 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erjian Wang, Steven G DuBois, Cynthia Wetmore, Arnauld C Verschuur, Reza Khosravan. Population Pharmacokinetics of Sunitinib and its Active Metabolite SU012662 in Pediatric Patients with Gastrointestinal Stromal Tumors or Other Solid Tumors.
European journal of drug metabolism and pharmacokinetics.
2021 May; 46(3):343-352. doi:
10.1007/s13318-021-00671-7. [PMID: 33852135] - Elena Marangon, Mauro Buzzo, Bianca Posocco, Sara Gagno, Martina Zanchetta, Valentina Iacuzzi, Ariana Soledad Poetto, Michela Guardascione, Luciana Giodini, Giuseppe Toffoli. A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of sunitinib and N-desethyl sunitinib in human plasma: Light-induced isomerism overtaking towards therapeutic drug monitoring in clinical routine.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):112949. doi:
10.1016/j.jpba.2019.112949. [PMID: 31784210] - Murari Gurjar, Parsshava Mehta, Jyoti Sharma, Sneha Patil, Preeti Kulkarni, Anand Patil, Manjunath Nookala, Amit Joshi, Vikram Gota. An HPLC method for simultaneous quantification of sunitinib and its active metabolite, SU12662, using hydrophilic interaction chromatography principle.
Bioanalysis.
2020 Jan; 12(2):75-85. doi:
10.4155/bio-2019-0188. [PMID: 31928228] - Noriko Matsunaga, Takashi Kitahara, Makiko Yamada, Kayoko Sato, Yukinobu Kodama, Hitoshi Sasaki. The influence of light sources on sunitinib measurements with photoisomerization.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4407. doi:
10.1002/bmc.4407. [PMID: 30315654] - Bianca Posocco, Mauro Buzzo, Luciana Giodini, Sara Crotti, Sara D'Aronco, Pietro Traldi, Marco Agostini, Elena Marangon, Giuseppe Toffoli. Analytical aspects of sunitinib and its geometric isomerism towards therapeutic drug monitoring in clinical routine.
Journal of pharmaceutical and biomedical analysis.
2018 Oct; 160(?):360-367. doi:
10.1016/j.jpba.2018.08.013. [PMID: 30119000] - M H Diekstra, A Fritsch, F Kanefendt, J J Swen, Djar Moes, F Sörgel, M Kinzig, C Stelzer, D Schindele, T Gauler, S Hauser, D Houtsma, M Roessler, B Moritz, K Mross, L Bergmann, E Oosterwijk, L A Kiemeney, H J Guchelaar, U Jaehde. Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer.
CPT: pharmacometrics & systems pharmacology.
2017 09; 6(9):604-613. doi:
10.1002/psp4.12210. [PMID: 28571114] - Jung-Woo Chae, Yi Ling Teo, Han Kiat Ho, Jaeyeon Lee, Hyun-Moon Back, Hwi-Yeol Yun, Mats O Karlsson, Kwang-Il Kwon, Alexandre Chan. BSA and ABCB1 polymorphism affect the pharmacokinetics of sunitinib and its active metabolite in Asian mRCC patients receiving an attenuated sunitinib dosing regimen.
Cancer chemotherapy and pharmacology.
2016 Sep; 78(3):623-32. doi:
10.1007/s00280-016-3104-9. [PMID: 27485537] - K Sobańska, A Karbownik, E Szałek, W Płotek, T Grabowski, A Szewczyk, D Marcinkowska, W Połom, M Matuszewski, E Grześkowiak. The influence of the time-of-day administration of sunitinib on the penetration through the blood-brain and blood-aqueous humour barriers in rabbits.
European review for medical and pharmacological sciences.
2016; 20(1):166-73. doi:
NULL. [PMID: 26813470] - Yi Ling Teo, Xiu Ping Chue, Noan Minh Chau, Min-Han Tan, Ravindran Kanesvaran, Hwee Lin Wee, Han Kiat Ho, Alexandre Chan. Association of drug exposure with toxicity and clinical response in metastatic renal cell carcinoma patients receiving an attenuated dosing regimen of sunitinib.
Targeted oncology.
2015 Sep; 10(3):429-37. doi:
10.1007/s11523-014-0349-2. [PMID: 25502986] - Jacqueline S L Kloth, Lisette Binkhorst, Annelieke S de Wit, Peter de Bruijn, Paul Hamberg, Mei H Lam, Herman Burger, Ines Chaves, Erik A C Wiemer, Gijsbertus T J van der Horst, Ron H J Mathijssen. Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence.
Clinical pharmacokinetics.
2015 Aug; 54(8):851-8. doi:
10.1007/s40262-015-0239-5. [PMID: 25647628] - Juana Rodríguez, Gregorio Castañeda, Lorena Muñoz, Jose C Villa. Quantitation of sunitinib, an oral multitarget tyrosine kinase inhibitor, and its metabolite in urine samples by nonaqueous capillary electrophoresis time of flight mass spectrometry.
Electrophoresis.
2015 Jul; 36(14):1580-7. doi:
10.1002/elps.201400588. [PMID: 25873554] - Xiao Chen, Zhong Wang, Mengping Liu, Min Liao, Xinfeng Wang, Huajuan Du, Jiefeng Chen, Meicun Yao, Qing Li. Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies.
Biomedical chromatography : BMC.
2015 May; 29(5):679-88. doi:
10.1002/bmc.3331. [PMID: 25294592] - Huixin Yu, Neeltje Steeghs, Jacqueline S L Kloth, Djoeke de Wit, J G Coen van Hasselt, Nielka P van Erp, Jos H Beijnen, Jan H M Schellens, Ron H J Mathijssen, Alwin D R Huitema. Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.
British journal of clinical pharmacology.
2015 May; 79(5):809-19. doi:
10.1111/bcp.12550. [PMID: 25393890] - Edyta Szałek, Agnieszka Karbownik, Katarzyna Sobańska, Tomasz Grabowski, Wojciech Połom, Małgorzata Lewandowska, Anna Wolc, Marcin Matuszewski, Edmund Grześkowiak. The pharmacokinetics and hypoglycaemic effect of sunitinib in the diabetic rabbits.
Pharmacological reports : PR.
2014 Oct; 66(5):892-6. doi:
10.1016/j.pharep.2014.05.011. [PMID: 25149997] - Djoeke de Wit, Nielka P van Erp, Reza Khosravan, Robin Wiltshire, Randy Allred, George D Demetri, Henk-Jan Guchelaar, Hans Gelderblom. Effect of gastrointestinal resection on sunitinib exposure in patients with GIST.
BMC cancer.
2014 Aug; 14(?):575. doi:
10.1186/1471-2407-14-575. [PMID: 25102852] - E Szałek, A Karbownik, K Sobańska, W Połom, T Grabowski, A Wolc, M Matuszewski, E Grześkowiak. The influence of the time-of-day administration of the drug on the pharmacokinetics of sunitinib in rabbits.
European review for medical and pharmacological sciences.
2014 Aug; 18(16):2393-9. doi:
NULL. [PMID: 25219843] - N A G Lankheet, J S L Kloth, C G M Gadellaa-van Hooijdonk, G A Cirkel, R H J Mathijssen, M P J K Lolkema, J H M Schellens, E E Voest, S Sleijfer, M J A de Jonge, J B A G Haanen, J H Beijnen, A D R Huitema, N Steeghs. Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.
British journal of cancer.
2014 May; 110(10):2441-9. doi:
10.1038/bjc.2014.194. [PMID: 24736581] - Yi Ling Teo, Xue Jing Chong, Xiu Ping Chue, Noan Minh Chau, Min-Han Tan, Ravindran Kanesvaran, Hwee Lin Wee, Han Kiat Ho, Alexandre Chan. Role of sunitinib and SU12662 on dermatological toxicities in metastatic renal cell carcinoma patients: in vitro, in vivo, and outcomes investigation.
Cancer chemotherapy and pharmacology.
2014 Feb; 73(2):381-8. doi:
10.1007/s00280-013-2360-1. [PMID: 24306119] - Edyta Szałek, Agnieszka Karbownik, Tomasz Grabowski, Katarzyna Sobańska, Anna Wolc, Edmund Grześkowiak. Pharmacokinetics of sunitinib in combination with fluoroquinolones in rabbit model.
Pharmacological reports : PR.
2013; 65(5):1383-90. doi:
10.1016/s1734-1140(13)71497-x. [PMID: 24399735] - Rana Rais, Ming Zhao, Ping He, Linping Xu, John F Deeken, Michelle A Rudek. Quantitation of unbound sunitinib and its metabolite N-desethyl sunitinib (SU12662) in human plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Nov; 26(11):1315-24. doi:
10.1002/bmc.2697. [PMID: 22259028] - Bill Speed, Hai-Zhi Bu, William F Pool, Geoffrey W Peng, Ellen Y Wu, Shem Patyna, Carlo Bello, Ping Kang. Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):539-55. doi:
10.1124/dmd.111.042853. [PMID: 22180047] - Michael Rodamer, Paul W Elsinghorst, Martina Kinzig, Michael Gütschow, Fritz Sörgel. Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of sunitinib (SU11248) and its active metabolite, N-desethyl sunitinib (SU12662), in human plasma: application to an explorative study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Apr; 879(11-12):695-706. doi:
10.1016/j.jchromb.2011.02.006. [PMID: 21367676] - Peter de Bruijn, Stefan Sleijfer, Mei-Ho Lam, Ron H J Mathijssen, Erik A C Wiemer, Walter J Loos. Bioanalytical method for the quantification of sunitinib and its n-desethyl metabolite SU12662 in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2010 Mar; 51(4):934-41. doi:
10.1016/j.jpba.2009.10.020. [PMID: 19931354] - George Fountzilas, Anna Fragkoulidi, Anna Kalogera-Fountzila, Martha Nikolaidou, Mattheos Bobos, Julien Calderaro, Felipe Andreiuolo, Marios Marselos. A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer.
Cancer chemotherapy and pharmacology.
2010 Mar; 65(4):649-60. doi:
10.1007/s00280-009-1070-1. [PMID: 19655144] - Marie-Christine Etienne-Grimaldi, Nicole Renée, Hassan Izzedine, Gérard Milano. A routine feasible HPLC analysis for the anti-angiogenic tyrosine kinase inhibitor, sunitinib, and its main metabolite, SU12662, in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(29):3757-61. doi:
10.1016/j.jchromb.2009.09.011. [PMID: 19797000] - Brett E Houk, Carlo L Bello, Dongwoo Kang, Michael Amantea. A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2009 Apr; 15(7):2497-506. doi:
10.1158/1078-0432.ccr-08-1893. [PMID: 19258444] - Carlo L Bello, Laurie Sherman, Jihao Zhou, Lev Verkh, John Smeraglia, Janessa Mount, Karen J Klamerus. Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects.
Anti-cancer drugs.
2006 Mar; 17(3):353-8. doi:
10.1097/00001813-200603000-00015. [PMID: 16520665]