naproxcinod (BioDeep_00000831276)
代谢物信息卡片
化学式: C18H21NO6 (347.13688060000004)
中文名称: (S)-2-(6-甲氧基-2-萘基)丙酸 4-硝基氧丁基酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCCCO[N+](=O)[O-]
InChI: InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:76254
- KEGGdrug: D09568
- PubChem: 9884642
- DrugBank: DB06682
- ChEMBL: CHEMBL2103831
- CAS: 163133-43-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaowei Shi, Weiding Shang, Shuang Wang, Na Xue, Yanxia Hao, Yabo Wang, Mengmeng Sun, Yumin Du, Deying Cao, Kai Zhang, Qingwen Shi. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC-MS/MS: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jan; 978-979(?):157-62. doi:
10.1016/j.jchromb.2014.12.001. [PMID: 25550191] - Marcus A Björnsson, Ulrika S H Simonsson. Modelling of pain intensity and informative dropout in a dental pain model after naproxcinod, naproxen and placebo administration.
British journal of clinical pharmacology.
2011 Jun; 71(6):899-906. doi:
10.1111/j.1365-2125.2011.03924.x. [PMID: 21272053] - Małgorzata Dzielska-Olczak. [Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part II].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2011 Jan; 30(175):82-6. doi:
. [PMID: 21542252] - Mitali Chattopadhyay, Satindra Goswami, Deborah B Rodes, Ravinder Kodela, Carlos A Velazquez, Daniel Boring, James A Crowell, Khosrow Kashfi. NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation.
Cancer letters.
2010 Dec; 298(2):204-11. doi:
10.1016/j.canlet.2010.07.006. [PMID: 20674154] - Lin Ji, Lu-Ping Li, Thomas Schnitzer, Hongyan Du, Pottumarthi V Prasad. Intra-renal oxygenation in rat kidneys during water loading: effects of cyclooxygenase (COX) inhibition and nitric oxide (NO) donation.
Journal of magnetic resonance imaging : JMRI.
2010 Aug; 32(2):383-7. doi:
10.1002/jmri.22253. [PMID: 20677266] - Clive H Wilder-Smith, Bror Jonzon, Bodil Fornstedt-Wallin, Ann Hedman, Pär Karlsson. Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects.
Scandinavian journal of gastroenterology.
2006 Mar; 41(3):264-73. doi:
10.1080/00365520510024197. [PMID: 16497612] - Urban Fagerholm, Marcus A Björnsson. Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582.
The Journal of pharmacy and pharmacology.
2005 Dec; 57(12):1539-54. doi:
10.1211/jpp.57.12.0004. [PMID: 16354398] - Delano V Young, Edward D Cochran, Vijay Dhawan, Richard A Earl, James L Ellis, David S Garvey, David R Janero, Subhash P Khanapure, L Gordon Letts, Terry L Melim, Madhavi G Murty, Matthew J Shumway, Shiow-Jyi Wey, Irina S Zemtseva, William M Selig. A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods.
Biochemical pharmacology.
2005 Nov; 70(9):1343-51. doi:
10.1016/j.bcp.2005.08.004. [PMID: 16168964] - Gunilla Huledal, Bror Jonzon, Maria Malmenäs, Ann Hedman, Lars I Andersson, Bo Odlind, D Craig Brater. Renal effects of the cyclooxygenase-inhibiting nitric oxide donator AZD3582 compared with rofecoxib and naproxen during normal and low sodium intake.
Clinical pharmacology and therapeutics.
2005 May; 77(5):437-50. doi:
10.1016/j.clpt.2005.01.011. [PMID: 15900289] - U Fagerholm, O Breuer, S Swedmark, J Hoogstraate. Pre-clinical pharmacokinetics of the cyclooxygenase-inhibiting nitric oxide donor (CINOD) AZD3582.
The Journal of pharmacy and pharmacology.
2005 May; 57(5):587-97. doi:
10.1211/0022357056028. [PMID: 15901348] - Stefano Fiorucci, Annarita Di Lorenzo, Barbara Renga, Silvana Farneti, Antonio Morelli, Giuseppe Cirino. Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection.
The Journal of pharmacology and experimental therapeutics.
2004 Dec; 311(3):1264-71. doi:
10.1124/jpet.104.072843. [PMID: 15297470] - Georg Berndt, Nina Grosser, Janet Hoogstraate, Henning Schröder. A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2004 Feb; 21(2-3):331-5. doi:
10.1016/j.ejps.2003.10.020. [PMID: 14757506] - C Cicala, A Ianaro, S Fiorucci, A Calignano, M Bucci, R Gerli, L Santucci, J L Wallace, G Cirino. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis.
British journal of pharmacology.
2000 Jul; 130(6):1399-405. doi:
10.1038/sj.bjp.0703449. [PMID: 10903982] - M N Muscará, W McKnight, P Del Soldato, J L Wallace. Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
Life sciences.
1998; 62(15):PL235-40. doi:
10.1016/s0024-3205(98)00072-1. [PMID: 9566780]