naproxcinod (BioDeep_00000831276)

   


代谢物信息卡片


naproxcinod

化学式: C18H21NO6 (347.1369)
中文名称: (S)-2-(6-甲氧基-2-萘基)丙酸 4-硝基氧丁基酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCCCO[N+](=O)[O-]
InChI: InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor

同义名列表

1 个代谢物同义名

naproxcinod



数据库引用编号

6 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Xiaowei Shi, Weiding Shang, Shuang Wang, Na Xue, Yanxia Hao, Yabo Wang, Mengmeng Sun, Yumin Du, Deying Cao, Kai Zhang, Qingwen Shi. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC-MS/MS: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Jan; 978-979(?):157-62. doi: 10.1016/j.jchromb.2014.12.001. [PMID: 25550191]
  • Marcus A Björnsson, Ulrika S H Simonsson. Modelling of pain intensity and informative dropout in a dental pain model after naproxcinod, naproxen and placebo administration. British journal of clinical pharmacology. 2011 Jun; 71(6):899-906. doi: 10.1111/j.1365-2125.2011.03924.x. [PMID: 21272053]
  • Małgorzata Dzielska-Olczak. [Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part II]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2011 Jan; 30(175):82-6. doi: . [PMID: 21542252]
  • Mitali Chattopadhyay, Satindra Goswami, Deborah B Rodes, Ravinder Kodela, Carlos A Velazquez, Daniel Boring, James A Crowell, Khosrow Kashfi. NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation. Cancer letters. 2010 Dec; 298(2):204-11. doi: 10.1016/j.canlet.2010.07.006. [PMID: 20674154]
  • Lin Ji, Lu-Ping Li, Thomas Schnitzer, Hongyan Du, Pottumarthi V Prasad. Intra-renal oxygenation in rat kidneys during water loading: effects of cyclooxygenase (COX) inhibition and nitric oxide (NO) donation. Journal of magnetic resonance imaging : JMRI. 2010 Aug; 32(2):383-7. doi: 10.1002/jmri.22253. [PMID: 20677266]
  • Clive H Wilder-Smith, Bror Jonzon, Bodil Fornstedt-Wallin, Ann Hedman, Pär Karlsson. Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. Scandinavian journal of gastroenterology. 2006 Mar; 41(3):264-73. doi: 10.1080/00365520510024197. [PMID: 16497612]
  • Urban Fagerholm, Marcus A Björnsson. Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582. The Journal of pharmacy and pharmacology. 2005 Dec; 57(12):1539-54. doi: 10.1211/jpp.57.12.0004. [PMID: 16354398]
  • Delano V Young, Edward D Cochran, Vijay Dhawan, Richard A Earl, James L Ellis, David S Garvey, David R Janero, Subhash P Khanapure, L Gordon Letts, Terry L Melim, Madhavi G Murty, Matthew J Shumway, Shiow-Jyi Wey, Irina S Zemtseva, William M Selig. A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods. Biochemical pharmacology. 2005 Nov; 70(9):1343-51. doi: 10.1016/j.bcp.2005.08.004. [PMID: 16168964]
  • Gunilla Huledal, Bror Jonzon, Maria Malmenäs, Ann Hedman, Lars I Andersson, Bo Odlind, D Craig Brater. Renal effects of the cyclooxygenase-inhibiting nitric oxide donator AZD3582 compared with rofecoxib and naproxen during normal and low sodium intake. Clinical pharmacology and therapeutics. 2005 May; 77(5):437-50. doi: 10.1016/j.clpt.2005.01.011. [PMID: 15900289]
  • U Fagerholm, O Breuer, S Swedmark, J Hoogstraate. Pre-clinical pharmacokinetics of the cyclooxygenase-inhibiting nitric oxide donor (CINOD) AZD3582. The Journal of pharmacy and pharmacology. 2005 May; 57(5):587-97. doi: 10.1211/0022357056028. [PMID: 15901348]
  • Stefano Fiorucci, Annarita Di Lorenzo, Barbara Renga, Silvana Farneti, Antonio Morelli, Giuseppe Cirino. Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. The Journal of pharmacology and experimental therapeutics. 2004 Dec; 311(3):1264-71. doi: 10.1124/jpet.104.072843. [PMID: 15297470]
  • Georg Berndt, Nina Grosser, Janet Hoogstraate, Henning Schröder. A common pathway of nitric oxide release from AZD3582 and glyceryl trinitrate. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2004 Feb; 21(2-3):331-5. doi: 10.1016/j.ejps.2003.10.020. [PMID: 14757506]
  • C Cicala, A Ianaro, S Fiorucci, A Calignano, M Bucci, R Gerli, L Santucci, J L Wallace, G Cirino. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis. British journal of pharmacology. 2000 Jul; 130(6):1399-405. doi: 10.1038/sj.bjp.0703449. [PMID: 10903982]
  • M N Muscará, W McKnight, P Del Soldato, J L Wallace. Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat. Life sciences. 1998; 62(15):PL235-40. doi: 10.1016/s0024-3205(98)00072-1. [PMID: 9566780]