NEDOCROMIL SODIUM (BioDeep_00000831272)
代谢物信息卡片
NEDOCROMIL SODIUM
化学式: C19H15NNa2O7 (415.0644)
中文名称: 奈多罗米钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)[O-])C(=O)C=C(N2CC)C(=O)[O-].[Na+].[Na+]
InChI: /q
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D000893 - Anti-Inflammatory Agents > D000082142 - Mast Cell Stabilizers
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D018926 - Anti-Allergic Agents
D007155 - Immunologic Factors
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:7493
- KEGGdrug: D00527
- PubChem: 50295
- ChEMBL: CHEMBL915
- MeSH: Nedocromil
- CAS: 69049-74-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Vinicius A do Rosario, Ricardo Fernandes, Erasmo B S de M Trindade. Vegetarian diets and gut microbiota: important shifts in markers of metabolism and cardiovascular disease.
Nutrition reviews.
2016 07; 74(7):444-54. doi:
10.1093/nutrit/nuw012. [PMID: 27261272] - Jianping Li, Shaiban Jubair, Joseph S Janicki. Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling.
Hypertension (Dallas, Tex. : 1979).
2015 Feb; 65(2):328-34. doi:
10.1161/hypertensionaha.114.04238. [PMID: 25403608] - Keisuke Kawai, Seinosuke Kawashima, Toshiyuki Miyazaki, Eiichi Tajiri, Masuki Mori, Kazuhisa Kitazaki, Tomohiko Shirotani, Tetsuya Inatome, Hiroshi Yamabe, Ken-Ichi Hirata, Mitsuhiro Yokoyama. Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients.
Journal of cardiology.
2010 Jan; 55(1):99-107. doi:
10.1016/j.jjcc.2009.10.003. [PMID: 20122555] - Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.
Biochemical pharmacology.
2009 Jun; 77(12):1814-26. doi:
10.1016/j.bcp.2009.03.010. [PMID: 19428336] - Elizabeth W Holt, Earl Francis Cook, Ronina A Covar, Joseph Spahn, Anne L Fuhlbrigge. Identifying the components of asthma health status in children with mild to moderate asthma.
The Journal of allergy and clinical immunology.
2008 May; 121(5):1175-80. doi:
10.1016/j.jaci.2008.02.015. [PMID: 18466785] - Ronina A Covar, Joseph D Spahn, Richard J Martin, Philip E Silkoff, D A Sundstrom, James Murphy, Stanley J Szefler. Safety and application of induced sputum analysis in childhood asthma.
The Journal of allergy and clinical immunology.
2004 Sep; 114(3):575-82. doi:
10.1016/j.jaci.2004.06.036. [PMID: 15356559] - Iwona Stelmach, Pawel Majak, Joanna Jerzynska, Wlodzimierz Stelmach, Piotr Kuna. Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2004 Aug; 15(4):359-64. doi:
10.1111/j.1399-3038.2004.00153.x. [PMID: 15305946] - Barbara Masten, Bennie McWilliams, Mary Lipscomb, Teressa Archibeque, Clifford Qualls, H William Kelly, Mark Schuyler. Immune response to hepatitis B vaccine in asthmatic children.
Pediatric pulmonology.
2003 Dec; 36(6):522-8. doi:
10.1002/ppul.10362. [PMID: 14618645] - Ronina A Covar, Stanley J Szefler, Richard J Martin, D A Sundstrom, Philip E Silkoff, James Murphy, David A Young, Joseph D Spahn. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.
The Journal of pediatrics.
2003 May; 142(5):469-75. doi:
10.1067/mpd.2003.187. [PMID: 12756375] - C Blondin, B Cholley, N Haeffner-Cavaillon, P Goldschmidt. [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].
Journal francais d'ophtalmologie.
2003 Apr; 26(4):328-36. doi:
. [PMID: 12843888] - Iwona Stelmach, Tomasz Grzelewski, Włodzimierz Stelmach, Paweł Majak, Joanna Jerzyńska, Paweł Górski, Piotr Kuna. [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2002 Mar; 12(69):208-13. doi:
. [PMID: 12053590] - Iwona Stelmach, Tomasz Grzelewski, Włodzimierz Stelmach, Paweł Majak, Joanna Jerzyńska, Paweł Górski, Piotr Kuna. [The effect of nedocromil sodium on levels of IL-4 and IgE in serum of children with bronchial asthma].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2002 Mar; 12(69):214-7. doi:
. [PMID: 12053591] - Iwona Stelmach, Joanna Jerzyńska, Paweł Majak, Tomasz Grzelewski, Paweł Górski, Włodzimierz Stelmach, Piotr Kuna. [The effect of triamcinolone acetonide, montelukast, nedocromil sodium, formoterol on levels levels of sICAM-1, sIL-2R in serum and clinical course of asthma in children].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2002 Feb; 12(68):99-103. doi:
. [PMID: 11995262] - Iwona Stelmach, Joanna Jerzyńska, Monika Bobrowska, Agnieszka Brzozowska, Paweł Majak, Piotr Kuna. [IL-10 serum levels in children with moderate asthma].
Pneumonologia i alergologia polska.
2002; 70(1-2):25-33. doi:
. [PMID: 12148173] - I Stelmach, J Jerzynska, A Brzozowska, P Kuna. Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust mite.
Allergy.
2001 Jun; 56(6):518-24. doi:
10.1034/j.1398-9995.2001.056006518.x. [PMID: 11421896] - A Xaubet, J Mullol, J Roca-Ferrer, L Pujols, M Fuentes, M Pérez, J M Fabra, C Picado. Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells.
Respiratory medicine.
2001 May; 95(5):408-14. doi:
10.1053/rmed.2001.1061. [PMID: 11392584] - M N Blumenthal, R H Schwartz, H Kaiser. Nedocromil sodium 2\% ophthalmic solution for the treatment of ragweed pollen seasonal allergic conjunctivitis.
Ocular immunology and inflammation.
2000 Sep; 8(3):159-67. doi:
". [PMID: 11120577] - J Mullol, J Roca-Ferrer, A Xaubet, J Raserra, C Picado. Inhibition of GM-CSF secretion by topical corticosteroids and nedocromil sodium. A comparison study using nasal polyp epithelial cells.
Respiratory medicine.
2000 May; 94(5):428-31. doi:
10.1053/rmed.1999.0756. [PMID: 10868704] - F R Coulson, S R O'Donnell. The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea-pigs in vivo.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2000 Mar; 49(3):123-7. doi:
10.1007/s000110050569. [PMID: 10807500] - S Kannisto, M Korppi, K Remes, R Voutilainen. Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids.
The Journal of clinical endocrinology and metabolism.
2000 Feb; 85(2):652-7. doi:
10.1210/jcem.85.2.6336. [PMID: 10690871] - Z L Huang, T Mochizuki, H Watanabe, K Maeyama. Histamine release induced by immobilization, gentle handling and decapitation from mast cells and its inhibition by nedocromil in rats.
Japanese journal of pharmacology.
1999 Jul; 80(3):255-62. doi:
10.1254/jjp.80.255. [PMID: 10461771] - O A Aswania, S A Corlett, H Chrystyn. Validation of a high-performance liquid chromatography assay for urinary nedocromil sodium following oral and inhaled administration.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Nov; 718(2):290-5. doi:
10.1016/s0378-4347(98)00379-x. [PMID: 9840441] - O A Aswania, S A Corlett, H Chrystyn. Determination of the relative bioavailability of nedocromil sodium to the lung following inhalation using urinary excretion.
European journal of clinical pharmacology.
1998 Aug; 54(6):475-8. doi:
10.1007/s002280050496. [PMID: 9776438] - D F Schoonbrood, T A Out, A A Hart, F J Habets, C M Roos, H M Jansen. Nedocromil sodium in obstructive airways disease: effect on symptoms and plasma protein leakage in sputum.
The European respiratory journal.
1997 Jul; 10(7):1500-6. doi:
10.1183/09031936.97.10071500. [PMID: 9230237] - R Sorva, T Metso, M Turpeinen, K Juntunen-Backman, F Björksten, T Haahtela. Eosinophil cationic protein in induced sputum as a marker of inflammation in asthmatic children.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
1997 Feb; 8(1):45-50. doi:
10.1111/j.1399-3038.1997.tb00142.x. [PMID: 9260219] - K F Chung. Effects of nedocromil sodium on airway neurogenic mechanisms.
The Journal of allergy and clinical immunology.
1996 Nov; 98(5 Pt 2):S112-6; discussion S116. doi:
10.1016/s0091-6749(96)70026-x. [PMID: 8939186] - R Sorva, R Tähtelä, M Turpeinen, K Juntunen-Backman, T Haahtela, L Risteli, J Risteli, A Sorva. Changes in bone markers in children with asthma during inhaled budesonide and nedocromil treatments.
Acta paediatrica (Oslo, Norway : 1992).
1996 Oct; 85(10):1176-80. doi:
10.1111/j.1651-2227.1996.tb18224.x. [PMID: 8922079] - J Merayo-Lloves, T Z Zhao, J E Dutt, C S Foster. A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium.
The Journal of allergy and clinical immunology.
1996 May; 97(5):1129-40. doi:
10.1016/s0091-6749(96)70268-3. [PMID: 8626992] - I G Knottnerus, P A Riley. A clinical overview of Tilarin.
Allergy.
1996; 51(28 Suppl):28-34. doi:
10.1111/j.1398-9995.1996.tb04776.x. [PMID: 8651474] - S Reggio, S Bustacchini, R Pistelli, S Valente. Equivalence of pharmacokinetic characteristics and bronchodilating effect between two combined formulations of nedocromil sodium and salbutamol: MDI and nebulizer solution.
International journal of clinical pharmacology research.
1996; 16(1):19-27. doi:
NULL. [PMID: 9001926] - I Grzelewska-Rzymowska, J Grzegorczyk, W Grabski, J Kroczyńska-Bednarek, B Kuźmińska, J Rozniecki. [Chemotactic serum activity for neutrophils and eosinophils and spontaneous production of histamine releasing factor in patients with seasonal bronchial asthma treated with nedocromil sodium].
Pneumonologia i alergologia polska.
1996; 64(3-4):132-40. doi:
NULL. [PMID: 8754956] - D A Bukstein, R M Biondi, M M Blumenthal, R J Dockhorn, W V Filley, J Fink, S Goldstein, D F Graft, S R Hirsch, T H Joos, J Melamed, M S Rowe, R G Townley. Tilarin in combination with astemizole.
Allergy.
1996; 51(28 Suppl):20-7. doi:
10.1111/j.1398-9995.1996.tb04775.x. [PMID: 8651473] - R A Pauwels, P R Germonpré, J C Kips, G F Joos. Genetic control of indirect airway responsiveness in the rat.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1995 Nov; 25 Suppl 2(?):55-60. doi:
10.1111/j.1365-2222.1995.tb00423.x. [PMID: 8590345] - P Javdan, M Figini, C Emanueli, P Geppetti. Nedocromil sodium reduces allergen-induced plasma extravasation in the guinea pig nasal mucosa by inhibition of tachykinin release.
Allergy.
1995 Oct; 50(10):825-9. doi:
10.1111/j.1398-9995.1995.tb05056.x. [PMID: 8607565] - J Raud, D Konrad, S E Dahlén. Delayed anti-inflammatory action of nedocromil sodium in the rat paw is dependent on de novo protein synthesis.
European journal of pharmacology.
1995 Aug; 282(1-3):207-11. doi:
10.1016/0014-2999(95)00327-h. [PMID: 7498278] - P R Baker, J J Gardner, D Wilkinson. Automated high-performance liquid chromatographic method for the determination of nedocromil sodium in human urine using bimodal column switching.
Journal of chromatography. B, Biomedical applications.
1995 Jun; 668(1):59-65. doi:
10.1016/0378-4347(95)00049-o. [PMID: 7550982] - E Crimi, U Orefice, F De Benedetto, V Grassi, V Brusasco. Nedocromil sodium versus theophylline in the treatment of reversible obstructive airway disease.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
1995 Jun; 74(6):501-8. doi:
NULL. [PMID: 7788518] - M W Turner, P Boulton, S Strobel. Experimental intestinal hypersensitivity. Effect of four anti-allergic drugs on protein uptake, permeability to sugars and mucosal mast-cell activation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1995 May; 25(5):448-55. doi:
10.1111/j.1365-2222.1995.tb01076.x. [PMID: 7553248] - C Möller, I M Berg, T Berg, M Kjellman, L Strömberg. Nedocromil sodium 2\% eye drops for twice-daily treatment of seasonal allergic conjunctivitis: a Swedish multicentre placebo-controlled study in children allergic to birch pollen.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1994 Sep; 24(9):884-7. doi:
10.1111/j.1365-2222.1994.tb01811.x. [PMID: 7812890] - C Mirone, A Fontana, S Mosca, M Bosetti, A Sala, J Scibilia, C Ortolani. Effects of nedocromil sodium on bronchospasm and HS-NCA release induced by allergen inhalation in asthmatic patients.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1994 Mar; 24(3):281-7. doi:
10.1111/j.1365-2222.1994.tb00232.x. [PMID: 8012860] - S K Ghosh, M G Neale, K R Patel. The effect of physiological manoeuvres on the absorption of inhaled nedocromil sodium.
British journal of clinical pharmacology.
1994 Mar; 37(3):305-8. doi:
10.1111/j.1365-2125.1994.tb04281.x. [PMID: 8198943] - P J Barnes. Effect of nedocromil sodium on microvascular leakage.
The Journal of allergy and clinical immunology.
1993 Jul; 92(1 Pt 2):197-9. doi:
10.1016/0091-6749(93)90107-q. [PMID: 8393029] - B Clark. General pharmacology, pharmacokinetics, and toxicology of nedocromil sodium.
The Journal of allergy and clinical immunology.
1993 Jul; 92(1 Pt 2):200-2. doi:
10.1016/0091-6749(93)90108-r. [PMID: 8393030] - P L Bruijnzeel, R A Warringa, P T Kok, M L Hamelink, H Kreukniet, L Koenderman. Effects of nedocromil sodium on in vitro induced migration, activation, and mediator release from human granulocytes.
The Journal of allergy and clinical immunology.
1993 Jul; 92(1 Pt 2):159-64. doi:
10.1016/0091-6749(93)90099-2. [PMID: 8393021] - C S Bailey, R J Buckley. Nedocromil sodium in contact-lens-associated papillary conjunctivitis.
Eye (London, England).
1993; 7 ( Pt 3 Suppl )(?):29-33. doi:
NULL. [PMID: 8253222] - Q A Summers, S Singh, R G Honeywell, A G Renwick, S T Holgate. The effect of respiratory manoeuvres and pharmacological agents on the pharmacokinetics of nedocromil sodium after inhalation.
British journal of clinical pharmacology.
1992 Apr; 33(4):431-8. doi:
10.1111/j.1365-2125.1992.tb04063.x. [PMID: 1315564] - C H Marquette, M Joseph, A B Tonnel, H Vorng, P Lassalle, A Tsicopoulos, A Capron. The abnormal in vitro response to aspirin of platelets from aspirin-sensitive asthmatics is inhibited after inhalation of nedocromil sodium but not of sodium cromoglycate.
British journal of clinical pharmacology.
1990 May; 29(5):525-31. doi:
10.1111/j.1365-2125.1990.tb03675.x. [PMID: 2161678] - P L Bruijnzeel, R A Warringa, P T Kok, J Kreukniet. Inhibition of neutrophil and eosinophil induced chemotaxis by nedocromil sodium and sodium cromoglycate.
British journal of pharmacology.
1990 Apr; 99(4):798-802. doi:
10.1111/j.1476-5381.1990.tb13009.x. [PMID: 2163279] - Q A Summers, R Honeywell, A G Renwick, S T Holgate. The protective efficacy of inhaled, oral and intravenous nedocromil sodium against adenosine-5'-monophosphate-induced bronchoconstriction in asthmatic volunteers.
Pulmonary pharmacology.
1990; 3(4):190-7. doi:
10.1016/0952-0600(90)90016-c. [PMID: 1966907] - M K Albazzaz, M G Neale, K R Patel. Dose-response study of nebulised nedocromil sodium in exercise induced asthma.
Thorax.
1989 Oct; 44(10):816-9. doi:
10.1136/thx.44.10.816. [PMID: 2556807] - J Greif, G Fink, Y Smorzik, M Topilsky, I Bruderman, S A Spitzer. Nedocromil sodium and placebo in the treatment of bronchial asthma. A multicenter, double-blind, parallel-group comparison.
Chest.
1989 Sep; 96(3):583-8. doi:
10.1378/chest.96.3.583. [PMID: 2548815] - P L Bruijnzeel, R A Warringa, P T Kok. Inhibition of platelet-activating factor- and zymosan-activated serum-induced chemotaxis of human neutrophils by nedocromil sodium, BN 52021 and sodium cromoglycate.
British journal of pharmacology.
1989 Aug; 97(4):1251-7. doi:
10.1111/j.1476-5381.1989.tb12586.x. [PMID: 2551444] - P L Bruijnzeel, R A Warringa, P T Kok, M L Hamelink, J Kreukniet. Inhibitory effects of nedocromil sodium on the in vitro induced migration and leukotriene formation of human granulocytes.
Drugs.
1989; 37 Suppl 1(?):9-18; discussion 69. doi:
10.2165/00003495-198900371-00004. [PMID: 2547570] - P Bellioni, F Salvinelli, F Patalano, F Ruggieri. A double-blind group comparative study of nedocromil sodium in the treatment of seasonal allergic rhinitis.
Rhinology.
1988 Dec; 26(4):281-7. doi:
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The American review of respiratory disease.
1988 Aug; 138(2):395-9. doi:
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British journal of clinical pharmacology.
1987 Oct; 24(4):493-501. doi:
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