L-768242 (BioDeep_00000830598)

   


代谢物信息卡片


(2,3-dichlorophenyl)(5-methoxy-2-methyl-3-(2-morpholinoethyl)-1H-indol-1-yl)methanone

化学式: C23H24Cl2N2O3 (446.1163894)
中文名称: GW405833 盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C2=C(N1C(=O)C3=C(C(=CC=C3)Cl)Cl)C=CC(=C2)OC)CCN4CCOCC4
InChI: InChI=1S/C23H24Cl2N2O3/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25/h3-7,14H,8-13H2,1-2H3



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Sheng-Lan Cai, Xue-Gong Fan, Jie Wu, Yang Wang, Xing-Wang Hu, Si-Ya Pei, Yi-Xiang Zheng, Jun Chen, Yan Huang, Ning Li, Ze-Bing Huang. CB2R agonist GW405833 alleviates acute liver failure in mice via inhibiting HIF-1α-mediated reprogramming of glycometabolism and macrophage proliferation. Acta pharmacologica Sinica. 2023 Jul; 44(7):1391-1403. doi: 10.1038/s41401-022-01037-8. [PMID: 36697976]
  • Ze-Bing Huang, Yi-Xiang Zheng, Ning Li, Sheng-Lan Cai, Yan Huang, Juan Wang, Xing-Wang Hu, Yang Wang, Jie Wu, Xue-Gong Fan. Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice. Acta pharmacologica Sinica. 2019 Nov; 40(11):1404-1411. doi: 10.1038/s41401-019-0213-0. [PMID: 30918343]
  • Amey Dhopeshwarkar, Natalia Murataeva, Alex Makriyannis, Alex Straiker, Ken Mackie. Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists. The Journal of pharmacology and experimental therapeutics. 2017 Feb; 360(2):300-311. doi: 10.1124/jpet.116.236539. [PMID: 27927913]
  • Linjing Mu, Daniel Bieri, Roger Slavik, Konstantin Drandarov, Adrienne Müller, Stjepko Cermak, Markus Weber, Roger Schibli, Stefanie D Krämer, Simon M Ametamey. Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor. Journal of neurochemistry. 2013 Sep; 126(5):616-24. doi: 10.1111/jnc.12354. [PMID: 23795580]
  • Nele Evens, Caroline Vandeputte, Giulio G Muccioli, Didier M Lambert, Veerle Baekelandt, Alfons M Verbruggen, Zeger Debyser, Koen Van Laere, Guy M Bormans. Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. Bioorganic & medicinal chemistry. 2011 Aug; 19(15):4499-505. doi: 10.1016/j.bmc.2011.06.033. [PMID: 21737287]
  • Kenneth J Valenzano, Laykea Tafesse, Gary Lee, James E Harrison, Jamie M Boulet, Susan L Gottshall, Lilly Mark, Michelle S Pearson, Wendy Miller, Shen Shan, Leyana Rabadi, Yakov Rotshteyn, Suzanne M Chaffer, Paul I Turchin, David A Elsemore, Mathew Toth, Lee Koetzner, Garth T Whiteside. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology. 2005 Apr; 48(5):658-72. doi: 10.1016/j.neuropharm.2004.12.008. [PMID: 15814101]