Isoxsuprine hydrochloride (BioDeep_00000830548)
代谢物信息卡片
Isoxsuprine hydrochloride
化学式: C18H24ClNO3 (337.1445)
中文名称: 盐酸苯氧丙酚胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(COC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.Cl
InChI: 1H
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31735
- KEGGdrug: D81952
- KEGGdrug: D01748
- PubChem: 11368
- ChEMBL: CHEMBL559180
- MeSH: Isoxsuprine
- CAS: 34331-89-0
- CAS: 579-56-6
- medchemexpress: HY-B1270
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ahmed S Saad, Eman S Elzanfaly, Michael K Halim, Khadiga M Kelani. Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Aug; 219(?):444-449. doi:
10.1016/j.saa.2019.04.064. [PMID: 31063959] - Fereshteh Shiri, Somaye Shahraki, Amin Shahriyar, Mostafa Heidari Majd. Exploring isoxsuprine hydrochloride binding with human serum albumin in the presence of folic acid and ascorbic acid using multispectroscopic and molecular modeling methods.
Journal of photochemistry and photobiology. B, Biology.
2017 May; 170(?):152-163. doi:
10.1016/j.jphotobiol.2017.04.007. [PMID: 28432945] - Handan Aydin Vural, Lora Koenhemsi, Remzi Gonul, Hasret Demircan Yardibi, Tevfik Gulyasar, Erman Or, Gulhan Turkay Hosturk, Bora Barutcu, Huriye Balci. Effects of isoxsuprine hydrochloride on electrocardiographic and trace element status in sheeps.
JPMA. The Journal of the Pakistan Medical Association.
2016 Aug; 66(8):938-42. doi:
NULL. [PMID: 27524523] - Biswarup Das, Sukrit Dutta, Amit Kumar Nayak, Upendranath Nanda. Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: development and optimization.
International journal of biological macromolecules.
2014 Sep; 70(?):506-15. doi:
10.1016/j.ijbiomac.2014.07.030. [PMID: 25062990] - Antonio Marzo, Dario Zava, Katrin Coa, Lorenzo Dal Bo, Shefqet Ismaili, Simona Tavazzi, Vittorio Cantoni. Pharmacokinetics of isoxsuprine hydrochloride administered orally and intramuscularly to female healthy volunteers.
Arzneimittel-Forschung.
2009; 59(9):455-60. doi:
10.1055/s-0031-1296425. [PMID: 19856793] - Leslie C Dickson, James D MacNeil, Stephen Lee, Adrian C E Fesser. Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry.
Journal of AOAC International.
2005 Jan; 88(1):46-56. doi:
. [PMID: 15759725] - J M Bosken, A F Lehner, C G Hughes, W E Woods, F C Camargo, J D Harkins, J Boyles, T Tobin. A GC-MS method for the determination of isoxsuprine in biological fluids of the horse utilizing electron impact ionization.
Journal of analytical toxicology.
2004 Jan; 28(1):27-34. doi:
10.1093/jat/28.1.27. [PMID: 14987421] - N El-Enany, F Belal, M Rizk. A simple kinetic spectrophotometric method for the determination of isoxsuprine in dosage forms.
Farmaco (Societa chimica italiana : 1989).
2002 Aug; 57(8):641-8. doi:
10.1016/s0014-827x(02)01236-3. [PMID: 12361231] - Nawal A A Alarfaj. Fluorimetric determination of isoxsuprine hydrochloride in pharmaceuticals and biological fluids.
Journal of pharmaceutical and biomedical analysis.
2002 Apr; 28(2):331-5. doi:
10.1016/s0731-7085(01)00619-7. [PMID: 11929676] - R S Erkert, C G Macallister. Isoxsuprine hydrochloride in the horse: a review.
Journal of veterinary pharmacology and therapeutics.
2002 Apr; 25(2):81-7. doi:
10.1046/j.1365-2885.2002.00386.x. [PMID: 12000527] - F A Aly, S A Al-Tamimi, A A Alwarthan. Determination of phenolic sympathomimetic drugs in pharmaceutical samples and biological fluids by flow-injection chemiluminescence.
Journal of AOAC International.
2000 Nov; 83(6):1299-305. doi:
10.1093/jaoac/83.6.1299. [PMID: 11128130] - F Belal, H A Al-Malaq, A A Al-Majed. Voltammetric determination of isoxsuprine and fenoterol in dosage forms and biological fluids through nitrosation.
Journal of pharmaceutical and biomedical analysis.
2000 Nov; 23(6):1005-15. doi:
10.1016/s0731-7085(00)00373-3. [PMID: 11095302] - J M Bosken, A F Lehner, A Hunsucker, J D Harkins, W E Woods, W Karpiesiuk, W G Carter, J Boyles, M Fisher, T Tobin. Direct MS-MS identification of isoxsuprine-glucuronide in post-administration equine urine.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2000 Apr; 64(2):112-6. doi:
NULL. [PMID: 10805250] - K Törneke, C I Larsson, L E Appelgren. Melanin affinity: a possible explanation of isoxsuprine retention in the horse.
Equine veterinary journal.
2000 Mar; 32(2):114-8. doi:
10.2746/042516400777591606. [PMID: 10743966] - F Marques, M P Bicho. Activation of a NADH dehydrogenase in the human erythrocyte by beta-adrenergic agonists: possible involvement of a G protein in enzyme activation.
Biological signals.
1997 Mar; 6(2):52-61. doi:
10.1159/000109109. [PMID: 9266092] - G Pompa, F Caloni, M Montana, C Pasqualucci. Prolonged presence of isoxsuprine in equine serum after oral administration.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Apr; 24(4):339-46. doi:
10.3109/00498259409045897. [PMID: 8059537] - B F Abraham. Prescribing for racehorses.
The Veterinary record.
1993 Jan; 132(5):119-20. doi:
10.1136/vr.132.5.119. [PMID: 8480411] - J Deumer, F de Haan, M T Tulp, R van den Hoven. Effect of an isoxsuprine-resin preparation on blood flow in the equine thoracic limb.
The Veterinary record.
1991 Nov; 129(19):427-9. doi:
10.1136/vr.129.19.427. [PMID: 1776223] - M C Dumasia, E Houghton. Screening and confirmatory analysis of beta-agonists, beta-antagonists and their metabolites in horse urine by capillary gas chromatography-mass spectrometry.
Journal of chromatography.
1991 Apr; 564(2):503-13. doi:
10.1016/0378-4347(91)80519-i. [PMID: 1874855] - A Hashem, B Lubczyk. Determination of isoxsuprine in equine plasma by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography.
1991 Jan; 563(1):216-23. doi:
10.1016/0378-4347(91)80299-r. [PMID: 2061392] - M Gemelli, F De Luca, R Manganaro, R Leonardi, F Rando, A Agnetti, C Mami, G Di Pasquale. Transient electrocardiographic changes suggesting myocardial ischaemia in newborn infants following tocolysis with beta-sympathomimetics.
European journal of pediatrics.
1990 Jul; 149(10):730-3. doi:
10.1007/bf01959533. [PMID: 1976519] - F D Galey, V R Beasley, D J Schaeffer, L E Davis. Antagonism in isolated equine digital vessels of contraction induced by epinephrine in the presence of hydrocortisone and an aqueous extract of black walnut (Juglans nigra).
Journal of veterinary pharmacology and therapeutics.
1989 Dec; 12(4):411-20. doi:
10.1111/j.1365-2885.1989.tb00692.x. [PMID: 2614858] - N S Matthews, R D Gleed, C E Short, K Burrows. Cardiovascular and pharmacokinetic effects of isoxsuprine in the horse.
American journal of veterinary research.
1986 Oct; 47(10):2130-3. doi:
NULL. [PMID: 3777634] - P A Aarts, J D Banga, H C van Houwelingen, R M Heethaar, J J Sixma. Increased red blood cell deformability due to isoxsuprine administration decreases platelet adherence in a perfusion chamber: a double-blind cross-over study in patients with intermittent claudication.
Blood.
1986 May; 67(5):1474-81. doi:
NULL. [PMID: 3516258] - S Caneschi, C Bonaventi, F Finzi, P Tito. [Resinated isoxsuprine in the therapy of cerebral ischemic vascular diseases].
Minerva medica.
1984 Nov; 75(45-46):2769-76. doi:
". [PMID: 6521948] - N B Segal, F M Guttman. Rabbit kidney function in vitro: the effect of colloids, energy substrate, a vasodilator, perfusion pressure, and bovine serum albumin.
Cryobiology.
1983 Oct; 20(5):527-41. doi:
10.1016/0011-2240(83)90041-x. [PMID: 6194936] - R J Rose, J R Allen, D R Hodgson, J R Kohnke. Studies on isoxsuprine hydrochloride for the treatment of navicular disease.
Equine veterinary journal.
1983 Jul; 15(3):238-43. doi:
10.1111/j.2042-3306.1983.tb01778.x. [PMID: 6349984] - D Cova, R Colombo, G Cellini. Determination of isoxsuprine in human plasma by gas chromatography with electron capture detection.
Pharmacology.
1983; 27(2):117-24. doi:
10.1159/000137843. [PMID: 6611650] - K Bremme, P Eneroth, L Hagenfeld, M Hellgren. Changes in maternal serum aldosterone, potassium and prolactin levels during beta-receptor agonist treatment in third trimester pregnancies.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1982 Apr; 14(4):198-204. doi:
10.1055/s-2007-1018968. [PMID: 6282724] - K Thomas, L Vankrieken, M Van Lierde. Characterization of ritodrine radioimmunoassay. Standard curves, cross-reactions and serum levels in women.
Gynecologic and obstetric investigation.
1982; 14(2):151-5. doi:
10.1159/000299462. [PMID: 7117921] - B G Guernsey, Y Villarreal, M D Snyder, H A Gabert. Pulmonary edema associated with the use of betamimetic agents in preterm labor.
American journal of hospital pharmacy.
1981 Dec; 38(12):1942-8. doi:
10.1093/ajhp/38.12.1942. [PMID: 6119903] - K Bremme, P Eneroth. Serum estriol levels during beta-receptor agonist infusion in the third trimester of pregnancy.
Gynecologic and obstetric investigation.
1981; 12(2):93-8. doi:
10.1159/000299572. [PMID: 6114905] - P L Ogburn, P P Williams, S B Johnson, R T Holman. Serum free fatty acid and arachidonic acid response to successful inhibition of premature labor with isoxsuprine.
Progress in lipid research.
1981; 20(?):827-30. doi:
10.1016/0163-7827(81)90156-9. [PMID: 6804987] - J E Brazy, V Little, J Grimm. Isoxsuprine in the perinatal period. II. Relationships between neonatal symptoms, drug exposure, and drug concentration at the time of birth.
The Journal of pediatrics.
1981 Jan; 98(1):146-51. doi:
10.1016/s0022-3476(81)80561-6. [PMID: 7192732] - E S Ogata. Isoxsuprine infusion in the rat: alterations in maternal, fetal and neonatal glucose homeostasis.
Journal of perinatal medicine.
1981; 9(6):293-301. doi:
10.1515/jpme.1981.9.6.293. [PMID: 7035644] - R L Hillelson, J Glowacki, N A Healey, J B Mulliken. A microangiographic study of hematoma-associated flap necrosis and salvage with isoxsuprine.
Plastic and reconstructive surgery.
1980 Oct; 66(4):528-33. doi:
10.1097/00006534-198010000-00004. [PMID: 7208666] - R Lammintausta, R Erkkola, P Katainen. Effect of intravenous infusion of betasympathomimetic agents on plasma renin activity during pregnancy.
British journal of obstetrics and gynaecology.
1978 Nov; 85(11):828-31. doi:
10.1111/j.1471-0528.1978.tb15837.x. [PMID: 31167] - A Kauppila, R Tuimala, O Ylikorkala, J Haapalahti, H Karppanen, L Viinikka. Effects of ritodrine and isoxsuprine with and without dexamethasone during late pregnancy.
Obstetrics and gynecology.
1978 Mar; 51(3):288-92. doi:
10.1097/00006250-197803000-00007. [PMID: 203880] - T Di Perri, S Forconi, D Agnusdei, M Guerrini, F Laghi Pasini. The effects of intravenous isoxsuprine on blood viscosity in patients with occlusive peripheral arterial disease.
British journal of clinical pharmacology.
1978 Mar; 5(3):255-60. doi:
10.1111/j.1365-2125.1978.tb01633.x. [PMID: 656271] - O Ylikorkala, A Kauppila, R Tuimala, J Haapalahti, H Karppanen, L Viinikka. Effects of intravenous isoxsuprine and ritodrine, with and without concomitant dexamethasone, on fetoplacental and pituitary hormones and cyclic adenosine monophosphate during late pregnancy.
American journal of obstetrics and gynecology.
1978 Feb; 130(3):302-6. doi:
. [PMID: 203192] - S Sybulski. Umbilical cord plasma cortisol levels in association with pregnancy complications.
Obstetrics and gynecology.
1977 Sep; 50(3):308-12. doi:
NULL. [PMID: 896100] - S Sybulski, G B Maughan. The effect of isoxsuprine treatment of estrogen levels in maternal and umbilical cord plasma.
The Journal of reproductive medicine.
1975 Dec; 15(6):232-6. doi:
NULL. [PMID: 1195263] - K Raij, M Härkönen, O Castrén, S Saarikoski, H Adlercreutz. Urinary cyclic AMP excretion in toxaemia of pregnancy.
Scandinavian journal of clinical and laboratory investigation.
1973 Nov; 32(3):193-7. doi:
10.3109/00365517309082458. [PMID: 4358670] - A H Jeske, M C Fonteles, A M Karow. Functional preservation of the mammalian kidney. II. Ultrastructure with low flow perfusion at normothermia.
The Journal of surgical research.
1973 Jul; 15(1):4-13. doi:
10.1016/0022-4804(73)90157-1. [PMID: 4718015] - E Marmo, A P Caputi, R K Saini. Cardiac histological and serum-biochemical changes produced by various adrenergic stimulant drugs in the rat.
Basic research in cardiology.
1973 May; 68(3):318-34. doi:
10.1007/bf01906131. [PMID: 4146717] - M C Fonteles, A H Jeske, A M Karow. Blockade of vasoconstriction by isoxsuprine (vasodilan) in the isolated perfused rabbit kidney.
Research communications in chemical pathology and pharmacology.
1973 Mar; 5(2):333-44. doi:
NULL. [PMID: 4699471] - E Marmo, R K Saini, A P Caputi. Effects of various beta-adrenergic stimulant drugs on the serum cholinesterase levels of rats.
Research communications in chemical pathology and pharmacology.
1973 Jan; 5(1):219-22. doi:
NULL. [PMID: 4405563] - Y Kato. [Secretion of human growth hormone (HGH). 2. Effects of adrenergic stimulating or blocking drugs on serum HGH].
Nihon Naibunpi Gakkai zasshi.
1972 Aug; 48(5):352-63. doi:
10.1507/endocrine1927.48.5_352. [PMID: 4404067] - A Rangel Abundis, J L Salgado Escobar, R Cervantes Santillán, R Limón Lason. [Measurement of instantaneous renal flow with dye dilution curves. Preliminary report].
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion.
1972 Jan; 24(1):57-75. doi:
NULL. [PMID: 4555759] - M Rubegni, C Bandinelli, D Provvedi, P G Bellini, G De Mauro. [Effect of vasodilator agents on lipid metabolism and on platelet aggregation in humans].
Bollettino della Societa italiana di cardiologia.
1972; 17(8):561-7. doi:
". [PMID: 4144153] - G HERTTING, M LOUDON. [Effect of phenoxy-isopropyl-nor-suprifen (duvadilan) and phenyl-isobutyl-nor suprifen (dilatol) on renal blood flow and glomerular filtrate in non-anesthetized dogs].
Wiener klinische Wochenschrift.
1956 Jul; 68(30):604-7. doi:
NULL. [PMID: 13392857]
