alpha-Methyltryptophan (BioDeep_00000830480)
代谢物信息卡片
alpha-Methyltryptophan
化学式: C12H14N2O2 (218.1055224)
中文名称: Α-甲基-L-色氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CNC2=CC=CC=C21)(C(=O)O)N
InChI: InChI=1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)/t12-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis. The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation.
Biomolecules.
2021 10; 11(10):. doi:
10.3390/biom11101522. [PMID: 34680153] - Sathish Sivaprakasam, Sabarish Ramachandran, Mohd Omar Faruk Sikder, Yangzom D Bhutia, Mitchell W Wachtel, Vadivel Ganapathy. α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice.
The Biochemical journal.
2021 04; 478(7):1347-1358. doi:
10.1042/bcj20210100. [PMID: 33720280] - Yong Chen, Florian Palm, Klaus-Peter Lesch, Manfred Gerlach, Rainald Moessner, Claudia Sommer. 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice.
Molecular pain.
2011 Mar; 7(?):21. doi:
10.1186/1744-8069-7-21. [PMID: 21447193] - Sujatha Kannan, Fadoua Saadani-Makki, Bindu Balakrishnan, Hui Dai, Pulak K Chakraborty, James Janisse, Otto Muzik, Roberto Romero, Diane C Chugani. Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2011 Feb; 31(2):738-49. doi:
10.1038/jcbfm.2010.156. [PMID: 20827261] - Linda Booij, Richard E Tremblay, Marco Leyton, Jean R Séguin, Frank Vitaro, Paul Gravel, Elisabeth Perreau-Linck, Mélissa L Lévesque, France Durand, Mirko Diksic, Gustavo Turecki, Chawki Benkelfat. Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study.
PloS one.
2010 Jun; 5(6):e11255. doi:
10.1371/journal.pone.0011255. [PMID: 20582306] - Senthil Karunakaran, Nagavedi S Umapathy, Muthusamy Thangaraju, Takahiro Hatanaka, Shiro Itagaki, David H Munn, Puttur D Prasad, Vadivel Ganapathy. Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.
The Biochemical journal.
2008 Sep; 414(3):343-55. doi:
10.1042/bj20080622. [PMID: 18522536] - Pinelopi Lundquist, Per Hartvig, Gunnar Blomquist, Margareta Hammarlund-Udenaes, Bengt Långström. 5-Hydroxy-L-[beta-11C]tryptophan versus alpha-[11C]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2007 Apr; 27(4):821-30. doi:
10.1038/sj.jcbfm.9600381. [PMID: 16896348] - Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksic. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study.
Brain research bulletin.
2006 Mar; 69(2):101-8. doi:
10.1016/j.brainresbull.2005.11.008. [PMID: 16533657] - M Nishikawa, Y Kumakura, S N Young, P Fiset, N Vogelzangs, M Leyton, C Benkelfat, M Diksic. Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-L-tryptophan and positron emission tomography.
Neurochemistry international.
2005 Dec; 47(8):556-64. doi:
10.1016/j.neuint.2005.07.006. [PMID: 16157418] - Shu Hasegawa, Kazuya Kanemaru, Maurice Gittos, Mirko Diksic. The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study.
Brain research bulletin.
2005 Oct; 67(3):248-55. doi:
10.1016/j.brainresbull.2005.07.009. [PMID: 16144662] - F-Y Tsai, J E Brotherton, J M Widholm. Overexpression of the feedback-insensitive anthranilate synthase gene in tobacco causes tryptophan accumulation.
Plant cell reports.
2005 Jan; 23(8):548-56. doi:
10.1007/s00299-004-0849-0. [PMID: 15375628] - Hidehiko Okazawa, Sadahiko Nishizawa, Tatsuro Tsuchida, Yoshiharu Yonekura, Mirko Diksic. A simplified autoradiographic method with alpha-[14C]methyl-tryptophan to measure serotonin synthesis rate in the rat brain.
Nuclear medicine and biology.
2004 Nov; 31(8):1013-9. doi:
10.1016/j.nucmedbio.2004.08.002. [PMID: 15607483] - Nela Pivac, Dorotea Mück-Seler, Mirko Diksic. Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies.
Neurochemistry international.
2003 Dec; 43(7):611-9. doi:
10.1016/s0197-0186(03)00096-2. [PMID: 12892648] - M Diksic. Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system.
Journal of psychiatry & neuroscience : JPN.
2001 Sep; 26(4):293-303. doi:
NULL. [PMID: 11590969] - M Diksic, S N Young. Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan.
Journal of neurochemistry.
2001 Sep; 78(6):1185-200. doi:
10.1046/j.1471-4159.2001.00536.x. [PMID: 11579128] - Y Tohyama, F Yamane, M F Merid, M Diksic. Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2001 Jun; 11(3):193-202. doi:
10.1016/s0924-977x(01)00076-1. [PMID: 11418278] - A Gharib, C Balende, N Sarda, D Weissmann, A Plenevaux, A Luxen, P Bobillier, J F Pujol. Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method.
Journal of neurochemistry.
1999 Jun; 72(6):2593-600. doi:
10.1046/j.1471-4159.1999.0722593.x. [PMID: 10349871] - H Okazawa, F Yamane, P Blier, M Diksic. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain.
Journal of neurochemistry.
1999 May; 72(5):2022-31. doi:
10.1046/j.1471-4159.1999.0722022.x. [PMID: 10217280] - S N Young, M Leyton, C Benkelfat. Pet studies of serotonin synthesis in the human brain.
Advances in experimental medicine and biology.
1999; 467(?):11-8. doi:
10.1007/978-1-4615-4709-9_2. [PMID: 10721033] - S E Shoaf, R Carson, D Hommer, W Williams, J D Higley, B Schmall, P Herscovitch, W Eckelman, M Linnoila. Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1998 Nov; 19(5):345-53. doi:
10.1016/s0893-133x(98)00032-3. [PMID: 9778657] - S Nishizawa, M Leyton, H Okazawa, C Benkelfat, S Mzengeza, M Diksic. Validation of a less-invasive method for measurement of serotonin synthesis rate with alpha-[11C]methyl-tryptophan.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1998 Oct; 18(10):1121-9. doi:
10.1097/00004647-199810000-00009. [PMID: 9778189] - H Okazawa, M Diksic. Image generation of serotonin synthesis rates using alpha-methyltryptophan and PET.
Journal of computer assisted tomography.
1998 Sep; 22(5):777-85. doi:
10.1097/00004728-199809000-00021. [PMID: 9754116] - D C Chugani, O Muzik, P Chakraborty, T Mangner, H T Chugani. Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan.
Synapse (New York, N.Y.).
1998 Jan; 28(1):33-43. doi:
10.1002/(sici)1098-2396(199801)28:1<33::aid-syn5>3.0.co;2-d. [PMID: 9414016] - S E Shoaf, B Schmall. Pharmacokinetics of alpha-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis.
The Journal of pharmacology and experimental therapeutics.
1996 Apr; 277(1):219-24. doi:
NULL. [PMID: 8613922] - J A Kreps, T Ponappa, W Dong, C D Town. Molecular basis of alpha-methyltryptophan resistance in amt-1, a mutant of Arabidopsis thaliana with altered tryptophan metabolism.
Plant physiology.
1996 Apr; 110(4):1159-65. doi:
10.1104/pp.110.4.1159. [PMID: 8934623] - M Vanier, K Tsuiki, M Grdisa, K Worsley, M Diksic. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis.
Journal of neurochemistry.
1995 Feb; 64(2):624-35. doi:
10.1046/j.1471-4159.1995.64020624.x. [PMID: 7830055] - S E Silverstone, D G Gilchrist, R M Bostock, T Kosuge. The 73-kb pIAA plasmid increases competitive fitness of Pseudomonas syringae subspecies savastanoi in oleander.
Canadian journal of microbiology.
1993 Jul; 39(7):659-64. doi:
10.1139/m93-095. [PMID: 8364801] - A Takada, M Grdisa, M Diksic. Blood-brain barrier transfer of L-Trp and alpha-MTrp in Li-treated rats.
Neurochemistry international.
1992 Dec; 21(4):513-9. doi:
10.1016/0197-0186(92)90082-3. [PMID: 1303732]
