flurithromycin (BioDeep_00000829484)

   


代谢物信息卡片


6-[4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione

化学式: C37H66FNO13 (751.4517958)
中文名称: 8-氟红霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)(C)F)C)O)(C)O
InChI: InChI=1S/C37H66FNO13/c1-14-24-37(10,46)29(42)21(5)28(41)34(7,38)17-35(8,45)31(52-33-26(40)23(39(11)12)15-18(2)48-33)19(3)27(20(4)32(44)50-24)51-25-16-36(9,47-13)30(43)22(6)49-25/h18-27,29-31,33,40,42-43,45-46H,14-17H2,1-13H3

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

flurithromycin; 6-[4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-9-fluoro-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • V Fanos, R Mormile, D Benini, S Vecchini, L Cuzzolin. Flurithromycin-induced acute interstitial nephritis. The Pediatric infectious disease journal. 2000 Apr; 19(4):366-7. doi: 10.1097/00006454-200004000-00027. [PMID: 10783037]
  • P M Furneri, A Cianci, L Campo, L S Roccasalva, G Tempera, G Fiore, G Palumbo, A M Lepore, G Nicoletti. Levels of flurithromycin in female genital tissue. Antimicrobial agents and chemotherapy. 1995 Aug; 39(8):1899-901. doi: 10.1128/aac.39.8.1899. [PMID: 7486945]
  • C E Cocuzza, R Mattina, A Lanzafame, L Romoli, A M Lepore. Serum levels of flurithromycin ethylsuccinate in healthy volunteers. Chemotherapy. 1994 May; 40(3):157-60. doi: 10.1159/000239187. [PMID: 8205933]
  • D Saverino, E A Debbia, A Pesce, A M Lepore, G C Schito. Antibacterial profile of flurithromycin, a new macrolide. The Journal of antimicrobial chemotherapy. 1992 Sep; 30(3):261-72. doi: 10.1093/jac/30.3.261. [PMID: 1452490]
  • L Cuzzolin, M E Fracasso, R Leone, G Benoni. Effects of erythromycin, flurithromycin and teicoplanin on rat microflora. Journal of chemotherapy (Florence, Italy). 1989 Jul; 1(4 Suppl):196-7. doi: NULL. [PMID: 16312366]
  • G B Galioto, E Mevio, P Galioto, G Zanuso, A M Lepore. Concentrations of flurithromycin in serum and tonsils. International journal of clinical pharmacology, therapy, and toxicology. 1989 Mar; 27(3):126-8. doi: NULL. [PMID: 2722307]
  • G Benoni, L Cuzzolin, R Leone, U Consolo, G Ferronato, C Bertrand, V Puchetti, M E Fracasso. Pharmacokinetics and human tissue penetration of flurithromycin. Antimicrobial agents and chemotherapy. 1988 Dec; 32(12):1875-8. doi: 10.1128/aac.32.12.1875. [PMID: 3245699]
  • A M Lepore, G Bonardi, G C Maggi. Influence of food on the absorption of flurithromycin in man. International journal of clinical pharmacology research. 1988; 8(4):253-7. doi: NULL. [PMID: 3182114]
  • N Barzaghi, G Gatti, F Crema, A Faja, M Monteleone, C Amione, L Leone, E Perucca. Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects. International journal of clinical pharmacology research. 1988; 8(2):101-5. doi: NULL. [PMID: 3378851]
  • G Benoni, L Cuzzolin, P Del Soldato, M Raichi, G Velo. The influence of erythromycin and flurithromycin on the normal gastrointestinal flora of humans. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1987 Jun; 6(2 Suppl):341-3. doi: NULL. [PMID: 3509441]
  • P Villa, J M Bégué, A Guillouzo. Erythromycin toxicity in primary cultures of rat hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems. 1985 Aug; 15(8-9):767-73. doi: 10.3109/00498258509047439. [PMID: 4072263]