Idoxifene (BioDeep_00000829436)

   


代谢物信息卡片


Idoxifene

化学式: C28H30INO (523.137204)
中文名称: 伊多昔芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=C(C1=CC=C(C=C1)OCCN2CCCC2)C3=CC=C(C=C3)I)C4=CC=CC=C4
InChI: InChI=1S/C28H30INO/c1-2-27(22-8-4-3-5-9-22)28(23-10-14-25(29)15-11-23)24-12-16-26(17-13-24)31-21-20-30-18-6-7-19-30/h3-5,8-17H,2,6-7,18-21H2,1H3/b28-27-

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
C1892 - Chemopreventive Agent

同义名列表

1 个代谢物同义名

Idoxifene



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • S R D Johnston, L A Gumbrell, T R J Evans, R E Coleman, I E Smith, C J Twelves, M Soukop, D W Rea, H M Earl, A Howell, A Jones, P Canney, T J Powles, B P Haynes, B Nutley, R Grimshaw, M Jarman, G W Halbert, M Brampton, J Haviland, M Dowsett, R C Coombes. A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen. Cancer chemotherapy and pharmacology. 2004 Apr; 53(4):341-8. doi: 10.1007/s00280-003-0733-6. [PMID: 14722733]
  • Guangming Lu, Ichiro Shimizu, Xuezhi Cui, Mina Itonaga, Katsuyoshi Tamaki, Hiroshi Fukuno, Hiroshi Inoue, Hirohito Honda, Susumu Ito. Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats. Life sciences. 2004 Jan; 74(7):897-907. doi: 10.1016/j.lfs.2003.08.004. [PMID: 14659978]
  • Hiroshi Inoue, Ichiro Shimizu, Guangming Lu, Mina Itonaga, Xuezhi Cui, Yoshihito Okamura, Masayuki Shono, Hirohito Honda, Satoshi Inoue, Masami Muramatsu, Susumu Ito. Idoxifene and estradiol enhance antiapoptotic activity through estrogen receptor-beta in cultured rat hepatocytes. Digestive diseases and sciences. 2003 Mar; 48(3):570-80. doi: 10.1023/a:1022553119715. [PMID: 12757172]
  • Changming Yang, Jack Henion. Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma. Journal of chromatography. A. 2002 Sep; 970(1-2):155-65. doi: 10.1016/s0021-9673(02)00882-8. [PMID: 12350090]
  • Matthieu Gutman, Steeve Couillard, Jenny Roy, Fernand Labrie, Bernard Candas, Claude Labrie. Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice. International journal of cancer. 2002 May; 99(2):273-8. doi: 10.1002/ijc.10302. [PMID: 11979444]
  • H Zhang, J Henion. Comparison between liquid chromatography-time of-flight mass spectrometry and selected reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of idoxifene in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jun; 757(1):151-9. doi: 10.1016/s0378-4347(01)00132-3. [PMID: 11419740]
  • T Omoya, I Shimizu, Y Zhou, Y Okamura, H Inoue, G Lu, M Itonaga, H Honda, M Nomura, S Ito. Effects of idoxifene and estradiol on NF-kappaB activation in cultured rat hepatocytes undergoing oxidative stress. Liver. 2001 Jun; 21(3):183-91. doi: 10.1034/j.1600-0676.2001.021003183.x. [PMID: 11422781]
  • X L Ma, F Gao, J Chen, T A Christopher, B L Lopez, E H Ohlstein, T Yue. Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats. American journal of physiology. Heart and circulatory physiology. 2001 Feb; 280(2):H876-84. doi: 10.1152/ajpheart.2001.280.2.h876. [PMID: 11158989]
  • J M Onorato, J D Henion, P M Lefebvre, J P Kiplinger. Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection. Analytical chemistry. 2001 Jan; 73(1):119-25. doi: 10.1021/ac000845t. [PMID: 11195494]
  • T L Yue, L Vickery-Clark, C S Louden, J L Gu, X L Ma, P K Narayanan, X Li, J Chen, B Storer, R Willette, K A Gossett, E H Ohlstein. Selective estrogen receptor modulator idoxifene inhibits smooth muscle cell proliferation, enhances reendothelialization, and inhibits neointimal formation in vivo after vascular injury. Circulation. 2000 Nov; 102(19 Suppl 3):III281-8. doi: 10.1161/01.cir.102.suppl_3.iii-281. [PMID: 11082402]
  • M E Nuttall, G B Stroup, P W Fisher, D P Nadeau, M Gowen, L J Suva. Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells. American journal of physiology. Cell physiology. 2000 Nov; 279(5):C1550-7. doi: 10.1152/ajpcell.2000.279.5.c1550. [PMID: 11029302]
  • J Zweigenbaum, J Henion. Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 samples/day. Analytical chemistry. 2000 Jun; 72(11):2446-54. doi: 10.1021/ac991413p. [PMID: 10857619]
  • A M Badger, S M Blake, R A Dodds, D E Griswold, B A Swift, D J Rieman, G B Stroup, S J Hoffman, M Gowen. Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis. The Journal of pharmacology and experimental therapeutics. 1999 Dec; 291(3):1380-6. doi: NULL. [PMID: 10565864]
  • A C Fleischer, J E Wheeler, I T Yeh, B Kravitz, C Jensen, B MacDonald. Sonographic assessment of the endometrium in osteopenic postmenopausal women treated with idoxifene. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 1999 Jul; 18(7):503-12. doi: 10.7863/jum.1999.18.7.503. [PMID: 10400054]
  • M E Nuttall, J N Bradbeer, G B Stroup, D P Nadeau, S J Hoffman, H Zhao, S Rehm, M Gowen. Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats. Endocrinology. 1998 Dec; 139(12):5224-34. doi: 10.1210/endo.139.12.6343. [PMID: 9832463]
  • J Ziegler. Raloxifene, retinoids, and lavender: 'me too' tamoxifen alternatives under study. Journal of the National Cancer Institute. 1996 Aug; 88(16):1100-2. doi: 10.1093/jnci/88.16.1100. [PMID: 8757185]