methoxamine hydrochloride (BioDeep_00000829233)

   


代谢物信息卡片


methoxamine hydrochloride

化学式: C11H18ClNO3 (247.0975148)
中文名称: 甲氧胺 盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N.Cl
InChI: 1H

描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents

同义名列表

1 个代谢物同义名

methoxamine hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Gustavo de-Los-Santos-Cocotle, Juan Carlos Martínez-Morales, M Teresa Romero-Ávila, Guadalupe Reyes-Cruz, J Adolfo García-Sáinz. Effects of agonists and phorbol esters on α1A-adrenergic receptor-Rab protein interactions. European journal of pharmacology. 2020 Oct; 885(?):173423. doi: 10.1016/j.ejphar.2020.173423. [PMID: 32750368]
  • Xiaowei Guo, Jie Hu, Hanbing Xiao, Tianyu Liu, Zheng Niu, Min Wang, Dunyi Qi. Effect of continuous intraoperative infusion of methoxamine on renal function in elderly patients undergoing gastrointestinal tumor surgery: a randomized controlled trial. BMC anesthesiology. 2020 06; 20(1):148. doi: 10.1186/s12871-020-01064-0. [PMID: 32534584]
  • Qian Qin, Disheng Feng, Chunxiu Hu, Bohong Wang, Mengmeng Chang, Xinyu Liu, Peiyuan Yin, Xianzhe Shi, Guowang Xu. Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones. Journal of chromatography. A. 2020 Mar; 1614(?):460709. doi: 10.1016/j.chroma.2019.460709. [PMID: 31784081]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Maki Kotaka, Taro Toyoda, Katsutaro Yasuda, Yuko Kitano, Chihiro Okada, Akira Ohta, Akira Watanabe, Motonari Uesugi, Kenji Osafune. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Scientific reports. 2017 12; 7(1):16734. doi: 10.1038/s41598-017-16858-5. [PMID: 29196668]
  • S Afzal, M A Sattar, Edward J Johns, Mohammed H Abdulla, Safia Akhtar, Fayyaz Hashmi, Nor Azizan Abdullah. Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats. Journal of physiology and biochemistry. 2016 Dec; 72(4):593-604. doi: 10.1007/s13105-016-0497-1. [PMID: 27405250]
  • Kai Y Mak, Ruth Chin, Sharon C Cunningham, Miriam R Habib, Joseph Torresi, Alexandra F Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath. ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2015 Sep; 23(9):1434-43. doi: 10.1038/mt.2015.92. [PMID: 25997428]
  • Ashfaq Ahmad, Munavvar A Sattar, Hassaan A Rathore, Mohammad H Abdulla, Safia A Khan, Nor A Abdullah, Gurjeet Kaur, Edward J Johns. Functional contribution of α1D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar-Kyoto rats. Canadian journal of physiology and pharmacology. 2014 Dec; 92(12):1029-35. doi: 10.1139/cjpp-2014-0236. [PMID: 25403946]
  • Defeng Sun, Yue Wu, Lin Yang, Jun Han, Ruochuan Liu, Lijie Wang. Effects of continuous intravenous infusion of methoxamine on the intraoperative hemodynamics of elderly patients undergoing total hip arthroplasty. Medical science monitor : international medical journal of experimental and clinical research. 2014 Oct; 20(?):1969-76. doi: 10.12659/msm.890760. [PMID: 25326008]
  • D Bell, A Duffin, A Jacobs, C Pediconi, H J Gruss. A double-blind, placebo-controlled, randomised, parallel-group, dose-escalating, repeat dose study in healthy volunteers to evaluate the safety, tolerability, pharmacodynamic effects and pharmacokinetics of the once daily rectal application of NRL001 suppositories for 14 days. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):36-50. doi: 10.1111/codi.12544. [PMID: 24499495]
  • L Siproudhis, D Jones, R Ng Kwet Shing, D Walker, J H Scholefield. Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):59-66. doi: 10.1111/codi.12546. [PMID: 24499497]
  • D Bell, A Duffin, H J Gruss, C Pediconi, A Jacobs. A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):27-35. doi: 10.1111/codi.12543. [PMID: 24499494]
  • J A D Simpson, D Bush, H J Gruss, A Jacobs, C Pediconi, J H Scholefield. A randomised, controlled, crossover study to investigate the safety and response of 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):5-15. doi: 10.1111/codi.12541. [PMID: 24499492]
  • Sevgi Tatar Ulu. Determination of methoxamine in human plasma and urine by a validated HPLC-fluorescence detection method. Journal of AOAC International. 2013 Sep; 96(5):987-90. doi: 10.5740/jaoacint.10-479. [PMID: 24282936]
  • Punnee Nusuetrong, Uthai Sotanaphun, Patcharin Tep-Areenan. Effects of Phikud Navakot extract on vascular reactivity in the isolated rat aorta. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2012 Dec; 95 Suppl 12(?):S1-7. doi: . [PMID: 23513458]
  • Sven Francque, Wim Laleman, Len Verbeke, Christophe Van Steenkiste, Christophe Casteleyn, Wilhelmus Kwanten, Christophe Van Dyck, Michiel D'Hondt, Albert Ramon, Wim Vermeulen, Benedicte De Winter, Eric Van Marck, Veerle Van Marck, Paul Pelckmans, Peter Michielsen. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture. Laboratory investigation; a journal of technical methods and pathology. 2012 Oct; 92(10):1428-39. doi: 10.1038/labinvest.2012.103. [PMID: 22890552]
  • Mohammed H Abdulla, Munavvar A Sattar, Edward J Johns, Nor A Abdullah, Md Abdul Hye Khan. Evidence for the role of α1A-adrenoceptor subtype in the control of renal haemodynamics in fructose-fed Sprague-Dawley rat. European journal of nutrition. 2011 Dec; 50(8):689-97. doi: 10.1007/s00394-011-0180-9. [PMID: 21373947]
  • Mohammed H Abdulla, Munavvar A Sattar, Nor A Abdullah, Abdul Hye Khan, Kolla R L Anand Swarup, Hassaan A Rathore, Raisa N Kazi, Fathihah Basri, Edward J Johns. Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats. Upsala journal of medical sciences. 2011 Mar; 116(1):18-25. doi: 10.3109/03009734.2010.526723. [PMID: 21047287]
  • Ingemar Jacobson, Leif Carlsson, Göran Duker. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. Journal of pharmacological and toxicological methods. 2011 Jan; 63(1):40-6. doi: 10.1016/j.vascn.2010.04.010. [PMID: 20451633]
  • Lan Wang, Jing Ren, Meng Sun, Sicen Wang. A combined cell membrane chromatography and online HPLC/MS method for screening compounds from Radix Caulophylli acting on the human alpha(1A)-adrenoceptor. Journal of pharmaceutical and biomedical analysis. 2010 Apr; 51(5):1032-6. doi: 10.1016/j.jpba.2009.11.007. [PMID: 20004544]
  • G Fanciulli, P A Tomasi, A P Delitala, G Delitala. Activation of alpha1-adrenoceptors inhibits growth hormone secretion in humans. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2009 Oct; 117(9):460-2. doi: 10.1055/s-0029-1202796. [PMID: 19373756]
  • Md Abdul Hye Khan, Munavvar Abdul Sattar, Nor Azizan Abdullah, Mohammed H Abdulla, Ibrahim M Salman, Raisa N Kazi, K R L Anand Swarup, Hassaan A Rathore, Fathihah Basri, Nurjannah M Hussain, Aidiahmad Dewa, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy. Kidney & blood pressure research. 2009; 32(5):349-59. doi: 10.1159/000249149. [PMID: 19844130]
  • A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica. 2008 May; 29(5):564-72. doi: 10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364]
  • M H Abdulla, M A Sattar, I M Salman, N A Abdullah, O Z Ameer, Md A H Khan, E J Johns. Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats. Autonomic & autacoid pharmacology. 2008 Apr; 28(2-3):87-94. doi: 10.1111/j.1474-8673.2008.00421.x. [PMID: 18598290]
  • M A Sattar, N A Abdullah, Md A H Khan, E J Johns. Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats. Autonomic & autacoid pharmacology. 2008 Jan; 28(1):1-10. doi: 10.1111/j.1474-8673.2007.00412.x. [PMID: 18257746]
  • Frédéric Michel, Serge Simonet, Christine Vayssettes-Courchay, Florence Bertin, Patricia Sansilvestri-Morel, Fabienne Bernhardt, Jérôme Paysant, Jean-Sébastien Silvestre, Bernard I Levy, Michel Félétou, Tony J Verbeuren. Altered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice. American journal of physiology. Renal physiology. 2008 Jan; 294(1):F120-9. doi: 10.1152/ajprenal.00111.2007. [PMID: 17942572]
  • Han Liu, Fang Feng, Ming Ma, Shuangjin Cui, Darong Xie, Sizhi Xu. Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Oct; 858(1-2):42-8. doi: 10.1016/j.jchromb.2007.08.004. [PMID: 17766197]
  • P J Nisar, H-J Gruss, D Bush, A G Acheson, J H Scholefield. Intra-anal application of L-erythro methoxamine gel increases anal resting pressure in patients with incontinence. The British journal of surgery. 2007 Sep; 94(9):1155-61. doi: 10.1002/bjs.5821. [PMID: 17542041]
  • Abdul H Khan, Munavvar A Sattar, Nor A Abdullah, Edward J Johns. Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat. European journal of pharmacology. 2007 Aug; 569(1-2):110-8. doi: 10.1016/j.ejphar.2007.04.063. [PMID: 17559832]
  • U Deniz Dincer, Alberto G Araiza, Jarrod D Knudson, Patricia E Molina, Johnathan D Tune. Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome. Microcirculation (New York, N.Y. : 1994). 2006 Oct; 13(7):587-95. doi: 10.1080/10739680600885228. [PMID: 16990217]
  • P J Nisar, H-J Gruss, D Bush, N Barras, A G Acheson, J H Scholefield. Intra-anal and rectal application of L-erythro methoxamine gel increases anal resting pressure in healthy volunteers. The British journal of surgery. 2005 Dec; 92(12):1539-45. doi: 10.1002/bjs.5171. [PMID: 16231282]
  • Jörg Heller, Jonel Trebicka, Thomas Shiozawa, Michael Schepke, Markus Neef, Martin Hennenberg, Tilman Sauerbruch. Vascular, hemodynamic and renal effects of low-dose losartan in rats with secondary biliary cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2005 Jun; 25(3):657-66. doi: 10.1111/j.1478-3231.2005.01053.x. [PMID: 15910503]
  • Dongzhe Song, Simon Hutchings, Catherine C Y Pang. Chronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in rats. European journal of pharmacology. 2005 Jan; 508(1-3):205-10. doi: 10.1016/j.ejphar.2004.12.018. [PMID: 15680273]
  • A Armenia, A S Munavvar, N A Abdullah, A Helmi, E J Johns. The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British journal of pharmacology. 2004 Jun; 142(4):719-26. doi: 10.1038/sj.bjp.0705842. [PMID: 15172958]
  • Beatriz Civantos, Amaya Aleixandre. Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca. European journal of pharmacology. 2004 Apr; 489(1-2):101-10. doi: 10.1016/j.ejphar.2004.02.032. [PMID: 15063161]
  • Matthew R Farmer, Richard E Roberts, Sheila M Gardiner, Vera Ralevic. Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta. The Journal of pharmacology and experimental therapeutics. 2003 Aug; 306(2):538-45. doi: 10.1124/jpet.103.051805. [PMID: 12730359]
  • Rabelais Tatchum-Talom, Céline Martel, Fernand Labrie, André Marette. Acute vascular effects of the selective estrogen receptor modulator EM-652 (SCH 57068) in the rat mesenteric vascular bed. Cardiovascular research. 2003 Feb; 57(2):535-43. doi: 10.1016/s0008-6363(02)00666-1. [PMID: 12566126]
  • Roger G Pertwee, Ruth A Ross, Susan J Craib, Adèle Thomas. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. European journal of pharmacology. 2002 Dec; 456(1-3):99-106. doi: 10.1016/s0014-2999(02)02624-9. [PMID: 12450575]
  • Ayako Makino, Katsuo Kamata. Effects of chronic administration of L-arginine on vasoactive responses induced by endothelin-1 and its plasma level in streptozotocin-induced diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2002 Oct; 38(4-5):101-15. doi: 10.1540/jsmr.38.101. [PMID: 12596889]
  • Christine E Wright, James A Angus, Paul I Korner. Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade. Journal of hypertension. 2002 Mar; 20(3):471-83. doi: 10.1097/00004872-200203000-00023. [PMID: 11875315]
  • D A Misurski, R L Hopfner, V Gopalakrishnan. Attenuated agonist evoked vasoconstrictor responses in the perfused mesenteric vascular bed of streptozotocin diabetic rats. Experimental biology and medicine (Maywood, N.J.). 2001 Nov; 226(10):940-6. doi: 10.1177/153537020122601010. [PMID: 11682701]
  • P Dutta, D E Ryan, R Tabrizchi. The influence of phosphodiesterase inhibitor, rolipram, on hemodynamics in lipopolysaccharide-treated rats. Japanese journal of pharmacology. 2001 Mar; 85(3):241-9. doi: 10.1254/jjp.85.241. [PMID: 11325016]
  • A Kiss, G Aguilera. Role of alpha-1-adrenergic receptors in the regulation of corticotropin-releasing hormone mRNA in the paraventricular nucleus of the hypothalamus during stress. Cellular and molecular neurobiology. 2000 Dec; 20(6):683-94. doi: 10.1023/a:1007098724683. [PMID: 11100976]
  • J Nakasone, M Higuchi, K Miyagi, T Matsuzaki, K Noguchi, M Sakanashi, S Yamashiro, T Itomine, M Sakanashi. Comparison of contractile responses relative to protein between isolated diabetic and non-diabetic rat aortae to KCl and alpha-adrenoceptor agonists in different extracellular calcium concentrations. Arzneimittel-Forschung. 2000 Dec; 50(12):1078-83. doi: 10.1055/s-0031-1300344. [PMID: 11190772]
  • K A Harrison, S S Davies, G K Marathe, T McIntyre, S Prescott, K M Reddy, J R Falck, R C Murphy. Analysis of oxidized glycerophosphocholine lipids using electrospray ionization mass spectrometry and microderivatization techniques. Journal of mass spectrometry : JMS. 2000 Feb; 35(2):224-36. doi: 10.1002/(sici)1096-9888(200002)35:2<224::aid-jms933>3.0.co;2-g. [PMID: 10679985]
  • R L Hopfner, D A Misurski, J R McNeill, V Gopalakrishnan. Effect of sodium orthovanadate treatment on cardiovascular function in the hyperinsulinemic, insulin-resistant obese Zucker rat. Journal of cardiovascular pharmacology. 1999 Dec; 34(6):811-7. doi: 10.1097/00005344-199912000-00007. [PMID: 10598124]
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