gallium nitrate (BioDeep_00000829063)
代谢物信息卡片
gallium nitrate
化学式: GaN3O9 (254.889038)
中文名称: 硝酸镓(III)溶液,Ga 9-10％w/w
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Ga+3]
InChI: 3*-1
描述信息
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D000077264 - Calcium-Regulating Hormones and Agents
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Seoung-Ryoung Choi, Bradley E Britigan, Prabagaran Narayanasamy. Dual Inhibition of Klebsiella pneumoniae and Pseudomonas aeruginosa Iron Metabolism Using Gallium Porphyrin and Gallium Nitrate.
ACS infectious diseases.
2019 09; 5(9):1559-1569. doi:
10.1021/acsinfecdis.9b00100. [PMID: 31264851] - Federica Runci, Carlo Bonchi, Emanuela Frangipani, Daniela Visaggio, Paolo Visca. Acinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.01563-16. [PMID: 27799219] - Caroline S Monk, Raymond W Sweeney, Lawrence R Bernstein, Marie-Eve Fecteau. Serum and tissue concentrations of gallium after oral administration of gallium nitrate and gallium maltolate to neonatal calves.
American journal of veterinary research.
2016 Feb; 77(2):151-5. doi:
10.2460/ajvr.77.2.151. [PMID: 27027708] - Carlo Bonchi, Emanuela Frangipani, Francesco Imperi, Paolo Visca. Pyoverdine and proteases affect the response of Pseudomonas aeruginosa to gallium in human serum.
Antimicrobial agents and chemotherapy.
2015 Sep; 59(9):5641-6. doi:
10.1128/aac.01097-15. [PMID: 26149986] - Yuanyuan Zhu, Yan Qiu, Ruiqi Chen, Lianming Liao. The Inhibition of Escherichia coli Biofilm Formation by Gallium Nitrate-Modified Titanium.
Journal of nanoscience and nanotechnology.
2015 Aug; 15(8):5605-9. doi:
10.1166/jnn.2015.10305. [PMID: 26369125] - Xiao-Zhang Yu, Xing-Hui Feng, Yu-Xi Feng. Phytotoxicity and Transport of Gallium (Ga) in Rice Seedlings for 2-Day of Exposure.
Bulletin of environmental contamination and toxicology.
2015 Jul; 95(1):122-5. doi:
10.1007/s00128-015-1471-2. [PMID: 25634322] - Xiao-Zhang Yu, Xue-Hong Zhang. DNA-protein cross-links involved in growth inhibition of rice seedlings exposed to Ga.
Environmental science and pollution research international.
2015 Jul; 22(14):10830-8. doi:
10.1007/s11356-015-4305-1. [PMID: 25772880] - Louis de Léséleuc, Greg Harris, Rhonda KuoLee, H Howard Xu, Wangxue Chen. Serum resistance, gallium nitrate tolerance and extrapulmonary dissemination are linked to heme consumption in a bacteremic strain of Acinetobacter baumannii.
International journal of medical microbiology : IJMM.
2014 May; 304(3-4):360-9. doi:
10.1016/j.ijmm.2013.12.002. [PMID: 24440358] - Jae-Hyeog Choi, Jong-Hwan Lee, Kug-Hwan Roh, Su-Kil Seo, Il-Whan Choi, Sae-Gwang Park, Jun-Goo Lim, Won-Jin Lee, Myoung-Hun Kim, Kwang-rae Cho, Young-Jae Kim. Gallium nitrate ameliorates type II collagen-induced arthritis in mice.
International immunopharmacology.
2014 May; 20(1):269-75. doi:
10.1016/j.intimp.2014.03.005. [PMID: 24656780] - Ildikó Radványi, Agnes Csikós, Sándor Balogh. [The significance of early diagnosis of cancer-related hypercalcaemia].
Orvosi hetilap.
2013 Sep; 154(35):1367-73. doi:
10.1556/oh.2013.29665. [PMID: 23974972] - Luísa C S Antunes, Francesco Imperi, Fabrizia Minandri, Paolo Visca. In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii.
Antimicrobial agents and chemotherapy.
2012 Nov; 56(11):5961-70. doi:
10.1128/aac.01519-12. [PMID: 22964249] - M-E Fecteau, R H Whitlock, T L Fyock, S C McAdams, R C Boston, R W Sweeney. Antimicrobial activity of gallium nitrate against Mycobacterium avium subsp. paratuberculosis in neonatal calves.
Journal of veterinary internal medicine.
2011 Sep; 25(5):1152-5. doi:
10.1111/j.1939-1676.2011.0768.x. [PMID: 21781171] - George Eby. Is gallium nitrate an effective kidney stone, calcified uterine fibroid, atherosclerosis and cataract anti-nanobacteria treatment? A case history and hypothesis.
Medical hypotheses.
2010 Feb; 74(2):393-4. doi:
10.1016/j.mehy.2009.08.039. [PMID: 19758769] - O Landré, C Bougerol, H Renevier, B Daudin. Nucleation mechanism of GaN nanowires grown on (111) Si by molecular beam epitaxy.
Nanotechnology.
2009 Oct; 20(41):415602. doi:
10.1088/0957-4484/20/41/415602. [PMID: 19755728] - Michael Groessl, Anna Bytzek, Christian G Hartinger. The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques.
Electrophoresis.
2009 Aug; 30(15):2720-7. doi:
10.1002/elps.200800745. [PMID: 19621374] - George A Eby. A hypothesis for anti-nanobacteria effects of gallium with observations from treating kidney disease.
Medical hypotheses.
2008 Oct; 71(4):584-90. doi:
10.1016/j.mehy.2008.04.025. [PMID: 18579317] - G Arumugam, P Shanthi, P Sachdanandam. Effect of gallium nitrate on tamoxifen induced hypercalcemia in rats bearing mammary tumor.
Experimental oncology.
2006 Jun; 28(2):141-5. doi:
NULL. [PMID: 16837906] - Frédérique Cvitkovic, Jean-Pierre Armand, Michèle Tubiana-Hulin, Jean-François Rossi, Raymond P Warrell. Randomized, double-blind, phase II trial of gallium nitrate compared with pamidronate for acute control of cancer-related hypercalcemia.
Cancer journal (Sudbury, Mass.).
2006 Jan; 12(1):47-53. doi:
10.1097/00130404-200601000-00009. [PMID: 16613662] - Govinda Pillai Arumugam, Sengoden Sundravel, Palanivel Shanthi, Panchanadham Sachdanandam. Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usage.
Journal of bone and mineral metabolism.
2006; 24(3):243-7. doi:
10.1007/s00774-005-0678-4. [PMID: 16622738] - Brian Leyland-Jones. Treating cancer-related hypercalcemia with gallium nitrate.
The journal of supportive oncology.
2004 Nov; 2(6):509-16. doi:
. [PMID: 15605917] - Brian Leyland-Jones. Treatment of cancer-related hypercalcemia: the role of gallium nitrate.
Seminars in oncology.
2003 Apr; 30(2 Suppl 5):13-9. doi:
10.1016/s0093-7754(03)00171-4. [PMID: 12776255] - T G Davidson. Conventional treatment of hypercalcemia of malignancy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2001 Nov; 58 Suppl 3(?):S8-15. doi:
10.1093/ajhp/58.suppl_3.s8. [PMID: 11757206] - Moschèn, K Schweizer, C A Wagner, J Geis-Gerstorfer, F Lang. Effects of gallium and mercury ions on transport systems.
Journal of dental research.
2001 Aug; 80(8):1753-7. doi:
10.1177/00220345010800081401. [PMID: 11669488] - A M Ghazi, S Shuttleworth, S J Angulo, D H Pashley. Gallium diffusion in human root dentin: quantitative measurements by pulsed Nd:YAG laser ablation combined with an inductively coupled plasma mass spectrometer.
Journal of clinical laser medicine & surgery.
2000 Aug; 18(4):173-83. doi:
10.1089/10445470050144029. [PMID: 11573509] - L K Webster, I N Olver, K H Stokes, R G Sephton, B L Hillcoat, J F Bishop. A pharmacokinetic and phase II study of gallium nitrate in patients with non-small cell lung cancer.
Cancer chemotherapy and pharmacology.
2000; 45(1):55-8. doi:
10.1007/pl00006743. [PMID: 10647502] - M E Krecic-Shepard, D R Shepard, D Mullet, G Apseloff, S E Weisbrode, N Gerber. Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock.
Life sciences.
1999; 65(13):1359-71. doi:
10.1016/s0024-3205(99)00375-6. [PMID: 10503955] - A M Senderowicz, R Reid, D Headlee, T Abornathy, J Horti, R M Lush, E Reed, W D Figg, E A Sausville. A phase II trial of gallium nitrate in patients with androgen-metastatic prostate cancer.
Urologia internationalis.
1999; 63(2):120-5. doi:
10.1159/000030430. [PMID: 10592501] - C R Chitambar, P Boon, J P Wereley. Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1996 Jun; 2(6):1009-15. doi:
NULL. [PMID: 9816262] - C G Orosz, E Wakely, S D Bergese, A M VanBuskirk, R M Ferguson, D Mullet, G Apseloff, N Gerber. Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody.
Transplantation.
1996 Mar; 61(5):783-91. doi:
10.1097/00007890-199603150-00019. [PMID: 8607184] - R S Bockman, F Wilhelm, E Siris, F Singer, A Chausmer, R Bitton, J Kotler, B J Bosco, D R Eyre, D Levenson. A multicenter trial of low dose gallium nitrate in patients with advanced Paget's disease of bone.
The Journal of clinical endocrinology and metabolism.
1995 Feb; 80(2):595-602. doi:
10.1210/jcem.80.2.7852526. [PMID: 7852526] - J R Lin, I Bekersky, N S Brown, S Mong, F Lee, R A Newman, D H Ho. Normocalcemic effect of gallium nitrate in a hypercalcemic rat model.
Cancer research.
1995 Jan; 55(2):307-11. doi:
NULL. [PMID: 7812963] - P Ridefelt, E Gylfe, G Akerström, J Rastad. Effects of the antihypercalcemic drugs gallium nitrate and pamidronate on hormone release of pathologic human parathyroid cells.
Surgery.
1995 Jan; 117(1):56-61. doi:
10.1016/s0039-6060(05)80230-2. [PMID: 7809837] - H Okada, J I Merryman, C C Capen, T J Rosol. Ultrastructural and histomorphometric evaluations of gallium nitrate on bone in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy.
Veterinary pathology.
1995 Jan; 32(1):36-42. doi:
10.1177/030098589503200105. [PMID: 7725596] - J I Merryman, C C Capen, T J Rosol. Effects of gallium nitrate in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1994 May; 9(5):725-32. doi:
10.1002/jbmr.5650090518. [PMID: 8053402] - H T Whelan, M B Williams, D M Bajic, A D Segura, T L McAuliffe, C R Chitambar. Prevention of gallium toxicity by hyperhydration in treatment of medulloblastoma.
Pediatric neurology.
1994 May; 10(3):217-20. doi:
10.1016/0887-8994(94)90026-4. [PMID: 8060423] - H Okada, J I Merryman, T J Rosol, C C Capen. Effects of humoral hypercalcemia of malignancy and gallium nitrate on thyroid C cells in nude mice: immunohistochemical and ultrastructural investigations.
Veterinary pathology.
1994 May; 31(3):349-57. doi:
10.1177/030098589403100308. [PMID: 8053130] - R S Bockman, B Bosco. Treatment of patients with advanced Paget's disease of bone with two cycles of gallium nitrate.
Seminars in arthritis and rheumatism.
1994 Feb; 23(4):268-9. doi:
10.1016/0049-0172(94)90057-4. [PMID: 8009250] - S H Ralston. Pathogenesis and management of cancer associated hypercalcaemia.
Cancer surveys.
1994; 21(?):179-96. doi:
NULL. [PMID: 8564993] - L G Jenis, C E Waud, G S Stein, J B Lian, D T Baran. Effect of gallium nitrate in vitro and in normal rats.
Journal of cellular biochemistry.
1993 Jul; 52(3):330-6. doi:
10.1002/jcb.240520309. [PMID: 8366144] - A L Boskey, W Ziecheck, P Guidon, S B Doty. Gallium nitrate inhibits alkaline phosphatase activity in a differentiating mesenchymal cell culture.
Bone and mineral.
1993 Feb; 20(2):179-92. doi:
10.1016/s0169-6009(08)80026-8. [PMID: 8453333] - J Baselga, M G Kris, H I Scher, M Phillips, R T Heelan. Phase II trial of gallium nitrate in previously treated patients with small cell lung cancer.
Investigational new drugs.
1993 Feb; 11(1):85-6. doi:
10.1007/bf00873918. [PMID: 8394297] - T G Hall, R A Schaiff. Update on the medical treatment of hypercalcemia of malignancy.
Clinical pharmacy.
1993 Feb; 12(2):117-25. doi:
. [PMID: 8453860] - P A Seligman, P L Moran, R B Schleicher, E D Crawford. Treatment with gallium nitrate: evidence for interference with iron metabolism in vivo.
American journal of hematology.
1992 Dec; 41(4):232-40. doi:
10.1002/ajh.2830410403. [PMID: 1337663] - M Gómez, D J Sánchez, J L Domingo, J Corbella. Developmental toxicity evaluation of gallium nitrate in mice.
Archives of toxicology.
1992; 66(3):188-92. doi:
10.1007/bf01974013. [PMID: 1497482] - N J Vogelzang. Nephrotoxicity from chemotherapy: prevention and management.
Oncology (Williston Park, N.Y.).
1991 Oct; 5(10):97-102, 105; disc. 105, 109. doi:
NULL. [PMID: 1838278] - R P Warrell, W K Murphy, P Schulman, P J O'Dwyer, G Heller. A randomized double-blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1991 Aug; 9(8):1467-75. doi:
10.1200/jco.1991.9.8.1467. [PMID: 1906532] - R P Warrell, B Bosco, S Weinerman, B Levine, J Lane, R S Bockman. Gallium nitrate for advanced Paget disease of bone: effectiveness and dose-response analysis.
Annals of internal medicine.
1990 Dec; 113(11):847-51. doi:
10.7326/0003-4819-113-11-847. [PMID: 2240900] - M L Frank. A promising new treatment for hypercalcemia.
RN.
1990 Oct; 53(10):10. doi:
NULL. [PMID: 2218316] - V Matkovic, G Apseloff, D R Shepard, N Gerber. Use of gallium to treat Paget's disease of bone: a pilot study.
Lancet (London, England).
1990 Jan; 335(8681):72-5. doi:
10.1016/0140-6736(90)90540-l. [PMID: 1967419] - K Jabboury, D Frye, F A Holmes, G Fraschini, G Hortobagyi. Phase II evaluation of gallium nitrate by continuous infusion in breast cancer.
Investigational new drugs.
1989 Jul; 7(2-3):225-9. doi:
10.1007/bf00170863. [PMID: 2793377] - R P Warrell, R Israel, M Frisone, T Snyder, J J Gaynor, R S Bockman. Gallium nitrate for acute treatment of cancer-related hypercalcemia. A randomized, double-blind comparison to calcitonin.
Annals of internal medicine.
1988 May; 108(5):669-74. doi:
10.7326/0003-4819-108-5-669. [PMID: 3282463] - R P Warrell, M Issacs, N W Alcock, R S Bockman. Gallium nitrate for treatment of refractory hypercalcemia from parathyroid carcinoma.
Annals of internal medicine.
1987 Nov; 107(5):683-6. doi:
10.7326/0003-4819-107-5-683. [PMID: 2821862] - H I Scher, T Curley, N Geller, D Dershaw, E Chan, J Nisselbaum, N Alcock, P Hollander, A Yagoda. Gallium nitrate in prostatic cancer: evaluation of antitumor activity and effects on bone turnover.
Cancer treatment reports.
1987 Oct; 71(10):887-93. doi:
NULL. [PMID: 3308078] - G Cournot-Witmer, A Bourdeau, M Lieberherr, C L Thil, J J Plachot, G Enault, R Bourdon, S Balsan. Bone modeling in gallium nitrate-treated rats.
Calcified tissue international.
1987 May; 40(5):270-5. doi:
10.1007/bf02555260. [PMID: 3107780] - R P Warrell, N W Alcock, R S Bockman. Gallium nitrate inhibits accelerated bone turnover in patients with bone metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1987 Feb; 5(2):292-8. doi:
10.1200/jco.1987.5.2.292. [PMID: 3806170] - B J Foster, K Clagett-Carr, D Hoth, B Leyland-Jones. Gallium nitrate: the second metal with clinical activity.
Cancer treatment reports.
1986 Nov; 70(11):1311-9. doi:
NULL. [PMID: 3533251] - R P Warrell, A Skelos, N W Alcock, R S Bockman. Gallium nitrate for acute treatment of cancer-related hypercalcemia: clinicopharmacological and dose response analysis.
Cancer research.
1986 Aug; 46(8):4208-12. doi:
NULL. [PMID: 3731088] - R P Warrell, M Isaacs, C J Coonley, N W Alcock, R S Bockman. Metabolic effects of gallium nitrate administered by prolonged infusion.
Cancer treatment reports.
1985 Jun; 69(6):653-5. doi:
NULL. [PMID: 4016769] - R Rizzoli, A Jung, J P Bonjour. [Tumoral hypercalcemia: physiopathology and treatment].
Schweizerische medizinische Wochenschrift.
1985 Mar; 115(10):326-32. doi:
NULL. [PMID: 3157214] - S Schwartz, A Yagoda. Phase I-II trial of gallium nitrate for advanced hypernephroma.
Anticancer research.
1984 Jul; 4(4-5):317-8. doi:
NULL. [PMID: 6486736] - R P Warrell, R S Bockman, C J Coonley, M Isaacs, H Staszewski. Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia.
The Journal of clinical investigation.
1984 May; 73(5):1487-90. doi:
10.1172/jci111353. [PMID: 6715548] - B Leyland-Jones, R B Bhalla, F Farag, L Williams, C J Coonley, R P Warrell. Administration of gallium nitrate by continuous infusion: lack of chronic nephrotoxicity confirmed by studies of enzymuria and beta 2-microglobulinuria.
Cancer treatment reports.
1983 Oct; 67(10):941-2. doi:
NULL. [PMID: 6354440] - R P Warrell, C J Coonley, D J Straus, C W Young. Treatment of patients with advanced malignant lymphoma using gallium nitrate administered as a seven-day continuous infusion.
Cancer.
1983 Jun; 51(11):1982-7. doi:
10.1002/1097-0142(19830601)51:11<1982::aid-cncr2820511104>3.0.co;2-l. [PMID: 6839291] - G Powis. Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs.
Cancer treatment reviews.
1982 Jun; 9(2):85-124. doi:
10.1016/s0305-7372(82)80012-1. [PMID: 6181872] - D P Kelsen, N Alcock, S Yeh, J Brown, C Young. Pharmacokinetics of gallium nitrate in man.
Cancer.
1980 Nov; 46(9):2009-13. doi:
10.1002/1097-0142(19801101)46:9<2009::aid-cncr2820460919>3.0.co;2-a. [PMID: 7427907]