MG-115 (BioDeep_00000828360)

   


代谢物信息卡片


Cbz-DL-Leu-DL-Leu-DL-Nva-al

化学式: C25H39N3O5 (461.2889564)
中文名称: MG115,蛋白酶体抑制剂
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI: InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D007976 - Leupeptins

同义名列表

3 个代谢物同义名

Z-LL-Nva-CHO; MG-115; Cbz-DL-Leu-DL-Leu-DL-Nva-al



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen, Jun Wang. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell research. 2020 08; 30(8):678-692. doi: 10.1038/s41422-020-0356-z. [PMID: 32541865]
  • Rui Ding, Ting Zhang, Daniel J Wilson, Jiashu Xie, Jessica Williams, Yue Xu, Yihong Ye, Liqiang Chen. Discovery of Irreversible p97 Inhibitors. Journal of medicinal chemistry. 2019 03; 62(5):2814-2829. doi: 10.1021/acs.jmedchem.9b00144. [PMID: 30830772]
  • Marcin Rucinski, Cinzia Tortorella, Agnieszka Ziolkowska, Magdalena Nowak, Gastone G Nussdorfer, Ludwik K Malendowicz. Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: in vivo studies on the regenerating rat adrenal cortex. International journal of molecular medicine. 2008 May; 21(5):593-7. doi: NULL. [PMID: 18425351]
  • Vivian Gama, Tomoyuki Yoshida, Jose A Gomez, David P Basile, Lindsey D Mayo, Arthur L Haas, Shigemi Matsuyama. Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Experimental cell research. 2006 Feb; 312(4):488-99. doi: 10.1016/j.yexcr.2005.11.016. [PMID: 16368436]
  • José Lequeu, Françoise Simon-Plas, Jérome Fromentin, Philippe Etienne, Anne-Sophie Petitot, Jean-Pierre Blein, Lydie Suty. Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions. FEBS letters. 2005 Aug; 579(21):4879-86. doi: 10.1016/j.febslet.2005.07.073. [PMID: 16111682]
  • Min Hong, Mingqing Li, Changhui Mao, Amy S Lee. Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6. Journal of cellular biochemistry. 2004 Jul; 92(4):723-32. doi: 10.1002/jcb.20118. [PMID: 15211570]
  • Qunxing Ding, Edgardo Dimayuga, Sarah Martin, Annadora J Bruce-Keller, Vidya Nukala, Ana Maria Cuervo, Jeffrey N Keller. Characterization of chronic low-level proteasome inhibition on neural homeostasis. Journal of neurochemistry. 2003 Jul; 86(2):489-97. doi: 10.1046/j.1471-4159.2003.01885.x. [PMID: 12871590]
  • María José Pérez, Arthur I Cederbaum. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology (Baltimore, Md.). 2003 Jun; 37(6):1395-404. doi: 10.1053/jhep.2003.50228. [PMID: 12774019]
  • Hitoshi Sawada, Youko Takahashi, Junko Fujino, Sandra Y Flores, Hideyoshi Yokosawa. Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi. Molecular reproduction and development. 2002 Jun; 62(2):271-6. doi: 10.1002/mrd.10089. [PMID: 11984838]
  • K W Bang, E R Speck, V S Blanchette, J Freedman, J W Semple. Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens. Blood. 2000 Mar; 95(5):1735-42. doi: 10.1182/blood.v95.5.1735.005k47_1735_1742. [PMID: 10688832]
  • R L Mellgren. Specificities of cell permeant peptidyl inhibitors for the proteinase activities of mu-calpain and the 20 S proteasome. The Journal of biological chemistry. 1997 Nov; 272(47):29899-903. doi: 10.1074/jbc.272.47.29899. [PMID: 9368065]
  • F Tokunaga, H Shirotani, K Hara, D Kozuki, S Omura, T Koide. Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors. FEBS letters. 1997 Jul; 412(1):65-9. doi: 10.1016/s0014-5793(97)00745-x. [PMID: 9257691]