Ertapenem Sodium (BioDeep_00000828234)
代谢物信息卡片
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)-
化学式: C22H24N3NaO7S (497.12325940000005)
中文名称: 尔他培南钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)O)C(=O)[O-])C(C)O.[Na+]
InChI: /q
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
4 个代谢物同义名
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)-; sodium (4R,5S,6S)-3-({(3S,5S)-5-[(m-carboxylatophenyl)carbamoyl]pyrrolidinium-3-yl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; sodium;(4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; Ertapenem Sodium
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:60070
- KEGGdrug: D04049
- PubChem: 23674512
- PubChem: 11145493
- PubChem: 23721821
- ChEMBL: CHEMBL1232
- MeSH: Ertapenem
- CAS: 153773-82-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Baher I Salman, Roshdy E Saraya. Bio-analytically fluorimetric method for estimation of ertapenem in real human plasma and commercial samples; application to pharmacokinetics study.
Luminescence : the journal of biological and chemical luminescence.
2022 May; 37(5):796-802. doi:
10.1002/bio.4223. [PMID: 35274447] - George G Zhanel, Marianna Pozdirca, Alyssa R Golden, Courtney K Lawrence, Sheryl Zelenitsky, Liam Berry, Frank Schweizer, Denice Bay, Heather Adam, Michael A Zhanel, Philippe Lagacé-Wiens, Andrew Walkty, Neal Irfan, Kurt Naber, Joseph P Lynch, James A Karlowsky. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.
Drugs.
2022 Apr; 82(5):533-557. doi:
10.1007/s40265-022-01688-1. [PMID: 35294769] - Ibrahim H Eissa, Mohamed S Alesawy, Abdulrahman M Saleh, Eslam B Elkaeed, Bshra A Alsfouk, Abdul-Aziz M M El-Attar, Ahmed M Metwaly. Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs.
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072287. [PMID: 35408684] - Chongmei Tian, Mengyu Xing, Yaping Zhao, Xueyu Fan, Yongfeng Bai, Liping Fu, Siwei Wang. Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla CTX-M-15 and one rmpA2-associated virulence plasmid.
Frontiers in cellular and infection microbiology.
2022; 12(?):984479. doi:
10.3389/fcimb.2022.984479. [PMID: 36250056] - Ahmed S Fayed, Rania M Youssif, Nahla N Salama, Eman S Elzanfaly, Hassan A M Hendawy. Utility of Silver-nanoparticles for Nano Spectrofluorimetric Determination of Meropenem and Ertapenem: Bio-analytical Validation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 262(?):120077. doi:
10.1016/j.saa.2021.120077. [PMID: 34175763] - Belén Gutiérrez-Gutiérrez, Elena Pérez-Nadales, Salvador Pérez-Galera, Mario Fernández-Ruiz, Jordi Carratalà, Isabel Oriol, Elisa Cordero, José Antonio Lepe, Ban Hock Tan, Laura Corbella, Mical Paul, Alejandra M Natera, Miruna D David, Miguel Montejo, Ranganathan N Iyer, Ligia Camera Pierrotti, Esperanza Merino, Seema Mehta Steinke, Meenakshi M Rana, Patricia Muñoz, Alessandra Mularoni, Christian van Delden, Paolo Antonio Grossi, Elena María Seminari, Filiz Gunseren, Erika D Lease, Emmanuel Roilides, Jesús Fortún, Hande Arslan, Julien Coussement, Zeliha Koçak Tufan, Benoit Pilmis, Marco Rizzi, Belén Loeches, Britt Marie Eriksson, Edson Abdala, Fabio Soldani, Warren Lowman, Wanessa Trindade Clemente, Marta Bodro, María Carmen Fariñas, Esra Kazak, Luis Martínez-Martínez, José María Aguado, Julián Torre-Cisneros, Álvaro Pascual, Jesús Rodríguez-Baño. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0110221. doi:
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International journal of antimicrobial agents.
2021 Oct; 58(4):106417. doi:
10.1016/j.ijantimicag.2021.106417. [PMID: 34391903] - José Antonio Hernández-Ramos, José Manuel Caro-Telle, Miguel Ángel Bruni-Montero, Dolores Canales-Siguero, José Miguel Ferrari-Piquero. Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria.
2021 09; 45(6):335-339. doi:
NULL. [PMID: 34806574] - Arzu Nazli Zeka, Vildan Avkan-Oguz, Caglar Irmak, Oya Eren Kutsoylu, Sema Alp Cavus, Ziya Kuruüzüm, M Cem Ergon. Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID-19 pandemic.
International journal of clinical practice.
2021 Jul; 75(7):e14230. doi:
10.1111/ijcp.14230. [PMID: 33864405] - Wasim S El Nekidy, Hazem Elrefaei, Terrence J Lee St John, Nizar M Attallah, Farah Kablaoui, Ahmad Nusair, Bartlomiej Piechowski-Jozwiak, Janise Phillips, Islam M Ghazi. Ertapenem Neurotoxicity in Hemodialysis Patients-Safe and Effective Dosing Is Still Needed: A Retrospective Study and Literature Review.
The Annals of pharmacotherapy.
2021 01; 55(1):52-58. doi:
10.1177/1060028020938059. [PMID: 32618479] - Jayesh A Dhanani, Benjamin Ahern, Liad Lupinsky, Karen Jackson, Steven C Wallis, Mohd H Abdul-Aziz, Jeffrey Lipman, Jason A Roberts. Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.02584-19. [PMID: 32366707] - Rebecca Adams, Priya Chopra, Richard Miranda, Aaron Calderon. Ertapenem-induced encephalopathy.
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Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
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Zhonghua nei ke za zhi.
2020 Jan; 59(1):82-85. doi:
10.3760/cma.j.issn.0578-1426.2020.01.016. [PMID: 31887844] - Maria Loose, Isabell Link, Kurt G Naber, Florian M E Wagenlehner. Carbapenem-Containing Combination Antibiotic Therapy against Carbapenem-Resistant Uropathogenic Enterobacteriaceae.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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BMC nephrology.
2019 07; 20(1):274. doi:
10.1186/s12882-019-1461-4. [PMID: 31331289] - J C Bader, E A Lakota, G E Dale, H S Sader, J H Rex, P G Ambrose, S M Bhavnani. Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.00318-19. [PMID: 30962339] - Jonathan Chambers, Madhu Page-Sharp, Sam Salman, John Dyer, Timothy M E Davis, Kevin T Batty, Laurens Manning. Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations.
European journal of clinical pharmacology.
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10.1007/s00228-018-2597-z. [PMID: 30511329] - Ying Jiang, Jun Li, Yingrui Zhang, Xinlan Hu, Xiaoguang Zhang, Xiuling Shang, Shurong Gong, Rongguo Yu. Clinical Situations of Bacteriology and Prognosis in Patients with Urosepsis.
BioMed research international.
2019; 2019(?):3080827. doi:
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2018 10; 62(10):. doi:
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Journal of global antimicrobial resistance.
2018 09; 14(?):228-232. doi:
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The Journal of surgical research.
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10.1016/j.jss.2018.02.011. [PMID: 29804866] - M A Zuur, S Ghimire, M S Bolhuis, A M A Wessels, R van Altena, W C M de Lange, J G W Kosterink, D J Touw, T S van der Werf, O W Akkerman, J W C Alffenaar. Pharmacokinetics of 2,000 Milligram Ertapenem in Tuberculosis Patients.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
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The Journal of antimicrobial chemotherapy.
2018 04; 73(4):987-994. doi:
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2018 02; 62(2):. doi:
10.1128/aac.02280-17. [PMID: 29133551] - Tomas Almorza, Marina Muñoz-Hernández, Antonio Lalueza. Ertapenem-induced neurological toxicity in a patient with stage IV chronic kidney disease.
Enfermedades infecciosas y microbiologia clinica.
2017 11; 35(9):607-608. doi:
10.1016/j.eimc.2016.12.003. [PMID: 28069335] - Michael Seitz, Christian Stief, Raphaela Waidelich, Markus Bader, Derya Tilki. Transrectal ultrasound guided prostate biopsy in the era of increasing fluoroquinolone resistance: prophylaxis with single-dose ertapenem.
World journal of urology.
2017 Nov; 35(11):1681-1688. doi:
10.1007/s00345-017-2043-3. [PMID: 28470334] - Amel Abderrahim, Nassima Djahmi, Charlotte Pujol, Sabina Nedjai, Mohamed Cherif Bentakouk, Djamila Kirane-Gacemi, Mazouz Dekhil, Albert Sotto, Jean-Philippe Lavigne, Alix Pantel. First Case of NDM-1-Producing Klebsiella pneumoniae in Annaba University Hospital, Algeria.
Microbial drug resistance (Larchmont, N.Y.).
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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Antimicrobial agents and chemotherapy.
2017 04; 61(4):. doi:
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2017 01; 61(1):. doi:
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Turkish journal of medical sciences.
2016 Dec; 46(6):1760-1764. doi:
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ACS chemical biology.
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Microbial pathogenesis.
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The Journal of antimicrobial chemotherapy.
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Biomedical chromatography : BMC.
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The Journal of antimicrobial chemotherapy.
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Minerva anestesiologica.
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Antimicrobial agents and chemotherapy.
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International journal of clinical pharmacology and therapeutics.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
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Antimicrobial agents and chemotherapy.
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Clinical nephrology.
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International journal of antimicrobial agents.
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Obesity surgery.
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The Journal of antimicrobial chemotherapy.
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