Aglepristone (BioDeep_00000828225)
代谢物信息卡片
Aglepristone
化学式: C29H37NO2 (431.2824142)
中文名称: 安哥司酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC=CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
InChI: InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
描述信息
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C1891 - Progesterone Antagonist
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chunsumon Limmanont, Preeda Lertwatcharasarakul, Suppawiwat Ponglowhapan, Kaitkanoke Sirinarumitr. Molecular studies on oestrogen α and progesterone receptors and histomorphometric analysis of canine uteri following aglepristone treatment.
Reproduction in domestic animals = Zuchthygiene.
2021 Jul; 56(7):1015-1023. doi:
10.1111/rda.13945. [PMID: 33914997] - Alessandro Troisi, Angela Polisca, Lucia Cardinali, Riccardo Orlandi, Gabriele Brecchia, Laura Menchetti, Massimo Zerani, Margherita Maranesi, Walter Di Mari, John Paul Verstegen. Effect of aglepristone (RU534) administration during follicular phase on progesterone, estradiol-17β and LH serum concentrations in bitches.
Reproduction in domestic animals = Zuchthygiene.
2020 Dec; 55(12):1794-1802. doi:
10.1111/rda.13846. [PMID: 33080098] - L Ferré-Dolcet, S Romagnoli, T Banzato, L Cavicchioli, R Di Maggio, A Cattai, M Berlanda, M Schrank, A Mollo. Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch.
BMC veterinary research.
2020 Aug; 16(1):284. doi:
10.1186/s12917-020-02507-z. [PMID: 32778114] - Juliette Roos, Cindy Maenhoudt, Luca Zilberstein, Fernando Mir, Paulo Borges, Etienne Furthner, Zuzanna Niewiadomska, Nicolas Nudelmann, Alain Fontbonne. Neonatal puppy survival after planned caesarean section in the bitch using aglepristone as a primer: A retrospective study on 74 cases.
Reproduction in domestic animals = Zuchthygiene.
2018 Nov; 53 Suppl 3(?):85-95. doi:
10.1111/rda.13353. [PMID: 30474341] - E Sinem Ozdemir Salci, Serpil Kahya Demirbilek, Nazmiye Gunes, Gulsen Goncagul, Ender Uzabacı, Tayfun Carli, Kamil Seyrek-Intas. Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes.
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere.
2018 Feb; 46(1):22-28. doi:
10.15653/tpg-170136. [PMID: 29099900] - M C García Mitacek, M C Bonaura, R G Praderio, R Nuñez Favre, R L de la Sota, M A Stornelli. Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy.
Theriogenology.
2017 Jan; 88(?):106-117. doi:
10.1016/j.theriogenology.2016.09.050. [PMID: 27865408] - Karine Reynaud, Marie Saint-Dizier, Muhammad Zahid Tahir, Tiphaine Havard, Grégoire Harichaux, Valérie Labas, Sandra Thoumire, Alain Fontbonne, Bénédicte Grimard, Sylvie Chastant-Maillard. Progesterone plays a critical role in canine oocyte maturation and fertilization.
Biology of reproduction.
2015 Oct; 93(4):87. doi:
10.1095/biolreprod.115.130955. [PMID: 26333993] - D Kaya, I Küçükaslan, A R Ağaoğlu, S S Ay, S Schäfer-Somi, B Emre, Y Bal, A Einspanier, I S Gürcan, N Gültiken, S Aslan. The effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches.
Animal reproduction science.
2014 May; 146(3-4):210-7. doi:
10.1016/j.anireprosci.2014.03.002. [PMID: 24703776] - Enrico Bigliardi, Carla Bresciani, Daniela Callegari, Francesco Di Ianni, Giorgio Morini, Enrico Parmigiani, Ezio Bianchi. Use of aglepristone for the treatment of P4 induced insulin resistance in dogs.
Journal of veterinary science.
2014; 15(2):267-71. doi:
10.4142/jvs.2014.15.2.267. [PMID: 24378588] - M Batista, R Reyes, M Santana, D Alamo, J Vilar, F González, F Cabrera, A Gracia. Induction of parturition with aglepristone in the Majorera goat.
Reproduction in domestic animals = Zuchthygiene.
2011 Oct; 46(5):882-8. doi:
10.1111/j.1439-0531.2011.01759.x. [PMID: 21320179] - A R Agaoglu, S Schäfer-Somi, D Kaya, I Kucukaslan, B Emre, N Gultiken, B S Mulazımoglu, A Colak, S Aslan. The intravaginal application of misoprostol improves induction of abortion with aglepristone.
Theriogenology.
2011 Jul; 76(1):74-82. doi:
10.1016/j.theriogenology.2011.01.019. [PMID: 21458052] - Mariusz Pawel Kowalewski, Hakki Bülent Beceriklisoy, Christiane Pfarrer, Selim Aslan, Hans Kindahl, Ibrahim Kücükaslan, Bernd Hoffmann. Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition.
Reproduction (Cambridge, England).
2010 Mar; 139(3):655-64. doi:
10.1530/rep-09-0140. [PMID: 19934344] - A R Günzel-Apel, T Höftmann, S Nottorf, E Politt, A Meyer-Lindenberg, H O Hoppen, A Einspanier, H M Knijn, R Mischke. Influence of progesterone withdrawal on pregnancy-related parameters during post-implantation early pregnancy loss.
Reproduction in domestic animals = Zuchthygiene.
2009 Jul; 44 Suppl 2(?):174-81. doi:
10.1111/j.1439-0531.2009.01381.x. [PMID: 19754562] - G R Ozalp, K Seyrek-Intaş, C Calişkan, A Wehrend. Mid-gestation pregnancy termination in rabbits by the progesterone antagonist aglepristone.
Theriogenology.
2008 Jun; 69(9):1056-60. doi:
10.1016/j.theriogenology.2008.01.016. [PMID: 18377972] - M Baan, M A M Taverne, J de Gier, H S Kooistra, H Kindahl, S J Dieleman, A C Okkens. Hormonal changes in spontaneous and aglépristone-induced parturition in dogs.
Theriogenology.
2008 Mar; 69(4):399-407. doi:
10.1016/j.theriogenology.2007.10.008. [PMID: 18054071] - S Schäfer-Somi, O A Aksoy, H B Beceriklisoy, A Einspanier, H O Hoppen, S Aslan. Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17beta.
Theriogenology.
2007 Oct; 68(6):889-95. doi:
10.1016/j.theriogenology.2007.07.012. [PMID: 17719622] - Francis Fieni, Jacques Martal, Pierre Guy Marnet, Brigitte Siliart, Franck Guittot. Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone.
Theriogenology.
2006 Oct; 66(6-7):1721-8. doi:
10.1016/j.theriogenology.2006.02.026. [PMID: 16563487] - F Fieni. Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches.
Theriogenology.
2006 Oct; 66(6-7):1550-6. doi:
10.1016/j.theriogenology.2006.02.009. [PMID: 16563489] - S F M Bhatti, L Duchateau, A C Okkens, L M L Van Ham, J A Mol, H S Kooistra. Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglépristone.
Theriogenology.
2006 Sep; 66(4):797-803. doi:
10.1016/j.theriogenology.2006.01.052. [PMID: 16497368] - Simone P Breukelman, Otto Szenci, Jean-Francois Beckers, Hans Kindahl, Edu J H Mulder, F Herman Jonker, Bert van der Weijden, Dénes Revy, Károly Pogany, José Sulon, István Némedi, Marcel A M Taverne. Ultrasonographic appearance of the conceptus, fetal heart rate and profiles of pregnancy-associated glycoproteins (PAG) and prostaglandin F2alpha-metabolite (PGF2alpha-metabolite) after induction of fetal death with aglepristone during early gestation in cattle.
Theriogenology.
2005 Sep; 64(4):917-33. doi:
10.1016/j.theriogenology.2004.12.016. [PMID: 16054496] - Y Corrada, P García, P E de la Sota, M Huzman, M F Landoni, C Gobello. Decrease of body temperature after aglepristone treatment in bitches.
Animal reproduction science.
2005 Jul; 87(3-4):295-9. doi:
10.1016/j.anireprosci.2004.11.012. [PMID: 15911178] - M Baan, M A M Taverne, H S Kooistra, J de Gier, S J Dieleman, A C Okkens. Induction of parturition in the bitch with the progesterone-receptor blocker aglépristone.
Theriogenology.
2005 Apr; 63(7):1958-72. doi:
10.1016/j.theriogenology.2004.09.008. [PMID: 15823352] - S Galac, H S Kooistra, S J Dieleman, V Cestnik, A C Okkens. Effects of aglépristone, a progesterone receptor antagonist, administered during the early luteal phase in non-pregnant bitches.
Theriogenology.
2004 Aug; 62(3-4):494-500. doi:
10.1016/j.theriogenology.2003.11.004. [PMID: 15226005] - Cristina Gobello, Gervasio Castex, Liliana Klima, Raúl Rodríguez, Yanina Corrada. A study of two protocols combining aglepristone and cloprostenol to treat open cervix pyometra in the bitch.
Theriogenology.
2003 Sep; 60(5):901-8. doi:
10.1016/s0093-691x(03)00094-3. [PMID: 12935867] - D Meisl, M Hubler, S Arnold. [Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglépristone (Alizine)].
Schweizer Archiv fur Tierheilkunde.
2003 Mar; 145(3):130-6. doi:
10.1024/0036-7281.145.3.130. [PMID: 12677773] - F Fieni, P G Marnet, J Martal, B Siliart, N Touzeau, J F Bruyas, D Tainturier. Comparison of two protocols with a progesterone antagonist aglepristone (RU534) to induce parturition in bitches.
Journal of reproduction and fertility. Supplement.
2001; 57(?):237-42. doi:
NULL. [PMID: 11787156] - F Fieni, J Martal, P G Marnet, B Siliart, F Bernard, M Riou, J F Bruyas, D Tainturier. Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534).
Journal of reproduction and fertility. Supplement.
2001; 57(?):243-8. doi:
NULL. [PMID: 11787157]