[Glu2]-TRH (BioDeep_00000827586)
代谢物信息卡片
Pyroglutamyl-glutamyl-proline amide
化学式: C15H22N4O6 (354.1539272)
中文名称: GLP-GLU-PRO-NH2: GLP-EP-NH2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C(CCC(=O)O)NC(=O)C2CCC(=O)N2)C(=O)N
InChI: InChI=1S/C15H22N4O6/c16-13(23)10-2-1-7-19(10)15(25)9(4-6-12(21)22)18-14(24)8-3-5-11(20)17-8/h8-10H,1-7H2,(H2,16,23)(H,17,20)(H,18,24)(H,21,22)/t8-,9-,10-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(Glu2)-TRH, a metabolically stable analogue of
同义名列表
3 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:183942
- PubChem: 122148
- ChEMBL: CHEMBL3895280
- CAS: 85541-78-2
- medchemexpress: HY-P3960
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lynn R Fraser, Susan Adeoya-Osiguwa, Rhona W Baxendale, Samra Mededovic, Olufunmilayo O Osiguwa. First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP.
The Journal of reproduction and development.
2005 Feb; 51(1):37-46. doi:
10.1262/jrd.51.37. [PMID: 15750295] - Lynn R Fraser, Olufunmilayo O Osiguwa. Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients.
Human reproduction (Oxford, England).
2004 Mar; 19(3):596-606. doi:
10.1093/humrep/deh126. [PMID: 14998958] - A J Ruiz-Alcaraz, J del Rio-Garcia. Characterization of a circulating N-extended form of the thyrotropin-releasing hormone-like peptide pGlu-Glu-Pro amide in human plasma.
The Journal of clinical endocrinology and metabolism.
2003 Dec; 88(12):6002-7. doi:
10.1210/jc.2003-030681. [PMID: 14671203] - Lynn R Fraser, Susan A Adeoya-Osiguwa, Rhona W Baxendale. First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery.
Molecular human reproduction.
2003 Dec; 9(12):739-48. doi:
10.1093/molehr/gag097. [PMID: 14614035] - Stephan Schilling, Susanne Manhart, Torsten Hoffmann, Hans-Henning Ludwig, Claus Wasternack, Hans-Ulrich Demuth. Substrate specificity of glutaminyl cyclases from plants and animals.
Biological chemistry.
2003 Dec; 384(12):1583-92. doi:
10.1515/bc.2003.175. [PMID: 14719800] - Katalin Prokai-Tatrai, Vien Nguyen, Alevtina D Zharikova, April C Braddy, Stanley M Stevens, Laszlo Prokai. Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.
Bioorganic & medicinal chemistry letters.
2003 Mar; 13(6):1011-4. doi:
10.1016/s0960-894x(03)00081-7. [PMID: 12643900] - L R Fraser, M D Pondel, G P Vinson. Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function.
Molecular human reproduction.
2001 Mar; 7(3):245-53. doi:
10.1093/molehr/7.3.245. [PMID: 11228244] - L R Fraser, S A Adeoya-Osiguwa. Fertilization promoting peptide--a possible regulator of sperm function in vivo.
Vitamins and hormones.
2001; 63(?):1-28. doi:
10.1016/s0083-6729(01)63001-2. [PMID: 11358112] - H Funahashi, A Asano, T Fujiwara, T Nagai, K Niwa, L R Fraser. Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss in ejaculated boar spermatozoa in vitro.
Molecular reproduction and development.
2000 Jan; 55(1):117-24. doi:
10.1002/(sici)1098-2795(200001)55:1<117::aid-mrd16>3.0.co;2-7. [PMID: 10602282] - L R Fraser. New insights into possible causes of male infertility.
Human reproduction (Oxford, England).
1999 Sep; 14 Suppl 1(?):38-46. doi:
10.1093/humrep/14.suppl_1.38. [PMID: 10573023] - L R Fraser. The modulation of sperm function by fertilization promoting peptide.
Human reproduction (Oxford, England).
1998 Dec; 13 Suppl 4(?):1-10. doi:
10.1093/humrep/13.suppl_4.1. [PMID: 10091053] - S A Adeoya-Osiguwa, R K Dudley, R Hosseini, L R Fraser. FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway.
Molecular reproduction and development.
1998 Dec; 51(4):468-76. doi:
10.1002/(sici)1098-2795(199812)51:4<468::aid-mrd14>3.0.co;2-6. [PMID: 9820206] - L R Fraser. Role of fertilization promoting peptide (FPP) in modulating mammalian sperm function.
Frontiers in bioscience : a journal and virtual library.
1998 Dec; 3(?):D1187-91. doi:
10.2741/a355. [PMID: 9835650] - A Cremades, R Peñafiel, V Rausell, J Del Rio-Garcia, D G Smyth. The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone.
European journal of pharmacology.
1998 Sep; 358(1):63-7. doi:
10.1016/s0014-2999(98)00593-7. [PMID: 9809870] - L R Fraser. Fertilization promoting peptide: an important regulator of sperm function in vivo?.
Reviews of reproduction.
1998 Sep; 3(3):151-4. doi:
10.1530/ror.0.0030151. [PMID: 9829549] - L R Fraser. Modulation of mammalian sperm function by fertilization promoting peptide (FPP).
Andrologia.
1998 Aug; 30(4-5):241-7. doi:
10.1111/j.1439-0272.1998.tb01166.x. [PMID: 9739421] - L R Fraser. Sperm capacitation and the acrosome reaction.
Human reproduction (Oxford, England).
1998 Apr; 13 Suppl 1(?):9-19. doi:
10.1093/humrep/13.suppl_1.9. [PMID: 9663766] - L R Fraser, A Hanyaloglu, S M Cockle. A fertilization promoting peptide (FPP)-related tripeptide competitively inhibits responses to FPP: a cause of male subfertility?.
Molecular reproduction and development.
1997 Dec; 48(4):529-35. doi:
10.1002/(sici)1098-2795(199712)48:4<529::aid-mrd14>3.0.co;2-o. [PMID: 9364448] - W J de Greef, W W de Herder, C B Lambalk, W Klootwijk, E Sleddens-Linkels, F H de Jong, T J Visser. Evidence that the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in human serum may not be secreted by the pituitary gland.
The Journal of endocrinology.
1997 Nov; 155(2):393-9. doi:
10.1677/joe.0.1550393. [PMID: 9415074] - W Klootwijk, E Sleddens-Linkels, R de Boer, C A Jansen, R Autar, W W de Herder, E R Boevé, T J Visser, W J de Greef. Renal clearance of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in humans.
The Journal of clinical endocrinology and metabolism.
1997 Sep; 82(9):3068-73. doi:
10.1210/jcem.82.9.4219. [PMID: 9284745] - W Klootwijk, R D de Boer, E Sleddens-Linkels, S M Cockle, W W de Herder, K Bauer, T J Visser, W J de Greef. Urinary excretion of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in rats.
The Journal of endocrinology.
1997 Jun; 153(3):411-21. doi:
10.1677/joe.0.1530411. [PMID: 9203995] - A M Kennedy, J M Morrell, R J Siviter, S M Cockle. Fertilization-promoting peptide in reproductive tissues and semen of the male marmoset (Callithrix jacchus).
Molecular reproduction and development.
1997 May; 47(1):113-9. doi:
10.1002/(sici)1098-2795(199705)47:1<113::aid-mrd15>3.0.co;2-2. [PMID: 9110322] - C M Green, S M Cockle, P F Watson, L R Fraser. A possible mechanism of action for fertilization promoting peptide, a TRH-related tripeptide that promotes capacitation and fertilizing ability in mammalian spermatozoa.
Molecular reproduction and development.
1996 Oct; 45(2):244-52. doi:
10.1002/(sici)1098-2795(199610)45:2<244::aid-mrd19>3.0.co;2-0. [PMID: 8914084] - W Klootwijk, W W de Herder, D J Kwekkeboom, S W Lamberts, E P Krenning, T J Visser, W J de Greef. High serum levels of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in patients with carcinoid tumors.
The Journal of clinical endocrinology and metabolism.
1996 Aug; 81(8):2816-20. doi:
10.1210/jcem.81.8.8768836. [PMID: 8768836] - J M Rondeel, W Klootwijk, E Linkels, P H Jeucken, W Allaerts, L J Hofland, M E Everts, P Kramer, F H de Jong, G A van Haasteren. Further studies on the regulation, localization and function of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in the rat anterior pituitary gland.
The Journal of endocrinology.
1995 Aug; 146(2):293-300. doi:
10.1677/joe.0.1460293. [PMID: 7561642] - R J Siviter, S M Cockle. Peptides related to thyrotrophin-releasing hormone are degraded in seminal plasma by an enzyme similar to prolyl endopeptidase.
The Journal of endocrinology.
1995 Jan; 144(1):61-6. doi:
10.1677/joe.0.1440061. [PMID: 7891026] - J M Rondeel, W Klootwijk, E Linkels, W J de Greef, T J Visser. Neural differentiation of the human neuroblastoma cell line IMR32 induces production of a thyrotropin-releasing hormone-like peptide.
Brain research.
1994 Dec; 665(2):262-8. doi:
10.1016/0006-8993(94)91346-3. [PMID: 7895062] - S M Cockle, G V Prater, C R Thetford, C Hamilton, P R Malone, A R Mundy. Peptides related to thyrotrophin-releasing hormone (TRH) in human prostate and semen.
Biochimica et biophysica acta.
1994 Oct; 1227(1-2):60-6. doi:
10.1016/0925-4439(94)90107-4. [PMID: 7522575] - C M Green, S M Cockle, P F Watson, L R Fraser. Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH-related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro.
Molecular reproduction and development.
1994 Jun; 38(2):215-21. doi:
10.1002/mrd.1080380213. [PMID: 8080651]