2-(2-Ethoxyethoxy)ethanol (BioDeep_00000827339)

   


代谢物信息卡片


Diethylene Glycol Monoethyl Ether

化学式: C6H14O3 (134.0943)
中文名称: 乙氧基二甘醇, 二甘醇单乙醚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOCCOCCO
InChI: InChI=1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3

描述信息

同义名列表

3 个代谢物同义名

Diethylene Glycol Monoethyl Ether; 2-(2-Ethoxyethoxy)ethanol; Diethylene glycol monoethyl ether



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Amal M Sindi, Waleed Y Rizg, Muhammad Khalid Khan, Hala M Alkhalidi, Waleed S Alharbi, Fahad Y Sabei, Eman Alfayez, Hanaa Alkharobi, Mohammed Korayem, Mohammed Majrashi, Majed Alharbi, Mohammed Alissa, Awaji Y Safhi, Abdulmajeed M Jali, Khaled M Hosny. Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole-thyme oil nanoemulsion for oral candidiasis. Drug delivery. 2023 Dec; 30(1):2173337. doi: 10.1080/10717544.2023.2173337. [PMID: 36708105]
  • Hongyu Zhang, Jingwen Guo, Zhi Wang, Na Wang, Nianping Feng, Yongtai Zhang. Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles. Acta pharmaceutica (Zagreb, Croatia). 2023 Mar; 73(1):133-143. doi: 10.2478/acph-2023-0009. [PMID: 36692464]
  • Bakr Ahmed, Md Rizwanullah, Showkat Rasool Mir, M Shaheer Akhtar, Saima Amin. Development of cannabidiol nanoemulsion for direct nose to brain delivery: statistical optimization,in vitroandin vivoevaluation. Biomedical materials (Bristol, England). 2022 Sep; 17(6):. doi: 10.1088/1748-605x/ac9267. [PMID: 36108625]
  • Rubén R López, Paula G Font de Rubinat, Luz-María Sánchez, Thupten Tsering, Anas Alazzam, Karl-F Bergeron, Catherine Mounier, Julia V Burnier, Ion Stiharu, Vahé Nerguizian. The effect of different organic solvents in liposome properties produced in a periodic disturbance mixer: Transcutol®, a potential organic solvent replacement. Colloids and surfaces. B, Biointerfaces. 2021 Feb; 198(?):111447. doi: 10.1016/j.colsurfb.2020.111447. [PMID: 33223347]
  • K Z Isoardi, C B Page, M S Roberts, G K Isbister. Life-threatening triclopyr poisoning due to diethylene glycol monoethyl ether solvent. Clinical toxicology (Philadelphia, Pa.). 2021 Jan; 59(1):61-64. doi: 10.1080/15563650.2020.1757103. [PMID: 32336161]
  • Nimrit Kaur Soni, L J Sonali, Archu Singh, Bharti Mangla, Yub Raj Neupane, Kanchan Kohli. Nanostructured lipid carrier potentiated oral delivery of raloxifene for breast cancer treatment. Nanotechnology. 2020 Nov; 31(47):475101. doi: 10.1088/1361-6528/abaf81. [PMID: 32886644]
  • P A Makoni, K W Kasongo, R B Walker. Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques. Die Pharmazie. 2020 09; 75(9):417-423. doi: 10.1691/ph.2020.0053. [PMID: 32797766]
  • Yongtai Zhang, Kai Zhang, Zhi Wang, Hongmei Hu, Qian Jing, Yanyan Li, Teng Guo, Nianping Feng. Transcutol® P/Cremophor® EL/Ethyl Oleate-Formulated Microemulsion Loaded into Hyaluronic Acid-Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen. AAPS PharmSciTech. 2019 Dec; 21(1):22. doi: 10.1208/s12249-019-1584-8. [PMID: 31823083]
  • Vaishali Y Londhe, Bhavya Bhasin. Transdermal lipid vesicular delivery of iloperidone: Formulation, in vitro and in vivo evaluation. Colloids and surfaces. B, Biointerfaces. 2019 Nov; 183(?):110409. doi: 10.1016/j.colsurfb.2019.110409. [PMID: 31386933]
  • Tarek M Ibrahim, Marwa H Abdallah, Nagia A El-Megrab, Hanan M El-Nahas. Transdermal ethosomal gel nanocarriers; a promising strategy for enhancement of anti-hypertensive effect of carvedilol. Journal of liposome research. 2019 Sep; 29(3):215-228. doi: 10.1080/08982104.2018.1529793. [PMID: 30272506]
  • Sonal Srivastava, Sakshi Mishra, Jayant Dewangan, Aman Divakar, Nidhi Gupta, Navodayam Kalleti, Madhav Nilakanth Mugale, Sadan Kumar, Sharad Sharma, Srikanta Kumar Rath. Safety assessment of the pharmacological excipient, diethylene glycol monoethyl ether (DEGEE), using in vitro and in vivo systems. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2019 Jun; 27(1):219-231. doi: 10.1007/s40199-019-00264-5. [PMID: 31001735]
  • Petra Nnamani, Agatha Ugwu, Emmanuel Ibezim, Simon Onoja, Amelia Odo, Maike Windbergs, Chiara Rossi, Claus-Michael Lehr, Anthony Attama. Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection. Journal of microencapsulation. 2019 Jan; 36(1):32-42. doi: 10.1080/02652048.2019.1582724. [PMID: 30758259]
  • Hery Mitsutake, Simone R Castro, Eneida de Paula, Ronei J Poppi, Douglas N Rutledge, Márcia C Breitkreitz. Comparison of different chemometric methods to extract chemical and physical information from Raman images of homogeneous and heterogeneous semi-solid pharmaceutical formulations. International journal of pharmaceutics. 2018 Dec; 552(1-2):119-129. doi: 10.1016/j.ijpharm.2018.09.058. [PMID: 30266516]
  • Pratibha G Kakadia, Barbara R Conway. Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention. Journal of microencapsulation. 2018 Nov; 35(7-8):695-704. doi: 10.1080/02652048.2019.1576796. [PMID: 30699002]
  • Sarunya Tuntiyasawasdikul, Ekapol Limpongsa, Napaphak Jaipakdee, Bungorn Sripanidkulchai. Development and evaluation of topical films containing phytoestrogenic diaryheptanoids from Curcuma comosa extract. Drug development and industrial pharmacy. 2018 Aug; 44(8):1385-1394. doi: 10.1080/03639045.2018.1453518. [PMID: 29542340]
  • Thomas Briot, Emilie Roger, Nolwenn Lautram, Alexis Verger, Anne Clavreul, Frederic Lagarce. Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia. International journal of nanomedicine. 2017; 12(?):8427-8442. doi: 10.2147/ijn.s147659. [PMID: 29200853]
  • Guy Healing, Tabassum Sulemann, Peter Cotton, Jayne Harris, Adam Hargreaves, Rowena Finney, Sarah Kirk, Carolin Schramm, Clare Garner, Perrine Pivette, Lisa Burdett. Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: administration of hydroxypropyl-ß-cyclodextrin causes renal toxicity. Journal of applied toxicology : JAT. 2016 Jan; 36(1):140-50. doi: 10.1002/jat.3155. [PMID: 25959454]
  • Jinyang Shen, Jianping Bi, Hongli Tian, Ye Jin, Yuan Wang, Xiaolin Yang, Zhonglin Yang, Junping Kou, Fei Li. Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D-phospholipid complex. International journal of nanomedicine. 2016 ; 11(?):4919-4929. doi: 10.2147/ijn.s108765. [PMID: 27713630]
  • Thiago Caon, Carlos Eduardo Maduro Campos, Cláudia Maria Oliveira Simões, Marcos Antônio Segatto Silva. Novel perspectives in the tuberculosis treatment: Administration of isoniazid through the skin. International journal of pharmaceutics. 2015 Oct; 494(1):463-70. doi: 10.1016/j.ijpharm.2015.08.067. [PMID: 26319631]
  • Yongtai Zhang, Kai Zhang, Teng Guo, Yuan Li, Chunyun Zhu, Nianping Feng. Transdermal baicalin delivery using diethylene glycol monoethyl ether-mediated cubic phase gel. International journal of pharmaceutics. 2015 Feb; 479(1):219-26. doi: 10.1016/j.ijpharm.2014.12.055. [PMID: 25543112]
  • Laxmi Narayana, Naveen Chella, Dinesh Kumar, Nalini R Shastri. Design of a novel type IV lipid-based delivery system for improved delivery of drugs with low partition coefficient. Journal of liposome research. 2015; 25(4):325-33. doi: 10.3109/08982104.2015.1010544. [PMID: 25776099]
  • Petra O Nnamani, Steffi Hansen, Maike Windbergs, Claus-Michael Lehr. Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. International journal of pharmaceutics. 2014 Dec; 477(1-2):208-17. doi: 10.1016/j.ijpharm.2014.10.004. [PMID: 25290810]
  • Dexter W Sullivan, Shayne C Gad, Marjorie Julien. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Oct; 72(?):40-50. doi: 10.1016/j.fct.2014.06.028. [PMID: 25016034]
  • Swati Pund, Rohit Thakur, Umesh More, Amita Joshi. Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy. Colloids and surfaces. B, Biointerfaces. 2014 Aug; 120(?):110-7. doi: 10.1016/j.colsurfb.2014.05.016. [PMID: 24905685]
  • Hongxing Ma, Mingjuan Chu, Kiyoshi Itagaki, Ping Xin, Xuegang Zhou, Dawei Zhang, Youzhi Wang, Jia Fu, Shiqin Sun. Formulation and in vitro characterization of a novel solid lipid-based drug delivery system. Chemical & pharmaceutical bulletin. 2014; 62(12):1173-9. doi: 10.1248/cpb.c14-00339. [PMID: 25450625]
  • Wei Meng Lim, Paruvathanahalli Siddalingam Rajinikanth, Chitneni Mallikarjun, Yew Beng Kang. Formulation and delivery of itraconazole to the brain using a nanolipid carrier system. International journal of nanomedicine. 2014; 9(?):2117-26. doi: 10.2147/ijn.s57565. [PMID: 24833900]
  • Feng-Qin Lü, Huang Li, Wei Xu, Xun Zhang, Ming-Qing Huang, Jian Zheng, Ke-Dan Chu. [Preparation of self-microemulsion drug delivery system of the mixture of paeonol and borneol based on Xingbi Fang]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Oct; 48(10):1602-10. doi: ". [PMID: 24417089]
  • S Scalia, E Franceschinis, D Bertelli, V Iannuccelli. Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin. Skin pharmacology and physiology. 2013; 26(2):57-67. doi: 10.1159/000345210. [PMID: 23207877]
  • Li-Jiang Chen, Yang Liu, Yu Liu, Li Li, Fei Gao. Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Dec; 47(12):1678-86. doi: ". [PMID: 23460976]
  • Hongda Ma, Qingchun Zhao, Yongjun Wang, Tao Guo, Ye An, Guobing Shi. Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts. Drug development and industrial pharmacy. 2012 Oct; 38(10):1200-6. doi: 10.3109/03639045.2011.643897. [PMID: 22512784]
  • Kasongo Wa Kasongo, Rainer H Müller, Roderick B Walker. The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients. Pharmaceutical development and technology. 2012 May; 17(3):353-62. doi: 10.3109/10837450.2010.542163. [PMID: 21241166]
  • Robert K Sylvester, Caroline Schauer, John Thomas, Preston Steen, Alan Weisenberger. Evaluation of methadone absorption after topical administration to hospice patients. Journal of pain and symptom management. 2011 May; 41(5):828-35. doi: 10.1016/j.jpainsymman.2010.07.018. [PMID: 21330095]
  • Rui Liu, Zhidong Liu, Lexin Shu, Chengui Zhang, Boli Zhang. [Effect of three penetration enhancers on corneal permeability of mangiferin in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(23):3131-5. doi: 10.4268/cjcmm20102308. [PMID: 21355232]
  • J-L Delongeas, G Vermeil de Conchard, A Beamonte, H Bertheux, C Spire, C Maisonneuve, N Becourt-Lhote, F Goldfain-Blanc, N Claude. Assessment of Labrasol/Labrafil/Transcutol (4/4/2, v/v/v) as a non-clinical vehicle for poorly water-soluble compounds after 4-week oral toxicity study in Wistar rats. Regulatory toxicology and pharmacology : RTP. 2010 Jul; 57(2-3):284-90. doi: 10.1016/j.yrtph.2010.03.008. [PMID: 20347907]
  • Jeoung Hee Yoo, Srinivasan Shanmugam, Pritam Thapa, Eung-Seok Lee, Prabagar Balakrishnan, Rengarajan Baskaran, Sang-Kwon Yoon, Han-Gon Choi, Chul Soon Yong, Bong Kyu Yoo, Kun Han. Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Archives of pharmacal research. 2010 Mar; 33(3):417-26. doi: 10.1007/s12272-010-0311-5. [PMID: 20361307]
  • Yong-Mei Yin, Fu-De Cui, Chao-Feng Mu, Min-Koo Choi, Jung Sun Kim, Suk-Jae Chung, Chang-Koo Shim, Dae-Duk Kim. Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation. Journal of controlled release : official journal of the Controlled Release Society. 2009 Dec; 140(2):86-94. doi: 10.1016/j.jconrel.2009.08.015. [PMID: 19709639]
  • Jia Xi, Qi Chang, Chak K Chan, Zhao Yu Meng, Geng Nan Wang, Jia Bei Sun, Yi Tao Wang, Henry H Y Tong, Ying Zheng. Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid. AAPS PharmSciTech. 2009; 10(1):172-82. doi: 10.1208/s12249-009-9190-9. [PMID: 19224372]
  • Xiang Li, Shu-fang Nie, Jun Kong, Ning Li, Cheng-yi Ju, Wei-san Pan. A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. International journal of pharmaceutics. 2008 Nov; 363(1-2):177-82. doi: 10.1016/j.ijpharm.2008.07.017. [PMID: 18706987]
  • Taekyung Kim, Eunyoung Kang, Inkoo Chun, Hyesun Gwak. Pharmacokinetics of formulated tenoxicam transdermal delivery systems. The Journal of pharmacy and pharmacology. 2008 Jan; 60(1):135-8. doi: 10.1211/jpp.60.1.0017. [PMID: 18088513]
  • Herbert M Himmel. Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential. Journal of pharmacological and toxicological methods. 2007 Sep; 56(2):145-58. doi: 10.1016/j.vascn.2007.04.004. [PMID: 17590357]
  • Nicola Celli, Luana K Dragani, Stefania Murzilli, Tommaso Pagliani, Andreina Poggi. In vitro and in vivo stability of caffeic acid phenethyl ester, a bioactive compound of propolis. Journal of agricultural and food chemistry. 2007 May; 55(9):3398-407. doi: 10.1021/jf063477o. [PMID: 17394337]
  • Seok Hyun Eom, Hyun Seuk Yang, Leslie A Weston. An evaluation of the allelopathic potential of selected perennial groundcovers: foliar volatiles of catmint (Nepeta x faassenii) inhibit seedling growth. Journal of chemical ecology. 2006 Aug; 32(8):1835-48. doi: 10.1007/s10886-006-9112-1. [PMID: 16900434]
  • Ji-Yeon Hong, Jin-Ki Kim, Yun-Kyoung Song, Jeong-Sook Park, Chong-Kook Kim. A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption. Journal of controlled release : official journal of the Controlled Release Society. 2006 Jan; 110(2):332-338. doi: 10.1016/j.jconrel.2005.10.002. [PMID: 16297483]
  • J Laitinen, J Pulkkinen. Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids. Toxicology letters. 2005 Mar; 156(1):117-26. doi: 10.1016/j.toxlet.2003.09.022. [PMID: 15705492]
  • Dong-Woon Kim, Jin-Sook Kwon, Young-Gyu Kim, Maeng Sup Kim, Gwan-Sun Lee, Tae-Jin Youn, Myeong-Chan Cho. Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model. Circulation. 2004 Mar; 109(12):1558-63. doi: 10.1161/01.cir.0000124063.74526.be. [PMID: 15006998]
  • G C Ceschel, P Maffei, M D Moretti, S Demontis, A T Peana. In vitro permeation through porcine buccal mucosa of Salvia desoleana Atzei & Picci essential oil from topical formulations. International journal of pharmaceutics. 2000 Feb; 195(1-2):171-7. doi: 10.1016/s0378-5173(99)00381-6. [PMID: 10675694]
  • S O Williams, S Long, J Allen, M L Wells. Scale-up of an oil/water cream containing 40\% diethylene glycol monoethyl ether. Drug development and industrial pharmacy. 2000 Jan; 26(1):71-7. doi: 10.1081/ddc-100100329. [PMID: 10677812]
  • D W Hobson, A P D'Addario, R H Bruner, D E Uddin. A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1986 Feb; 6(2):339-48. doi: 10.1016/0272-0590(86)90249-6. [PMID: 3699323]
  • H H Edel. [Interstitial nephropathies]. MMW, Munchener medizinische Wochenschrift. 1978 Oct; 120(43):1405-6. doi: NULL. [PMID: 101798]