Phthalazine (BioDeep_00000827326)
代谢物信息卡片
化学式: C8H6N2 (130.0530956)
中文名称: 酞嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C=NN=CC2=C1
InChI: InChI=1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- V Plichta, W Völkel, L Fembacher, M Wöckner, D Nowak, H Fromme. The oral bioavailability of di-2-ethylhexyl phthalate (DEHP), di-isononyl phthalate (DiNP) and di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in house dust.
Toxicology letters.
2022 Feb; 355(?):82-87. doi:
10.1016/j.toxlet.2021.11.010. [PMID: 34801639] - Min Gan, Wei Wang, Haitao Wang, Yuqiang Wang, Xiaojian Jiang. Enantioselective Halolactonizations Using Amino-Acid-Derived Phthalazine Catalysts.
Organic letters.
2019 10; 21(20):8275-8279. doi:
10.1021/acs.orglett.9b03028. [PMID: 31584284] - Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta. Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions.
Biochemical pharmacology.
2018 08; 154(?):28-38. doi:
10.1016/j.bcp.2018.04.017. [PMID: 29678521] - Chrysoula Spanou, Aristidis S Veskoukis, Thalia Kerasioti, Maria Kontou, Apostolos Angelis, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Dimitrios Kouretas. Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidase.
PloS one.
2012; 7(3):e32214. doi:
10.1371/journal.pone.0032214. [PMID: 22396752] - John T Barr, Jeffrey P Jones. Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Dec; 39(12):2381-6. doi:
10.1124/dmd.111.041806. [PMID: 21940905] - Brad Herberich, Guo-Qiang Cao, Partha P Chakrabarti, James R Falsey, Liping Pettus, Robert M Rzasa, Anthony B Reed, Andreas Reichelt, Kelvin Sham, Maya Thaman, Ryan P Wurz, Shimin Xu, Dawei Zhang, Faye Hsieh, Matthew R Lee, Rashid Syed, Vivian Li, David Grosfeld, Matthew H Plant, Bradley Henkle, Lisa Sherman, Scot Middleton, Lu Min Wong, Andrew S Tasker. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
Journal of medicinal chemistry.
2008 Oct; 51(20):6271-9. doi:
10.1021/jm8005417. [PMID: 18817365] - Philip C Burcham, Lisa M Kaminskas, Frank R Fontaine, Dennis R Petersen, Simon M Pyke. Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.
Toxicology.
2002 Dec; 181-182(?):229-36. doi:
10.1016/s0300-483x(02)00287-1. [PMID: 12505316] - J C Pelletier, D P Hesson, K A Jones, A M Costa. Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor.
Journal of medicinal chemistry.
1996 Jan; 39(2):343-6. doi:
10.1021/jm950740w. [PMID: 8558499] - F C REUBI. Renal hyperemia induced in man by a new phthalazine derivative.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1950 Jan; 73(1):102. doi:
10.3181/00379727-73-17591. [PMID: 15402536]