N-(2-HYDROXYPROPYL)METHACRYLAMIDE (BioDeep_00000824897)
代谢物信息卡片
N-(2-HYDROXYPROPYL)METHACRYLAMIDE
化学式: C7H13NO2 (143.0946238)
中文名称: N-(2-羟丙基)甲基丙烯酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CNC(=O)C(=C)C)O
InChI: InChI=1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Eva Randárová, Hideaki Nakamura, Rayhanul Islam, Martin Studenovský, Haratake Mamoru, Jun Fang, Petr Chytil, Tomáš Etrych. Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization.
Acta biomaterialia.
2020 04; 106(?):256-266. doi:
10.1016/j.actbio.2020.02.011. [PMID: 32058082] - Lei Wu, Min Liu, Wei Shan, Yi Cui, Zhirong Zhang, Yuan Huang. Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration.
International journal of pharmaceutics.
2017 Mar; 520(1-2):216-227. doi:
10.1016/j.ijpharm.2017.02.015. [PMID: 28185960] - Hideaki Nakamura, Eva Koziolová, Petr Chytil, Kenji Tsukigawa, Jun Fang, Mamoru Haratake, Karel Ulbrich, Tomáš Etrych, Hiroshi Maeda. Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.
Molecular pharmaceutics.
2016 12; 13(12):4106-4115. doi:
10.1021/acs.molpharmaceut.6b00697. [PMID: 27934482] - Libin Zhang, Rui Zhang, Jiyuan Yang, Jiawei Wang, Jindřich Kopeček. Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate.
Journal of controlled release : official journal of the Controlled Release Society.
2016 08; 235(?):306-318. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2015 Nov; 217(?):1-9. doi:
10.1016/j.jconrel.2015.08.036. [PMID: 26302904] - Rui Zhang, Jiyuan Yang, Te-Wei Chu, Jonathan M Hartley, Jindřich Kopeček. Multimodality imaging of coiled-coil mediated self-assembly in a 'drug-free' therapeutic system.
Advanced healthcare materials.
2015 May; 4(7):1054-65. doi:
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Biomaterials.
2014 Aug; 35(24):6622-35. doi:
10.1016/j.biomaterials.2014.04.059. [PMID: 24814427] - Hideaki Nakamura, Tomas Etrych, Petr Chytil, Manami Ohkubo, Jun Fang, Karel Ulbrich, Hiroshi Maeda. Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.
Journal of controlled release : official journal of the Controlled Release Society.
2014 Jan; 174(?):81-7. doi:
10.1016/j.jconrel.2013.11.011. [PMID: 24269967] - Brandon Buckway, Yongjian Wang, Abhijit Ray, Hamidreza Ghandehari. In vitro evaluation of HPMA-copolymers targeted to HER2 expressing pancreatic tumor cells for image guided drug delivery.
Macromolecular bioscience.
2014 Jan; 14(1):92-9. doi:
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2013 Feb; 165(3):191-8. doi:
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Nanomedicine (London, England).
2012 Nov; 7(11):1683-95. doi:
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Macromolecular bioscience.
2012 Oct; 12(10):1413-22. doi:
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Macromolecular bioscience.
2012 Mar; 12(3):412-22. doi:
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Biomaterials.
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Toxins.
2011 09; 3(9):1065-88. doi:
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Bioconjugate chemistry.
2011 Aug; 22(8):1503-12. doi:
10.1021/bc100525y. [PMID: 21688826] - Mingqian Tan, Zheng-Rong Lu. Integrin Targeted MR Imaging.
Theranostics.
2011 Jan; 1(?):83-101. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2010 Nov; 26(22):17375-82. doi:
10.1021/la103382j. [PMID: 20942427] - Roberta Censi, Tina Vermonden, Hendrik Deschout, Kevin Braeckmans, Piera di Martino, Stefaan C De Smedt, Cornelus F van Nostrum, Wim E Hennink. Photopolymerized thermosensitive poly(HPMAlactate)-PEG-based hydrogels: effect of network design on mechanical properties, degradation, and release behavior.
Biomacromolecules.
2010 Aug; 11(8):2143-51. doi:
10.1021/bm100514p. [PMID: 20614933] - Ling-Dong Quan, Fang Yuan, Xin-Ming Liu, Jian-Geng Huang, Yazen Alnouti, Dong Wang. Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model.
Molecular pharmaceutics.
2010 Aug; 7(4):1041-9. doi:
10.1021/mp100132h. [PMID: 20557133] - Mark P Borgman, Omer Aras, Sandra Geyser-Stoops, Edward A Sausville, Hamidreza Ghandehari. Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery.
Molecular pharmaceutics.
2009 Nov; 6(6):1836-47. doi:
10.1021/mp900134c. [PMID: 19743884] - Matthias M Herth, Matthias Barz, Dorothea Moderegger, Mareli Allmeroth, Markus Jahn, Oliver Thews, Rudolf Zentel, Frank Rösch. Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography.
Biomacromolecules.
2009 Jul; 10(7):1697-703. doi:
10.1021/bm8014736. [PMID: 19425549] - Ningning Yang, Zhaoyang Ye, Feng Li, Ram I Mahato. HPMA polymer-based site-specific delivery of oligonucleotides to hepatic stellate cells.
Bioconjugate chemistry.
2009 Feb; 20(2):213-21. doi:
10.1021/bc800237t. [PMID: 19133717] - Mark P Borgman, Tomika Coleman, Rohit B Kolhatkar, Sandra Geyser-Stoops, Bruce R Line, Hamidreza Ghandehari. Tumor-targeted HPMA copolymer-(RGDfK)-(CHX-A''-DTPA) conjugates show increased kidney accumulation.
Journal of controlled release : official journal of the Controlled Release Society.
2008 Dec; 132(3):193-9. doi:
10.1016/j.jconrel.2008.07.014. [PMID: 18687371] - Fang Yuan, Xuan Qin, Dan Zhou, Qing-Yu Xiang, Min-Ting Wang, Zhi-Rong Zhang, Yuan Huang. In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2008 Nov; 70(3):770-6. doi:
10.1016/j.ejpb.2008.06.028. [PMID: 18656539] - Fang Yuan, Zhi-Rong Zhang, Yun-Xia Yang, Yuan Huang. [In vitro release study, in vivo evaluation of biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates].
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2008 Nov; 43(11):1152-6. doi:
NULL. [PMID: 19239037] - Bahar Zarabi, Anjan Nan, Jiachen Zhuo, Rao Gullapalli, Hamidreza Ghandehari. Macrophage targeted N-(2-hydroxypropyl)methacrylamide conjugates for magnetic resonance imaging.
Molecular pharmaceutics.
2006 Sep; 3(5):550-7. doi:
10.1021/mp060072i. [PMID: 17009854] - Ondrej Hovorka, Tomás Etrych, Vladimír Subr, Jirí Strohalm, Karel Ulbrich, Blanka Ríhová. HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition.
Journal of drug targeting.
2006 Jul; 14(6):391-403. doi:
10.1080/10611860600833591. [PMID: 17092839] - Rainer Haag, Felix Kratz. Polymer therapeutics: concepts and applications.
Angewandte Chemie (International ed. in English).
2006 Feb; 45(8):1198-215. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2005 Dec; 110(1):103-18. doi:
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Biophysical chemistry.
2004 Aug; 110(3):281-95. doi:
10.1016/j.bpc.2004.03.004. [PMID: 15228964] - Yuan Huang, Zhi-rong Zhang. [Selective tumor-accumulation of HPMA copolymer-mitoxantrone conjugates].
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Current pharmaceutical biotechnology.
2003 Oct; 4(5):311-22. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2003 Aug; 91(1-2):53-9. doi:
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European journal of nuclear medicine and molecular imaging.
2002 Aug; 29(8):1055-62. doi:
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