Sodium Orotate (BioDeep_00000821435)
代谢物信息卡片
sodium 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate
化学式: C5H3N2NaO4 (177.9990518)
中文名称: 乳清酸单钠盐, 乳清酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(NC(=O)NC1=O)C(=O)[O-].[Na+]
InChI: /q
描述信息
An organic sodium salt comprising equal numbers of sodium and orotate ions.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:132101
- PubChem: 23683036
- MeSH: Orotic Acid
- CAS: 456-72-4
- CAS: 154-85-8
- MetaboLights: MTBLC132101
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Lukas Babylon, Julia Meißner, Gunter P Eckert. Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
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Archives of toxicology.
2023 Apr; ?(?):. doi:
10.1007/s00204-023-03490-8. [PMID: 37046073] - Xiaoyue Li, Beibei Zeng, Lu Wen, Yingcai Zhao, Zhaojie Li, Changhu Xue, Tiantian Zhang, Yuming Wang. Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats.
Marine drugs.
2022 Nov; 20(11):. doi:
10.3390/md20110703. [PMID: 36355027] - Austin Clyde, Stephanie Galanie, Daniel W Kneller, Heng Ma, Yadu Babuji, Ben Blaiszik, Alexander Brace, Thomas Brettin, Kyle Chard, Ryan Chard, Leighton Coates, Ian Foster, Darin Hauner, Vilmos Kertesz, Neeraj Kumar, Hyungro Lee, Zhuozhao Li, Andre Merzky, Jurgen G Schmidt, Li Tan, Mikhail Titov, Anda Trifan, Matteo Turilli, Hubertus Van Dam, Srinivas C Chennubhotla, Shantenu Jha, Andrey Kovalevsky, Arvind Ramanathan, Martha S Head, Rick Stevens. High-Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Noncovalent Inhibitor.
Journal of chemical information and modeling.
2022 01; 62(1):116-128. doi:
10.1021/acs.jcim.1c00851. [PMID: 34793155] - Daniel W Kneller, Hui Li, Stephanie Galanie, Gwyndalyn Phillips, Audrey Labbé, Kevin L Weiss, Qiu Zhang, Mark A Arnould, Austin Clyde, Heng Ma, Arvind Ramanathan, Colleen B Jonsson, Martha S Head, Leighton Coates, John M Louis, Peter V Bonnesen, Andrey Kovalevsky. Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease.
Journal of medicinal chemistry.
2021 12; 64(23):17366-17383. doi:
10.1021/acs.jmedchem.1c01475. [PMID: 34705466] - Cheng Zheng, Rongxin Miao, Yingmiao Liu, Yang Cao, Dong Liu, Junzhi Wang, Hanjie Ying. A Procedure to Design One-Pot Multi-enzyme System for Industrial CDP-Choline Production.
Applied biochemistry and biotechnology.
2021 Sep; 193(9):2769-2780. doi:
10.1007/s12010-021-03564-2. [PMID: 34117628] - Mihaela Zabulica, Raghuraman C Srinivasan, Pinar Akcakaya, Gabriella Allegri, Burcu Bestas, Mike Firth, Christina Hammarstedt, Tomas Jakobsson, Towe Jakobsson, Ewa Ellis, Carl Jorns, Georgios Makris, Tanja Scherer, Nicole Rimann, Natalie R van Zuydam, Roberto Gramignoli, Anna Forslöw, Susanna Engberg, Marcello Maresca, Olav Rooyackers, Beat Thöny, Johannes Häberle, Barry Rosen, Stephen C Strom. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Molecular therapy : the journal of the American Society of Gene Therapy.
2021 05; 29(5):1903-1917. doi:
10.1016/j.ymthe.2021.01.024. [PMID: 33484963] - Go Sugahara, Chihiro Yamasaki, Ami Yanagi, Suzue Furukawa, Yuko Ogawa, Akinari Fukuda, Shin Enosawa, Akihiro Umezawa, Yuji Ishida, Chise Tateno. Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency.
Journal of inherited metabolic disease.
2021 05; 44(3):618-628. doi:
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Magnesium research.
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Circulation. Heart failure.
2021 01; 14(1):e007275. doi:
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International journal of molecular sciences.
2020 Nov; 21(22):. doi:
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BMC complementary medicine and therapies.
2020 Aug; 20(1):257. doi:
10.1186/s12906-020-03052-w. [PMID: 32807146] - Johanna Matilainen, Anne-Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P Sihvo, Petteri Nieminen. Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism.
Lipids in health and disease.
2020 Apr; 19(1):70. doi:
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Canadian journal of physiology and pharmacology.
2020 Mar; 98(3):169-176. doi:
10.1139/cjpp-2019-0383. [PMID: 31652406] - Si-Jian Wang, Qian Chen, Meng-Yang Liu, Hai-Yang Yu, Jing-Qi Xu, Jia-Qi Wu, Yi Zhang, Tao Wang. Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats.
Food & function.
2019 Nov; 10(11):7356-7365. doi:
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Fungal genetics and biology : FG & B.
2019 03; 124(?):1-7. doi:
10.1016/j.fgb.2018.12.002. [PMID: 30562583] - Naoyoshi Kumakura, Akiko Ueno, Ken Shirasu. Establishment of a selection marker recycling system for sequential transformation of the plant-pathogenic fungus Colletotrichum orbiculare.
Molecular plant pathology.
2019 03; 20(3):447-459. doi:
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AAPS PharmSciTech.
2019 Jan; 20(2):53. doi:
10.1208/s12249-018-1238-2. [PMID: 30617521] - Won Seok Bang, Ye Ran Hwang, Zhengri Li, Inchul Lee, Hee Eun Kang. Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2019; 22(1):98-111. doi:
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Analytical biochemistry.
2018 12; 563(?):9-14. doi:
10.1016/j.ab.2018.09.016. [PMID: 30267708] - Yong Tan, Cheng Lu, Miao Jiang, Ning Zhao, Li Li, Shanshan Shen, Fulan Guan, Bing He, Cheng Xiao, Aiping L, Shiping Cheng, Xianpeng Zu, Weidong Zhang, Xinru Liu. Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2018 10; 38(5):773-780. doi:
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Journal of agricultural and food chemistry.
2018 Feb; 66(6):1408-1418. doi:
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Journal of inherited metabolic disease.
2017 05; 40(3):423-431. doi:
10.1007/s10545-017-0015-9. [PMID: 28205048] - Yanjun Liu, Di Shi, Yingying Tian, Yuntao Liu, Qiping Zhan, Jie Xu, Jingfeng Wang, Changhu Xue. Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease.
Lipids.
2017 02; 52(2):119-127. doi:
10.1007/s11745-016-4222-1. [PMID: 28012135] - Yu Kyong Kim, Mun Ju Choi, Tae Young Oh, Kyung-Sang Yu, SeungHwan Lee. A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects.
Drug design, development and therapy.
2017; 11(?):3171-3177. doi:
10.2147/dddt.s149125. [PMID: 29158663] - William L Nyhan, Jon A Gangoiti. Hereditary Orotic Aciduria and the Excretion of Orotidine.
Neuropediatrics.
2016 Dec; 47(6):408-409. doi:
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Nucleosides, nucleotides & nucleic acids.
2016 Dec; 35(10-12):566-577. doi:
10.1080/15257770.2016.1147580. [PMID: 27906623] - John A Duley, Michael G Henman, Kevin H Carpenter, Michael J Bamshad, George A Marshall, Chee Y Ooi, Bridget Wilcken, Jason R Pinner. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine.
Molecular genetics and metabolism.
2016 09; 119(1-2):83-90. doi:
10.1016/j.ymgme.2016.06.008. [PMID: 27370710] - Takehito Nakazawa, Masami Tsuzuki, Toshikazu Irie, Masahiro Sakamoto, Yoichi Honda. Marker recycling via 5-fluoroorotic acid and 5-fluorocytosine counter-selection in the white-rot agaricomycete Pleurotus ostreatus.
Fungal biology.
2016 09; 120(9):1146-55. doi:
10.1016/j.funbio.2016.06.011. [PMID: 27567720] - NULL. In brief: Uridine triacetate (Xuriden) for hereditary orotic aciduria.
The Medical letter on drugs and therapeutics.
2016 Mar; 58(1491):e49. doi:
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Bioscience, biotechnology, and biochemistry.
2016; 80(4):735-43. doi:
10.1080/09168451.2015.1123608. [PMID: 26775542] - Asher Mullard. FDA approves ultra-orphan drug on a 4-patient trial.
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2015 Oct; 14(10):669. doi:
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Journal of fluorescence.
2015 Jul; 25(4):1005-11. doi:
10.1007/s10895-015-1584-3. [PMID: 26026930] - Wenjia Tong, Danqun Jin, Jingmin Sun. [Report of a case with late-onset ornithine transcarbamylase deficiency with gas chromatography-mass spectrometry and DNA sequencing confirmation and literatures review].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2015 May; 53(5):366-9. doi:
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The Journal of toxicological sciences.
2015 Apr; 40(2):181-91. doi:
10.2131/jts.40.181. [PMID: 25786523] - You-Jin Choi, Yujin Yoon, Kang-Yo Lee, Yun-Pyo Kang, Dong Kyu Lim, Sung Won Kwon, Keon-Wook Kang, Seung-Mi Lee, Byung-Hoon Lee. Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Apr; 144(2):307-17. doi:
10.1093/toxsci/kfv003. [PMID: 25601987] - Tatyana N Tarasenko, Odrick R Rosas, Larry N Singh, Kara Kristaponis, Hilary Vernon, Peter J McGuire. A new mouse model of mild ornithine transcarbamylase deficiency (spf-j) displays cerebral amino acid perturbations at baseline and upon systemic immune activation.
PloS one.
2015; 10(2):e0116594. doi:
10.1371/journal.pone.0116594. [PMID: 25647322] - Katsumi Shibata, Nobuya Morita, Tomoyo Kawamura, Ai Tsuji, Tsutomu Fukuwatari. Effects of Fatty Liver Induced by Excess Orotic Acid on B-Group Vitamin Concentrations of Liver, Blood, and Urine in Rats.
Journal of nutritional science and vitaminology.
2015; 61(5):355-61. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2014 Sep; 436(?):249-55. doi:
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Zhonghua yi xue za zhi.
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Clinica chimica acta; international journal of clinical chemistry.
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Drug testing and analysis.
2013 May; 5(5):353-60. doi:
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Journal of proteome research.
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10.1021/pr400050u. [PMID: 23448543] - Mala Nath, Monika Vats, Partha Roy. Tri- and diorganotin(IV) complexes of biologically important orotic acid: synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities.
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Human molecular genetics.
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Antiviral chemistry & chemotherapy.
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Lipids in health and disease.
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Molecular genetics and metabolism.
2012 Feb; 105(2):203-11. doi:
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The Journal of toxicological sciences.
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Journal of lipid research.
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Molecular genetics and metabolism.
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2011 Aug; 153(3):288-96. doi:
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The Plant cell.
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The Biochemical journal.
2011 Jun; 436(2):305-12. doi:
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Plant physiology.
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Zhonghua er ke za zhi = Chinese journal of pediatrics.
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The journal of physiological sciences : JPS.
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Nutrition (Burbank, Los Angeles County, Calif.).
2011 May; 27(5):571-5. doi:
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Bioscience, biotechnology, and biochemistry.
2011; 75(8):1466-71. doi:
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Lipids in health and disease.
2010 Mar; 9(?):25. doi:
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Journal of separation science.
2010 Mar; 33(6-7):966-73. doi:
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Methods in molecular biology (Clifton, N.J.).
2010; 603(?):445-51. doi:
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Journal of inherited metabolic disease.
2009 Dec; 32 Suppl 1(?):S227-33. doi:
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Molecular therapy : the journal of the American Society of Gene Therapy.
2009 Aug; 17(8):1340-6. doi:
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Gene therapy.
2009 Jun; 16(6):820-3. doi:
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Experimental parasitology.
2009 Mar; 121(3):274-8. doi:
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Alternative medicine review : a journal of clinical therapeutic.
2008 Sep; 13(3):205-15. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Sep; 36(9):1780-5. doi:
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The journal of gene medicine.
2008 Aug; 10(8):890-6. doi:
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Medicinal chemistry (Shariqah (United Arab Emirates)).
2008 Jul; 4(4):371-8. doi:
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Archives of physiology and biochemistry.
2008 Jul; 114(3):178-82. doi:
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Southern medical journal.
2008 May; 101(5):543-5. doi:
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Life sciences.
2008 Apr; 82(15-16):876-83. doi:
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Molecular pharmaceutics.
2008 Mar; 5(2):257-65. doi:
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Acta biochimica Polonica.
2008; 55(1):107-18. doi:
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BMC microbiology.
2007 Nov; 7(?):104. doi:
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The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):770-7. doi:
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The Journal of nutrition.
2007 06; 137(6 Suppl 2):1656S-1661S. doi:
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Journal of plant physiology.
2007 Apr; 164(4):429-41. doi:
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Archives of pharmacal research.
2007 Mar; 30(3):387-95. doi:
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The Journal of veterinary medical science.
2007 Mar; 69(3):313-6. doi:
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European journal of pediatrics.
2006 Sep; 165(9):618-24. doi:
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Molecular therapy : the journal of the American Society of Gene Therapy.
2006 Jul; 14(1):25-33. doi:
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Journal of chromatography. A.
2006 Feb; 1107(1-2):130-8. doi:
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Metabolism: clinical and experimental.
2006 Feb; 55(2):224-31. doi:
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Journal of inherited metabolic disease.
2006 Feb; 29(1):179-81. doi:
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Journal of experimental botany.
2006; 57(14):3563-73. doi:
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The Plant cell.
2005 Jul; 17(7):2077-88. doi:
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Nutrition (Burbank, Los Angeles County, Calif.).
2005 Jul; 21(7-8):867-73. doi:
10.1016/j.nut.2004.11.019. [PMID: 15975496] - Satoshi Sumi, Masayuki Imaeda, Tetsuya Ito, Akihito Ueta, Kyoko Ban, Yumiko Ohkubo, Hajime Togari. Urinary uracil in female patients with ornithine transcarbamylase deficiency.
Pediatrics international : official journal of the Japan Pediatric Society.
2005 Jun; 47(3):262-6. doi:
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Biochemical pharmacology.
2005 Feb; 69(4):709-17. doi:
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Journal of experimental botany.
2004 Dec; 55(408):2513-22. doi:
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JPEN. Journal of parenteral and enteral nutrition.
2004 Sep; 28(5):315-23. doi:
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Journal of nutritional science and vitaminology.
2004 Aug; 50(4):272-6. doi:
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Plant & cell physiology.
2004 Jun; 45(6):667-71. doi:
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