Sodium Cholate (BioDeep_00000821206)

   

Bile acids


代谢物信息卡片


SODIUM CHOLATE

化学式: C24H39NaO5 (430.2695044)
中文名称: 水合胆酸钠
谱图信息: 最多检出来源 Homo sapiens(bile_acids) 86.17%

Reviewed

Last reviewed on 2024-07-19.

Cite this Page

Sodium Cholate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sodium_cholate (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000821206). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C.[Na+]
InChI: /q

描述信息

Digestion and Absorption of Fats: Bile acids are crucial for the digestion and absorption of dietary fats and fat-soluble vitamins (A, D, E, and K) in the small intestine. They achieve this by emulsifying large fat droplets into smaller droplets, increasing the surface area for action by lipase, an enzyme that breaks down fats.
Cholesterol Metabolism: Bile acids are synthesized from cholesterol in the liver. They play a key role in cholesterol homeostasis by facilitating the excretion of cholesterol from the body. This process is important for regulating blood cholesterol levels.
Bile Formation: Bile acids are a major component of bile, which is produced by the liver and stored in the gallbladder. Bile is released into the small intestine to aid in the digestion and absorption of fats.
Hormone-like Functions: Bile acids can act as signaling molecules, influencing various metabolic processes through activation of nuclear receptors such as the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5).
Lipid Solubility: Bile acids are amphipathic molecules, meaning they have both hydrophobic and hydrophilic regions. This property allows them to solubilize lipids and lipid-soluble substances, aiding in their transport and absorption.
Microbial Metabolism: In the intestine, bile acids can influence the composition of the gut microbiota by affecting the growth of different bacterial species. The gut microbiota, in turn, can modify bile acids, influencing their function and the overall metabolic state of the host.

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

1 个代谢物同义名

SODIUM CHOLATE



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Nina Kubatova, Thomas Schmidt, Charles D Schwieters, G Marius Clore. Quantitative analysis of sterol-modulated monomer-dimer equilibrium of the β1-adrenergic receptor by DEER spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 2023 Feb; 120(7):e2221036120. doi: 10.1073/pnas.2221036120. [PMID: 36745787]
  • Linyu Pan, Ze Yu, Xiaolin Liang, Jiyou Yao, Yanfang Fu, Xu He, Xiaoling Ren, Jiajia Chen, Xuejuan Li, Minqiang Lu, Tian Lan. Sodium cholate ameliorates nonalcoholic steatohepatitis by activation of FXR signaling. Hepatology communications. 2023 02; 7(2):e0039. doi: 10.1097/hc9.0000000000000039. [PMID: 36706173]
  • Xinya Huang, Hai Gao, Wenli Zhang, Jianping Liu, Qiqi Zhang. Regulating the Size of Simvastatin-loaded Discoidal Reconstituted Highdensity Lipoprotein: Preparation, Characterization, and Investigation of Cellular Cholesterol Efflux. Current drug delivery. 2023; 20(5):629-641. doi: 10.2174/1567201819666220414120901. [PMID: 35430991]
  • Roxana Coreas, Carmen Castillo, Zongbo Li, Dong Yan, Ziting Gao, Junyi Chen, Dimitrios Bitounis, Dorsa Parviz, Michael S Strano, Philip Demokritou, Wenwan Zhong. Biological Impacts of Reduced Graphene Oxide Affected by Protein Corona Formation. Chemical research in toxicology. 2022 07; 35(7):1244-1256. doi: 10.1021/acs.chemrestox.2c00042. [PMID: 35706338]
  • Wen Zhang, Qian-Yu Zhang, Jian-Jun Wang, Le-Le Zhang, Zhen-Zhen Dong. Efficiency Assessment of Bacterial Cellulose on Lowering Lipid Levels In Vitro and Improving Lipid Metabolism In Vivo. Molecules (Basel, Switzerland). 2022 May; 27(11):. doi: 10.3390/molecules27113495. [PMID: 35684437]
  • Xiaoyi Huang, Yang Chu, Hua Ren, Xiaofen Pang. Antioxidation Function of EGCG by Activating Nrf2/HO-1 Pathway in Mice with Coronary Heart Disease. Contrast media & molecular imaging. 2022; 2022(?):8639139. doi: 10.1155/2022/8639139. [PMID: 35919501]
  • Myeongsu Na, Kitae Kim, Kyoungjoon Oh, Hyung Jin Choi, ChangMan Ha, Sunghoe Chang. Sodium Cholate-Based Active Delipidation for Rapid and Efficient Clearing and Immunostaining of Deep Biological Samples. Small methods. 2022 01; 6(1):e2100943. doi: 10.1002/smtd.202100943. [PMID: 35041279]
  • Aicha Mekkaoui, Yang Liu, Pingping Zhang, Sana Ullah, Ce Wang, Baocai Xu. Effect of Bile Salts on the Interfacial Dilational Rheology of Lecithin in the Lipid Digestion Process. Journal of oleo science. 2021 Aug; 70(8):1069-1080. doi: 10.5650/jos.ess21081. [PMID: 34248099]
  • Chongyan Zhao, Fang Yang, Feng Lin, Qingsong Qu, Zhixun Li, Xing Liu, Lu Han, Xinyuan Shi. Process optimization in ginseng fermentation by Monascus ruber and study on bile acid-binding ability of fermentation products in vitro. Preparative biochemistry & biotechnology. 2021; 51(2):120-126. doi: 10.1080/10826068.2020.1799389. [PMID: 33342390]
  • Tyler Camp, Stephen G Sligar. Nanodisc self-assembly is thermodynamically reversible and controllable. Soft matter. 2020 Jun; 16(24):5615-5623. doi: 10.1039/d0sm00336k. [PMID: 32524103]
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  • Shen-Zhi Wang, Hui-Qian Dai, Ke-Xian Chen, Juan Li, Zhong-Xiu Chen. Synergistic interaction between exogenous and endogenous emulsifiers and its impact on in vitro digestion of lipid in crowded medium. Food chemistry. 2019 Nov; 299(?):125164. doi: 10.1016/j.foodchem.2019.125164. [PMID: 31319345]
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  • Linlin Ma, Xiaoyun Wang, Jinglei Wu, Dongdong Zhang, Lin Zhang, Xinran Song, Huoyan Hong, Chuanglong He, Xiumei Mo, Sufang Wu, Guoyin Kai, Hongsheng Wang. Polyethylenimine and sodium cholate-modified ethosomes complex as multidrug carriers for the treatment of melanoma through transdermal delivery. Nanomedicine (London, England). 2019 09; 14(18):2395-2408. doi: 10.2217/nnm-2018-0398. [PMID: 31456475]
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  • J Abraham Domínguez-Avila, Humberto Astiazaran-Garcia, Abraham Wall-Medrano, Laura A de la Rosa, Emilio Alvarez-Parrilla, Gustavo A González-Aguilar. Mango phenolics increase the serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets. Journal of the science of food and agriculture. 2019 Mar; 99(4):1604-1612. doi: 10.1002/jsfa.9340. [PMID: 30187493]
  • Erik Henrich, Frank Löhr, Julija Mezhyrova, Aisha Laguerre, Frank Bernhard, Volker Dötsch. Synthetic Biology-Based Solution NMR Studies on Membrane Proteins in Lipid Environments. Methods in enzymology. 2019; 614(?):143-185. doi: 10.1016/bs.mie.2018.08.019. [PMID: 30611423]
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  • Elisabetta Esposito, Markus Drechsler, Paolo Mariani, Anna Maria Panico, Venera Cardile, Lucia Crascì, Federica Carducci, Adriana Carol Eleonora Graziano, Rita Cortesi, Carmelo Puglia. Nanostructured lipid dispersions for topical administration of crocin, a potent antioxidant from saffron (Crocus sativus L.). Materials science & engineering. C, Materials for biological applications. 2017 Feb; 71(?):669-677. doi: 10.1016/j.msec.2016.10.045. [PMID: 27987758]
  • Xiaomin Zhang, Yibo Wu, Min Zhang, Jing Mao, Yun Wu, Yingxin Zhang, Ju Yao, Chang Xu, Wenli Guo, Bo Yu. Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel. International journal of nanomedicine. 2017; 12(?):8779-8799. doi: 10.2147/ijn.s150196. [PMID: 29263668]
  • Luis E Gomez-Quiroz, Daekwan Seo, Yun-Han Lee, Mitsuteru Kitade, Timo Gaiser, Matthew Gillen, Seung-Bum Lee, Ma Concepcion Gutierrez-Ruiz, Elizabeth A Conner, Valentina M Factor, Snorri S Thorgeirsson, Jens U Marquardt. Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress. Toxicology. 2016 06; 361-362(?):39-48. doi: 10.1016/j.tox.2016.07.004. [PMID: 27394961]
  • Luis F Padilla-Morales, José O Colón-Sáez, Joel E González-Nieves, Orestes Quesada-González, José A Lasalde-Dominicci. Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology. Biochimica et biophysica acta. 2016 Jan; 1858(1):47-56. doi: 10.1016/j.bbamem.2015.10.002. [PMID: 26454038]
  • Elisabetta Esposito, Claudia Sticozzi, Laura Ravani, Markus Drechsler, Ximena M Muresan, Franco Cervellati, Rita Cortesi, Giuseppe Valacchi. Effect of new curcumin-containing nanostructured lipid dispersions on human keratinocytes proliferative responses. Experimental dermatology. 2015 Jun; 24(6):449-54. doi: 10.1111/exd.12696. [PMID: 25808217]
  • M Haustein, M Wahab, H-J Mögel, P Schiller. Vesicle solubilization by bile salts: comparison of macroscopic theory and simulation. Langmuir : the ACS journal of surfaces and colloids. 2015 Apr; 31(14):4078-86. doi: 10.1021/acs.langmuir.5b00035. [PMID: 25798787]
  • Wei Xu, Xiaohui Fan, Yanli Zhao, Lingbing Li. Cysteine modified and bile salt based micelles: preparation and application as an oral delivery system for paclitaxel. Colloids and surfaces. B, Biointerfaces. 2015 Apr; 128(?):165-171. doi: 10.1016/j.colsurfb.2015.02.031. [PMID: 25747310]
  • Narayani Ghosh, Ramakanta Mondal, Saptarshi Mukherjee. Hydrophobicity is the governing factor in the interaction of human serum albumin with bile salts. Langmuir : the ACS journal of surfaces and colloids. 2015 Jan; 31(3):1095-104. doi: 10.1021/la504270a. [PMID: 25549008]
  • Masanori Nozako, Takashi Koyama, Chifumi Nagano, Makoto Sato, Satoshi Matsumoto, Kiminobu Mitani, Reiko Yasufuku, Masayuki Kohashi, Tomohiro Yoshikawa. An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats. PloS one. 2015; 10(11):e0143979. doi: 10.1371/journal.pone.0143979. [PMID: 26606054]
  • Ying Yang, Eric Andrew Decker, Hang Xiao, David Julian McClements. Enhancing vitamin E bioaccessibility: factors impacting solubilization and hydrolysis of α-tocopherol acetate encapsulated in emulsion-based delivery systems. Food & function. 2015 Jan; 6(1):84-97. doi: 10.1039/c4fo00725e. [PMID: 25312787]
  • Yanli Zhao, Yanan Cui, Yimu Li, Lingbing Li. Stable phosphatidylcholine-bile salt mixed micelles enhance oral absorption of paclitaxel: preparation and mechanism in rats. Journal of drug targeting. 2014 Dec; 22(10):901-12. doi: 10.3109/1061186x.2014.945090. [PMID: 25077358]
  • Dolores C Carrer, Leticia H Higa, Maria Victoria Defain Tesoriero, Maria Jose Morilla, Diana I Roncaglia, Eder Lilia Romero. Structural features of ultradeformable archaeosomes for topical delivery of ovalbumin. Colloids and surfaces. B, Biointerfaces. 2014 Sep; 121(?):281-9. doi: 10.1016/j.colsurfb.2014.05.015. [PMID: 24974012]
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  • Monalisa Mohapatra, Ashok K Mishra. Photophysical behavior of 8-anilino-1-naphthalenesulfonate in vesicles of pulmonary surfactant dipalmitoylphosphatidylcholine (DPPC) and its sensitivity toward the bile salt-vesicle interaction. Langmuir : the ACS journal of surfaces and colloids. 2013 Sep; 29(36):11396-404. doi: 10.1021/la402355j. [PMID: 23930911]
  • Zhiwen Zhang, Fang Gao, Shijun Jiang, Lingli Chen, Zeying Liu, Haijun Yu, Yaping Li. Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats. International journal of pharmaceutics. 2013 Aug; 452(1-2):374-81. doi: 10.1016/j.ijpharm.2013.05.021. [PMID: 23694804]
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