Sodium Cholate (BioDeep_00000821206)
Bile acids
代谢物信息卡片
化学式: C24H39NaO5 (430.2695044)
中文名称: 水合胆酸钠
谱图信息:
最多检出来源 Homo sapiens(bile_acids) 86.17%
Last reviewed on 2024-07-19.
Cite this Page
Sodium Cholate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/sodium_cholate (retrieved
2024-11-08) (BioDeep RN: BioDeep_00000821206). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C.[Na+]
InChI: /q
描述信息
Digestion and Absorption of Fats: Bile acids are crucial for the digestion and absorption of dietary fats and fat-soluble vitamins (A, D, E, and K) in the small intestine. They achieve this by emulsifying large fat droplets into smaller droplets, increasing the surface area for action by lipase, an enzyme that breaks down fats.
Cholesterol Metabolism: Bile acids are synthesized from cholesterol in the liver. They play a key role in cholesterol homeostasis by facilitating the excretion of cholesterol from the body. This process is important for regulating blood cholesterol levels.
Bile Formation: Bile acids are a major component of bile, which is produced by the liver and stored in the gallbladder. Bile is released into the small intestine to aid in the digestion and absorption of fats.
Hormone-like Functions: Bile acids can act as signaling molecules, influencing various metabolic processes through activation of nuclear receptors such as the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5).
Lipid Solubility: Bile acids are amphipathic molecules, meaning they have both hydrophobic and hydrophilic regions. This property allows them to solubilize lipids and lipid-soluble substances, aiding in their transport and absorption.
Microbial Metabolism: In the intestine, bile acids can influence the composition of the gut microbiota by affecting the growth of different bacterial species. The gut microbiota, in turn, can modify bile acids, influencing their function and the overall metabolic state of the host.
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:26711
- PubChem: 23668194
- ChEMBL: CHEMBL1421383
- MeSH: Sodium Cholate
- CAS: 206986-87-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Nina Kubatova, Thomas Schmidt, Charles D Schwieters, G Marius Clore. Quantitative analysis of sterol-modulated monomer-dimer equilibrium of the β1-adrenergic receptor by DEER spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America.
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Hepatology communications.
2023 02; 7(2):e0039. doi:
10.1097/hc9.0000000000000039
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Current drug delivery.
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Molecules (Basel, Switzerland).
2022 May; 27(11):. doi:
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Small methods.
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Phytochemical analysis : PCA.
2018 Sep; 29(5):425-431. doi:
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Drug delivery.
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Materials science & engineering. C, Materials for biological applications.
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. [PMID: 27987758] - Xiaomin Zhang, Yibo Wu, Min Zhang, Jing Mao, Yun Wu, Yingxin Zhang, Ju Yao, Chang Xu, Wenli Guo, Bo Yu. Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel.
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Toxicology.
2016 06; 361-362(?):39-48. doi:
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Experimental dermatology.
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