3-Methyl-1-phenyl-1H-pyrazol-5-ol (BioDeep_00000820418)

   

Volatile Flavor Compounds


代谢物信息卡片


5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

化学式: C10H10N2O (174.079309)
中文名称: 5-甲基-2-苯基-1,2-二氢吡唑-3-酮, 3-甲基-1-苯基-1H-吡唑-5-醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)N(N1)C2=CC=CC=C2
InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-7,11H,1H3



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Somasundaram Arumugam, Rajarajan A Thandavarayan, Punniyakoti T Veeraveedu, Vijayasree V Giridharan, Vivian Soetikno, Meilei Harima, Kenji Suzuki, Masaki Nagata, Ritsuo Tagaki, Makoto Kodama, Kenichi Watanabe. Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. Experimental and molecular pathology. 2012 Oct; 93(2):183-9. doi: 10.1016/j.yexmp.2012.04.012. [PMID: 22542793]
  • Laura Monturiol-Gross, Marietta Flores-Díaz, Cindy Araya-Castillo, María-José Pineda-Padilla, Graeme C Clark, Richard W Titball, Alberto Alape-Girón. Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C. The Journal of infectious diseases. 2012 Oct; 206(8):1218-26. doi: 10.1093/infdis/jis496. [PMID: 22904339]
  • Panagiota Tsounapi, Motoaki Saito, Fotios Dimitriadis, Sotirios Koukos, Shogo Shimizu, Keisuke Satoh, Atsushi Takenaka, Nikolaos Sofikitis. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Molecular and cellular biochemistry. 2012 Oct; 369(1-2):195-204. doi: 10.1007/s11010-012-1382-z. [PMID: 22763673]
  • Keisuke Sugimoto, Yoshinori Iba, Shinsuke Fujita, Naoki Sakata, Mitsuru Okada, Tsukasa Takemura. Nephrotic syndrome complicated by renal and cerebral infarctions in a 14-year-old girl. Pediatrics international : official journal of the Japan Pediatric Society. 2012 Aug; 54(4):549-52. doi: 10.1111/j.1442-200x.2011.03552.x. [PMID: 22830545]
  • Hao Li, Kun Xu, Yongqing Wang, Hongwen Zhang, Tianping Li, Ling Meng, Xiaojian Gong, Haibo Zhang, Ning Ou, Jinman Ruan. Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions. Drugs in R&D. 2012 Jun; 12(2):65-70. doi: 10.2165/11634290-000000000-00000. [PMID: 22762844]
  • Hunter K C Laidlaw, Jelle Lahnstein, Rachel A Burton, Geoffrey B Fincher, Stephen A Jobling. Analysis of the arabinoxylan arabinofuranohydrolase gene family in barley does not support their involvement in the remodelling of endosperm cell walls during development. Journal of experimental botany. 2012 May; 63(8):3031-45. doi: 10.1093/jxb/ers019. [PMID: 22378943]
  • Liping Ma, Jianguo Sun, Ying Peng, Rong Zhang, Feng Shao, Xiaoling Hu, Jianping Zhu, Xiaojin Wang, Xuefang Cheng, Yinci Zhu, Ping Wan, Dong Feng, Hui Wu, Guangji Wang. Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform. Drug metabolism and disposition: the biological fate of chemicals. 2012 Apr; 40(4):734-41. doi: 10.1124/dmd.111.043356. [PMID: 22238289]
  • Kenji Isahaya, Koji Yamada, Masato Yamatoku, Kenzo Sakurai, Satoshi Takaishi, Bunta Kato, Toshikazu Hirayama, Yasuhiro Hasegawa. Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2012 Feb; 21(2):102-7. doi: 10.1016/j.jstrokecerebrovasdis.2010.05.009. [PMID: 21215657]
  • Feng Lu, Takehiro Nakamura, Tetsuhiko Toyoshima, Yanan Liu, Kazuyuki Hirooka, Nobuyuki Kawai, Naohiko Okabe, Fumio Shiraga, Takashi Tamiya, Osamu Miyamoto, Richard F Keep, Toshifumi Itano. Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils. Neuroscience letters. 2012 Jan; 506(1):28-32. doi: 10.1016/j.neulet.2011.10.041. [PMID: 22040669]
  • Hiroshi Asano, Takahiro Horinouchi, Yosuke Mai, Osamu Sawada, Shunsuke Fujii, Tadashi Nishiya, Masabumi Minami, Takahiro Katayama, Toshihiko Iwanaga, Koji Terada, Soichi Miwa. Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase. Journal of pharmacological sciences. 2012; 118(2):275-87. doi: 10.1254/jphs.11166fp. [PMID: 22302021]
  • Barbara Dołęgowska, Wojciech Błogowski, Leszek Domański. Association between the perioperative antioxidative ability of platelets and early post-transplant function of kidney allografts: a pilot study. PloS one. 2012; 7(1):e29779. doi: 10.1371/journal.pone.0029779. [PMID: 22279544]
  • Ramón Rodrigo. Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system. Frontiers in physiology. 2012; 3(?):93. doi: 10.3389/fphys.2012.00093. [PMID: 22518106]
  • Noah M Walton, Rick Shin, Katsunori Tajinda, Carrie L Heusner, Jeffrey H Kogan, Shinichi Miyake, Qian Chen, Kouichi Tamura, Mitsuyuki Matsumoto. Adult neurogenesis transiently generates oxidative stress. PloS one. 2012; 7(4):e35264. doi: 10.1371/journal.pone.0035264. [PMID: 22558133]
  • Akiko Muroyama, Aya Fujita, Cheng Lv, Shota Kobayashi, Yoshiyasu Fukuyama, Yasuhide Mitsumoto. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease. Parkinson's disease. 2012; 2012(?):985157. doi: 10.1155/2012/985157. [PMID: 22655218]
  • Chengjian Wang, Wancui Fan, Ping Zhang, Zhongfu Wang, Linjuan Huang. One-pot nonreductive O-glycan release and labeling with 1-phenyl-3-methyl-5-pyrazolone followed by ESI-MS analysis. Proteomics. 2011 Nov; 11(21):4229-42. doi: 10.1002/pmic.201000677. [PMID: 21956845]
  • Koji Abe. [Therapeutic time window for ischemic stroke]. Rinsho shinkeigaku = Clinical neurology. 2011 Nov; 51(11):1182-4. doi: 10.5692/clinicalneurol.51.1182. [PMID: 22277527]
  • Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical gas research. 2011 Oct; 1(1):24. doi: 10.1186/2045-9912-1-24. [PMID: 22146674]
  • Yong-Qian Zhang, Ming-Zhang Zuo, Tian-Zuo Li, En-Ming Qing, Jia-Kai Lu, Jian-Ying Yue, Yun Yue. [Effects of intraoperative application of radical scavenger edaravone in severe elderly cases]. Zhonghua yi xue za zhi. 2011 Sep; 91(33):2319-23. doi: NULL. [PMID: 22321744]
  • J Xu, J Guan, X J Chen, J Zhao, S P Li. Comparison of polysaccharides from different Dendrobium using saccharide mapping. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):977-83. doi: 10.1016/j.jpba.2011.03.041. [PMID: 21530129]
  • Keita Shibata, Terumasa Hashimoto, Koji Nobe, Keiji Hasumi, Kazuo Honda. Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Jul; 384(1):103-8. doi: 10.1007/s00210-011-0642-x. [PMID: 21533990]
  • Fumiya Ohmasa, Motoaki Saito, Panagiota Tsounapi, Fotios Dimitriadis, Seiya Inoue, Kohei Shomori, Shogo Shimizu, Yukako Kinoshita, Keisuke Satoh. Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat. The journal of sexual medicine. 2011 Jun; 8(6):1638-49. doi: 10.1111/j.1743-6109.2011.02238.x. [PMID: 21477013]
  • Yonglei Lu, Haibo Bu, Lei Yang, Xiangri Li, Fei Li. [Comparasion of polysaccharides in parent root, daughter root and rootlet of Aconitum carmichaeli]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 May; 36(9):1154-7. doi: 10.4268/cjcmm20110909. [PMID: 21842639]
  • Hidemi Yoshida, Junsei Mimura, Tadaatsu Imaizumi, Tomoh Matsumiya, Akira Ishikawa, Norifumi Metoki, Kunikazu Tanji, Ken Ota, Ryo Hayakari, Kunio Kosaka, Ken Itoh, Kei Satoh. Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation. Neuroscience research. 2011 Apr; 69(4):291-8. doi: 10.1016/j.neures.2010.12.016. [PMID: 21241747]
  • Sachiko Yamaguchi, Mohamed Hamed Hussein, Ghada AbdEl-Hamid Daoud, Tatenobu Goto, Shin Kato, Hiroki Kakita, Haruo Mizuno, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Satoshi Suzuki, Takashi Hashimoto, Hajime Togari. Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis. The Tohoku journal of experimental medicine. 2011 04; 223(4):235-41. doi: 10.1620/tjem.223.235. [PMID: 21415574]
  • Xuebing Ding, Fengxin Zhu, Tang Li, Qiugen Zhou, Fan Fan Hou, Jing Nie. Numb protects renal proximal tubular cells from puromycin aminonucleoside-induced apoptosis through inhibiting Notch signaling pathway. International journal of biological sciences. 2011 Mar; 7(3):269-78. doi: 10.7150/ijbs.7.269. [PMID: 21448337]
  • Hai-Ping Wang, Xiao-Long Deng, Guang-Qian Li. [Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2011 Mar; 13(3):231-5. doi: . [PMID: 21426644]
  • Huaizhong Guo, Wenyue Jiang, Zhihao Du, Xiaomin Pang, Qiuling Wang. [Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of traditional Chinese medicine oligosaccharides by capillary zone electrophoresis]. Se pu = Chinese journal of chromatography. 2011 Mar; 29(3):254-8. doi: 10.3724/sp.j.1123.2011.00254. [PMID: 21657057]
  • Yuuko Tsukamoto, Shunya Takizawa, Wakoh Takahashi, Hiroyasu Mase, Hayato Miyachi, Toshio Miyata, Shigeharu Takagi. Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2011 Mar; 20(2):111-6. doi: 10.1016/j.jstrokecerebrovasdis.2009.11.008. [PMID: 20580255]
  • Yong-Gang Xia, Qiu-Hong Wang, Jun Liang, Bing-You Yang, Guo-Yu Li, Hai-Xue Kuang. Development and application of a rapid and efficient CZE method coupled with correction factors for determination of monosaccharide composition of acidic hetero-polysaccharides from Ephedra sinica. Phytochemical analysis : PCA. 2011 Mar; 22(2):103-11. doi: 10.1002/pca.1235. [PMID: 21204150]
  • John Sowell, Tim Wood. Towards a selected reaction monitoring mass spectrometry fingerprint approach for the screening of oligosaccharidoses. Analytica chimica acta. 2011 Feb; 686(1-2):102-6. doi: 10.1016/j.aca.2010.11.047. [PMID: 21237314]
  • Masanori Hirano. Clinical evaluation of liver injury in patients with acute ischemic brain stroke treated with edaravone. Hepatology research : the official journal of the Japan Society of Hepatology. 2011 Feb; 41(2):142-50. doi: 10.1111/j.1872-034x.2010.00751.x. [PMID: 21269384]
  • Souichi Ohta, Yasushi Iwashita, Ryosuke Kakinoki, Takashi Noguchi, Takashi Nakamura. Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats. Journal of neurotrauma. 2011 Feb; 28(2):289-98. doi: 10.1089/neu.2010.1477. [PMID: 21142437]
  • Rosamaria Lappano, Anna Grazia Recchia, Ernestina Marianna De Francesco, Tommaso Angelone, Maria Carmela Cerra, Didier Picard, Marcello Maggiolini. The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. PloS one. 2011 Jan; 6(1):e16631. doi: 10.1371/journal.pone.0016631. [PMID: 21304949]
  • Jade W Wei, Yining Huang, Ji-Guang Wang, Ming Liu, Lawrence K S Wong, Qifang Huang, Li'e Wu, Emma L Heeley, Hisatomi Arima, Craig S Anderson. Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register study. BMC neurology. 2011 Jan; 11(?):16. doi: 10.1186/1471-2377-11-16. [PMID: 21276264]
  • Guang-Qian Li, Hai-Ping Wang, Chun-Ming Jiang. [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2011 Jan; 49(1):53-9. doi: . [PMID: 21429313]
  • Satoru Nagatani, Takeshi Sudo, Yoshiaki Murakami, Kenichiro Uemura, Eiso Hiyama, Taijiro Sueda. Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells. Pancreas. 2011 Jan; 40(1):126-30. doi: 10.1097/mpa.0b013e3181f7e436. [PMID: 20938366]
  • Yanfei Xin, Sheng Zhang, Liqiang Gu, Shupeng Liu, Haiyan Gao, Zhenqiang You, Guoliang Zhou, Lei Wen, Jian Yu, Yaoxian Xuan. Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs. Biological & pharmaceutical bulletin. 2011; 34(10):1523-6. doi: 10.1248/bpb.34.1523. [PMID: 21963490]
  • Erkin Ozgiray, Yurdal Serarslan, Oktay Hasan Oztürk, Murat Altaş, Mustafa Aras, Sadık Söğüt, Taşkın Yurtseven, Ismail Oran, Mehmet Zileli. Protective effects of edaravone on experimental spinal cord injury in rats. Pediatric neurosurgery. 2011; 47(4):254-60. doi: 10.1159/000335400. [PMID: 22310070]
  • Zhihong Lin, Danni Zhu, Yongqing Yan, Boyang Yu, Qiujuan Wang, Pingniang Shen, Kefeng Ruan. An antioxidant phytotherapy to rescue neuronal oxidative stress. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):519517. doi: 10.1093/ecam/nen053. [PMID: 18955358]
  • Kundan Singh Bora, Anupam Sharma. Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):792167. doi: 10.1093/ecam/neq019. [PMID: 21785631]
  • Violeta Lukic-Panin, Kentaro Deguchi, Toru Yamashita, Jingwei Shang, Xuemei Zhang, FengFeng Tian, Ning Liu, Hiromi Kawai, Tohru Matsuura, Koji Abe. Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage. Current neurovascular research. 2010 Nov; 7(4):319-29. doi: 10.2174/156720210793180747. [PMID: 20854248]
  • Seyed Sajad Mohseni-Salehi-Monfared, Ebad Habibollahzadeh, Hooman Sadeghi, Maryam Baeeri, Mohammad Abdollahi. Efficacy of Setarud (IMOD™), a novel electromagnetically-treated multi-herbal compound, in mouse immunogenic type-1 diabetes. Archives of medical science : AMS. 2010 Oct; 6(5):663-9. doi: 10.5114/aoms.2010.17078. [PMID: 22419922]
  • Jun-ichi Oyama, Shinji Satoh, Nobuhiro Suematsu, Toshiaki Kadokami, Toyoki Maeda, Masahiro Sugano, Naoki Makino. Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo. Heart and vessels. 2010 Sep; 25(5):379-85. doi: 10.1007/s00380-009-1221-7. [PMID: 20676959]
  • Xiaoping Huang, Hua Tan, Beiyang Chen, Changqing Deng. [Influence of astragalosides and Panax notoginseng saponins compatibility on MMP-9 and TIMP-1 after cerebral ischemia-reperfusion in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Aug; 35(16):2187-91. doi: 10.4268/cjcmm20101634. [PMID: 21046759]
  • Timothy C Nielsen, Tomas Rozek, John J Hopwood, Maria Fuller. Determination of urinary oligosaccharides by high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry: Application to Hunter syndrome. Analytical biochemistry. 2010 Jul; 402(2):113-20. doi: 10.1016/j.ab.2010.04.002. [PMID: 20382108]
  • Yan Li, An-zhou Xia, Shu-hua Xing. Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Jul; 45(7):840-8. doi: NULL. [PMID: 20931780]
  • Yong-Hui Pan, Yong-Chen Wang, Li-Ming Zhang, Shu-Rong Duan. Protective effect of edaravone against PrP106-126-induced PC12 cell death. Journal of biochemical and molecular toxicology. 2010 Jul; 24(4):235-41. doi: 10.1002/jbt.20330. [PMID: 20806394]
  • Michelle Ierna, Alison Kerr, Hannah Scales, Kjetil Berge, Mikko Griinari. Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. BMC musculoskeletal disorders. 2010 Jun; 11(?):136. doi: 10.1186/1471-2474-11-136. [PMID: 20587038]
  • Hua Tan, Xiao-ping Huang, Chang-qing Deng. [Effects of astragaloside and Panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2010 May; 8(5):448-52. doi: 10.3736/jcim20100508. [PMID: 20456843]
  • Tim T Lögters, Jens Altrichter, Adnana Paunel-Görgülü, Martin Sager, Ingo Witte, Annina Ott, Sarah Sadek, Jessica Baltes, José Bitu-Moreno, Alberto Schek, Wolfram Müller, Teresa Jeri, Joachim Windolf, Martin Scholz. Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model. Journal of inflammation (London, England). 2010 Apr; 7(?):18. doi: 10.1186/1476-9255-7-18. [PMID: 20406470]
  • G Mariappan, B P Saha, N R Bhuyan, P R Bharti, Deepak Kumar. Evaluation of antioxidant potential of pyrazolone derivatives. Journal of advanced pharmaceutical technology & research. 2010 Apr; 1(2):260-7. doi: ". [PMID: 22247854]
  • Ling-Min Tian, Xue-Mei Qiu, Zi-Jing Pan, You Lü, Xing-Bin Yang. [Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Apr; 45(4):498-504. doi: ". [PMID: 21355218]
  • Tao Yang, Yan-Fei Mao, Shuang-Qing Liu, Jiong Hou, Zhi-Yang Cai, Jin-Yu Hu, Xin Ni, Xiao-Ming Deng, Xiao-Yan Zhu. Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. European journal of pharmacology. 2010 Mar; 630(1-3):152-7. doi: 10.1016/j.ejphar.2009.12.025. [PMID: 20035747]
  • Chunyan Gao, Xiaorong Li, Yuhang Li, Lijuan Wang, Ming Xue. Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. The Journal of pharmacy and pharmacology. 2010 Mar; 62(3):360-7. doi: 10.1211/jpp.62.03.0011. [PMID: 20487220]
  • Hai-Ping Wang, Guang-Qian Li. [Protection of edaravone on neurons and its effects on the expression of interleukin-lbeta in juvenile rat hippocampus following status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2010 Mar; 12(3):205-10. doi: ". [PMID: 20350432]
  • Mayuko Tamamura, Motoaki Saito, Yukako Kinoshita, Shogo Shimizu, Itaru Satoh, Kohei Shomori, Fotios Dimitriadis, Keisuke Satoh. Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis. BJU international. 2010 Mar; 105(6):870-6. doi: 10.1111/j.1464-410x.2009.08798.x. [PMID: 19694712]
  • Giancarlo Aldini, Giulio Vistoli, Luca Regazzoni, Maria Carmela Benfatto, Ilaria Bettinelli, Marina Carini. Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms. Antioxidants & redox signaling. 2010 Mar; 12(3):381-92. doi: 10.1089/ars.2009.2814. [PMID: 19722825]
  • J Guan, S P Li. Discrimination of polysaccharides from traditional Chinese medicines using saccharide mapping--enzymatic digestion followed by chromatographic analysis. Journal of pharmaceutical and biomedical analysis. 2010 Feb; 51(3):590-8. doi: 10.1016/j.jpba.2009.09.026. [PMID: 19850432]
  • Mitsuhiro Yamamura, Yuji Miyamoto, Masataka Mitsuno, Hiroe Tanaka, Masaaki Ryomoto. Edaravone protects against tissue damage in the lung and kidney induced by myonephropathic metabolic syndrome. The International journal of angiology : official publication of the International College of Angiology, Inc. 2010; 19(1):e38-40. doi: 10.1055/s-0031-1278366. [PMID: 22477573]
  • Yoshinori Nakamura, Yoshihiro Yamada, Hideki Shimomura, Yasuhiro Nagayoshi, Kenichi Tsujita, Takuro Yamashita, Masaya Fukuda, Keisuke Ohba, Hisato Nako, Yuji Ogura, Tadasuke Chitose, Munetaka Yamaguchi, Takeshi Nagata, Hirofumi Soejima, Koichi Kaikita, Seigo Sugiyama, Hisao Ogawa. Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction. Journal of cardiology. 2009 Dec; 54(3):416-24. doi: 10.1016/j.jjcc.2009.07.001. [PMID: 19944317]
  • Tatsuki Itoh, Takao Satou, Shozo Nishida, Masahiro Tsubaki, Shigeo Hashimoto, Hiroyuki Ito. The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury. Neurotoxicity research. 2009 Nov; 16(4):378-89. doi: 10.1007/s12640-009-9081-6. [PMID: 19590930]
  • Shogo Shimizu, Motoaki Saito, Yukako Kinoshita, Emi Kazuyama, Mayuko Tamamura, Itaru Satoh, Keisuke Satoh. Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger. BJU international. 2009 Sep; 104(5):713-7. doi: 10.1111/j.1464-410x.2009.08471.x. [PMID: 19338546]
  • Fumiaki Oka, Hirosuke Fujisawa, Sadahiro Nomura, Koji Kajiwara, Shoichi Kato, Masami Fujii, Hiroshi Izuma, Kanako Uozumi, Toshikazu Gondo, Michiyasu Suzuki. Mechanistic insight into neurotoxicity of tissue plasminogen activator-induced thrombolysis products in a rat intraluminal middle cerebral artery occlusion model. Journal of neurotrauma. 2009 Sep; 26(9):1577-84. doi: 10.1089/neu.2008.0768. [PMID: 19275467]
  • Y Ueno, N Zhang, N Miyamoto, R Tanaka, N Hattori, T Urabe. Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model. Neuroscience. 2009 Aug; 162(2):317-27. doi: 10.1016/j.neuroscience.2009.04.065. [PMID: 19409967]
  • A Sonoda, N Nitta, A Seko, S Ohta, S Takemura, Y Miyagawa, M Takahashi, K Murata. Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model. The British journal of radiology. 2009 Aug; 82(981):711-5. doi: 10.1259/bjr/13797020. [PMID: 19221189]
  • Xue-Yuan Liu, Ling-Ling Yao, Yu-Juan Chen, Bei-Bei Tao, Yong-Chun Yu, Wei-Hong Bian, Jing Yu, Yong-Gang Wang. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells. Molecular and cellular biochemistry. 2009 Jul; 327(1-2):21-8. doi: 10.1007/s11010-009-0037-1. [PMID: 19224341]
  • Hitoshi Maekawa, Takeshi Matsunobu, Hitoshi Tsuda, Kaoru Onozato, Yukihiro Masuda, Tetsuya Tanabe, Akihiro Shiotani. Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig. Neurochemistry international. 2009 Jul; 54(8):513-8. doi: 10.1016/j.neuint.2009.02.011. [PMID: 19428796]
  • Kiyoshi Kikuchi, Ko-ichi Kawahara, Salunya Tancharoen, Fumiyo Matsuda, Yoko Morimoto, Takashi Ito, Kamal Krishna Biswas, Kazunori Takenouchi, Naoki Miura, Yoko Oyama, Yuko Nawa, Noboru Arimura, Masahiro Iwata, Yutaka Tajima, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Yoshihiro Yoshida, Teruto Hashiguchi, Ikuro Maruyama. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. The Journal of pharmacology and experimental therapeutics. 2009 Jun; 329(3):865-74. doi: 10.1124/jpet.108.149484. [PMID: 19293391]
  • Catherine N Hall, Robert G Keynes, John Garthwaite. Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain. The Biochemical journal. 2009 Apr; 419(2):411-8. doi: 10.1042/bj20082419. [PMID: 19152507]
  • Akira Hishida. Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone. Clinical and experimental nephrology. 2009 Apr; 13(2):118-122. doi: 10.1007/s10157-008-0108-8. [PMID: 19057980]
  • Irit Rubinstein, Zaid Abassi, Felix Milman, Elena Ovcharenko, Rymond Coleman, Joseph Winaver, Ori S Better. Hyperbaric oxygen treatment improves GFR in rats with ischaemia/reperfusion renal injury: a possible role for the antioxidant/oxidant balance in the ischaemic kidney. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Feb; 24(2):428-36. doi: 10.1093/ndt/gfn511. [PMID: 18799609]
  • Yorihiro Yamamoto, Makoto Yanagisawa, Nyou Wei Tak, Kazutoshi Watanabe, Chizuko Takahashi, Akio Fujisawa, Misato Kashiba, Masahiko Tanaka. Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion. Redox report : communications in free radical research. 2009; 14(6):251-8. doi: 10.1179/135100009x12525712409779. [PMID: 20003710]
  • Takehito Ogawa, Satoka Aoyagi, Takehiro Miyasaka, Kiyotaka Sakai. Fluorescence enhancement of fluorescein isothiocyanate-labeled protein a caused by affinity binding with immunoglobulin g in bovine plasma. Sensors (Basel, Switzerland). 2009; 9(10):8271-7. doi: 10.3390/s91008271. [PMID: 22408505]
  • Antonella Mandas, Eugenio Luigi Iorio, Maria Gabriella Congiu, Cinzia Balestrieri, Antonello Mereu, Daniela Cau, Sandra Dessì, Nicoletta Curreli. Oxidative imbalance in HIV-1 infected patients treated with antiretroviral therapy. Journal of biomedicine & biotechnology. 2009; 2009(?):749575. doi: 10.1155/2009/749575. [PMID: 19884983]
  • S Tajima, M Bando, Y Ishii, T Hosono, H Yamasawa, S Ohno, T Takada, E Suzuki, F Gejyo, Y Sugiyama. Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice. The European respiratory journal. 2008 Nov; 32(5):1337-43. doi: 10.1183/09031936.00164407. [PMID: 18614556]
  • Xue-jun Kang, Li-qin Chen, Yi-yun Zhang, Yang-wei Liu, Zhong-ze Gu. Performance of electrospun nanofibers for SPE of drugs from aqueous solutions. Journal of separation science. 2008 Oct; 31(18):3272-8. doi: 10.1002/jssc.200800285. [PMID: 18773420]
  • Masaki Fujita, Yuichi Mizuta, Satoshi Ikegame, Hiroshi Ouchi, Qing Ye, Eiji Harada, Ichiro Inoshima, Michihiro Yoshimi, Kentaro Watanabe, Yoichi Nakanishi. Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis. Pulmonary pharmacology & therapeutics. 2008 Oct; 21(5):805-11. doi: 10.1016/j.pupt.2008.06.006. [PMID: 18655842]
  • Xingbin Yang, Yan Zhao, Yun Ruan, Ying Yang. Development and application of a capillary electrophoretic method for the composition analysis of a typical heteropolysaccharide from Codonopsis pilosula NANNF. Biological & pharmaceutical bulletin. 2008 Oct; 31(10):1860-5. doi: 10.1248/bpb.31.1860. [PMID: 18827344]
  • Yong-ming Zhang, Yu Wang, Xiu-hua Liu, Da-wei Zhang. [Cardioprotective effect of edaravone pharmacological postconditioning on acute myocardial ischemia/reperfusion injury: experiment with rats]. Zhonghua yi xue za zhi. 2008 Sep; 88(36):2558-61. doi: NULL. [PMID: 19080651]
  • Shunji Tajima, Manabu Soda, Masashi Bando, Munehiro Enomoto, Hideaki Yamasawa, Shoji Ohno, Toshinori Takada, Eiichi Suzuki, Fumitake Gejyo, Yukihiko Sugiyama. Preventive effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced lung injury in mice. Respirology (Carlton, Vic.). 2008 Sep; 13(5):646-53. doi: 10.1111/j.1440-1843.2008.01322.x. [PMID: 18713088]
  • A Nakamura, Y Akamatsu, S Miyagi, T Fukumori, S Sekiguchi, S Satomi. A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors. Transplantation proceedings. 2008 Sep; 40(7):2171-4. doi: 10.1016/j.transproceed.2008.06.049. [PMID: 18790183]
  • Jin-zhi Xu, Bao-zhong Shen, Ye Li, Tong Zhang, Wan-hai Xu, Xiao-wei Liu, Hong-guang Lu. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chinese medical journal. 2008 Aug; 121(16):1583-7. doi: 10.1097/00029330-200808020-00016. [PMID: 18982873]
  • Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Araki. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). 2008 Jun; 115(6):831-42. doi: 10.1007/s00702-008-0019-6. [PMID: 18235988]
  • Ryohei Miyamoto, Shuichi Shimakawa, Shuhei Suzuki, Tohru Ogihara, Hiroshi Tamai. Edaravone prevents kainic acid-induced neuronal death. Brain research. 2008 May; 1209(?):85-91. doi: 10.1016/j.brainres.2008.02.064. [PMID: 18406401]
  • Ge Zhang, Qiu-ping Xu, Hai-ying Huang. [Protective effects of edaravone on renal ischemia-reperfusion injury in rats]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2008 05; 37(3):308-11. doi: 10.3785/j.issn.1008-9292.2008.03.017. [PMID: 18546537]
  • Geethalakshmi Radhakrishnan, Ryoko Suzuki, Hironori Maeda, Morio Yamamoto, Nobuyuki Hirose, Rajesh Katare Gopalrao, Gang-Hang Lee, Yoshihiro Hayashi, Parijatha Rao, Shiro Sasaguri. Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway. Circulation journal : official journal of the Japanese Circulation Society. 2008 May; 72(5):800-6. doi: 10.1253/circj.72.800. [PMID: 18441462]
  • Daisuke Fukudome, Maki Matsuda, Toshiyuki Kawasaki, Yukio Ago, Toshio Matsuda. The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice. European journal of pharmacology. 2008 Mar; 583(1):164-9. doi: 10.1016/j.ejphar.2008.01.033. [PMID: 18291360]
  • Yuko Izuhara, Masaomi Nangaku, Shunya Takizawa, Satoru Takahashi, Jing Shao, Hisashi Oishi, Hiroyuki Kobayashi, Charles van Ypersele de Strihou, Toshio Miyata. A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Feb; 23(2):497-509. doi: 10.1093/ndt/gfm601. [PMID: 17928329]
  • Koji Ito, Hisashi Ozasa, Yumi Noda, Shigeki Arii, Saburo Horikawa. Effects of free radical scavenger on acute liver injury induced by d-galactosamine and lipopolysaccharide in rats. Hepatology research : the official journal of the Japan Society of Hepatology. 2008; 38(2):194-201. doi: 10.1111/j.1872-034x.2007.00252.x. [PMID: 17727650]
  • Fernando P Secin. Importance and limits of ischemia in renal partial surgery: experimental and clinical research. Advances in urology. 2008; ?(?):102461. doi: 10.1155/2008/102461. [PMID: 18645616]
  • Akira Hishida. Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance. Clinical and experimental nephrology. 2007 Dec; 11(4):292-296. doi: 10.1007/s10157-007-0495-2. [PMID: 18085390]
  • Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, John D Schuetz, Takuro Niwa, Yuichi Sugiyama. Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one). Drug metabolism and disposition: the biological fate of chemicals. 2007 Nov; 35(11):2045-52. doi: 10.1124/dmd.107.016352. [PMID: 17682070]
  • Naomi Mizuno, Tsuyoshi Takahashi, Yumiko Iwase, Hiroyuki Kusuhara, Takuro Niwa, Yuichi Sugiyama. Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug metabolism and disposition: the biological fate of chemicals. 2007 Aug; 35(8):1429-34. doi: 10.1124/dmd.106.013912. [PMID: 17502342]
  • Anuj Kumar Saini, Arun Kumar H S, Shyam Sunder Sharma. Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy. European journal of pharmacology. 2007 Jul; 568(1-3):164-72. doi: 10.1016/j.ejphar.2007.04.016. [PMID: 17521626]
  • Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, Toshio Matsuda. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. The Journal of pharmacology and experimental therapeutics. 2007 Jul; 322(1):274-81. doi: 10.1124/jpet.106.119206. [PMID: 17429058]
  • Xingbin Yang, Yan Zhao, You Lv. Chemical composition and antioxidant activity of an acidic polysaccharide extracted from Cucurbita moschata Duchesne ex Poiret. Journal of agricultural and food chemistry. 2007 Jun; 55(12):4684-90. doi: 10.1021/jf070241r. [PMID: 17511465]
  • Masanori Abe, Kazo Kaizu, Koichi Matsumoto. A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2007 Jun; 11(3):235-40. doi: 10.1111/j.1744-9987.2007.00480.x. [PMID: 17498008]
  • Yasuhiro Kotani, Kozo Ishino, Satoru Osaki, Osami Honjo, Takanori Suezawa, Kazushige Kanki, Chikao Yutani, Shunji Sano. Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts. The Journal of thoracic and cardiovascular surgery. 2007 Jun; 133(6):1626-32. doi: 10.1016/j.jtcvs.2007.01.068. [PMID: 17532966]