DL-AP4 (BioDeep_00000819460)
代谢物信息卡片
2-Amino-4-phosphonobutyric acid
化学式: C4H10NO5P (183.029658)
中文名称: DL-2-氨基-4-磷丁酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CP(=O)(O)O)C(C(=O)O)N
InChI: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tanja Babic, Kirsteen N Browning, Yasunori Kawaguchi, Xiaorui Tang, R Alberto Travagli. Pancreatic insulin and exocrine secretion are under the modulatory control of distinct subpopulations of vagal motoneurones in the rat.
The Journal of physiology.
2012 Aug; 590(15):3611-22. doi:
10.1113/jphysiol.2012.234955. [PMID: 22711959] - Pasano Bojang, Ronald G Gregg. Topological analysis of small leucine-rich repeat proteoglycan nyctalopin.
PloS one.
2012; 7(4):e33137. doi:
10.1371/journal.pone.0033137. [PMID: 22485138] - Junzo Kinoshita, Noriaki Iwata, Mitsuhiro Ohba, Tomofumi Kimotsuki, Mitsuya Yasuda. Mechanism of voriconazole-induced transient visual disturbance: reversible dysfunction of retinal ON-bipolar cells in monkeys.
Investigative ophthalmology & visual science.
2011 Jul; 52(8):5058-63. doi:
10.1167/iovs.11-7183. [PMID: 21436272] - Yaling Zhang, Yanqiu Bai. [Development of a functional cell-based HTS assay for the identification mGluR4 modulators].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2009 Mar; 25(3):457-63. doi:
NULL. [PMID: 19621591] - Victoria F Safiulina, Giorgia Fattorini, Fiorenzo Conti, Enrico Cherubini. GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Jan; 26(2):597-608. doi:
10.1523/jneurosci.4493-05.2006. [PMID: 16407558] - Erica Rosemond, Minghua Wang, Yi Yao, Laura Storjohann, Thomas Stormann, Edwin C Johnson, David R Hampson. Molecular basis for the differential agonist affinities of group III metabotropic glutamate receptors.
Molecular pharmacology.
2004 Oct; 66(4):834-42. doi:
10.1124/mol.104.002956. [PMID: 15231870] - Rick B Meeker. Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.
Pharmacology, biochemistry, and behavior.
2002 Sep; 73(2):475-84. doi:
10.1016/s0091-3057(02)00836-5. [PMID: 12117603] - K Nakashima, H Katsukawa, K Sasamoto, Y Ninomiya. Behavioral taste similarities and differences among monosodium L-glutamate and glutamate receptor agonists in C57BL mice.
Journal of nutritional science and vitaminology.
2001 Apr; 47(2):161-6. doi:
10.3177/jnsv.47.161. [PMID: 11508708] - A P Kozikowski, D Steensma, G L Araldi, W Tückmantel, S Wang, S Pshenichkin, E Surina, J T Wroblewski. Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Journal of medicinal chemistry.
1998 May; 41(10):1641-50. doi:
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The Journal of biological chemistry.
1997 Dec; 272(52):33100-4. doi:
10.1074/jbc.272.52.33100. [PMID: 9407094] - L Eriksen, C Thomsen. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.
British journal of pharmacology.
1995 Dec; 116(8):3279-87. doi:
10.1111/j.1476-5381.1995.tb15136.x. [PMID: 8719808] - P A Johansen, L A Chase, A D Sinor, J F Koerner, R L Johnson, M B Robinson. Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats.
Molecular pharmacology.
1995 Jul; 48(1):140-9. doi:
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Neuroreport.
1994 Dec; 5(18):2417-20. doi:
10.1097/00001756-199412000-00003. [PMID: 7696571] - L Prézeau, J Carrette, B Helpap, K Curry, J P Pin, J Bockaert. Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.
Molecular pharmacology.
1994 Apr; 45(4):570-7. doi:
. [PMID: 8183235] - J A Saugstad, J M Kinzie, E R Mulvihill, T P Segerson, G L Westbrook. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.
Molecular pharmacology.
1994 Mar; 45(3):367-72. doi:
NULL. [PMID: 8145723] - C Thomsen, E R Mulvihill, B Haldeman, D S Pickering, D R Hampson, P D Suzdak. A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
Brain research.
1993 Aug; 619(1-2):22-8. doi:
10.1016/0006-8993(93)91592-g. [PMID: 7690672] - C Thomsen, P Kristensen, E Mulvihill, B Haldeman, P D Suzdak. L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase.
European journal of pharmacology.
1992 Nov; 227(3):361-2. doi:
10.1016/0922-4106(92)90018-q. [PMID: 1361913] - E M Lieberman, E Sanzenbacher. Mechanisms of glutamate activation of axon-to-Schwann cell signaling in the squid.
Neuroscience.
1992; 47(4):931-9. doi:
10.1016/0306-4522(92)90041-y. [PMID: 1349735] - E E Mena, M J Pagnozzi, M F Gullak. Characterization of L-glutamate binding sites in rat spinal cord synaptic membranes: evidence for multiple chloride ion-dependent sites.
Journal of neurochemistry.
1986 Oct; 47(4):1052-60. doi:
10.1111/j.1471-4159.1986.tb00719.x. [PMID: 2875127] - S L Crooks, M B Robinson, J F Koerner, R L Johnson. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding.
Journal of medicinal chemistry.
1986 Oct; 29(10):1988-95. doi:
10.1021/jm00160a031. [PMID: 3020251] - R J Bridges, T J Hearn, D T Monaghan, C W Cotman. A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain.
Brain research.
1986 Jun; 375(1):204-9. doi:
10.1016/0006-8993(86)90977-7. [PMID: 3013370] - G E Fagg, T H Lanthorn. Cl-/Ca2+-dependent L-glutamate binding sites do not correspond to 2-amino-4-phosphonobutanoate-sensitive excitatory amino acid receptors.
British journal of pharmacology.
1985 Nov; 86(3):743-51. doi:
10.1111/j.1476-5381.1985.tb08954.x. [PMID: 2998527] - M B Robinson, S L Crooks, R L Johnson, J F Koerner. Displacement of DL-[3H]-2-amino-4-phosphonobutanoic acid ( [3H]APB) binding with methyl-substituted APB analogues and glutamate agonists.
Biochemistry.
1985 May; 24(10):2401-5. doi:
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