Maribavir (BioDeep_00000817680)
代谢物信息卡片
Maribavir
化学式: C15H19Cl2N3O4 (375.0753)
中文名称: BENZIMIDAVIR 苯并咪唑核苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
InChI: InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D04859
- PubChem: 471161
- DrugBank: DB06234
- ChEMBL: CHEMBL515408
- CAS: 176161-24-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kefeng Sun, Devin Welty. Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches.
Drug metabolism and disposition: the biological fate of chemicals.
2021 11; 49(11):1025-1037. doi:
10.1124/dmd.121.000493. [PMID: 34462268] - Marta Santos Bravo, Nicolas Plault, Sonsoles Sánchez Palomino, María Mar Mosquera Gutierrez, Francesc Fernández Avilés, María Suarez Lledo, Nuria Sabé Fernández, Montserrat Rovira, Sophie Alain, M Ángeles Marcos Maeso. Phenotype and Genotype Study of Novel C480F Maribavir-Ganciclovir Cross-Resistance Mutation Detected in Hematopoietic Stem Cell and Solid Organ Transplant Recipients.
The Journal of infectious diseases.
2021 09; 224(6):1024-1028. doi:
10.1093/infdis/jiab029. [PMID: 33475730] - Katarina Ilic, Ivy Song, Jingyang Wu, Patrick Martin. Evaluation of the Effect of Maribavir on Cardiac Repolarization in Healthy Participants: Thorough QT/QTc Study.
Clinical and translational science.
2020 11; 13(6):1260-1270. doi:
10.1111/cts.12814. [PMID: 32506738] - Ivy H Song, Katarina Ilic, Joseph Murphy, Kenneth Lasseter, Patrick Martin. Effects of Maribavir on P-Glycoprotein and CYP2D6 in Healthy Volunteers.
Journal of clinical pharmacology.
2020 01; 60(1):96-106. doi:
10.1002/jcph.1504. [PMID: 31385617] - Valentine Faure Bardon, Gilles Peytavin, Minh Patrick Lê, Tiffany Guilleminot, Elisabeth Elefant, Julien Stirnemann, Marianne Leruez-Ville, Yves Ville. Placental transfer of Letermovir & Maribavir in the ex vivo human cotyledon perfusion model. New perspectives for in utero treatment of congenital cytomegalovirus infection.
PloS one.
2020; 15(4):e0232140. doi:
10.1371/journal.pone.0232140. [PMID: 32353010] - Sunwen Chou, Jingyang Wu, Kening Song, Tien Bo. Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection.
Antiviral research.
2019 12; 172(?):104616. doi:
10.1016/j.antiviral.2019.104616. [PMID: 31568799] - Johan Maertens, Catherine Cordonnier, Peter Jaksch, Xavier Poiré, Marc Uknis, Jingyang Wu, Anna Wijatyk, Faouzi Saliba, Oliver Witzke, Stephen Villano. Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation.
The New England journal of medicine.
2019 09; 381(12):1136-1147. doi:
10.1056/nejmoa1714656. [PMID: 31532960] - Genovefa A Papanicolaou, Fernanda P Silveira, Amelia A Langston, Marcus R Pereira, Robin K Avery, Marc Uknis, Anna Wijatyk, Jingyang Wu, Michael Boeckh, Francisco M Marty, Stephen Villano. Maribavir for Refractory or Resistant Cytomegalovirus Infections in Hematopoietic-cell or Solid-organ Transplant Recipients: A Randomized, Dose-ranging, Double-blind, Phase 2 Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 04; 68(8):1255-1264. doi:
10.1093/cid/ciy706. [PMID: 30329038] - Marie Clémence Verdier, Solène Patrat-Delon, Florian Lemaitre, Matthieu Revest, Joseph Rivalan, Christian Michelet, Eric Bellissant. Suspicion of interaction between maribavir and everolimus in a renal transplant recipient.
Transplantation.
2014 Aug; 98(3):e20-1. doi:
10.1097/tp.0000000000000275. [PMID: 25089341] - Sunwen Chou, Morgan Hakki, Stephen Villano. Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo.
Antiviral research.
2012 Aug; 95(2):88-92. doi:
10.1016/j.antiviral.2012.05.013. [PMID: 22664236] - Francisco M Marty, Per Ljungman, Genovefa A Papanicolaou, Drew J Winston, Roy F Chemaly, Lynne Strasfeld, Jo-Anne H Young, Tulio Rodriguez, Johan Maertens, Michael Schmitt, Hermann Einsele, Augustin Ferrant, Jeffrey H Lipton, Stephen A Villano, Hongzi Chen, Michael Boeckh. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial.
The Lancet. Infectious diseases.
2011 Apr; 11(4):284-92. doi:
10.1016/s1473-3099(11)70024-x. [PMID: 21414843] - R K Avery, F M Marty, L Strasfeld, I Lee, A Arrieta, S Chou, W Tatarowicz, S Villano. Oral maribavir for treatment of refractory or resistant cytomegalovirus infections in transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2010 Dec; 12(6):489-96. doi:
10.1111/j.1399-3062.2010.00550.x. [PMID: 20682012] - M D Pescovitz, R Bloom, J Pirsch, J Johnson, S Gelone, S A Villano. A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2009 Oct; 9(10):2324-30. doi:
10.1111/j.1600-6143.2009.02768.x. [PMID: 19663892] - Drew J Winston, Jo-Anne H Young, Vinod Pullarkat, Genovefa A Papanicolaou, Ravi Vij, Estil Vance, George J Alangaden, Roy F Chemaly, Finn Petersen, Nelson Chao, Jared Klein, Kellie Sprague, Stephen A Villano, Michael Boeckh. Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study.
Blood.
2008 Jun; 111(11):5403-10. doi:
10.1182/blood-2007-11-121558. [PMID: 18285548] - Suzanne K Swan, William B Smith, Thomas C Marbury, Mary Schumacher, Carolyn Dougherty, Bruce A Mico, Stephen A Villano. Pharmacokinetics of maribavir, a novel oral anticytomegalovirus agent, in subjects with varying degrees of renal impairment.
Journal of clinical pharmacology.
2007 Feb; 47(2):209-17. doi:
10.1177/0091270006296765. [PMID: 17244772] - Earl R Kern, Caroll B Hartline, Rachel J Rybak, John C Drach, Leroy B Townsend, Karen K Biron, Deborah J Bidanset. Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.
Antimicrobial agents and chemotherapy.
2004 May; 48(5):1749-55. doi:
10.1128/aac.48.5.1749-1755.2004. [PMID: 15105130] - Laurene H Wang, Richard W Peck, Yin Yin, Jane Allanson, Rebecca Wiggs, Mary Beth Wire. Phase I safety and pharmacokinetic trials of 1263W94, a novel oral anti-human cytomegalovirus agent, in healthy and human immunodeficiency virus-infected subjects.
Antimicrobial agents and chemotherapy.
2003 Apr; 47(4):1334-42. doi:
10.1128/aac.47.4.1334-1342.2003. [PMID: 12654667] - Jacob P Lalezari, Judith A Aberg, Laurene H Wang, Mary Beth Wire, Richard Miner, Wendy Snowden, Christine L Talarico, Shuching Shaw, Mark A Jacobson, W Lawrence Drew. Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding.
Antimicrobial agents and chemotherapy.
2002 Sep; 46(9):2969-76. doi:
10.1128/aac.46.9.2969-2976.2002. [PMID: 12183255] - George W Koszalka, Nelson W Johnson, Steven S Good, Leslie Boyd, Stanley C Chamberlain, Leroy B Townsend, John C Drach, Karen K Biron. Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.
Antimicrobial agents and chemotherapy.
2002 Aug; 46(8):2373-80. doi:
10.1128/aac.46.8.2373-2380.2002. [PMID: 12121907]
