Atevirdine (BioDeep_00000817679)
代谢物信息卡片
化学式: C21H25N5O2 (379.200815)
中文名称: 阿替韦啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)OC
InChI: InChI=1S/C21H25N5O2/c1-3-22-18-5-4-8-23-20(18)25-9-11-26(12-10-25)21(27)19-14-15-13-16(28-2)6-7-17(15)24-19/h4-8,13-14,22,24H,3,9-12H2,1-2H3
描述信息
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bruce J Brew, Mark Halman, Jose Catalan, Ned Sacktor, Richard W Price, Steve Brown, Hamp Atkinson, David B Clifford, David Simpson, Gabriel Torres, Colin Hall, Christopher Power, Karen Marder, Justin C Mc Arthur, William Symonds, Carmen Romero. Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial.
PLoS clinical trials.
2007 Mar; 2(3):e13. doi:
10.1371/journal.pctr.0020013. [PMID: 17401456] - G D Morse, R C Reichman, M A Fischl, M Para, J Leedom, W Powderly, L M Demeter, L Resnick, Y Bassiakos, J Timpone, S Cox, D Batts. Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG 187 and 199 study teams.
Antiviral research.
2000 Jan; 45(1):47-58. doi:
10.1016/s0166-3542(99)00073-x. [PMID: 10774589] - M Chang, V K Sood, G J Wilson, D A Kloosterman, P E Sanders, M R Schuette, R W Judy, R L Voorman, S M Maio, J G Slatter. Absorption, distribution, metabolism, and excretion of atevirdine in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
1998 Oct; 26(10):1008-18. doi:
NULL. [PMID: 9763407] - L M Demeter, P M Meehan, G Morse, M A Fischl, M Para, W Powderly, J Leedom, J Holden-Wiltse, C Greisberger, K Wood, J Timpone, L K Wathen, T Nevin, L Resnick, D H Batts, R C Reichman. Phase I study of atevirdine mesylate (U-87201E) monotherapy in HIV-1-infected patients.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.
1998 Oct; 19(2):135-44. doi:
10.1097/00042560-199810010-00006. [PMID: 9768622] - G D Morse, M A Fischl, M J Shelton, M T Borin, M R Driver, M DeRemer, K Lee, C P Wajszczuk. Didanosine reduces atevirdine absorption in subjects with human immunodeficiency virus infections.
Antimicrobial agents and chemotherapy.
1996 Mar; 40(3):767-71. doi:
10.1128/aac.40.3.767. [PMID: 8851608] - A M Been-Tiktak, H M Vrehen, M M Schneider, M van der Feltz, T Branger, P Ward, S R Cox, J D Harry, J C Borleffs. Safety, tolerance, and pharmacokinetics of atevirdine mesylate (U-87201E) in asymptomatic human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy.
1995 Mar; 39(3):602-7. doi:
10.1128/aac.39.3.602. [PMID: 7793859] - L M Rosser, A M O'Donnell, K M Lee, G D Morse. In vitro protein-binding characteristics of atevirdine and its N-dealkylated metabolite.
Antiviral research.
1994 Dec; 25(3-4):193-200. doi:
10.1016/0166-3542(94)90003-5. [PMID: 7535991]