Pirmenol (BioDeep_00000817635)
代谢物信息卡片
Pirmenol
化学式: C22H30N2O (338.235801)
中文名称: 吡美诺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCCC(N1CCCC(C2=CC=CC=C2)(C3=CC=CC=N3)O)C
InChI: InChI=1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22?
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135436
- KEGGdrug: D08394
- PubChem: 65502
- ChEMBL: CHEMBL2110988
- CAS: 129885-18-3
- CAS: 129885-19-4
- CAS: 68252-19-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Junji Asano, Masakazu Kojima, Yuichi Sekizawa, Toshiharu Ooe, Noriyuki Miyamoto, Yoshiyuki Suzuki, Tetsuro Kohya, Michiya Kobayashi, Hiroshi Saitoh. [An approach to complete the manual for determination of serum pirmenol levels].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2003 Nov; 123(11):981-6. doi:
10.1248/yakushi.123.981. [PMID: 14631760] - Igor Sutovsky, Takao Katoh, Hideo Takayama, Tadaaki Ono, Teruo Takano. Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples.
Circulation journal : official journal of the Japanese Circulation Society.
2003 Mar; 67(3):195-8. doi:
10.1253/circj.67.195. [PMID: 12604865] - H Abe, T Numata, H Hanada, K Kohshi, Y Nakashima. Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.
Journal of UOEH.
1998 Dec; 20(4):339-43. doi:
10.7888/juoeh.20.339. [PMID: 9883483] - M Nakagomi, E Suzuki, M Kitashima, S Iida, M Abe, Y Matsuki, K Kaneko. Sex difference in the metabolism of pirmenol in rats.
Biological & pharmaceutical bulletin.
1997 Dec; 20(12):1279-84. doi:
10.1248/bpb.20.1279. [PMID: 9448104] - N Janiczek, D E Smith, T Chang, A J Sedman, K A Stringer. Pharmacokinetics of pirmenol enantiomers and pharmacodynamics of pirmenol racemate in patients with premature ventricular contractions.
Journal of clinical pharmacology.
1997 Jun; 37(6):502-13. doi:
10.1002/j.1552-4604.1997.tb04328.x. [PMID: 9208357] - N Janiczek, D E Smith, T Chang, A Ventura, T E Mertz. Pharmacokinetics and pharmacodynamics of pirmenol enantiomers in coronary artery ligated dogs.
Journal of pharmaceutical sciences.
1997 Apr; 86(4):443-9. doi:
10.1021/js960369f. [PMID: 9109046] - H Atarashi, A Kuruma, T Ino, Y Hirayama, H Saitoh, H Hayakawa. Clinical effects and pharmacokinetics of a single oral dose of pirmenol hydrochloride.
Journal of cardiovascular pharmacology.
1996 Apr; 27(4):556-62. doi:
10.1097/00005344-199604000-00015. [PMID: 8847873] - K A Stringer, M E Lebsack, A B Cetnarowski-Cropp, A L Goldfarb, L L Radulovic, H N Bockbrader, T Chang, A J Sedman. Effect of cimetidine administration on the pharmacokinetics of pirmenol.
Journal of clinical pharmacology.
1992 Jan; 32(1):91-4. doi:
10.1002/j.1552-4604.1992.tb03794.x. [PMID: 1740542] - V Ciaravino, M L Kropko, G Krishna, D K Monteith, J C Theiss. Genotoxicity assessment of pirmenol, a new antiarrhythmic drug.
Mutation research.
1992; 280(3):205-14. doi:
10.1016/0165-1218(92)90050-a. [PMID: 1381484] - N Janiczek, H N Bockbrader, T Chang, G L Amidon, D E Smith. Stereoselective high-performance liquid chromatographic assay for pirmenol enantiomers in dog plasma.
Journal of chromatography.
1991 Nov; 571(1-2):179-87. doi:
10.1016/0378-4347(91)80444-h. [PMID: 1810946] - K A Stringer, D F Switzer, R Abadier, M E Lebsack, A Sedman, M Chrymko. The effect of pirmenol administration on the anti-coagulant activity of warfarin.
Journal of clinical pharmacology.
1991 Jul; 31(7):607-10. doi:
10.1002/j.1552-4604.1991.tb03745.x. [PMID: 1894756] - G L Hoyer. Pirmenol determination by high-performance liquid chromatography.
Journal of chromatography.
1991 Apr; 565(1-2):497-503. doi:
10.1016/0378-4347(91)80416-a. [PMID: 1874899] - J Nitta, A Nogami, K Aonuma, H Akimoto, Y H Chung, A Takahashi, Y Iesaka, F Marumo, M Hiraoka. Effects of pirmenol on electrical induction of sustained ventricular tachycardia in a seven-day-old canine myocardial infarction.
Journal of cardiovascular pharmacology.
1991 Jan; 17(1):54-60. doi:
10.1097/00005344-199101000-00008. [PMID: 1708056] - K A Stringer, A B Cetnarowski, A Goldfarb, M E Lebsack, T Chang, A J Sedman. Enhanced pirmenol elimination by rifampin.
Journal of clinical pharmacology.
1988 Dec; 28(12):1094-7. doi:
10.1002/j.1552-4604.1988.tb05721.x. [PMID: 3243925] - K Hashimoto, K Watanabe, A Sugiyama. Antiarrhythmic plasma concentrations of pirmenol on canine ventricular arrhythmias.
Japanese journal of pharmacology.
1988 Oct; 48(2):273-82. doi:
10.1254/jjp.48.273. [PMID: 3210450] - D C Garg, N S Jallad, S Singh, K F Ng, D J Weidler. Efficacy and pharmacokinetics of oral pirmenol, a new antiarrhythmic drug.
Journal of clinical pharmacology.
1988 Sep; 28(9):812-7. doi:
10.1002/j.1552-4604.1988.tb03221.x. [PMID: 2466056] - B F Johnson, C I Haffajee, T Woodman, K L Sloan. The relation of the kinetics of pirmenol to its antiarrhythmic efficacy.
Journal of clinical pharmacology.
1988 May; 28(5):401-5. doi:
10.1002/j.1552-4604.1988.tb05748.x. [PMID: 3392237] - K G Morris, H R Phillips. Hemodynamic effects of intravenous pirmenol.
Angiology.
1988 Mar; 39(3 Pt 2):321-6. doi:
NULL. [PMID: 3354931] - M J Reiter. Clinical pharmacology and pharmacokinetics of pirmenol.
Angiology.
1988 Mar; 39(3 Pt 2):293-8. doi:
NULL. [PMID: 3281518] - H R Kaplan, T E Mertz, T J Steffe. Pirmenol: preclinical pharmacology.
Angiology.
1988 Mar; 39(3 Pt 2):281-92. doi:
NULL. [PMID: 3281517] - K A Ellenbogen, S F Roark, A L Sintetos, M S Smith, E A McCarthy, W M Smith, R E Kates, E L Pritchett. Pharmacodynamics and pharmacokinetics of oral pirmenol.
Clinical pharmacology and therapeutics.
1987 Oct; 42(4):405-10. doi:
10.1038/clpt.1987.170. [PMID: 3665339] - T Chang. Preclinical and clinical pharmacokinetics of pirmenol.
The American journal of cardiology.
1987 Jun; 59(16):15H-19H. doi:
10.1016/0002-9149(87)90139-1. [PMID: 2438922] - M S Nieminen, L Toivonen, V Manninen, H Frick. Hemodynamic effects of pirmenol and lidocaine: a placebo-controlled, double-blind, comparative study.
The American journal of cardiology.
1987 Jun; 59(16):27H-32H. doi:
10.1016/0002-9149(87)90141-x. [PMID: 3296728] - H R Kaplan, T E Mertz, T J Steffe. Preclinical pharmacology of pirmenol.
The American journal of cardiology.
1987 Jun; 59(16):2H-9H. doi:
10.1016/0002-9149(87)90137-8. [PMID: 3591710] - L B Liem, D A Clay, M R Franz, C D Swerdlow. Electrophysiology and antiarrhythmic efficacy of intravenous pirmenol in patients with sustained ventricular tachyarrhythmias.
American heart journal.
1987 Jun; 113(6):1390-6. doi:
10.1016/0002-8703(87)90653-3. [PMID: 3591608] - B F Johnson, V Shekar, T Woodman, A T Canada. Salivary concentrations of pirmenol as a possible cause of unpleasant taste.
British journal of clinical pharmacology.
1986 Nov; 22(5):613-5. doi:
10.1111/j.1365-2125.1986.tb02944.x. [PMID: 2431704] - M S Nieminen, L K Toivonen, V Manninen, M H Frick. Acute haemodynamic effects of the antiarrhythmic agent pirmenol in cardiac patients: a comparison with lidocaine.
European heart journal.
1986 Feb; 7(2):150-7. doi:
10.1093/oxfordjournals.eurheartj.a062038. [PMID: 3516703] - L K Toivonen, M S Nieminen, V Manninen, M H Frick. Antiarrhythmic efficacy of pirmenol in the treatment of premature ventricular complexes.
European heart journal.
1985 Sep; 6(9):737-44. doi:
10.1093/oxfordjournals.eurheartj.a061934. [PMID: 2416566] - A M Gillis, R E Kates. Clinical pharmacokinetics of the newer antiarrhythmic agents.
Clinical pharmacokinetics.
1984 Sep; 9(5):375-403. doi:
10.2165/00003088-198409050-00001. [PMID: 6437721] - E L Johnson, L A Pachla. Improved liquid chromatographic assay for the analysis of pirmenol in plasma and urine.
Journal of pharmaceutical sciences.
1984 Jun; 73(6):754-6. doi:
10.1002/jps.2600730612. [PMID: 6737258] - J L Anderson, J R Lutz, J M Nappi. Pirmenol for control of ventricular arrhythmias: oral dose-ranging and short-term maintenance study.
The American journal of cardiology.
1984 Feb; 53(4):522-7. doi:
10.1016/0002-9149(84)90024-9. [PMID: 6198894] - M J Reiter, S C Hammill, D G Shand, C Verghese, E McCarthy, E L Pritchett. Efficacy, safety, and pharmacokinetics of a concentration-maintaining regimen of intravenous pirmenol.
The American journal of cardiology.
1983 Jul; 52(1):83-7. doi:
10.1016/0002-9149(83)90074-7. [PMID: 6858934] - T G Lee, A D Goldberg, T Chang, M T Serkland, G J Yakatan, E L Johnson, J G Toole, S Goldstein. Pharmacokinetics and efficacy of pirmenol hydrochloride in the treatment of ventricular dysrhythmia.
Journal of cardiovascular pharmacology.
1983 Jul; 5(4):632-7. doi:
10.1097/00005344-198307000-00019. [PMID: 6193362] - S W Sanders, J M Nappi, R L Foltz, J R Lutz, J L Anderson. Disposition of intravenous pirmenol.
Journal of clinical pharmacology.
1983 Feb; 23(2-3):113-22. doi:
10.1002/j.1552-4604.1983.tb02713.x. [PMID: 6853743] - S C Hammill, D G Shand, F E Harrell, J M Zimmerman, M J Reiter, C Verghese, E L Pritchett. Pirmenol kinetics and effective oral dose.
Clinical pharmacology and therapeutics.
1982 Dec; 32(6):686-91. doi:
10.1038/clpt.1982.224. [PMID: 7140134] - T E Mertz, H R Kaplan. Pirmenol hydrochloride (CI-845) and reference antiarrhythmic agents: effects on early ventricular arrhythmias after acute coronary artery ligation in anesthetized rats.
The Journal of pharmacology and experimental therapeutics.
1982 Nov; 223(2):580-6. doi:
NULL. [PMID: 7131307] - H R Phillips, R S Stack, D D Davis, K G Morris, K L Lee, D G Shand, E L Pritchett. Hemodynamic effects of the antiarrhythmic drug pirmenol.
Clinical pharmacology and therapeutics.
1982 Aug; 32(2):235-9. doi:
10.1038/clpt.1982.153. [PMID: 7094511] - S C Hammill, D G Shand, P A Routledge, M C Hindman, J T Baker, E L Pritchett. Pirmenol, a new antiarrhythmic agent: initial study of efficacy, safety and pharmacokinetics.
Circulation.
1982 Feb; 65(2):369-75. doi:
10.1161/01.cir.65.2.369. [PMID: 7053896] - T E Mertz, T J Steffe. Pirmenol hydrochloride (CI-845): antiarrhythmic profile in coronary artery ligated conscious dogs.
Journal of cardiovascular pharmacology.
1980 Sep; 2(5):527-41. doi:
10.1097/00005344-198009000-00004. [PMID: 6157947] - R F Reder, P Danilo, M R Rosen. Effects of pirmenol HCl on electrophysiologic properties of cardiac Purkinje fibers.
European journal of pharmacology.
1980 Feb; 61(4):321-33. doi:
10.1016/0014-2999(80)90071-0. [PMID: 7371711]